Correlation between baseline magnetic resonance imaging features and serum carcinoembryonic antigen levels in patients with primary rectal cancer.

Background: Serum carcinoembryonic antigen (CEA) levels and magnetic resonance imaging (MRI) findings are widely used for the diagnosis and treatment of rectal cancer; however, research investigating their correlation remains limited.

Aim: To investigate the correlation between baseline MRI features and serum CEA levels in patients diagnosed with primary rectal cancer.

Methods: Eighty patients (age: 42-78 years) diagnosed with primary rectal cancer were enrolled.

Nucleophilic Ring-Opening of -Benzoylaziridine Combined with Spirolactamization of Rhodol Enables Ratiometric Fluorescence Imaging of Hydropersulfides in .

Hydropersulfides (RSSH) are an important class of reactive sulfur species (RSS) involved in a variety of physiological processes in biological systems. However, selective detection of RSSH is challenging since the persulfide group (-SSH) exhibits reactivity akin to biologically abundant biothiols. To address this issue, we designed as a ratiometric fluorescent probe for RSSH by integrating the nucleophilic ring-opening of an -benzoylaziridine and spirolactamization of a rhodol.

Maternal oxygen inhalation affects the fetal hemodynamic in low-risk with uncomplicated late pregnancy.

Background: Maternal oxygen inhalation during labor has not been shown to provide significant benefits to newborns. However, its impact on fetal hemodynamics in late pregnancy remains uncertain.

Objective: This study aimed to investigate the association between maternal oxygen inhalation in the late trimester and changes in fetal hemodynamics.

Early neurological wake-up test in intubated patients with traumatic brain injury.

Background: Daily wake-up has been implemented widely in intensive care units (ICU) and could improve the patients' prognosis. However, little is known about the benefit of early neurological wake-up test (ENWT) in patients with acute traumatic brain injury (TBI). We aimed to investigate the role of ENWT as a clinical monitoring tool for TBI and its association with prognosis.

1,2-Allenic Ketone-Based Fluorogenic Probes for Imaging of S-Sulfinylation in Living Cells.

Cysteine S-sulfinylation is an important oxidative post-translational modification on proteins that regulates a variety of cell and protein functions. Aberrant S-sulfinylation contributes to a range of human pathologies, such as cancer and cardiovascular disease. However, efforts to elucidate the roles of S-sulfinylation in physiology and disease have been hampered due to the lack of methodology for the selective and direct monitoring of this modification in living cells.

Effect of abnormal placental cord insertion on hemodynamic change of umbilical cord in a tertiary center: a prospective cohort study.

Background: Our study aims to evaluate the umbilical vein (UV) hemodynamic change in the prenatal cohort of pregnancies diagnosed with abnormal placental cord insertion (aPCI).

Methods: From January 2022 to December 2022, the fetal umbilical cord insertion site was sonographically examined in singleton fetuses, and umbilical cord blood flow was calculated. The umbilical artery and UV Doppler flow indexes were assessed in cases of normal and abnormal cord insertion.

Molecular mechanisms of flowering time differentiation revealed by transcriptomic sequencing and de novo analysis in Chinese invasive populations of Ambrosia artemisiifolia.

Background: Ambrosia artemisiifolia is a highly invasive herb with deleterious effects on public health and agricultural systems. Flowering time in this species has been reported to vary along a latitudinal gradient, which may contribute to local adaptation and invasion success in China. However, the molecular basis for the flowering time differentiation remains unclear.

SREBP1 induction mediates long-term statins therapy related myocardial lipid peroxidation and lipid deposition in TIIDM mice.

Statins therapy is efficacious in diminishing the risk of major cardiovascular events in diabetic patients. However, our research has uncovered a correlation between the prolonged administration of statins and an elevated risk of myocardial dysfunction in patients with type II diabetes mellitus (TIIDM). Here, we report the induction of sterol regulatory element-binding protein 1 (SREBP1) activation, associated lipid peroxidation, and the consequent diabetic myocardial dysfunction after statin treatment and explored the underlying mechanisms.

Systematic Evaluation of Guidelines for the Diagnosis and Treatment of Hepatitis E Virus Infection.

Background And Aims: The hepatitis E virus (HEV) is a zoonotic disease, and infection with HEV in humans primarily causes acute infections and can progress to chronic manifestation in immunocompromised individuals. Over the past decade, guidelines for diagnosing and treating HEV infection have been developed. This study aimed to systematically assess the quality of current guidelines for diagnosing and treating HEV infection, and we analyzed the differences in guideline quality and primary recommendations and explored possible reasons for these differences.

Blood pressure variability and prognostic significance in traumatic brain injury: analysis of the eICU-CRD database.

Background: Preliminary evidence demonstrates that visit-to-visit systolic blood pressure (SBP) variability is a prognostic factor of TBI. However, literature regarding the impact of initial blood pressure management on the outcomes of TBI patients is limited. We aimed to further validate the clinical significance of BPV on the prognostic outcomes of patients with TBI.

Physical Exercise Improves the Neuronal Function in Ischemic Stroke Via Microglial CBR/P2Y12 Signaling.

Physical exercise (PE) may be the single most important and accessible lifestyle habit throughout life, it inhibits the neuroinflammatory response and protects the brain against damage. As the innate cells in brain, microglia undergo morphological and functional changes to communicate with neurons protecting the neurons from injury. Herein, aiming at exploring the effects of PE on the communication between microglia-neuron during acute ischemic cerebral infarction, we carried out running wheel training before the conduction of transient middle cerebral artery occlusion (tMCAO) in C57BL/6 J and Cx3cr1-GFP mice.

[Value of SOX1 and PAX1 Gene Methylation Detection in Secondary Triage of High-Grade Cervical Lesions].

Objective To evaluate the value of SOX1 and PAX1 gene methylation detection in the secondary triage of high-grade cervical lesions.Methods Exfoliated cervical cells were collected from 122 patients tested positive for human papilloma virus (HPV) and subjected to thin-prep cytologic test (TCT) and SOX1/PAX1 gene methylation tests.Results The HPV test combined with TCT showed the sensitivity of 95.

Polyurethane-based three-dimensional printing for biological mesh carriers.

Repair and reconstruction of the myopectineal orifice area using meshes is the mainstay of surgical treatment of inguinal hernias. However, the limitations of existing meshes are becoming increasingly evident in clinical applications; thus, the idea of using three-dimensionally (3D)-printed biological meshes was put forward. According to the current level of the 3D printing technology and the inherent characteristics of biological materials, the direct use of the 3D printing technology for making biological materials into finished products suitable for clinical applications is not yet supported, but synthetic materials can be first printed into 3D form carriers, compounded with biological materials, and finally made into finished products.

SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome.

In this study, we observed worsening metabolic crosstalk in mouse models with concomitant metabolic disorders such as hyperhomocysteinemia (HHcy), hyperlipidemia, and hyperglycemia and in human coronary artery disease by analyzing metabolic profiles. We found that HHcy worsening is most sensitive to other metabolic disorders. To identify metabolic genes and metabolites responsible for the worsening metabolic crosstalk, we examined mRNA levels of 324 metabolic genes in Hcy, glucose-related and lipid metabolic systems.

The Global and Regional Prevalence of Hospital-Acquired Carbapenem-Resistant Infection: A Systematic Review and Meta-analysis.

Background: Due to scarce therapeutic options, hospital-acquired infections caused by (KP), particularly carbapenem-resistant KP (CRKP), pose enormous threat to patients' health worldwide. This study aimed to characterize the epidemiology and risk factors of CRKP among nosocomial KP infections.

Method: MEDLINE, Embase, PubMed, and Google Scholar were searched for studies reporting CRKP prevalence from inception to 30 March 2023.

Pararhizobium qamdonense sp. nov., Isolated from an Alpine Soil in Tibet and the Reclassification of Rhizobium gei Shi et al. 2016 as Pararhizobium gei comb. nov.

A novel Gram-stain-negative, aerobic, rod-shaped bacterium named T808 was isolated from an alpine soil in Qamdo, Tibet, PR China. Strain T808 grew at 5-30℃, pH 5.0-9.

The incidence of brain trauma caused by road injuries: Results from the Global Burden of Disease Study 2019.

Background: Road collisions are a significant source of traumatic brain injury (TBI). We aimed to determine the pattern of road injury related TBI (RI-TBI) incidence, as well as its temporal trends.

Methods: We collected detailed information on RI-TBI between 1990 and 2019, derived from the Global Burden of Disease Study 2019.

Functionalized pyrite nanozyme probe and imprinted polymer modified with hydrophilic layer for rapid colorimetric analysis of glycoprotein in serum.

The biological molecules used in the sandwich detection method have problems such as complex extraction processes, high costs, and uneven quality. Therefore we integrated glycoprotein molecularly controllable-oriented surface imprinted magnetic nanoparticles (GMC-OSIMN) and boric acid functionalized pyrite nanozyme probe (BPNP) to replace the traditional antibody and horseradish peroxidase for sensitive detection of glycoproteins through sandwich detection. In this work, a novel nanozyme functionalized with boric acid was used to label glycoproteins that were captured by GMC-OSIMN.

PIMT is a novel and potent suppressor of endothelial activation.

Proinflammatory agonists provoke the expression of cell surface adhesion molecules on endothelium in order to facilitate leukocyte infiltration into tissues. Rigorous control over this process is important to prevent unwanted inflammation and organ damage. Protein L-isoaspartyl O-methyltransferase (PIMT) converts isoaspartyl residues to conventional methylated forms in cells undergoing stress-induced protein damage.

Quantitative analysis of phenanthrene in soil by fluorescence spectroscopy coupled with the CARS-PLS model.

Polycyclic aromatic hydrocarbons (PAHs) are typical organic pollutants in soil and are teratogenic and carcinogenic. Therefore, rapid and accurate analysis of PAHs in soil can provide a theoretical basis and data support for soil contamination risk assessment. In this work, a fluorescence spectroscopy technique combined with partial least squares (PLS) was proposed for rapid quantitative analysis of phenanthrene (PHE) in soil.

Quality evaluation of guidelines for the diagnosis and treatment of radiation enteritis.

Objective: To systematically evaluate the guidelines for the diagnosis and treatment of radioactive enteritis, compare their differences and reasons and provide some reference for updating them.

Methods: This study used guidelines related to radiation enteritis by searching a database. Four independent reviewers used the AGREE II evaluation tool to evaluate the quality of the included guidelines, collate their main recommendations, and analyze the highest evidence supporting the main recommendations.

Nomogram for Early Prediction of Outcome in Coma Patients with Severe Traumatic Brain Injury Receiving Right Median Nerve Electrical Stimulation Treatment.

Background: Accurate outcome prediction can serve to approach, quantify and categorize severe traumatic brain injury (TBI) coma patients for right median electrical stimulation (RMNS) treatment, which can support rehabilitation plans. As a proof of concept for individual risk prediction, we created a novel nomogram model combining amplitude-integrated electroencephalography (AEEG) and clinically relevant parameters.

Methods: This study retrospective collected and analyzed a total of 228 coma patients after severe TBI in two medical centers.