BUB1B promotes homologous recombination‑mediated DNA damage repair in breast cancer cells through the PI3K/AKT signaling pathway.

Radioresistance is a major obstacle to effective radiotherapy in breast cancer. BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) is involved in numerous biological processes associated with cancer; however, its specific role in mediating radioresistance in breast cancer remains poorly characterized. The present study first evaluated its expression profile and association with patient prognosis through bioinformatics analysis.

4.5 W Er-doped ZBLAN fiber laser at 3.78 μm.

In this work, we demonstrate an efficient long-wavelength operation of an Er-doped ZBLAN fiber laser in the 3.5 μm band with F→I transition. A high-transmission bandpass filter (BPF) is employed in the laser cavity to select a specific lasing wavelength of around 3.

Stacked Ensemble Deep Random Vector Functional Link Network With Residual Learning for Medium-Scale Time-Series Forecasting.

The deep random vector functional link (dRVFL) and ensemble dRVFL (edRVFL) succeed in various tasks and achieve state-of-the-art performance compared with other randomized neural networks (NNs). However, existing edRVFL structures need more diversity and error correction ability in an independent network. Our work fills the gap by combining stacked deep blocks and residual learning with the edRVFL.

Ball Milling of LaO Tailors the Crystal Structure, Reactive Oxygen Species, and Free Radical and Non-Free Radical Photocatalytic Pathways.

Non-free radical photocatalysis with metal oxide catalysts is an important advanced oxidation process that enables the removal of various emerging environmental pollutants, such as tetracycline. Here, four hexagonal LaO photocatalysts with different densities of oxygen vacancy and crystalline features are synthesized and then further treated by ball milling. Ball milling of these LaO photocatalysts is found to increase the amount of oxygen vacancies on their surfaces and thereby the amount of O species produced by them.

Widely tunable single-frequency Er-doped ZBLAN fiber laser with emission from 3.37 to 3.72 µm.

We demonstrate a widely tunable single-frequency Er-doped ZBLAN fiber laser operating on a F→I transition band. An uncoated germanium (Ge) plate serves as a narrow-bandwidth etalon and is inserted in the cavity to achieve a single longitudinal mode selection. Wavelength tuning from 3373.

Pump quantum efficiency optimization of 3.5 μm Er-doped ZBLAN fiber laser for high-power operation.

976 nm + 1976 nm dual-wavelength pumped Er-doped ZBLAN fiber lasers are generally accepted as the preferred solution for achieving 3.5 μm lasing. However, the 2 μm band excited state absorption from the upper lasing level (F → F) depletes the Er ions population inversion, reducing the pump quantum efficiency and limiting the power scaling.

Green synthesis of manganese-cobalt-tungsten composite oxides for degradation of doxycycline via efficient activation of peroxymonosulfate.

The advanced oxidation process of peroxymonosulfate activated by solid catalyst is one of the main technologies to solve the pollution of antibiotics in water environment.In this work, a series of composites (MCW) containing Mn, Co, and W were synthesized using green ball milling, which does not produce the three wastes (waste gas, waste water and industrial residue). It shows a unique and high catalytic activity for peroxymonosulfate-based degradation of doxycycline (DC) under the pH condition between 4 and 9, and it can be reused five times.

Nanoparticle-Mediated Delivery of Emodin via Colonic Irrigation Attenuates Renal Injury in 5/6 Nephrectomized Rats.

Our previous study showed that emodin enema modulates gut microbiota and delays CKD progression. However, the poor solubility, limited colonic irrigation retention time, and inadequate colon adhesion of emodin hinder its clinical application. Based on the deficiencies of emodin, we prepared monomethoxy-poly (ethylene glycol)-poly (lactic acid)-chitosan-2-mercaptobenzimidazole nanoparticles with incorporated emodin (emodin-NP) and studied their efficacy in delaying CKD progression.

Efficient removal of Pb(II) through recycled biochar-mineral composite from the coagulation sludge of swine wastewater.

Zeolite-Mg/Fe chloride dual enhanced coagulation is a cost-effective method for advanced treatment of swine wastewater, but the sludge generated after the enhanced coagulation remains to be a problem. In this study, the precipitate from a swine wastewater coagulation unit was regenerated by pyrolysis treatment in an O-limited environment to develop a high efficient adsorbent (biochar-mineral composite, BMC) for the removal of Pb(II) from wastewater. SEM images indicate that complex Mg/Fe oxides and sludge biochar gathered around zeolite particles.

MiR-3653 inhibits the metastasis and epithelial-mesenchymal transition of colon cancer by targeting Zeb2.

Aberrant expression of microRNAs (miRNAs) has been widely recognized to play critical roles in the pathogenic processes of colon cancer. However, the expression and functions of miR-3653 in colon cancer remain uncovered. This study revealed for the first time that miR-3653 expression was significantly decreased in colon cancer tissues and cell lines.

Modified cellulose by polyethyleneimine and ethylenediamine with induced Cu(II) and Pb(II) adsorption potentialities.

In order to synthesize adsorbent that can effectively absorb heavy metals in a simple and economical way, this study described the fabrication of adsorbents based on cellulose acetate (CA). CA modified first by polyethyleneimine grafting (CAP) and then by ethylenediamine (CAPE) for enhancing Cu(II) and Pb(II) removal from water. The physico-chemical properties of the modified celluloses were analyzed.