[Therapeutic mechanism of Compound Xuanju Capsule on erectile dysfunction].

Objective: To investigate the pharmacological mechanism of Compound Xuanju Capsule in the treatment of erectile dysfunction (ED) by using network pharmacology and molecular docking technology.

Methods: The active ingredients and targets of Compound Xuanju Capsule were screened using Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform (TCMSP). TTD, OMIM, DrugBank and GeneCards databases were used to obtain genes related to ED, and the union of the results was taken as the disease genes of ED.

APPi: A Multiscale Qualitative-Quantitative Insecticide-Likeness Evaluation Platform and Application.

According to the Food and Agriculture Organization of the United Nations (FAO), pests reduce global crop production by 14% annually. The growing challenge of pest resistance, coupled with the relatively low success rates of pesticides, has prompted researchers to shift their attention towards the accurate evaluation of insecticide lead. In contrast to in vitro methods of structural similarity or target affinity, the 'insecticide-likeness' approach emphasises the in vivo biological effects of compounds, thereby constructing precise and comprehensive evaluation rules.

Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia.

Vascular dementia (VaD) is a neurodegenerative disorder characterized by chronic oxygen insufficiency, leading to the generation of oxygen-free radicals, inflammatory responses, disturbances in iron metabolism, lipid peroxidation, and other pathological changes that disrupt intracellular homeostasis. These processes ultimately lead to neuronal death and cognitive dysfunction. Normal neurological functions depend on the capacity of the iron homeostatic system to regulate the balance of oxidative states.

SPA-PNN ligand for the kinetic resolution of carbocyclic and heterocyclic spiranes by asymmetric hydrogenation.

The chiral carbocyclic and heterocyclic spirane scaffolds are widely present in natural products and pharmaceutical molecules. Efficient, concise, and enantioenriched synthesis of these structures is a significant objective in both academic and industrial fields. Here, we design and synthesize a series of chiral SPA-PNN ligands, which are used to kinetically resolve racemic spirocyclic 1,3-diketones and their analogs via Ir-catalyzed asymmetric direct hydrogenation to afford the corresponding chiral spirocyclic 1,3-diketones and chiral hydroxyspiroketones.

A nomogram based on multiparametric magnetic resonance imaging radiomics for prediction of acute pancreatitis activity.

Purpose: In acute pancreatitis (AP), disease activity is defined as the reversible manifestation of the disease. The aim of this study was to develop a nomogram for predicting disease activity in AP based on multiparametric magnetic resonance imaging (MRI) radiomics.

Methods: This retrospective study included 310 patients with first-episode AP from two medical centers in China.

Recent total synthesis of natural products leveraging a strategy of enamide cyclization.

Enamides are distinctive amphiphilic synthons that can be strategically incorporated into cyclization reactions. The iminium species generated from enamides via nucleophilic addition or substitution are capable of engaging in further electrophilic additions or isomerization processes. Exploiting the multiple reactivities of enamides facilitates the development of diverse cyclization modes that provide entries to various -heterocycles, some of which serve as key structural motifs in natural alkaloids.

Neuroplastin 65 deficiency leads to the impairment of visual function through affecting ribbon synapse in retina of mice.

Neuroplastin 65 (NP65) is a synapse-enriched glycoprotein in the central nervous system and is implicated in synaptic plasticity. In the present study, we found that NP65 knockout (NP65 KO) mice exhibit impaired visual function, including reductions in the amplitude of b-wave in scotopic flash electroretinogram (fERG), the amplitude of N1 and P1 waves in flash visual evoked potentials (fVEP), and the constriction rate in pupillary light reflexes (PLR). In wild-type (WT) mice, NP65 is specifically enriched in the synaptic ribbon (SR) of ribbon synapses labeled by Ribeye in the retina.

Combining ranibizumab with calcium dobesilate to reduce injection frequency in diabetic macular edema treatment.

Background: This study explores the potential of calcium dobesilate combined with intravitreal ranibizumab injections to reduce the treatment frequency in patients with DME-induced visual impairment and observes the clinical outcomes.

Methods: In this investigation involving 90 DME patients, a comparative analysis was conducted between a group treated with both ranibizumab injections and calcium dobesilate capsules (45 patients) and a control group receiving only the injections (45 patients). Treatment was monthly for 3 months, then adjusted as needed, with a follow-up at 12 months focusing on injection frequency, BCVA scores, and CMT to assess both treatment efficacy and safety.

The association between the number of teeth and frailty among older adults: a systematic review and meta-analysis.

Background: Tooth loss is common among the elderly and often correlates with aging. Existing studies on the link between tooth loss and frailty in older adults yield inconsistent results. This systematic review and meta-analysis aims to clarify the relationship.

Catalytic Enantioselective α-Ethynylation of Oxindoles: Total Synthesis of (-)-Corynoxine, (-)-Isorhynchophylline, (-)-Aspidospermidine, and (-)-Limaspermidine.

The all-carbon quaternary stereogenic center of oxindoles is a crucial structural element of a broad spectrum of indole alkaloids, imparting these molecules with rigid three-dimensional configurations essential for their biological activities. Here, we present a catalytic asymmetric α-ethynylation reaction of oxindoles taking advantage of the catalysis of a spiropyrrolidine amide (SPA) triazolium. This transformation enables the enantioselective construction of the C3 quaternary carbon stereocenter of oxindoles while introducing a versatile ethynyl functionality.

Comparison of Computed Tomography/Magnetic Resonance Imaging Characteristics of Acute Pancreatitis Between Cholecystectomy and Non-cholecystectomy Patients.

Objective: This study aimed to compare computed tomography (CT)/magnetic resonance imaging (MRI) characteristics of acute pancreatitis (AP) between patients with cholecystectomy and non-cholecystectomy and to validate the effect of prior cholecystectomy on the severity of subsequent pancreatitis.

Methods: This retrospective study included 384 inpatients with AP at our hospital from January 1, 2020 to December 31, 2023. Based on their history of cholecystectomy, the patients were split into cholecystectomy and non-cholecystectomy groups.

Enantio- and Diastereoselective Synthesis of P-Stereogenic Phospholane Oxides via Cobalt-Catalyzed Hydroalkylation.

Chiral phospholane ligands and catalysts have been widely applied in asymmetric catalysis and synthesis. However, the construction of the chiral phospholane skeleton remains challenging and primarily relies on the use of chiral auxiliaries or resolution. In this work, a highly enantioselective and diastereoselective synthesis of P-stereogenic phospholane oxides has been achieved through a cobalt-catalyzed desymmetric hydroalkylation strategy.

Effects of exercise training on left ventricular systolic and diastolic function after myocardial infarction: systematic review and meta-analysis.

Objectives: Exercise training is a rehabilitative approach to improve cardiac function in patients with myocardial infarction. However, evidence on the effectiveness of exercise training in these patients remains limited. In this meta-analysis, we aim to evaluate the extent to which exercise training improves cardiac function in patients with myocardial infarction.

Mechanism of LCN2 in cerebral ischemia-reperfusion injury.

Cerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process faced by brain tissues after ischemic stroke treatment, which involves mechanisms of inflammatory response, oxidative stress and apoptosis, and severely affects treatment outcome. Lipocalin-2 (LCN2), an acute-phase protein, is significantly up-regulated after CIRI and promotes neural repair by enhancing astrocyte phagocytosis, but its over-activation may also trigger secondary inflammation and demyelination injury. LCN2 also plays a key role in neuroinflammation regulation by regulating the polarization state of astrocytes and the release of inflammatory factors, and may affect the integrity of the blood-brain barrier and a variety of pathologic injury processes.

Application of Optogenetic Neuromodulation in Regulating Depression.

Depression is a multifaceted disorder with a largely unresolved etiology influenced by a complex interplay of pathogenic factors. Despite decades of research, it remains a major condition that significantly diminishes patients' quality of life. Advances in optogenetics have introduced a powerful tool for exploring the neural mechanisms underlying depression.

A novel pN stage prediction model for resectable rectal adenocarcinoma based on preoperative MRI features and multiregional apparent diffusion coefficients.

Objective: To develop and validate a novel model based on preoperative MRI features and multiregional apparent diffusion coefficients (ADCs) to improve the prediction of pN stage in resectable rectal adenocarcinoma (RA).

Methods: Two hundred fifty-four consecutive patients (median age [interquartile range], 67 [56-74] years; 156 males) with resectable RA were retrospectively collected at two medical centers from January 2017 to December 2023 and were divided into the training (n = 139), internal validation (n = 60), and external validation (n = 55) sets. All patients underwent preoperative MRI scans.

In-depth insight into structure-reactivity/regioselectivity relationship of Lewis acid catalyzed cascade 4πe-cyclization/dicycloexpansion reaction.

The Lewis acid-catalyzed tittle reaction of 1,3-dicycloalkenlidine ketones is recognized as so far the shortest and most effective 1-step method for construction of angular tricyclic scaffolds, which are extensively found in bioactive terpenoids. Here, a further kinetic study of this reaction with 30 reaction examples is carried out using in situ IR technology and DFT calculation. That enables the creation of well-fitted linear relationships of lnk/(ΔG/T), ΔG/ΔG, ln(k/k)/σ, reflecting the structure's effect on reactivity/selectivity, and validating the reaction mechanism.

Two treatment methods for hepatocellular carcinoma: Lenvatinib or bevacizumab combined with sintilimab and interventional therapy.

In their study, Han compared the efficacy of bevacizumab plus sindilizumab plus interventional therapy with that of lenvatinib plus sindilizumab plus interventional therapy for patients with intermediate and advanced hepatocellular carcinoma. The triple therapy, which integrates interventional therapy, targeted therapy, and immunotherapy, has emerged as a promising research focus in the treatment of liver cancer. Consequently, it is of utmost significance to select an appropriate combination of interventional therapy, targeted therapy, and immunotherapy for patients suffering from intermediate and advanced liver cancer.

Gold-catalyzed polyene cyclization and its application in the total synthesis of natural products.

Polyene cyclization has emerged as a powerful tool for increasing molecular complexity. In recent years, gold-catalyzed polyene cyclization reactions have made significant progress, particularly in the total synthesis of complex polycyclic natural products with biological activity. Simultaneously constructing multiple stereogenic centers and core polycyclic ring structures, especially through the catalytic asymmetric reactions, greatly improves the efficiency of natural product synthesis.

Association Between Frailty and Mortality, Falls and Hospitalisation Among Patients Undergoing Dialysis: A Systematic Review and Meta-Analysis.

Aim: Frailty is a risk factor for adverse events in older individuals; however, it has not been fully verified in patients undergoing dialysis. Our aim was to verify the association between frailty and adverse outcomes consisting of mortality, falls and hospitalisation among patients undergoing dialysis by a systematic review and meta-analysis.

Design: Systematic review and meta-analysis.

Catalytic Asymmetric 1,4-Hydrocarbonation of 1,3-Enynes via Photoredox/Cobalt/Chromium Triple Catalysis.

A synergistic photoredox/cobalt/chromium triple catalysis system for regioselective, enantioselective, and diastereoselective 1,4-hydrocarbonation of readily available 1,3-enyne precursors was explored, providing a modular synthetic platform for various trisubstituted axially chiral allenes bearing an extra central chirality. The protocol features a broad substrate scope, good functional group tolerance, excellent selectivity, and mild reaction conditions. Furthermore, a possible reaction mechanism is proposed based on numerous control experiments and density functional theory calculations.

Magnetic resonance imaging (MRI) and clinical features of different parts of the pancreas involved in acute pancreatitis: a cross-sectional study.

Background: Patients with acute pancreatitis (AP) have different sites of pancreatic involvement. The aim of this study was to investigate the differences in magnetic resonance imaging (MRI) findings and clinical features of different sites of involvement (subtypes) in AP, with a view to complement and complete the classification of AP based on anatomical imaging features.

Methods: We consecutively collected data from inpatients with AP from January 2018 to October 2022 at a tertiary care hospital.

Comparison of apparent diffusion coefficients of resectable mid‑high rectal adenocarcinoma and distal paracancerous tissue.

Paracancerous tissues actively communicate with the tumor and undergo molecular alterations associated with tumorigenesis. Apparent diffusion coefficient (ADC) can help distinguish between rectal adenocarcinoma (RA), tumor-adjacent and tumor-distant tissues. Preoperative determining optimal distal resection margin (DRM) is crucial for formulating surgical options.