Tactile-Transparent Wearable Sensor for Clinician-Friendly Pulse Wave Velocity Monitoring and Cardiovascular Risk Profiling.

Arterial stiffening is an independent risk factor for cardiovascular diseases, particularly affecting organs with low vascular resistance, such as the brain and kidneys. Pulse wave velocity (PWV) is the clinical gold standard for arterial stiffness assessment; however, conventional equipment requires complex setups and trained operators, limiting real-world and point-of-care monitoring. Here, we introduce a tactile-transparent wearable (TTW) sensor that preserves physicians' tactile pulse palpation abilities while providing quantitative cardiovascular risk assessment by integrating flexible Polydimethylsiloxane (PDMS) electrodes and ultrathin graphene oxide dielectric films.

Liquefaction analysis of marine diversion dike foundation and gravel pile reinforcement treatment based on the PL-Finn model.

This study investigates the liquefaction characteristics and failure mechanisms of sand foundations in the marine diversion dike of a coastal nuclear power plant, along with the anti-liquefaction performance of gravel pile-reinforced foundations. Using the three-dimensional finite difference software FLAC3D (Fast Lagrangian Analysis of Continua), we conducted numerical simulations of both unreinforced and reinforced liquefiable sand foundations. A three-dimensional model was developed, incorporating dynamic analysis with the PL-Finn constitutive model to simulate post-liquefaction large deformations.

Ultrasonic-assisted encapsulation of lemongrass essential oil in HP-β-CD: Optimization, characterization, and application for mango preservation.

Mangoes are highly susceptible to post-harvest spoilage, leading to significant losses. This study aimed to optimize the encapsulation of lemongrass essential oil (LEO) using ultrasonic-assisted hydroxypropyl-β-cyclodextrin (HP-β-CD) and response surface methodology (RSM). The ultrasonic-assisted inclusion complex (UIC) was characterized through various techniques including particle size analysis, SEM, UV-vis, FTIR, XRD, and TGA.

Adipose stem cell-derived nanovesicles for cardioprotection: production and identification of therapeutic components.

Extracellular vesicles (EVs) derived from stem cells have shown therapeutic benefits in myocardial injury. However, the challenges in their large-scale production and elusive molecular mechanisms underlying their therapeutic effects have been hindering their clinical translation. Here, in a mouse model of myocardial ischemia-reperfusion, EVs isolated from human adipose tissue and EV-like nanovesicles fabricated with adipose stem cells (ADSCs) via a membrane extrusion approach, termed ADSC-derived nanovesicles (ADSC-CDNs), exhibited comparable cardioprotective effects, validating this EV-mimetic strategy.

Research on collaborative filtering algorithm based on improved K-means algorithm for user attribute rating and co-rating.

In response to the challenges of information overload in large datasets, as well as issues related to data sparsity and cold starts in traditional recommendation algorithms, this paper proposes a collaborative filtering algorithm based on an enhanced K-means algorithm for user attribute rating and common rating. This proposed algorithm leverages a per-constructed user attribute rating matrix and computes the objective weights of user attribute rating features using variance analysis. Specifically, it is observed that larger sample variances exert greater influence on clustering outcomes.

Epitope-based antibody development against metalloproteinases and phospholipases A from venom.

Background: , or the hundred-pace snake, poses severe health risks due to its venom. Envenomation by this snake leads to complications such as hemorrhage, edema, and coagulopathy. Traditional antivenoms are limited by venom variability and often contain non-neutralizing antibodies, highlighting the need for more precise and effective immunogens.

Preparation, identification, and molecular mechanism of novel DPP-IV inhibitory peptides from pumpkin seed: In silico screening and experimental validation.

The rising prevalence of Type 2 diabetes mellitus (T2DM) and the limitations of synthetic DPP-IV inhibitors emphasize the need for natural alternatives with fewer side effects. This study explored pumpkin seed protein (PSP) as a source of potential DPP-IV inhibitory peptides. Through in silico screening and experimental validation, seven novel peptides were identified, with LPGFF, LPGF, and MPLPA exhibiting potent inhibitory activities (IC: 449.

[Application effect of A-PRF and CGF combined with nano-hydroxyapatite in external maxillary sinus lift implantation].

Purpose: To evaluate the clinical efficacy of advanced platelet-rich fibrin(A-PRF) and concentrated growth factor(CGF) combined with nano-hydroxyapatite in external maxillary sinus lift implantation.

Methods: A total of 68 patients who underwent external maxillary sinus lift implantation from April 2023 to March 2024 at Taikang Xianlin Gulou Hospital were selected. They were randomly assigned to the control group(n=34, using Bio-Oss large particle bone graft material) and combined group(n=34, using A-PRF and CGF combined with nano-hydroxyapatite).

Exploring the mechanism of (Bunge) Kitag's therapeutic strategy for rheumatoid arthritis: integrating network pharmacology, molecular docking and experiments.

Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by joint swelling, cartilage degradation, and joint deformity. The traditional Chinese herb (Bunge) Kitag has been utilized in the management of RA, but the underlying mechanisms are unknown. This study utilized network pharmacology analysis to identify 26 active compounds associated with RA treatment and elucidate their interactions with 23 critical targets linked to RA.

Structural and gelation properties of soy protein isolates-sesbania gum gels: effects of ultrasonic pretreatment and CaSO concentration.

This study aimed to investigate the influence of ultrasound treatment on the structural and gelation properties of soy protein isolate (SPI)-sesbania gum (SG) composite gels induced by varying concentrations of CaSO. The results showed that ultrasound treatment at amplitudes ranging from 20 % to 60 % for 10 min improved protein solubility, rheological properties and gel strength. The addition of CaSO (15 to 35 mM) further increased gel hardness but caused a decline in the water-holding capacity (WHC).

Lactylation of PLBD1 Facilitates Brain Injury Induced by Ischemic Stroke.

Background: Ischemic stroke is a prevalent global condition and its associated brain damage poses a significant threat to patient survival and outcomes. The underlying mechanisms of ischemic stroke-induced brain injury remain elusive, necessitating further investigation.

Methods: Ischemic stroke models were established using middle cerebral artery occlusion (MCAO) in animals and oxygen-glucose deprivation and reperfusion (OGD-R) in cells.

Does transurethral resection of the prostate before robot-assisted radical prostatectomy have adverse effects on patients diagnosed with prostate cancer: a comparative evidence-based analysis?

In clinical practice, it is not uncommon for a history of trans-urethral resection of the prostate (TURP) to complicate a future robotic-assisted radical prostatectomy (RARP). This study aims to determine if prior TURP adversely affects outcomes in subsequent RARP, analyzing perioperative, functional, and oncological results between the procedures. Research published in English before September 2024 was systematically reviewed using Web of Science, PubMed, Cochrane Library, and the EMBASE.

Association between Two Cardiovascular Health Algorithms and Kidney Stones: A Nationwide Cross-sectional Study.

Background And Objective: There is limited literature on the relationship between cardiovascular health (CVH) and kidney stones. This study aims to compare the association of Life's Simple 7 (LS7) and Life's Essential 8 (LE8) with kidney stone prevalence.

Methods: A cross-sectional analysis was conducted utilizing NHANES data (2007-2018).

Mass production of robust hydrogel electrolytes for high-performance zinc-ion batteries.

Hydrogel electrolytes are crucial for solving the problems of random zinc dendrite growth, hydrogen evolution reactions, and uncontrollable passivation. However, their complex fabrication processes pose challenges to achieving large-scale production with excellent mechanical properties required to withstand multiple cycles of mechanical loads while maintaining high electrochemical performance needed for the new-generation flexible zinc-ion batteries. Herein, we present a superspreading-based strategy to produce robust hydrogel electrolytes consisting of polyvinyl alcohol, sodium alginate and sodium acetate.

BA-ATEMNet: Bayesian Learning and Multi-Head Self-Attention for Theoretical Denoising of Airborne Transient Electromagnetic Signals.

Airborne transient electromagnetic (ATEM) surveys provide a fast, flexible approach for identifying conductive metal deposits across a variety of intricate terrains. Nonetheless, the secondary electromagnetic response signals captured by ATEM systems frequently suffer from numerous noise interferences, which impede effective data processing and interpretation. Traditional denoising methods often fall short in addressing these complex noise backgrounds, leading to less-than-optimal signal extraction.

Multimodal nanoenzyme-linked aptamer assay for Salmonella typhimurium based on catalysis and photothermal effect of PB@Au.

A composite nanomaterial of Prussian blue@gold nanoparticles (PB@Au) with catalytic and photothermal properties was proposed, which combined with anti-matrix interference aptamers to achieve robust specificity and sensitivity in the detection of Salmonella typhimurium (S. typhimurium). The detection probe, PB@Au-Aptamer (PB@Au-Apt), was designed to exhibit high specificity for the target and catalyze the signal generation to produce a color change, thereby enabling rapid detection.

Effect of an Endoscopy Screening on Upper Gastrointestinal Cancer Mortality: A Community-Based Multicenter Cluster Randomized Clinical Trial.

Background & Aims: Population-based observational studies suggest that endoscopic screening may reduce upper gastrointestinal cancer mortality. We aimed to quantify the effect of endoscopy screening.

Methods: This is a community-based, multicenter, cluster randomized clinical trial conducted in both high-risk and non-high-risk areas of China.

High strength chitosan-based nanocomposites with aligned nanosheets and crosslinked networks.

High strength/toughness nanocomposites are increasingly in demand due to the development needs of high-end applications. However, the aggregation and random orientation of nanofillers and the weak crosslinking of the polymer matrix lead to the degradation of the mechanical properties of nanocomposites. Here, we present a strategy to prepare chitosan-based nanocomposites with aligned nanosheets the photo-crosslinking of modified chitosan.

Proteomic Profiling of Venoms from and : Enzymatic Activities and Toxicity Assessment.

Kraits are venomous snakes of the genus from the family . Their venom typically demonstrates neurotoxicity; however, the toxicity is significantly influenced by the snake's species and geographical origin. Among the species, and have been poorly studied, with little to no information available regarding their venom composition.

Corrigendum: Radiosynthesis and identification of a molecular probe I-FAPI targeting cancer-associated fibroblasts.

[This corrects the article DOI: 10.3389/fonc.2024.

A comprehensive evaluation and meta-analysis of the perioperative and oncological outcomes of robotic radical prostatectomy using the DaVinci vs the Hugo RAS surgical platforms.

Because of the increasing popularity of Hugo RAS as a surgical platform, a comparison examination of intraoperative and oncological outcomes across DaVinci and Hugo RAS robotic surgery platforms is urgently needed. We carried out a comprehensive review and meta-analysis of the literature of current research, comprehensively searching PubMed, Cochrane and Embase for eligible studies comparing the results between the DaVinci and Hugo RAS. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria were followed in the conduct of this study, with language restricted to English and a final search date of June 2024.

Radiosynthesis and identification of a molecular probe I-FAPI targeting cancer-associated fibroblasts.

Purpose: Fibroblast activation protein (FAP) is highly expressed in the mesenchyme of most malignant epithelial tumors, while its expression is low in normal tissues. FAP inhibitors (FAPIs) bind specifically to FAP and are used for tumor-targeted diagnosis and therapy. The aim of this study was to radiosynthesize a novel molecular probe I-FAPI and evaluate its targeting and biological characteristics.

Characterization, mechanisms, structure-activity relationships, and antihypertensive effects of ACE inhibitory peptides: rapid screening from sufu hydrolysate.

This study investigates the characterization, mechanisms of action, structure-activity relationships, and antihypertensive effects of ACE inhibitory peptides derived from sufu hydrolysate following simulated gastrointestinal digestion. Sufu was enzymatically digested using pepsin, trypsin, and chymotrypsin to mimic gastrointestinal conditions, followed by ultrafiltration to fractionate the peptides based on molecular weight. The fraction under 1 kDa exhibited the highest ACE inhibitory activity.

Comparison of single-port versus multi-port robotic assisted partial nephrectomy: a systematic review and meta-analysis of perioperative and oncological outcomes.

The safety and efficacy of single-port and multi-port robot-assisted partial nephrectomy (SP-RAPN and MP-RAPN, respectively) were assessed for treating partial nephrectomy in this study. A systematic review of PubMed, Cochrane Library, and Web of Science databases was conducted up to June 2024 to compare studies on SP-RAPN and MP-RAPN. Primary outcomes included perioperative results, complications, and oncological outcomes.