ZnCe-LDO Nanozyme-Based Multifunctional Hydrogel Promotes Bone Regeneration by Inflammatory Macrophage Reprogramming and Piezo1 Activation.

Prolonged or excessive inflammation may lead to impaired vascularization and bone regeneration, hindering the normal repair process of bone tissue. Although the regulation of inflammation is crucial for promoting a conducive microenvironment for bone regeneration, individual anti-inflammatory interventions frequently are inadequate in facilitating effective bone repair. Here, a multifunctional hydrogel (GelMA-ZC-Yoda1) with multifaceted therapeutic strategy was designed by integrating Zinc/Cerium-layered double oxide nanozyme (ZnCe-LDO, with catalase-like activity) and Yoda1 (an activator of the mechanically sensitive Piezo1 ion channel) into photocurable GelMA hydrogel.

Identification of imidazo[1,2-a]pyridine skeleton as new bactericidal candidates: structural innovation and virulence-targeted behavior.

Background: Given the escalating challenges posed by antimicrobial resistance in phytobacterial infections, which are exacerbated by the suboptimal efficacy of existing bactericides, limited curative options, and mounting environmental concerns, there is a pressing need to develop innovative bactericidal agents with novel molecular architectures and distinctive modes of action.

Results: To identify novel molecular scaffolds for bactericide development, we systematically devised a wide series of imidazo[1,2-a]pyridine derivatives incorporating benzylpiperazinyl moieties, followed by evaluating their antibacterial activities. Bioassay results manifested that compound C exhibited remarkable antibacterial efficacy against Xanthomonas oryzae pv.

Dapagliflozin improves diabetic nephropathy by regulating autophagy and ferroptosis through CYP450s/ROS pathway.

Diabetic nephropathy (DN) is a severe complication of diabetes, presenting significant clinical challenges due to its refractory nature. Although dapagliflozin is used as a clinical intervention, its precise molecular mechanisms remain incompletely understood. Our study employed an integrative approach combining bioinformatics analysis with experimental validation to systematically investigate dapagliflozin's therapeutic potential in DN.

Moderating role of fasting insulin on the levels of vitamin D in idiopathic central precocious puberty girls.

Background: Vitamin D deficiency (VDD) is a risk factor for idiopathic central precocious puberty (ICPP), but the mechanism is unclear. The association between Vitamin D (Vit D) and insulin indicates that fasting insulin (FINS) may play a role in the influence of Vit D on the occurrence of ICPP.

Objective: This study aimed to investigate the role of FINS in the impact of Vit D on ICPP risk in girls.

Decoding the Enigmatic Link Between Sensory Impairment and Organic Mental Disorders: Insights From Biological Aging and Social Support in a Population Cohort Study.

Objectives: The objective of this study was to investigate the association between sensory impairments and organic mental disorders. We also examined biological age acceleration as a potential mediator and social support as a potential moderator of this association.

Design: This was a longitudinal cohort study using Cox proportional hazards models with mediation and moderation analyses.

Stable Zinc Electrode/Separator Interface Enabled by Phthalocyanine-Modified Separator for Advanced Zinc Metal Batteries.

Aqueous zinc (Zn) metal batteries (ZMBs) have received extensive attention as potential energy storage systems due to their inherent safety and low cost. However, the practical applications of ZMBs have been hindered by parasitic side reactions and Zn dendrite formation, undermining the efficiency of Zn anodes. With continuous research on the interfacial chemistry in ZMBs, increasing research interest is begun to focus on achieving dendrite-free Zn electrodeposition by constructing a stable separator/electrode interface.

De novo synthesis of tryptanthrin and its derivatives from indole: engineering a sustainable photocatalytic strategy.

Tryptanthrin is a natural alkaloidal molecule [IUPAC name 6,12-dihydro-6,12-dioxoindolo-(2,1-b)-quinazoline], possessing an indoloquinazoline moiety. Since first being discovered in 1979, it and its analogs generated great interest in the fields of medicinal chemistry, life science, and materials science. Protocols for synthesizing tryptanthrins with the features of facile, eco-friendly, and mild reaction conditions remain an underdeveloped area.

Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation.

Background: The disruption of renal cell homeostasis caused by aging has attracted considerable attention. A traditional Chinese medicine, ginseng, is a potential drug for treating aging-related diseases. The study investigates the effect and mechanism of ginsenoside Rg1, an active component of ginseng, on renal aging and injury.

[Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty].

Objectives: To investigate the association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty (ICPP).

Methods: A retrospective study was conducted involving 61 girls diagnosed with ICPP who visited the pediatric growth and development clinic of the Third Affiliated Hospital of Zhengzhou University between January 2022 and September 2024, designated as the ICPP group, and 61 normally developing girls as the control group. The differences in insulin resistance index (homeostasis model assessment of insulin resistance, HOMA-IR), uterine volume, and other indicators between the two groups were compared, and the relationship between insulin resistance and uterine volume in these girls was analyzed.

How does team reflexivity affect new generation employee cooperative behavior in China? A cross-level moderated mediation model.

Introduction: Employee cooperative behavior is crucial for enterprises navigating uncertainty in the rapidly evolving digital era. Drawing on social information processing theory, this study examines the impact of team reflexivity on employee cooperative behavior, with a focus on the mediating role of organizational trust and the moderating role of employee involvement climate.

Methods: A cross-level moderated mediation model was developed and tested using survey data from 412 employees across 84 project teams in China.

Construction of a diagnostic model utilizing m7G regulatory factors for the characterization of diabetic nephropathy and the immune microenvironment.

Diabetic nephropathy (DN), a prevalent and severe complication of diabetes, is associated with poor prognosis and limited treatment options. N7-Methylguanosine (m7G) modification plays a crucial role in regulating RNA structure and function, linking it closely to metabolic disorders. However, despite its biological significance, the interplay between m7G methylation and immune status in DN remains largely unexplored.

Efficacy and potential pharmacological mechanism of combination in diabetic nephropathy: integrating meta-analysis, network pharmacology, molecular docking, and experimental validation.

Background: Diabetic nephropathy (DN) is a diabetes mellitus (DM)-induced complication that poses high morbidity and mortality risks. The and couplet medicines (AS) are commonly employed in DN clinical treatment in China, but their clinical efficacy and potential pharmacological mechanisms are yet to be evaluated.

Material And Methods: A meta-analysis of 15 studies involving 1,443 patients was conducted.

Mapk7 enhances osteogenesis and suppresses adipogenesis by activating Lrp6/β-catenin signaling axis in mesenchymal stem cells.

The lineage commitment and differentiation of mesenchymal stem cells (MSCs) play a crucial role in bone homeostasis. MAPK7 (Mitogen-activated protein kinase 7), a member of MAPK family, controls cell differentiation, proliferation and survival. However, the specific role of Mapk7 in regulating osteogenic and adipogenic differentiation of MSCs remains to be determined.

A nomogram for predicting cancer-specific survival in patients with rectal mucinous adenocarcinoma following surgery.

Nomograms for predicting survival are well-established for colorectal adenocarcinoma but are less common for rectal mucinous adenocarcinoma (MAC). This study leverages Surveillance, Epidemiology, and End Results (SEER) database to develop a prognostic nomogram for rectal MAC, enhancing survival prediction and clinical decision-making. Data from the SEER (2004-2017) were analyzed, focusing on surgically treated rectal MAC patients.

Hypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis.

Gut dysbiosis has been associated with hypertension. Herein, we aimed to discover the potential association between gut microbiota and high-salt diet (HSD) induced endothelial dysfunction in conventional hypertensive mice. Dubosiella newyorkensis was found highly sensitive to salt in HSD-induced hypertension.

SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.

The pathogenesis of stress urinary incontinence (SUI), a condition common in women, remains to be fully elucidated. This study revealed that the incidence of SUI is associated with mitochondrial homeostasis dysregulation following oxidative stress in the fibrous connective tissue of the pelvic floor. SIRT1 is an essential factor for maintaining mitochondrial homeostasis; however, its potential role and mechanism of action in SUI pathogenesis remain unclear.

ArfGAP3 Protects Mitochondrial Function and Promotes Autophagy Through Rab5a-Mediated Signals in Ageing Skeletal Muscle.

Background: Few researches have investigated the molecular mechanism responsible for the age-related loss of the pelvic floor muscle (PFM) mass and functionality-a pivotal contributor to pelvic organ prolapse and diminished physical well-being. ADP ribosylation factor GTPase activating protein 3 (ArfGAP3) is a member of ArfGAPs, which regulates the vesicular trafficking pathway and intracellular proteins transporting. However, its effects on skeletal muscle ageing remain largely unknown.

Beyond conventional therapies: MSCs in the battle against nerve injury.

Nerve damage can cause abnormal motor and sensory consequences, including lifelong paralysis if not surgically restored. The yearly cost of healthcare in the United States is projected to be $150 billion, and millions of Americans suffer from peripheral nerve injuries as a result of severe traumas and disorders. For nerve injuries, the outcome of conventional therapies is suboptimal and may have unfavorable side effects.

Early and multiple doses of zoledronate mitigates rebound bone loss following withdrawal of receptor activator of nuclear factor kappa-B ligand inhibition.

Rebound bone loss following denosumab discontinuation is an important barrier in the effective long-term treatment of skeletal disorders. This is driven by increased osteoclastic bone resorption following the offset of RANKL inhibition, and sequential osteoclast-directed therapy has been utilized to mitigate this. However, current sequential treatment strategies intervene following the offset of RANKL inhibition and this approach fails to consistently prevent bone loss.

Diagnostic value of fasting insulin and insulin-like growth factor-1 levels in girls with central precocious puberty.

Objectives: The gonadotropin-releasing hormone (GnRH) provocation test is crucial for diagnosing central precocious puberty (CPP). However, due to its invasion and high cost, it is essential to find a simpler biomarker. This study aimed to investigate the feasibility of fasting insulin (FINS) and insulin-like growth factor-1 (IGF-1) as potential biomarkers for diagnosing girls with CPP and to analyze their effects on puberty development.

Observation of single-photon azimuthal backflow with weak measurement.

Quantum backflow (QB), a counterintuitive interference phenomenon where particles with positive momentum can propagate backward, is important in applications involving light-matter interactions. To date, experimental demonstrations of backflow have been restricted to classical optical systems using techniques such as slit scanning or Shack-Hartmann wavefront sensing, which suffer from low spatial resolution due to the inherent limitations in slit width and lenslet array density. Here, we report an observation of azimuthal backflow (AB) both theoretically and experimentally by employing the weak measurement technique, which enables the precise extraction of photon momentum at each pixel.

The More Realism, the Better? How Does the Realism of AI Customer Service Agents Influence Customer Satisfaction and Repeat Purchase Intention in Service Recovery.

Nowadays, human customer service is increasingly being replaced by artificial intelligence (AI) customer service agents. Service recovery plays a crucial role in shaping consumer experiences and business profitability. The realism of AI agents can significantly impact users' attitudes and behaviors.

Solanaceae pan-genomes reveal extensive fractionation and functional innovation of duplicated genes.

The Solanaceae family contains many agriculturally important crops, including tomato, potato, pepper, and tobacco, as well as other species with potential for agricultural development, such as the orphan crops groundcherry, wolfberry, and pepino. Research progress varies greatly among these species, with model crops like tomato being far ahead. This disparity limits the broader agricultural application of other Solanaceae species.

3D culture inhibits replicative senescence of SCAPs via UQCRC2-mediated mitochondrial oxidative phosphorylation.

Stem cells derived from the apical papilla (SCAPs) play a crucial role in tooth root development and dental pulp regeneration. They are important seed cells for bone/tooth tissue engineering. However, replicative senescence remains an unavoidable issue as in vitro amplification increases.