Ultrasensitive determination of insulin by an unlabelled fluorescent aptasensor based on FeO@SiO and an oxadiazole compound with AIEE activity.

A novel fluorescent organic compound, OBEI, exhibiting aggregation-induced emission enhancement (AIEE) characteristics was successfully synthesized. Leveraging its unique photophysical properties, a label-free fluorescent aptasensor was developed using OBEI as the fluorescent reporter and FeO@SiO magnetic beads as the adsorption substrate. The sensing mechanism relies on the formation of an INS-Apt/OBEI complex through electrostatic and hydrophobic interactions between OBEI and the insulin-specific aptamer (INS-Apt).

Synthesis of cuprous iodide coordination polymers using pyridine carbohydrazide as ligands and their application in drug detection.

Two coordination polymers named α-Copper(I) Iodide-3-pyridinecarbohydrazide (α-CuI-m-iah) and β-Copper(I) Iodide-3-pyridinecarbohydrazide (β-CuI-m-iah) with varying crystal structures and tunable emission wavelengths were obtained by adjusting the ligand (3-pyridinecarbohydrazide, m-iah) -to-metal clusters (CuI) ratio during the preparation process. α-CuI-m-iah was employed for the fluorescence detection of pesticide residues flumetralin, which demonstrated high selectivity, strong resistance to interference, and a wide linear detection range (1 μM-600 μM). It also exhibited a low detection limit (0.

The Hormesis effect of cadmium on Panax notoginseng and corresponding impact on the rhizosphere microorganism.

Panax notoginseng is a famous Chinese traditional medicinal. However, soil cadmium pollution seriously affected the yield and quality of notoginseng. This study systematically investigated the effects of soil Cd stress at different concentrations on the growth of one-year-old notoginseng.

Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral sp. and Sponge sp.

A chemical investigation of the soft coral sp. and the sponge sp. from the South China Sea led to the isolation of five steroids, including two new compounds ( and ) and one known natural product ().

Sensitive and selective colorimetric detection of thiophanate-methyl based on a novel Ru-FeO nanozyme with enhanced peroxidase-like activity.

A novel Ru-FeO nanozyme with enhanced peroxidase-like (POD-like) activity was synthesized through a hydrothermal method. Ru-FeO nanozyme was effectively utilized for the detection of thiophanate-methyl (TM) using a colorimetric technique. The POD-like activity of Ru-FeO was found to be superior compared to FeO, Rh-FeO, and Pd-FeO.

Cembranoid Diterpenes from South China Sea Soft Coral .

Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A-E (-), were isolated from the soft coral , along with five previously reported compounds (-). The structures and absolute configuration for new compounds - were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations.

Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect.

In this study, a novel label-free fluorescent aptasensor with an aggregation-induced emission enhancement effect was developed and applied for the detection of carcinoembryonic antigen (CEA). The sensor has a simple detection mechanism, easy operation, high sensitivity (with low limit of detection of 1 pg mL), good selectivity, and wide linear range (0.003-10 ng mL).

Novel Bioactive Natural Products from Marine-Derived Fungi: A Review (2021-2023).

Marine-derived fungi are productive sources of structurally unique and diverse bioactive secondary metabolites, representing a hot topic in natural product research. This review describes structural diversity, bioactivities and statistical research of 452 new natural products from marine-derived fungi covering 2021 to 2023. Sediments are the main sources of marine-derived fungi for producing nearly 56% new natural products.

Ultrasensitive Detection of Prostate Specific Antigen by an Unlabeled Fluorescence Aptasensor Based on the AIE Effect.

The accurate and sensitive detection of prostate specific antigen (PSA) is vital for the early diagnosis and treatment of prostate cancer. To this end, an unlabeled fluorescent aptasensor was constructed by using a novel Compound B {1,1'-(1,4-phenylene) bis(3-ethyl-1H-imidazol-3-ium) iodide} with aggregation-induced emission (AIE) activity as a fluorescence signal and NH-FeO particle as an adsorption platform. Compound B could combine with prostate specific antigen aptamers (PSA-Apt) to form a PSA-Apt/B complex, which further generated the AIE effect.

Molybdesum selenide-based platelet-rich plasma containing carboxymethyl chitosan/polyvinyl pyrrolidone composite antioxidant hydrogels dressing promotes the wound healing.

Excess free radicals at the wound site can cause an inflammatory response, which is not conducive to wound healing. Hydrogels with antioxidant properties can prevent inflammatory storms by scavenging free radicals from the wound site and inhibiting the release of inflammatory factors. In this study, we prepared the carboxymethyl chitosan (CMCS)/polyvinyl pyrrolidone (PVP)/Molybdenum (IV) Selenide (MoSe), and platelet-rich plasma (PRP) (CMCS/PVP/MoSe/PRP) hydrogels for accelerating the repair of wounds.

Triterpenoid saponins from and their anti-liver fibrotic activities.

A new triterpenoid saponin (), along with five known compounds (), was isolated from Wall. ex DC, of which compounds were obtained for the first time from this plant. The structures were confirmed by the analysis of 1D, 2D NMR, and HR-ESIMS data, and comparison with previous spectral data.

SERS-Temperature Dual-Mode T-type Lateral Flow Strip for Accurate Detection of Free and Total Prostate-Specific Antigens in Blood.

Accurate point-of-care (POC) analysis of cancer markers is the essence in the comprehensive early screening and treatment of cancer. Dual-mode synchronous detection is one of the effective approaches to reduce the probability of false negatives or false positives. As a result, this can greatly improve the accuracy of diagnosis.

Six Undescribed Capnosane-Type Macrocyclic Diterpenoids from South China Sea Soft Coral : Structural Determination and Biological Evaluation.

Six undescribed capnosane-type macrocyclic diterpenes sarcocrassolins A-F (-) and one related known analog pavidolide D () were isolated from , a soft coral collected off the Nansha Islands, in the South China Sea. Their complete structures, relative configurations and absolute configurations were established through comprehensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) and single-crystal X-ray diffraction. Sarcocrassolins D () and E () showed inhibitory activity against lipopolysaccharide (LPS)-stimulated inflammatory responses in RAW264.

Fluorometric detection of alpha-fetoprotein based on the use of a novel organic compound with AIE activity and aptamer-modified magnetic microparticles.

Background: Liver cancer is one of the most common cancers in the world, and it seriously threatens human life and health. Alpha-fetoprotein (AFP), as a carcinogenic glycoprotein, is an important serum marker for detecting liver cancer. Therefore, the accurate and sensitive determination of AFP is crucial for the early diagnosis and treatment of liver cancer.

Corrigendum: protects against pancreatic and intestinal injury after severe acute pancreatitis via downregulation of MMP9.

[This corrects the article DOI: 10.3389/fphar.2022.

Facial Preparation of Cyclometalated Iridium (III) Nanowires as Highly Efficient Electrochemiluminescence Luminophores for Biosensing.

In this study, highly efficient ECL luminophores composed of iridium complex-based nanowires (Ir-NCDs) were synthesized via covalently linking bis(2-phenylpyridine)-(4-carboxypropyl-2,2'-bipyridyl) iridium(III) hexafluorophosphate with nitrogen-doped carbon quantum dots (NCDs). The ECL intensity of the nanowires showed a five-fold increase in ECL intensity compared with the iridium complex monomer under the same experimental conditions. A label-free ECL biosensing platform based on Ir-NCDs was established for (SE) detection.

One-Step, On-Site Chemical Printing of a 3D Plasmon-Coupled Silver Nanocoral Substrate toward SERS-Based POCT.

Surface-enhanced Raman scattering (SERS) with the advantages of high sensitivity, nondestructive analysis, and a unique fingerprint effect shows great potential in point-of-care testing (POCT). However, SERS faces challenges in rapidly constructing a substrate with high repeatability, homogeneity, and sensitivity, which are the key factors that restrict its practical applications. In this study, we propose a one-step chemical printing strategy for synthesizing a three-dimensional (3D) plasmon-coupled silver nanocoral (AgNC) substrate (only need about 5 min) without any pretreatments and complex instruments.

[Cembranoids and their bioactivities in soft coral Sarcophyton glaucum].

Chemical constituents in soft coral Sarcophyton glaucum were separated and purified by various chromatographic methods. Based on the spectral data, physicochemical properties, and comparison with the data reported in the literature, nine cembranoids, including a new cembranoid named sefsarcophinolide(1) together with eight known cembranoids, namely(+)-isosarcophine(2), sarcomilitatin D(3), sarcophytonolide J(4),(1S,3E,7E,13S)-11,12-epoxycembra-3,7,15-triene-13-ol(5), sarcophytonin B(6),(-)-eunicenone(7), lobophytin B(8), and arbolide C(9), were identified. As revealed by biological activity experiment results, compounds 2-6 had weak acetylcholinesterase inhibitory activity, and compound 5 displayed weak cytotoxicity against K562 tumor cell line.

Chitosan-based multifunctional hydrogel for sequential wound inflammation elimination, infection inhibition, and wound healing.

In this study, a composite hydrogel (QMPD hydrogel) composed of methacrylate anhydride (MA) grafted quaternary ammonium chitosan (QCS-MA), polyvinylpyrrolidone (PVP), and dopamine (DA) was designed for the sequential wound inflammation elimination, infection inhibition, and wound healing. The QMPD hydrogel formation was initiated by the ultraviolet light-triggered polymerization of QCS-MA. Furthermore, hydrogen bonds, electrostatic interactions, and "π-π" stacking between QCS-MA, PVP, and DA were involved in the hydrogel formation.

A novel core-shell composite of PCN-222@MIPIL for ultrasensitive electrochemical sensing 4-nonylphenol.

A novel core-shell composite of PCN-222 and molecularly imprinted poly (ionic liquid) (PCN-222@MIPIL) with high conductivity and selectivity was prepared for electrochemical sensing 4-nonylphenol (4-NP). The electrical conductivities of some MOFs including PCN-222, ZIF-8, NH-UIO-66, ZIF-67, and HKUST-1 were explored. The results indicated that PCN-222 had the highest conductivity and was then used as a novel imprinted support.