Multifunctional antimicrobial wound dressing with photothermal promotion based on Bletilla striata polysaccharides and other natural materials.

Wound healing is often hindered by bacterial infection, oxidative stress, and bleeding. Traditional dressings cannot simultaneously regulate multiple microenvironments. To address the shortcomings of traditional dressings, this study constructed a dual-network photothermal responsive multifunctional hydrogel OBCTCu based on four natural ingredients, including Bletilla striata polysaccharide (BSP), chitosan (CS), tannic acid (TA), and Cu.

Traction-regulated persistence governs durotaxis across cell types.

Cell migration toward stiffer or softer environments (durotaxis) underlies processes from development to cancer metastasis, yet the underlying mechanism and its universality remain unclear. To resolve this, we investigated how traction forces and directional persistence dictate cell migration along stiffness gradients. We utilized tunable PEG hydrogels with stiffness gradients of 1-16 kPa and perturbed contractility (blebbistatin, oligomycin), and adhesion (vinculin mutants), in cancer cells exhibiting opposing durotactic biases.

Association between lipid accumulation product and cognitive impairment: a community-based 4-year prospective cohort study.

Objectives: The relationship between abdominal obesity and cognitive impairment is not fully understood. The lipid accumulation product (LAP) is a convenient and cost-effective indicator for abdominal obesity. In the present study, we investigated the association between the LAP and cognitive impairment in a community-based 4-year prospective cohort study.

Primary adrenal NK/T lymphoma: A case report of a rare tumor.

Natural killer/T-cell lymphoma (NKTCL) is a subtype of non-Hodgkin's lymphoma characterized by rapid progression. It infrequently involves the adrenal glands and exhibits swift advancement. A 52-year-old woman was admitted to the hospital with bilateral renal pain.

Engineering Aggregation-Induced Emission Photosensitizers through a Counterion-Modulation Strategy for Enhanced Photodynamic Immunotherapy.

The intersystem crossing (ISC) process of photosensitizers (PSs) is crucial for the generation of reactive oxygen species (ROS) in photodynamic immunotherapy. Herein, a counterion-regulation strategy is applied to enhance ISC efficiency in aggregation-induced emission (AIE) PSs, optimizing type-I ROS production. Three PSs with the same cationic donor-π-acceptor (D-π-A) structure, ,-diphenyl-4-(7-(pyridin-4-yl)benzo[][1,2,5]thiadiazol-4-yl)aniline (TBP), were synthesized with different counterions: iodide (I), hexafluorophosphate (PF), and tetraphenylborate (PhB).

Exogenous melatonin promotes anthocyanin accumulation and coloration in Chinese plum peels.

Melatonin (MT) is a growth regulator that influences anthocyanin synthesis during plant growth. However, the regulation mechanism of MT on the coloration of plum peels remains unclear. Here, the effects of MT on the anthocyanin accumulation and coloration in Chinese plum peels were examined after MT (100 μmol/L) or water (control) treatment.

Quantifying Landscape and Flux from Single-Cell Omics: Unraveling the Physical Mechanisms of Cell Function.

Recent advancements in single-cell sequencing technology have reshaped our understanding of cellular processes. While in the realm of biological research, the understanding of the underlying physical and chemical mechanisms from single-cell omics stands as a promising frontier, yet it is still not quite adequately explored. This knowledge gap stems from the complexities of mapping nonequilibrium physical and chemical principles onto the heterogeneous and complex dynamics of cellular functions.

Study on deformation law of coal pore mechanism characteristics under peak cluster landform.

In order to reveal the change rule of coal pore structure under the peak cluster landform, coal samples were taken from nine different mountain heights based on the vertical variability of the landform, and the pore structure of the coal samples was tested using a combination of high-pressure mercuric pressure method and low-temperature nitrogen adsorption experiments. The results show that compared with the traditional coal reservoir, the pore structure of coal under the peak cluster landform, such as pore content, specific surface area and pore volume, changes with the change of vertical principal stress in a multi-peak state. The variations in the maximum and minimum values of vertical principal stress at each peak level are 1.

Development of a Serum Proteomic-Based Diagnostic Model for Lung Cancer Using Machine Learning Algorithms and Unveiling the Role of SLC16A4 in Tumor Progression and Immune Response.

Early diagnosis of lung cancer is crucial for improving patient prognosis. In this study, we developed a diagnostic model for lung cancer based on serum proteomic data from the GSE168198 dataset using four machine learning algorithms (nnet, glmnet, svm, and XGBoost). The model's performance was validated on datasets that included normal controls, disease controls, and lung cancer data containing both.

Predicting spinal neurological prognosis in patients with surgical treatment for thoracic spinal stenosis based on neurological and neurophysiological evaluation.

Objective: We aim to investigate the spinal neurological outcomes in patients who have undergone surgery for thoracic spinal stenosis (TSS) and to identify high-risk factors for poor spinal neurological prognosis. 

Methods: Patients were categorized into four subgroups based on TSS causes: thoracic disk herniation (TDH), ossification of the posterior longitudinal ligaments (OPLL), ossification of the ligamentum flavum (OLF), and OPLL + OLF. The following data were collected: (1) demographic and clinical data; (2) neurological evaluation; and (3) neurophysiological evaluation by combining somatosensory- and motor- evoked potential (SSEP and MEP) baseline at both legs.

Extracellular matrix-related genes-based prognostic signature for cervical cancer: association of LAMA4 expression with prognosis and response to immunotherapy.

Background: Extracellular matrix-related genes (ERGs) are crucial in the tumorigenesis of various malignancies, including cervical cancer (CC), but their prognostic significance in CC has not been thoroughly investigated.

Methods: We interrogated RNA-seq expression profiles from the public datasets to identify differentially expressed ERGs. Cox regression analysis was utilized to evaluate their prognostic significance.

A Mathematical Perspective on the Influence of Allee Effects in Oncolytic Virotherapy.

This article is concerned with the mathematical modeling of cancer virotherapy, emphasizing the impact of Allee effects on tumor cell growth. We propose a modeling framework that describes the complex interaction between tumor cells and oncolytic viruses. The efficacy of this therapy against cancer is mathematically investigated.

Dynamic and thermodynamic origins of non-equilibrium phase transitions in infectious disease networks.

Understanding the mechanisms driving phase transitions in epidemic dynamics is essential for predicting and controlling infectious disease outbreaks. In this study, we apply the landscape and flux framework from nonequilibrium statistical physics to investigate the physical origins of bifurcations, or nonequilibrium phase transitions, in adaptive epidemic networks. Using a SIRS model, we systematically examine how variations in the rewiring rate (representing individuals' behavioral responses to avoid infection) and the average node degree (indicating the population's contact density) reshape the topography of the system's potential landscape and alter barrier heights, thereby triggering transitions between bistable and monostable regimes.

Bright Blue Light Emission of ZnCl-Doped CsPbClBr Perovskite Nanocrystals with High Photoluminescence Quantum Yield.

The future development of perovskite light-emitting diodes (LEDs) is significantly limited by the poor stability and low brightness of the pure-blue emission in the wavelength range of 460-470 nm. In this study, the Cl/Br element ratio in CsPbClBr perovskite nanocrystals (NCs) was modulated to precisely control their blue emission in the 428-512 nm spectral region. Then, the undoped CsPbClBr and the ZnCl-doped CsPbClBr perovskite NCs were synthesized via the hot-injection method and investigated using variable-temperature photoluminescence (PL) spectroscopy.

A common-sense model-based nursing intervention improves exercise compliance in coronary heart disease: a randomized controlled trial and a pilot study.

Aims: This study explored the effects of a Common-sense model of self-regulation-based nursing intervention on enhancing cardiac exercise rehabilitation compliance in coronary heart disease patients, aiming to improve cardiac function and overall health outcomes.

Design: This study was a two-arm, parallel prospective randomized controlled trial.

Methods: Participants were recruited from February to August 2024 at 3 Hospitals in Changsha, Hunan, China.

Methylation-mediated LncRNA CRAT40 promotes colorectal cancer progression by recruiting YBX1 to initiate RelA transcription.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Long noncoding RNAs (lncRNAs) have emerged as crucial regulators in the initiation and progression of various malignancies, including CRC. In this study, we found that lnc-CRAT40 was upregulated in CRC and associated with poor prognosis following CRC resection.

Research on microchannel fabrication in UV curable resin using combined beam processing.

To break through the limitations of traditional rectangular microchannel processing methods for microfluidic devices, this paper proposes a processing technique based on a holographic combined femtosecond laser beam. The phase and topology of the hologram are adjusted by SLM to flexibly control the spot width and energy distribution of a generated Bessel beam, thus realizing high-precision and multi-size processing. To achieve high-precision microchannel sidewalls and bottom surfaces, the positive first-order Bessel beam is shifted at an appropriate position after the zero-order light by using a blazed grating to obtain the suggested holographic combined beam required for processing.

Regulation of Octahedral Distortions and Interlayer Spacing in 2D Perovskite Capping Layer Toward Efficient and Stable Solar Cells.

2D perovskites as interfacial modifiers have demonstrated potential for improving the stability of perovskite solar cells (PSCs); however, 2D structures based on flexible long-chain cations often lead to a high degree of octahedral distortions and larger interlayer spacing. These factors hinder efficient charge extraction between the perovskite and charge transport layers and affect the stability of 2D/3D devices. Here, imidazolyl spacers with rigid ring structures are employed as interfacial modifiers.

Forecasting the diabetic retinopathy progression using generative adversarial networks.

Background: Diabetic retinopathy (DR) is the leading cause of blindness worldwide, making early prediction of DR progression crucial for effectively preventing visual loss. This study introduces a prediction framework DRForecastGAN (Diabetic Retinopathy Forecast Generative Adversarial Network), and investigates its clinical value in predicting DR development.

Methods: DRForecastGAN model, consisting of a generator, discriminator, and registration network, was trained, validated, and tested in training (12,852 images), internal validation (2734 images), and external test (8523 images) datasets.

Ternary-Active NiO-NiAlO-AlO Nanocomposite for Selective Upcycling of Polypropylene into Liquid Branched Olefins.

Chemical upcycling is an attractive platform for converting plastic waste into valuable products. Here, a tandem deconstruction-catalysis route was developed for upcycling polypropylene (PP). A ternary-active NiO-NiAlO-AlO nanocomposite was innovatively synthesized, with the NiO/NiAlO particle size lowering to ca.

Intestinal organoids as advanced modeling platform for food research: a review.

Intestinal organoids have emerged as powerful tools in biomedical research, offering a physiologically relevant model of the gut that can replicate the functions and microenvironments of the human intestine. In this study, we conducted a scientific review of the development and commonly used detection methods for intestinal organoids. Drawing from existing studies, we summarized the applications of intestinal organoids in food research.

CUX1 variant and 9p deletion: expanding the spectrum and resolving variable GDD/ID in a family.

Background: Intellectual disability (ID) significantly impacts individual development and imposes a societal burden. Although mild ID accounts for approximately 85% of total cases, research into its genetic etiology remains relatively limited. We investigated a two-generation pedigree exhibiting varying degrees of global developmental delay (GDD) and ID.

Single-crystal nickel-rich cathode materials: fundamentals, challenges and prospects.

Single-crystal nickel-rich materials are considered promising cathode materials for high-energy lithium-ion batteries. The reduction in grain boundaries reduces the initiation and propagation of microcracks, thereby improving cycling stability and thermal resistance. However, the dense structure of single-crystal particles restricts lithium-ion diffusion and weakens interfacial stability, leading to poor rate performance.

Safety and efficacy of HH2853, a novel EZH1/2 dual inhibitor, in patients with refractory solid tumours or non-Hodgkin lymphomas: a phase I study.

Background: HH2853 is a novel dual EZH1/2 inhibitor that exhibits superior antitumour activity compared to tazemetostat across various preclinical models. Here, we evaluated the safety, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy of HH2853 in patients with refractory advanced solid tumours and non-Hodgkin lymphomas (NHLs).

Methods: This open-label, global multicentre, phase I study was conducted at 12 centres in China and the USA, enrolling patients (aged ≥18 years) with relapsed or refractory solid tumours or NHLs.