Genetic Variants in Genes Regulating Lens Capsule Structure and Stability in Dead Bag Syndrome - Part 1.

Purpose: To investigate potential genetic variants associated with spontaneous Posterior Capsule Rupture (sPCR) in patients diagnosed with Dead Bag Syndrome (DBS).

Setting: Iladevi Cataract and Intraocular Lens (IOL) Research Centre and Raghudeep Eye Hospital, Ahmedabad, Gujarat, India.

Design: Laboratory Study.

Visual outcomes after implantation of a nondiffractive EDOF intraocular lens in patients with early dry macular degeneration.

Purpose: To evaluate visual outcomes after implantation of a nondiffractive extended depth-of-focus (EDOF) intraocular lens (IOL) in patients with early age-related dry macular degeneration (AMD).

Setting: Iladevi Cataract & IOL Research Centre, Ahmedabad, India.

Design: Prospective, interventional series.

Clinical Features, Risk Factors, and Outcomes Following Surgery for Late Intraocular Lens Decentration in the Dead Bag Syndrome.

Purpose: To evaluate demographic profile, risk factors, and outcomes following intraocular lens (IOL) exchange surgery for late decentration of IOLs in dead bag syndrome DESIGN: Prospective, interventional case series METHODS: This was a study conducted at Raghudeep Eye Hospital, India. Explantation of the decentered/dislocated IOL along with pars plana vitrectomy and intrascleral fixation of a 3-piece foldable IOL using the Yamane technique was performed for all eyes. A total of 46 eyes (43 patients) with late decentration/dislocation of IOLs and spontaneous posterior capsule rupture in a clear and relatively intact capsular bag were treated.

Long-Term Postoperative Outcomes Following Cionni Ring and In-the-Bag Intraocular Lens Implantation in Eyes With Subluxated Lenses.

Purpose: Evaluate long-term outcomes following Cionni modified capsule tension ring (MCTR) and in-the-bag intraocular lens (IOL) implantation in subluxated lenses.

Design: Retrospective case series.

Methods: Forty-one eyes of 31 patients from Raghudeep Eye Hospital, India, with subluxated lenses who had completed a minimum of 5 years' postoperative follow-up were included.

Intraoperative Performance and Early Postoperative Outcomes Following Phacoemulsification With Three Fluidic Systems: A Randomized Trial.

Purpose: To compare intraoperative performance and early postoperative outcomes following phacoemulsification with two systems using active fluidics and one using gravity-based fluidics.

Methods: In this prospective randomized trial, 200 eyes were randomized to the traditional and Active Sentry groups (n = 80 eyes each) where the Centurion Vision System was used with traditional or Active Sentry (Alcon Laboratories, Inc) hand-pieces, respectively, or the Infinit group (n = 40 eyes) where the Infiniti Vision System (Alcon Laboratories, Inc) was used. Within the traditional and Active Sentry groups, there were two subgroups with low (30 mm Hg) or high (55 mm Hg) intraocular pressure (IOP) used.

Visual outcomes comparing emmetropia vs mini-monovision after bilateral implantation of a nondiffractive extended vision intraocular lens: randomized trial.

Purpose: To compare visual outcomes and patient satisfaction after bilateral implantation of a nondiffractive extended vision intraocular lens (IOL) when targeting emmetropia vs mini-monovision.

Setting: Iladevi Cataract & IOL Research Centre, Ahmedabad, India.

Design: Prospective, randomized controlled trial.

Real-world experience with brolucizumab in neovascular age-related macular degeneration over 2 years: the REBA extension study.

Background: To determine long-term efficacy and safety of intravitreal brolucizumab therapy for neovascular age-related macular degeneration (nAMD) in the real-world setting.

Methods: Retrospective, observational, multicentric study and an extension of the REBA study (Real-world Experience with Brolucizumab in nAMD) to 24 months. The study entailed follow-up of 91 consecutive eyes (67 patients) with nAMD who received brolucizumab therapy and completed 24 months of follow-up.

Approach to a spontaneously ruptured posterior polar cataract.

A 61-year-old man presented with gradual blurring of vision and glare in both eyes for a couple of years, with worsening of the vision in his right eye over the past 2 months. He had no medical history of note. On clinical examination, his visual acuities were 20/80 in the right eye and 20/30 in the left eye, uncorrected.

FLACS vs conventional phacoemulsification by junior cataract surgeons: randomized trial.

Purpose: To report intraoperative performance and postoperative outcomes of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification (PE) in the hands of junior surgeons.

Setting: Iladevi Cataract & IOL Research Centre, Ahmedabad, Gujarat, India.

Design: Prospective single-masked randomized controlled trial.

Late onset corneal decompensation following retained lens fragment in anterior chamber years after uneventful phacoemulsification.

Purpose: To report a case of late onset corneal decompensation following cataract surgery due to retained lens fragment in anterior chamber.

Observations: A 65 year old female presented with complaint of gradual dimness of vision in left eye since 4 months. She underwent uneventful phacoemulsification with posterior chamber intraocular lens implantation elsewhere 4 years back.

Real-World Experience with Brolucizumab in Wet Age-Related Macular Degeneration: The REBA Study.

The aim of the present study was to determine the efficacy and safety of intravitreal brolucizumab therapy for neovascular age-related macular degeneration (AMD) in the real-world setting. The REBA study (real-world experience with brolucizumab in wet AMD) was a retrospective, observational, multicentric study that included 78 consecutive patients (105 eyes), with neovascular AMD, who received brolucizumab therapy. Both treatment-naive and switch-therapy patients were included.

Training Indian ophthalmologists in phacoemulsification surgery: Nine-year results of a unique two-week multicentric training program.

Purpose: To assess the outcome of 2 weeks phacoemulsification training program that is a unique collaboration between premier ophthalmic training institutes of India and Alcon Inc. initiated 10 years ago.

Methods: Cataract surgeons eager to adopt phacoemulsification surgery as the primary treatment modality were enrolled in an intensive 2 weeks training program across seven premier ophthalmic institutes in India.

Real-time dynamic changes in intraocular pressure after occlusion break: comparing 2 phacoemulsification systems.

Purpose: To compare real-time intraocular pressure (IOP) response to occlusion break event in 2 phacoemulsification systems.

Setting: Iladevi Cataract and IOL Research Center, India.

Design: Randomized, experimental study.

Real-time imaging of airflow patterns and impact of infection control measures in ophthalmic practice: a pandemic perspective.

Purpose: To analyze exhaled airflow patterns in a clinical scenario and the impact of infection control practices and room air circulation in context of the COVID-19 pandemic.

Setting: Raghudeep Eye Hospital, India.

Design: Experimental study.

Cortical aspiration - The "POPS" technique.

In the present study, we describe a step-by-step technique for cortex aspiration during cataract surgery- POPS (positioning, occlusion, posterior displacement, and swiping). Firstly, the aspiration probe is positioned under the bulk of cortical fibers beyond the capsulorhexis margin. Subsequently, the aspiration port is occluded with minimal vacuum, and the occluded port is displaced posteriorly to detach the cortical fibers off the anterior capsule.

Decoding fluid droplet generation during phacoemulsification and pars plana procedures in the COVID-19 era-An experimental study.

Purpose: The purpose of this study is to evaluate fluid droplet spray generation during phacoemulsification (PE), pars plana vitrectomy (PPV), and fragmatome lensectomy (FL) and assess factors affecting these.

Methods: This is an experimental study. PE through 2.

Comparison of Optical Low-Coherence Reflectometry and Swept-Source OCT-Based Biometry Devices in Dense Cataracts.

Purpose: To investigate agreement between biometric measurements obtained from the Lenstar LS 900 (Haag-Streit AG) based on optical low-coherence reflectometry (OLCR) and the Tomey OA-2000 (Tomey Corporation) based on swept-source optical coherence tomography (SS-OCT) in dense cataracts.

Methods: In this prospective observational study, axial length, keratometry, anterior chamber depth (ACD), lens thickness, and central corneal thickness (CCT) were measured in 124 eyes of 76 patients. Intraocular lens prediction errors and absolute prediction errors were assessed based on postoperative manifest refraction.

Intraoperative performance and long-term postoperative outcomes after scleral fixation of IOLs with polytetrafluoroethylene suture.

Purpose: To report intraoperative performance and long-term postoperative outcomes after scleral fixation of intraocular lenses (IOLs) with polytetrafluoroethylene suture (PTFE).

Setting: Raghudeep Eye Hospital, Ahmedabad, India.

Design: Prospective, interventional case series.

Visual outcomes after toric intraocular lens implantation in pediatric eyes undergoing cataract surgery.

Purpose: To evaluate long-term visual outcomes and complications after toric intraocular lens (IOL) implantation in children with preexisting corneal astigmatism undergoing cataract surgery.

Setting: Iladevi Cataract & IOL Research Center, Ahmedabad, India.

Design: Prospective, interventional case series.

Bevacizumab as an Adjunct to Trabeculectomy in Primary Open-Angle Glaucoma: A Randomized Trial.

Purpose: To compare the outcomes of trabeculectomy using two different routes of bevacizumab administration as an adjunct in patients with primary open angle glaucoma.

Methods: Prospective, randomized, masked trial that included 180 eyes of 180 patients of documented primary open angle glaucoma were eligible for surgery. Patients were randomized to receive either a single intraoperative dose of subconjunctival bevacizumab (1.

Sustained Intraocular Pressure Rise after the Treat and Extend Regimen at 3 Years: Aflibercept versus Ranibizumab.

Purpose: To determine the risk factors associated with sustained intraocular pressure (IOP) rise in patients enrolled in the treat and extend (T&E) protocol receiving aflibercept/ranibizumab therapy for 3 years.

Design: Retrospective, observational chart review. .

Impact of fluidic parameters during phacoemulsification on the anterior vitreous face behavior: Experimental study.

Purpose: To evaluate the eff ect of different aspiration flow rates (AFR) and bottle heights (BH) on vitreous face (AVF) during phacoemulsifi cation.

Methods: Experimental study in 20 porcine eyes. Transzonular viscodissection was performed between the posterior capsule(PC) and AVF to dissect out the Berger's space.