Hyperacmosin R, a New Decarbonyl Prenylphloroglucinol with Unusual Spiroketal Subunit from .

Two previously undescribed polycyclic polyprenylated acylphloroglucinols, hyperacmosins R-S (-), were obtained from the aerial parts of . Their structures were elucidated by extensive spectroscopic analysis and electronic circular dichroism calculation (ECD). Compound featured an unprecedented 5,8-spiroketal subunit as well as the loss of C-2' carbonyl in the phloroglucinol ring.

Polycyclic polyprenylated acylphloroglucinols from Hypericum beanii and their hepatoprotective activity.

Twenty-seven polycyclic polyprenylated acylphloroglucinols (PPAPs) with diverse skeletons, including seven previously undescribed ones (hyperbeanins A-G), were isolated from the aerial parts of Hypericum beanii. Their structures were established by comprehensive analysis of NMR, HRESIMS, and experimental electronic circular dichroism (ECD) spectra. Hyperbeanin A was a monocyclic polyprenylated acylphloroglucinols (MPAPs) with an unusual spiro-fused cyclopropane ring.

Hyperacmosins K-M, three new polycyclic polyprenylated acylphloroglucinols from .

Hyperacmosins K-M (1-3), three new polycyclic polyprenylated acylphloroglucinol (PPAPs) derivatives, were isolated from the air-dried aerial parts of . Compounds 1 and 2 both possessed a rare 5,5-spiroketal subunit with the loss of C-2' carbonyl in the phloroglucinal ring, while compound 3 featured an unusual 1,2--bicyclo[3.3.

Prenylaromadendrane-type diterpenoids from the gum resin of flueck and their cytotoxic effects.

Two new prenylaromadendrane-type diterpenoids, and three known analogues, were isolated from the ethanol extract of the gum resin of Flueck. The structures of the new compounds were elucidated using 1 D and 2 D NMR spectroscopic analyses, mass spectrometric data, circular dichroism spectra, and comparison with the other compounds in the literature. One diterpenoid represents the first example of an acetoxyl-substituted prenylaromadendranoid in frankincense.

Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum pseudohenryi.

Seven previously unidentified polycyclic polyprenylated acylphloroglucinol (PPAP) derivatives hypseudohenrins A-G, along with six known analogs, were isolated from the aerial portion of Hypericum pseudohenryi. Their structures were determined by NMR, ECD and X-ray crystallographic spectroscopy. These compounds were screened for anti-inflammatory activity, and hypseudohenrins B and G (at the concentration of 10 μM) showed NO production inhibition ratios of 52.

Hypseudohenrins I - K: three new polycyclic polyprenylated acylphloroglucinol derivatives from .

Three previously unidentified polycyclic polyprenylated acylphloroglucinols (PPAPs) derivatives, hypseudohenrins I-K (-), along with a known analogue hyphenrone X (), were isolated from the aerial part of . The structures of the new compounds were elucidated by NMR spectroscopy and ECD calculation. The anti-inflammatory activity of the compounds was evaluated.

Two new polycyclic polyprenylated acylphloroglucinols derivatives from .

Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C () and hyperacmosin D () were isolated from . Their structures were established by NMR, HREIMS, and experimental electronic circular dichroism spectra.

Ten undescribed cembrane-type diterpenoids from the gum resin of Boswellia sacra and their biological activities.

Ten undescribed cembrane-type diterpenes boscartins AL-AU, as well as five known analogues were isolated from Boswellia sacra Flueck. The relative configurations of these boscartins were established by extensive spectroscopic analysis of NMR spectra, IR and MS. The absolute configurations of boscartin AL, boscartin AN and isoincensole oxide were unequivocally assigned by single crystal X-ray diffraction.

Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from .

Three new polycyclic polyprenylated acylphloroglucinol derivatives, hyperacmosins H-J (), with four known compounds (), were isolated from the air-dried aerial parts of . Especially, compounds and were identified as methylated polycyclic polyprenylated acylphloroglucinol derivatives (mPPAPs). Their structures were established by NMR, HRESIMS and experimental electronic circular dichroism (ECD) spectra.

Hyperacmosins E-G, three new homoadamantane-type polyprenylated acylphloroglucinols from Hypericum acmosepalum.

Three new homoadamantane-type polyprenylated acylphloroglucinols, hyperacmosins E-G (1-3), with seven known compounds were isolated from the air-dried aerial parts of Hypericum asmosepalum. Their structures were determined by NMR, HRESIMS and experimental electronic circular dichroism (ECD) spectra. The hepatoprotective activity of these compounds were evaluated.