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Purpose: To evaluate the eff ect of different aspiration flow rates (AFR) and bottle heights (BH) on vitreous face (AVF) during phacoemulsifi cation.
Methods: Experimental study in 20 porcine eyes. Transzonular viscodissection was performed between the posterior capsule(PC) and AVF to dissect out the Berger's space. Triamcinolone acetonide was injected into this space to aid visualization with ultrasound B-Scan(USG). Realtime USG was performed during phacoemulsifi cation. Eyes were divided randomly into-Group I: Low parameters(AFR = 20 cc/min, BH = 90 cm, vacuum = 400 mmHg),and Group II: High parameters (AFR = 40 cc/min, BH = 110 cm, vacuum=650 mm Hg).
Results: 15 eyes were analysed (8 in Group I; 7 in Group II). In all eyes, forward and backward movement of the PC was seen when going from foot position 0 to 1, or on occlusion break. Amplitude of these movements was much greater in Group II compared to Group I. There was no PC rupture in either group. In 2 of the 7 eyes in Group II, USG showed a sudden, spontaneous dispersion appearance of sono-opaque echoes in the vitreous cavity alongwith disappearance of the well-defi ned, crescentic stained space despite an intact PC. This suggests rupture of the AVF, leading to dispersion of the triamcinolone into the entire vitreous cavity. No AVF rupture was seen in Group I.
Conclusion: We report a rarely described entity of AVF rupture with intact PC. The use of high AFR and BH may have clinically invisible detrimental consequences to the anterior vitreous face.
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http://dx.doi.org/10.4103/ijo.IJO_465_19 | DOI Listing |
Photodiagnosis Photodyn Ther
September 2025
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. Electronic address:
Purpose: To characterize the cavity hyperreflective-content and septum's motion artifact (CHASMA) in en face optical coherence tomography angiography (OCTA) across multiple ocular fundus abnormalities.
Methods: This was a cross-sectional, observational study. Subjects with extravascular OCTA signals arising from the cavity's hyperreflective-content and/or septum were enrolled.
NPG Asia Mater
August 2025
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 USA.
Microneedles (MNs) have emerged as a promising technology for minimally invasive drug delivery, offering significant advantages in the treatment of ocular diseases. These miniaturized needles enable precise, localized drug delivery directly into specific tissues of the eye, such as the cornea, sclera, vitreous, or retina, while minimizing pain and discomfort. MNs can be fabricated from various biocompatible materials, including metals, silicon, and biodegradable polymers, making them highly adaptable to various clinical applications.
View Article and Find Full Text PDFLife Sci Space Res (Amst)
August 2025
Department of Physics, University of Rome Tor Vergata and INFN Sect. Tor Vergata, Rome, Italy.
Space radiation interactions with the visual system have been the subject of many investigations, starting from astronauts reporting the perception of light flashes (visual illusions in absence of light stimuli). These perceptions have been attributed to single-ion hits, able to induce an electrophysiological response in the eye. Searching for a more general mechanism of radiation interaction with cortical neuronal networks and with sensory systems, a valuable hypothesis is that of the perturbation to calcium (Ca) homeostasis.
View Article and Find Full Text PDFJ Vitreoretin Dis
August 2025
Department of Ophthalmology, University Hospitals at Case Western Reserve, Cleveland, OH, USA.
To describe a case of syphilitic posterior placoid chorioretinopathy, a rare ocular manifestation of syphilis requiring prompt diagnosis and treatment. A single case was evaluated. Multimodality imaging including spectral-domain optical coherence tomography (SD-OCT), en face OCT, and OCT angiography (OCTA) were used to confirm a diagnosis in a patient presenting with symptoms of syphilitic posterior placoid chorioretinopathy.
View Article and Find Full Text PDFMol Pharm
August 2025
LYO-X AG, Henric Petri Strasse 6, Basel 4051, Switzerland.
Gene therapies are emerging as a new treatment modality. Due to their novelty, general pharmacological properties have yet to be established. For example, the translation from animal models to humans for first-in-human dose selection and the dose-exposure relationship remain poorly characterized.
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