GWAS identifies a molecular marker cluster associated with monoterpenoids in grapes.

Monoterpenoids are vital compounds that impart a distinctive floral flavor. They exist in both glycosidic and free forms in grapes. The breeding of improved monoterpenoid varieties has consistently been a topic of interest, yet only a limited number of molecular markers have been documented.

An unusually acute abdominal pain: A case report.

Rationale: Acute abdominal pain is a common clinical symptom. Its etiology is complex and intricate. This is a case of small intestinal obstruction caused by bezoar combined with diabetes ketoacidosis, which leads to abdominal pain.

The syntheses of the flexible TAPDA-based covalent organic frameworks utilized for capturing iodine and fluorescence sensing 2,4-dinitrophenol.

The hexa(4-formyl-phenoxy)cyclotriphosphazene (NOP-6--CHO) and 2,4,6-tris(4-formylphenoxy)-1,3,5-triazine (TPT-3-CHO) are common knots of the flexible covalent organic frameworks (COFs), which may undergo Schiff base reaction with diamide and ternary amine, but with no examples of quaternary amine. Herein, we chose quaternary amine -- N,N,N',N'-tetrakis(4-aminophenyl)-1,4-phenylenediamine (TAPDA) to react with NOP-6-CHO and TPT-3-CHO to synthesize flexible TAPDA-based COFs (HTAPDA and TTAPDA) for the first time. The flexible TAPDA-based COFs have flexible units and 3D triangular or 2D hexagonal pores which make the pores nimble and self-adaptable abilities.

Date determination using a combination of Raman and video spectroscopy for the examination of forged documents containing pre-inked stamp impressions.

The examination of stamp impressions is a routine task for questioned document examiners (QDEs) in determining the authenticity of disputed documents. Some studies have provided methods for date determination of stamp impressions, but each single method has its own limitations, so date determination of stamp impressions remains a challenge in case work. This study reports on the real case of a forged contract, in which pre-inked stamp impressions were made on blank paper without the knowledge of the stamp owner.

Evolution of Aroma Profiles in L. Marselan and Merlot from Grapes to Wines and Difference between Varieties.

The fermentation process has a significant impact on the aromatic profile of wines, particularly in relation to the difference in fermentation matrix caused by grape varieties. This study investigates the leaching and evolution patterns of aroma compounds in L. Marselan and Merlot during an industrial-scale vinification process, including the stages of cold soak, alcohol fermentation, malolactic fermentation, and one-year bottle storage.

Ethylene-responsive VviERF003 modulates glycosylated monoterpenoid synthesis by upregulating in grapes.

Terpenoids are important contributors to the aroma of grapes and wines. Grapes contain terpenoids in both volatile free form and non-volatile glycosidic form, with the latter being more abundant. Glycosylated terpenoids are deemed as latent aromatic potentials for their essential role in adding to the flowery and fruity bouquet of wines.

Integrated Analysis of Transcriptome and Metabolome to Unveil Impact on Enhancing Grape Aroma Quality with Synthetic Auxin: Spotlight the Mediation of ABA in Crosstalk with Auxin.

It is widely accepted that prevéraison application of naphthaleneacetic acid (NAA) can delay the ripening of grapes and improve their quality. However, how NAA impacts grape aroma compound concentrations remains unclear. This study incorporated the analyses of aroma metabolome, phytohormones, and transcriptome of L.

Effects of Inflammatory Response Genes on the Immune Microenvironment in Colorectal Cancer.

The close relationship between colorectal cancer and inflammation has been widely reported. However, the relationship between colorectal cancer and inflammation at the genetic level is not fully understood. From a genetic perspective, this study explored the relationship between inflammation-related genes and the immune microenvironment in colorectal cancer.

A neurovascular unit-on-a-chip: culture and differentiation of human neural stem cells in a three-dimensional microfluidic environment.

Biological studies typically rely on a simple monolayer cell culture, which does not reflect the complex functional characteristics of human tissues and organs, or their real response to external stimuli. Microfluidic technology has advantages of high-throughput screening, accurate control of the fluid velocity, low cell consumption, long-term culture, and high integration. By combining the multipotential differentiation of neural stem cells with high throughput and the integrated characteristics of microfluidic technology, an in vitro model of a functionalized neurovascular unit was established using human neural stem cell-derived neurons, astrocytes, oligodendrocytes, and a functional microvascular barrier.

Retrograde arterial perfusion and its outcome in robotic mitral-valve surgery.

Objective: Retrograde arterial perfusion is frequently used in minimally invasive cardiac surgery. However, there are concerns about its safety.

Methods: A prospective observational cohort study was conducted in a tertiary university affiliated medical center during 2016-2018.

Enhanced CO Electrochemical Reduction Performance over Cu@AuCu Catalysts at High Noble Metal Utilization Efficiency.

The electrochemical CO reduction reaction (CORR) represents a viable alternative to help close the anthropogenic carbon cycle and convert intermittent electricity from renewable energy sources to chemical energy in the form of value-added chemicals. The development of economic catalysts possessing high faradaic efficiency (FE) and mass activity (MA) toward CORR is critical in accelerating CO utilization technology. Herein, an elaborate Au-Cu catalyst where an alloyed AuCu shell caps on a Cu core (Cu@AuCu) is developed and evaluated for CO-to-CO electrochemical conversion.

Caveolin-1 downregulation promotes the dopaminergic neuron-like differentiation of human adipose-derived mesenchymal stem cells.

Previous studies have shown that caveolin-1 is involved in regulating the differentiation of mesenchymal stem cells. However, its role in the differentiation of human adipose mesenchymal stem cells into dopaminergic neurons remains unclear. The aim of this study was to investigate whether caveolin-1 regulates the differentiation of human adipose mesenchymal stem cells into dopaminergic-like neurons.

Mapping theme trends and knowledge structures for human neural stem cells: a quantitative and co-word biclustering analysis for the 2013-2018 period.

Neural stem cells, which are capable of multi-potential differentiation and self-renewal, have recently been shown to have clinical potential for repairing central nervous system tissue damage. However, the theme trends and knowledge structures for human neural stem cells have not yet been studied bibliometrically. In this study, we retrieved 2742 articles from the PubMed database from 2013 to 2018 using "Neural Stem Cells" as the retrieval word.

Assessment of signature handwriting evidence via score-based likelihood ratio based on comparative measurement of relevant dynamic features.

This paper extends on previous research on the extraction and statistical analysis on relevant dynamic features (width, grayscale and radian combined with writing sequence information) in forensic handwriting examinations. In this paper, a larger signature database was gathered, including genuine signatures, freehand imitation signatures, random forgeries and tracing imitation signatures, which are often encountered in casework. After applying Principle Component Analysis (PCA) of the variables describing the proximity between specimens, a two-dimensional kernel density estimation was used to describe the variability of within-genuine comparisons and genuine-forgery comparisons.

Effect of ATF3-deletion on apoptosis of cultured retinal ganglion cells.

Aim: To investigate the effect of activating transcription factor-3 (ATF3)-deletion on apoptosis of cultured retinal ganglion cells (RGCs).

Methods: Three ATF3 siRNA (ATF3-rat-651, ATF3-rat-319, ATF3-rat-520) were constructed, and were transiently transfected into RGC-5 cells. Quantitative real-time polymerase chain reaction (PCR) was used to examine ATF3 expression and the most effective ATF3 siRNA was selected for further studies.

The outcome of patients requiring multiple extracorporeal membrane oxygenation: how many runs of ECMO is reasonable?

Background: Extracorporeal membrane oxygenation (ECMO) has been proven effective in life support for patients with refractory cardiopulmonary failure. Deteriorating patients who have removed their first ECMO support and required second or more courses of ECMO support have rarely been discussed.

Methods And Results: All the records of the patients who experienced at least 2 courses of ECMO during single admission were retrieved.

Inhibition on Apoptosis Induced by Elevated Hydrostatic Pressure in Retinal Ganglion Cell-5 via Laminin Upregulating β1-integrin/Focal Adhesion Kinase/Protein Kinase B Signaling Pathway.

Background: Glaucoma is a progressive optic neuropathy characterized by degeneration of neurons due to loss of retinal ganglion cells (RGCs). High intraocular pressure (HIOP), the main risk factor, causes the optic nerve damage. However, the precise mechanism of HIOP-induced RGC death is not yet completely understood.

Heterogeneity of Monosymptomatic Resting Tremor in a Prospective Study: Clinical Features, Electrophysiological Test, and Dopamine Transporter Positron Emission Tomography.

Background: The relationship between monosymptomatic resting tremor (mRT) and Parkinson's disease (PD) remains controversial. In this study, we aimed to assess the function of presynaptic dopaminergic neurons in patients with mRT by dopamine transporter positron emission tomography (DAT-PET) and to evaluate the utility of clinical features or electrophysiological studies in differential diagnosis.

Methods: Thirty-three consecutive patients with mRT were enrolled prospectively.

Effects of antenatal corticosteroids on neonatal outcomes in very-low-birth-weight preterm newborns: a 10-year retrospective study in a medical center.

Objective: To evaluate the effects on neonatal outcomes between very-low-birth-weight (VLBW) preterm newborns with and without maternal use of antenatal corticosteroids (ACS).

Methods: We retrospectively reviewed medical records of VLBW premature infants who were admitted to Kaohsiung Medical University Hospital between 1999 and 2008. A total of 256 infants were enrolled in this study.

Comparing the survival between extracorporeal rescue and conventional resuscitation in adult in-hospital cardiac arrests: propensity analysis of three-year data.

Aim: Extracorporeal cardiopulmonary resuscitation (ECPR) has been shown to have survival benefit over conventional CPR (CCPR) in patients with in-hospital cardiac arrest of cardiac origin. We compared the survival of patients who had return of spontaneous beating (ROSB) after ECPR with the survival of those who had return of spontaneous circulation (ROSC) after conventional CPR.

Methods: Propensity score-matched cohort of adults with in-hospital prolonged CPR (>10min) of cardiac origin in a university-affiliated tertiary extracorporeal resuscitation center were included in this study.

Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine.

Bone marrow and intestinal damage limits the efficacy of radiotherapy for cancer and can result in death if the whole body is exposed to too high a dose, as might be the case in a nuclear accident or terrorist incident. Identification of an effective nontoxic biological radioprotector is therefore a matter of some urgency. In this study, we show that an orally administered hot-water extract from a Chinese herbal medicine, Cordyceps sinensis (CS), protects mice from bone marrow and intestinal injuries after total-body irradiation (TBI).