Early Efficacy and Safety of Finerenone on Type 2 Diabetes-Related Chronic Kidney Disease: A Real-World Observational Study in China.

Aims: This observational study aimed to assess the early efficacy and safety of finerenone in patients with type 2 diabetes-related chronic kidney disease (CKD) in China with or without sodium-glucose cotransporter-2 inhibitors (SGLT-2i) or renin-angiotensin system inhibitors (RASi).

Materials And Methods: Patients with type 2 diabetes-related CKD who initiated finerenone therapy between March 2023 and February 2024 at Zhongshan Hospital, Fudan University were retrospectively included. All patients were followed up at least once during the 12-week observation period.

Association between hemoglobin glycation index and carotid plaques in non-dialysis CKD stage 3-5 patients: a retrospective cross-sectional study.

Purpose: Carotid atherosclerosis is a major cardiovascular complication in patients with chronic kidney disease (CKD). The hemoglobin glycation index (HGI) has been linked to glycation stress and vascular inflammation, which may contribute to atherosclerosis. However, its relationship with carotid plaque in patients with CKD remains unclear.

Syndecan-1 regulates lipid metabolism and mitigates fibrosis during the transition from acute kidney injury to chronic kidney disease.

Background: The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) is characterized by persistent renal fibrosis, in which abnormal lipid metabolism plays a crucial role. Syndecan-1 (SDC-1) has been implicated in various tissue remodeling processes; however, its role in lipid metabolism and fibrosis during the progression from AKI to CKD is not well understood.

Methods: This study used a murine model of unilateral ischemia-reperfusion-induced AKI-to-CKD progression for in vivo analysis and employed transforming growth factor-beta (TGF-β)-induced fibrosis in Human Kidney-2 cells and primary mouse tubular epithelial cells for in vitro studies.

Association Between Estimated Pulse Wave Velocity and Carotid Plaques in Non-Dialysis CKD Stages 3-5: A Cross-Sectional Study.

Carotid plaques are common in CKD patients and serve as a key marker of cardiovascular risk. Arterial stiffness, assessed by estimated pulse wave velocity (ePWV), is a valuable non-invasive indicator of vascular health. However, the association between ePWV and carotid plaques in CKD stages 3-5 remains unclear.

Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin With Concomitant Piperacillin-Tazobactam Versus Other Beta-Lactams: A Systematic Review and Meta-Analysis.

: To explore whether vancomycin (VAN) plus piperacillin-tazobactam (PTZ) was associated with an increased risk of acute kidney injury (AKI) compared with VAN plus other beta-lactams (BLs) or monotherapy in critically ill patients, where the evidence remains controversial. PubMed, Cochrane, Web of Science, and Embase were searched from inception to June 2024. Studies comparing the risk of AKI with one group receiving VAN+PTZ, and other groups receiving VAN plus other BLs, or monotherapy in critically ill.

Farnesoid X Receptor Alleviates Cisplatin-Induced Kidney Inflammatory Injury by Inhibiting Tlr4/NF-κB Pathway.

Inflammatory responses play a critical role in cisplatin-induced acute kidney injury (AKI). Farnesoid X receptor (FXR) has been shown to mitigate kidney dysfunction, but its mechanism remains unclear. This study aims to explore whether FXR reduces cisplatin-induced AKI by modulating inflammation.

Elevated Monocyte-to-Lymphocyte Ratio at Peritoneal Dialysis Initiation Predicts Long-Term Peritonitis Risk: A Retrospective Cohort Study.

Introduction: Peritoneal dialysis (PD)-associated peritonitis is a major complication in PD patients, leading to increased morbidity and technique failure. Identifying reliable biomarkers for predicting peritonitis risk is crucial for early intervention. Monocyte-to-lymphocyte ratio (MLR) is an emerging inflammatory marker associated with adverse outcomes in end-stage renal disease, but its predictive value for peritonitis remains unclear.

Exploration of mortality-associated creatinine thresholds for acute kidney injury in cardiac surgery patients with impaired kidney function: a single-center retrospective cohort study.

Background: Acute kidney injury (AKI) is a frequent and severe complication following cardiac surgery, particularly in patients with impaired kidney function. The existing Kidney Disease: Improving Global Outcomes (KDIGO) criteria do not specifically address acute-on-chronic kidney injury in this high-risk population. Previous studies have proposed alternative diagnostic thresholds that identify more AKI cases than KDIGO and are associated with adverse outcomes.

Association Between the Preoperative Triglyceride-Glucose Index and Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Cardiac Surgery.

Background: Acute kidney injury (AKI) is a major complication of cardiac surgery, particularly in patients with pre-existing chronic kidney disease (CKD), who are at higher risk due to their compromised renal function. This study investigated the association between the triglyceride-glucose (TyG) index, a marker of insulin resistance, and postoperative AKI in CKD patients undergoing cardiac surgery to enhance risk stratification and perioperative management.

Methods: This retrospective study included 542 patients with impaired renal function (estimated glomerular filtration rate (eGFR) 15-60 mL/min/1.

Prediction of dust migration and distribution characteristics in open pits at different vehicle speeds.

Because an open-pit mine is an open operating environment, mining and stripping equipment inevitably pollutes the environment to some extent during the operation process. Therefore, the current dust concentration monitoring methods and technologies are relatively simple, and the dust distribution characteristics and diffusion laws of each production link in open-pit mines are not clear. Taking the transportation link of the Anjialing open-pit mine as the research object, a set of integrated monitoring methods combining ground and space and fixed and mobile technology is proposed.

The role of Tei index as an early predictor for evaluating experimental uremic cardiomyopathy model.

Background: Uremic cardiomyopathy (UCM) remains the leading cause of cardiovascular mortality in patients with end-stage renal disease (ESRD). Experimental animal models serve as essential tools for elucidating the potential mechanism underlying UCM. However, experimental UCM models are often challenged by inter-individual variability and inconsistent success rates.

Inhibition of epigenetic regulator UHRF1 attenuates renal fibrosis and retains transcription factor Krüppel-like factor 15 expression.

Aberrant DNA methylation modification is well-known to be involved in renal fibrogenesis. As a critical cooperator in DNA methyltransferase 1 (DNMT1)-mediated maintenance of DNA methylation, the role of ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) in renal fibrosis remains unknown. Here, upregulation of UHRF1 is observed in activated renal fibroblasts.

Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.

Background: The mechanisms underlying the progression of chronic kidney disease (CKD) following acute kidney injury (AKI) remain poorly understood. Senescent cells induce maladaptive repair have been identified as a significant contributor to CKD subsequent to AKI.

Purpose: The purpose of this study was to investigate the correlations between kidney fibrosis after unilateral ischemia injury and cellular senescence and explored the potential therapeutic effect of GM6001 on AKI to CKD transition.

Non-linear associations between serum manganese with chronic kidney disease: results from two nationwide studies in the United States and China.

Introduction: This study aimed to better evaluate the association between serum manganese (Mn) and chronic kidney disease (CKD) by using data from the United States National Health and Nutrition Examination Survey (NHANES) and the Chinese Longitudinal Healthy Longevity Study (CLHLS).

Materials And Methods: A total of 15411 and 451 participants were selected from NHANES and CLHLS, respectively. The primary diagnosis of CKD was defined as eGFR <60 mL/min/1.

Coenzyme Q10 supplementation in adult-onset focal segmental glomerulosclerosis caused by the Chinese common pathogenic variant c.737G > A (p.Ser246Asn) in the gene.

COQ8B nephropathy, a mitochondrial disorder caused by mutations in the gene, is a major pediatric genetic focal segmental glomerulosclerosis (GFSGS) etiology and stands out as one of the few treatable forms with good response to coenzyme Q10 (CoQ) supplementation. As the diagnosis and clinical experience of COQ8B nephropathy were predominantly in the pediatric population, the long-term efficacy of CoQ supplementation and its application in the adult-onset patients remains largely unknown. Here, we report three cases of adult-onset FSGS from unrelated families, all carrying the Chinese common  mutation (c.

Association of chronic kidney disease and cardiovascular disease risk with all-cause mortality: an interaction, joint and mediation analysis in Chinese adults.

Background: Chronic kidney disease (CKD) is a global public health problem. This study aimed to evaluate the complex relationship of CKD and cardiovascular disease (CVD) risk with mortality in different age groups and the mediation effect of CVD risk among Chinese adults.

Methods: A total of 7533 participants from the 2009 wave of China Health and Nutrition Survey (CHNS) cohort were included in this study and followed up to 2015.

Magnesium Lithospermate B Protects Against Ischemic AKI-to-CKD progression via regulating the KLF5/CDK1/Cyclin B1 pathway.

Background: Ischemia-reperfusion injury (IRI) is the primary cause of acute kidney injury (AKI), which can result in chronic kidney disease (CKD) with renal fibrosis. Magnesium lithospermate B (Mlb), a bioactive compound produced from Salvia miltiorrhiza Bunge, exerts nephroprotective effects against AKI. However, the significance of Mlb in the evolution of IRI-induced AKI in patients with CKD remains unclear.

Association of Uric Acid to High-Density Lipoprotein Cholesterol Ratio with Left Ventricular Hypertrophy in Chronic Kidney Disease.

Introduction: Chronic kidney disease (CKD) is associated with a high prevalence of cardiovascular complications, including left ventricular hypertrophy (LVH), which significantly increases morbidity and mortality. LVH in CKD results from a complex interplay of hemodynamic, neurohormonal, and metabolic factors. The uric acid-to-high density lipoprotein cholesterol ratio (UHR) has recently been proposed as a potential marker for cardiovascular outcomes, combining the effects of uric acid and HDL-C on inflammation and cardiovascular risk.

Remote ischaemic pre-conditioning, kidney injury, and outcomes after coronary angiography and intervention: a randomized trial.

Background And Aims: Remote ischaemic pre-conditioning (RIPC) delivered shortly prior to an angiographic procedure may reduce contrast-associated acute kidney injury (CA-AKI). Whether a longer interval between RIPC and contrast administration also reduces CA-AKI and post-procedural complications after coronary angiography (CAG) or percutaneous coronary intervention (PCI) is unknown.

Methods: This was a multicentre, randomized trial of patients at risk of CA-AKI undergoing elective CAG or PCI comparing delayed RIPC (four cycles of 5 min inflations on one upper arm 24 h before the procedure) with sham RIPC.

Integrated Single-Cell Transcriptome and eQTL Analyses Reveal the Role of PZP in Aging and Chronic Kidney Disease.

Background: Aging is a known driver of chronic kidney disease (CKD), yet the genetic mechanisms linking these two conditions remain unclear. This study aims to explore the role of CD8+ central memory T (T) cells and their associated gene expression in the interaction between aging and CKD.

Methods: Peripheral blood samples from young controls, elderly individuals, and CKD patients were analyzed using single-cell RNA sequencing to investigate immune cell populations.

Both carvedilol and cimetidine alleviate cisplatin-induced nephrotoxicity via downregulating OCT2.

Background: Cisplatin is a common chemotherapy agent for solid tumors but severe nephrotoxicity limits its application, with no effective pharmacological treatments. Organic cation transporter 2 (OCT2) is involved in cisplatin uptake in kidneys. This study aimed to find drugs with promising clinical applications that could prevent cisplatin-induced acute kidney injury (Cis-AKI) by inhibiting OCT2.

Five-Year Time Profiles of Clearances of Different Uremic Solutes in Incident Peritoneal Dialysis Patients.

Introduction: Different uremic solutes have varying degrees of clearances owing to different chemical properties and the pathological and physiological changes in the kidneys and peritoneum.

Methods: The 5-year time profiles of renal, peritoneal, and total clearances of creatinine, urea nitrogen (UN), uric acid (UA), trimethylamine n-oxide (TMAO), phosphate, beta-2-microglobulin (β2-MG), interleukin-6 (IL-6), indoxyl sulfate (IS), and p-cresol sulfate (PCS) were investigated in 64 peritoneal dialysis (PD) patients. The patients were divided into an early start and a late start group according to baseline estimated glomerular filtration rate to investigate the effect of dialysis initiation timing on uremic solutes clearances.