Potential -Glucosidase Inhibitors from the Deep-Sea Sediment-Derived Fungus .

Three new phenolic compounds, epicocconigrones C-D (-) and flavimycin C (), together with six known phenolic compounds: epicocconigrone A (); 2-(10-formyl-11,13-dihydroxy-12-methoxy-14-methyl)-6,7-dihydroxy-5-methyl-4-benzofurancarboxaldehyde (); epicoccolide B (); eleganketal A (); 1,3-dihydro-5-methoxy-7-methylisobenzofuran (); and 2,3,4-trihydroxy-6-(hydroxymethyl)-5-methylbenzyl-alcohol (), were isolated from fermentation cultures of a deep-sea sediment-derived fungus, . Their planar structures were elucidated based on the 1D and 2D NMR spectra and HRESIMS data. The absolute configurations of compounds - were determined by ECD calculations. Compound represented a rare fully symmetrical isobenzofuran dimer. All compounds were evaluated for their -glucosidase inhibitory activity, and compounds , -, and exhibited more potent -glucosidase inhibitory effect with IC values ranging from 17.04 to 292.47 μM than positive control acarbose with IC value of 822.97 μM, indicating that these phenolic compounds could be promising lead compounds of new hypoglycemic drugs.