Correction: Identification, functional analysis, and clinical applications of defective viral genomes.

[This corrects the article DOI: 10.3389/fmicb.2025.

Evaluation of prolonged use of topical glaucoma medications on gonioscopy-assisted transluminal trabeculotomy outcomes in juvenile open-angle glaucoma.

Purpose: To evaluate the impact of prolonged use of topical glaucoma medications on the surgical outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in juvenile open-angle glaucoma (JOAG).

Patients And Methods: This multicenter retrospective study included 100 eyes of 77 JOAG patients who underwent GATT with at least 12 months of follow-up. Patients were categorized into the short-duration (≤ 1.

Identification, functional analysis, and clinical applications of defective viral genomes.

Defective viral genomes (DVGs) are fragments derived from defective interfering particles (DIPs) that form during viral replication. They play important roles by interfering with complete virus replication and regulating host immune responses. Advances in high-throughput sequencing (HTS) and bioinformatic technology have significantly improved the ability to identify DIPs and DVGs.

A new wearable e monitoring technology for evaluation of left ventricular remodeling after transcatheter aortic valve replacement.

Aims: Pathological left ventricular (LV) remodelling following aortic stenosis (AS) confers high risk for heart failure and significantly decreases survival. This study aims to introduce a new wearable acoustic cardiography (ACG) device measuring electromechanical activation time (EMAT) to identify the regression of cardiac remodelling in AS patients undergoing transcatheter aortic valve replacement (TAVR).

Methods And Results: This prospective cohort study consecutively enrolled patients with severe symptomatic AS who underwent successful TAVR.

Accurate Prediction of ecDNA in Interphase Cancer Cells using Deep Neural Networks.

Oncogene amplification is a key driver of cancer pathogenesis and is often mediated by extrachromosomal DNA (ecDNA). EcDNA amplifications are associated with increased pathogenicity of cancer and poorer outcomes for patients. EcDNA can be detected accurately using fluorescence in situ hybridization (FISH) when cells are arrested in metaphase.

Metabolites profile and endogenous enzymes changes in pre-dehydrated surimi: Mechanistic insights into gelling properties and flavor characteristics.

The essence of traditional surimi processing is a balance between the loss of food chemical components and the quality of the protein gel. The washing process generates a large amount of wastewater, which urgently requires innovation and upgrading of the processing technology. This study investigated the changes in gel properties, endogenous enzyme activities, flavor characteristics and metabolic profile during mechanical pre-dehydration of minced fish, compared to the traditional washing process, in order to understand the relationship between changes in endogenous components and processing quality.

Factors and outcomes associated with adherence to statins among patients with newly diagnosed cardiovascular disease.

Background: Statin use is proven to be effective in lowering low-density lipoprotein cholesterol (LDL-C) levels and reducing risk of recurrent myocardial infarction, stroke, and mortality in individuals with established cardiovascular disease (CVD). We used medication dispensed data (e.g.

Performance of the American Heart Association's PREVENT Equations Among Disaggregated Racial and Ethnic Subgroups.

Importance: In the original validation, the Predicting Risk of Cardiovascular Disease (CVD) Events (PREVENT) equations demonstrated good discrimination and calibration among racial and ethnic groups, but the model performance among Asian and Hispanic disaggregated subgroups has not been previously described.

Objective: To assess the performance of the PREVENT equations by race and ethnicity, including disaggregated Asian and Hispanic subgroups.

Design, Setting, And Participants: This was an electronic health record-based retrospective cohort study of primary care patients aged 30 to 79 years across Sutter Health, a large integrated health system in Northern California, from January 2010 to September 2023.

IRF5 Mediates Artery Inflammation in Salt-Sensitive Hypertension by Regulating STAT1 and STAT2 Phosphorylation to Increase ESM1 Transcription: Insights from Bioinformatics and Mechanistic Analysis.

Salt-sensitive hypertension (SSH) is closely associated with arterial inflammation, yet its molecular mechanisms remain unclear. In this study, we utilized deoxycorticosterone acetate (DOCA)-salt-induced hypertensive mice, which exhibited elevated blood pressure and significant arterial inflammation. Single-cell RNA sequencing (scRNA-seq) identified interferon regulatory factor 5 (IRF5) and its downstream targets, signal transducer and activator of transcription (STAT), as key regulators of these inflammatory changes.

Composition and Biological Activity of Colored Rice-A Comprehensive Review.

Colored rice (black, purple, red and brown) has been consumed in China for nearly 4000 years. Recent research has focused on exploring its nutritional and metabolomic profiles and associated health benefits. Due to the improvement in detection and quantification techniques for health-promoting compounds and their activities, the number of studies has increased significantly.

Two-Year Outcomes of Phacogoniotomy vs Phacotrabeculectomy for Advanced Primary Angle-Closure Glaucoma With Cataract: A Noninferiority Randomized Clinical Trial.

Importance: Intraocular pressure (IOP) reduction with phacogoniotomy (phacoemulsification plus goniosynechialysis plus goniotomy) was not less than that of phacotrabeculectomy for advanced primary angle-closure glaucoma (PACG) with cataract at 1-year follow-up, but longer-term outcomes are needed.

Objective: To investigate if phacogoniotomy is noninferior to phacotrabeculectomy for advanced PACG with cataract at 2 years.

Design, Setting, And Participants: This multicenter, noninferiority, randomized clinical trial took place in 7 ophthalmology centers in China.

Peripheral Iridectomy With Goniosynechialysis and Goniotomy vs Trabeculectomy for Advanced PACG: A Randomized Clinical Trial.

Importance: The safety and effectiveness of combining surgical peripheral iridectomy (SPI) with goniosynechialysis (GSL) and goniotomy (GT) vs trabeculectomy for intraocular pressure (IOP) reduction remains unknown.

Objective: To investigate the safety and effectiveness at 1 year of SPI + GSL + GT vs trabeculectomy in advanced primary angle-closure glaucoma (PACG) without cataract.

Design, Setting, And Participants: This noninferiority randomized clinical trial was conducted at 8 tertiary eye centers in China.

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs.

Extrachromosomal DNA (ecDNA) amplifications are prevalent drivers of human cancers. We show that ecDNAs exhibit elevated structural variants leading to gene fusions that produce oncogene fusion transcripts. The long noncoding RNA (lncRNA) gene is the most recurrent structural variant across cancer genomes, with fusions arising most frequently on ecDNA.

A qualitative analysis on the implementation of a nudge intervention to reduce post-surgical opioid prescribing.

Background: Reducing above-guideline opioid prescribing is one approach to reducing the availability of unused opioids. We describe contextual factors affecting the implementation and outcomes of a successful email 'nudge' aimed at reducing post-operative opioid prescribing, with the goal of informing future implementation and dissemination efforts.

Methods: Between October 2021-September 2022, we sent email nudges to general, orthopedic, and obstetrics/gynecology surgeons at 19 hospitals in a large integrated healthcare system in California whose patients had post-operative opioid prescriptions that exceeded guideline-recommended quantities.

Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis.

Background: Vascular calcification is common and progressive in patients with chronic kidney disease. However, the risk factors associated with the progression of vascular calcification in patients receiving maintenance dialysis have not been fully elucidated. Here, we aimed to evaluate vascular calcification and identify the factors associated with its progression in patients receiving maintenance hemodialysis.

New wearable cardiac acoustic monitoring technology for evaluation of subclinical leaflet thrombosis after transcatheter aortic valve replacement.

Background: Subclinical leaflet thrombosis (SLT) is a common complication after transcatheter aortic valve replacement (TAVR). Multidimensional CT (MDCT) is the main imaging mortality for the diagnosis of SLT but it enhances the risk of contrast-induced nephropathy. Our study aimed to use an innovative wearable acoustic cardiography (ACG) device to diagnose SLT as an alternative option.

Effect and mechanisms of mechanical pre-dehydration treatment on gelling and physicochemical properties of unwashed silver carp (Hypophthalmichthys molitrix) surimi.

Washing improves the overall quality of surimi production. However, the washing process significantly increases wastewater discharge from factories, thus raising environmental concerns and highlighting the need for more sustainable methods of surimi production. This study aimed to investigate the possibility of improving the quality of unwashed freshwater surimi by mechanical pre-dehydration and to explore the changes in gelling properties and physicochemical characteristics during frozen storage.

Structural and functional properties of proteins isolated from four species of microalgae and their application in air-water interface stabilization.

Herein, we extracted proteins from four microalgae: Chlamydomonas reinhardtii (CHR), Euglena gracilis (EUG), Spirulina platensis (SPP), and Spirulina maxima (SPM). Subsequently, their physicochemical and functional properties, as well as air-water interface adsorption behavior were investigated. Results demonstrated that the solubility and emulsifying properties of these proteins were significantly affected by pH, with minimum values observed near their isoelectric point (3.

Coordinated inheritance of extrachromosomal DNAs in cancer cells.

The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently. Extrachromosomal DNAs (ecDNAs) are common in cancer and drive oncogene amplification, dysregulated gene expression and intratumoural heterogeneity through random segregation during cell division. Distinct ecDNA sequences, termed ecDNA species, can co-exist to facilitate intermolecular cooperation in cancer cells.

Factors Associated with Lipoprotein(a) Testing Among Multiethnic Individuals.

Background: Lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and clinical guidelines recommend incorporating Lp(a) testing in routine care.

Objective: Examine real-world, contemporary clinical testing patterns of Lp(a) among multiethnic populations.

Design: In this nested case-control study, we assessed the prevalence and factors associated with Lp(a) testing within a large Northern Californian health system between 2010 and 2021.

Dihydrotetrazine-Functionalized Zirconium-Based Metal-Organic Frameworks for High-Capacity Oil Denitrogenation.

High structural stability, dual organic-inorganic nature, and tunability in chemical functionality are promising characteristics of zirconium-based metal-organic frameworks (Zr-MOFs). These properties assist Zr-MOFs in extending their applications in various fields, especially adsorptive removal of pollutants. In this work, two well-known Zr-MOFs (UiO-66(Zr) and MIL-140(Zr) with the formula ZrO(OH)(BDC), HBDC is benzene 1,4-dicarboxylic acid) were synthesized and decorated with a dihydrotetrazine functional group through postsynthesis linker exchange (PSLE).

Mixed-Linker Zr-Metal-Organic Framework with Improved Lewis Acidic Sites for CO Fixation Reaction Catalysis.

Applying the mixed-linker strategy in synthesizing metal-organic frameworks (MOFs) has drawn considerable attention as a heterogeneous catalyst owing to their easy synthesis and different functional ligands in their frameworks. Following this strategy, we have developed a mixed linker Zr(IV)-based MOF, [ZrO(OH)(FUM)(PZDC-NO)] (PZDC-NO = 4-nitro-3,5-pyrazoledicarboxylic acid, FUM = fumaric acid) denoted as MOF-801(PZDC-NO) synthesized via this strategy which possess an electron-withdrawing group (-NO) on secondary linkers. The MOF-801(PZDC-NO) has been fully characterized via various analyses, such as Fourier transform infrared, powder X-ray diffraction, C/H nuclear magnetic resonance, XPS, TGA, and N adsorption/desorption, SEM, EDX, etc.

Effects of starch-tea polyphenol complexes on the structure features of reconstituted doughs and oil absorption of potato crisps.

The structural features of reconstituted doughs play a crucial role in determining the oil uptake properties of fried potato crisps. Wheat starch (WS), corn starch (CS), potato starch (PS), or tapioca starch (TS) and tea polyphenols (TPs) complexes were prepared, and their effects on the physicochemical and structural properties of reconstituted dough and oil uptake of potato crisps were investigated. A denser and consistent network structure was observed in the reconstituted dough produced by PS-TPs and TS-TPs complexes.