Relationship between serum ferritin and the risk of all-cause death in patients with coronary artery disease.

Objective: Ferritin is independently associated with oxidized Low-Density Lipoprotein (LDL). While high LDL levels are known independent risk factors for cardiovascular diseases, few studies have investigated the relationship between serum ferritin levels and long-term outcomes in CAD patients.

Methods: A prospective cohort study of CAD participants was performed in Xinjiang Medical University Affiliated First Hospital from December 2016 to October 2021.

The effect of resistance training for older adults with cognitive frailty: a randomized controlled trial.

Background: Cognitive decline and the progression to dementia are hastened in individuals with cognitive frailty. Exercise interventions benefit cognitive function in patients with Mild Cognitive Impairment (MCI) or frailty. While the optimal implementation of resistance training for cognitive frailty is still being explored.

Selective enhancement of fish gelatin emulsification via structural compatibility with sodium alginate: A comparative study with SPI and WPI.

This study systematically investigated the structure-dependent interactions between sodium alginate (SA) and three distinct proteins-fish gelatin (FG), soybean protein isolate (SPI), and whey protein isolate (WPI)-to elucidate their differential emulsification enhancement mechanisms. Mechanistic studies showed that FG exhibited unique structural compatibility with SA, driven by strong electrostatic interactions (ΔH = -6.59 kJ/mol, ΔS = 5.

Efficacy of different modes of exercise-based cardiac rehabilitation delivery for patients with heart failure: a systematic review and network meta-analysis.

Background: Cardiac rehabilitation (CR) has been shown to be an effective treatment for patients with heart failure (HF). However, the effect of different modes of CR delivery on HF remains unclear. The purpose of this study is to perform a large-scale pairwise and network meta-analysis (NMA) on the impact of various exercise types on patients with HF using multiple indicators.

Amorphous Nitride-chloride Solid-State Electrolytes for High Performance All-Solid-State Lithium Batteries.

High-performance solid-state electrolytes (SSEs) are crucial for advancing all-solid-state batteries (ASSBs). Amorphous SSEs, in particular, offer promising advantages due to their grain-boundary-free nature, which facilitates intimate solid-to-solid contact and uniform lithium-ion flux, thereby improving composite electrode performance. Here, we report a class of SSEs based on a nitrogen-chlorine dual-anion framework, formulated as Li ZrNCl, for high-voltage ASSBs.

A Nearly 50% Risk of MACCE Cutdown by Personalized Antiplatelet Therapy: The Subgroup Analysis of Hypertension in PATH-PCI Trial.

Background: Individualized antiplatelet therapy has been gradually chosen by more and more (percutaneous coronary intervention) PCI patients. Hypertension, as an important risk factor for a variety of adverse outcomes after PCI, has been found in many studies. Therefore, we are interested in whether patients who undergo PCI have a different benefit from individualized antiplatelet therapy when they have hypertension.

Precision Medicine in ICH Unveiling the Superior Predictive Power of a Joint Model.

This study examined the effectiveness of a combined model using non-contrast computed tomography (NCCT) imaging, clinical data, and radiomics for predicting early hematoma enlargement in patients with spontaneous intracerebral hemorrhage. The study involved 232 patients with primary cerebral hemorrhage who met the inclusion criteria at the General Hospital of the Western Theater Command, PLA, between January 2018 and December 2023. Imaging and clinical features were compared, radiomic features were extracted from head CT scans, and a multivariate logistic regression model identified key imaging markers and clinical features.

Global Landscape of Human Kinase Motifs in Viral Proteomes.

The successful establishment of infection relies on an ability to sense and adapt to the host signaling state. One key mechanism of virus-host sensing is host-mediated post-translational modifications of viral proteins. While viral protein phosphorylation by host kinases is known to modulate viral functions, the global prevalence of kinase motifs across diverse viruses, and the signaling pathways they reflect, remains to be systematically explored.

Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial.

Background: Metabolic syndrome (MetS) represents a constellation of metabolic abnormalities. Perirenal fat is a type of visceral fat surrounding the kidneys and possesses distinct anatomical and physiological features. This study aims to investigate the association between perirenal fat volume (PrFV) and MetS in Chinese adults.

Development and Initial Validation of the Multi-dimensional Attention Rating Scale in Highly Educated Adults.

Objectives: To report the development, validation, and findings of the Multi-dimensional Attention Rating Scale (MARS), a self-report tool crafted to evaluate six-dimension attention levels.

Methods: The MARS was developed based on Classical Test Theory (CTT) , with initial item selection and content validation conducted by six experts in psychiatry and psychology using the Delphi method. Healthy adult participants were recruited to complete the MARS and related scales, along with on-site measures.

Tailoring Self-Organized Growth of Biomimetic Inorganic-Organic Multilayers with a Permeable Microcompartment.

Organisms such as marine glass sponges, molluscan animals, crustaceans, and mammals develop inorganic-organic multilayers in ambient conditions. This structural motif of inorganic-organic multilayers has a central function in reconciling strength and toughness, nacre being a well-studied example. Although biomimetic multilayers have been successfully processed through particle assembly and multistep deposition, the development of a self-organized approach to transforming molecular subunits into this macroscopic architecture remains a challenging task.

DON-Apt19S bioactive scaffold transplantation promotes spinal cord repair in rats with transected spinal cord injury by effectively recruiting endogenous neural stem cells and mesenchymal stem cells.

The spinal cord's limited regeneration is attributed to the scarcity of endogenous stem cells and a poor post-injury microenvironment in adult mammals. To overcome these challenges, we transplanted a DNA aptamer 19S (Apt19S) sustained-release decellularized optic nerve (DON) scaffold (DON-A) into completely transected spinal cord injury (SCI) site in rats and investigated its effect on endogenous stem cell recruitment and differentiation, which subsequently contributed to SCI repair. It has been demonstrated that Apt19S specifically binds to the membrane receptor alkaline phosphatase highly expressed on neural stem cells (NSCs) and mesenchymal stem cells (MSCs), and our study further proved that Apt19S can simultaneously recruit endogenous NSCs and MSCs to the lesion of SCI.

Caspase-7 and Vitamin D Receptor Gene as Key Genes of Hypertension Caused by Pyroptosis in Human.

This study aims to elucidate the underlying mechanisms of pyroptosis in hypertension through bioinformatics and machine learning approaches. R language was utilized to integrate differentially expressed genes (DEGs) between hypertension samples and healthy control samples in GSE24752 and GSE75360 datasets, followed by GO analysis, KEGG enrichment analysis, and GSEA. Key genes were screened based on the expression levels of DEGs using logistic regression, LASSO regression, and support vector machine (SVM).

Determinants of Transitional Care Utilization Among Older Adults with Chronic Diseases: An Analysis Based on Andersen's Behavioral Model.

Objective: This study aims to assess the current utilization status of transitional care service among older adults with chronic diseases and identify factors influencing their use.

Methods: Utilizing Andersen's Behavioral Model, a cross-sectional survey was conducted in a specific region from October 2023 to December 2023 using convenience sampling. The survey aimed to analyze the impact of predisposing factors, enabling factors, and need factors on the utilization of transitional care services by older adults with chronic diseases.

Strong association between atherogenic index of plasma and obesity in college students.

Background: The issue of obesity is becoming more and more prominent. Understanding the metabolic profile of obese young adults and finding possible risk markers for early prediction and intervention is of great importance.

Methods: A total of 13,082 college students with an average age of 20 years were enrolled in this cross-sectional study.

Potential cost-savings of breastfeeding promotion to prevent breast cancer: a Monte Carlo simulation.

Background: Breastfeeding protects mothers against breast cancer. Our study aimed to estimate the healthcare cost-savings resulting from a reduction in breast cancer attributed to an increase in the breastfeeding rate in Hong Kong.

Methods: This is an economic evaluation.

Explainable machine learning model for predicting decline in platelet count after interventional closure in children with patent ductus arteriosus.

Background: This study aimed to apply four machine learning algorithms to develop the optimal model to predict decline in platelet count (DPC) after interventional closure in children with patent ductus arteriosus (PDA).

Methods: Data from children with PDA who underwent successful transcatheter closure at the Second Affiliated Hospital of Wenzhou Medical University and Yuying Children's Hospital from January 2016, to December 2022, were collected. The cohort data were split into training and testing sets.

Effects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational study.

Background: The impact of otolaryngological diseases on sleep quality, anxiety, and depression has garnered significant attention. However, research has primarily focused on unveiling the effects of only one or two specific diseases, without analyzing the impact of multiple concurrent diseases. Furthermore, investigation into the interaction mechanisms among these factors has been lacking.

Comparative survival outcomes of neoadjuvant and adjuvant therapy in patients with T1c, node-negative, triple-negative breast cancer: A population-based analysis.

Background: Ongoing discussions persist concerning the precedence of neoadjuvant therapy (NAT) relative to adjuvant therapy (AT) for patients with T1c, node-negative, triple-negative breast cancer (TNBC), and pertinent guidelines for these individuals are absent.

Methods: Women diagnosed with T1cN0M0-stage TNBC who received chemotherapy and surgery were selected from the Surveillance, Epidemiology and End Results database (2010-2020). To balance baseline characteristics and mitigate selection bias, propensity score matching (PSM) was used to create the NAT and AT cohorts.

Structure of the Kaposi's sarcoma-associated herpesvirus gB in post-fusion conformation.

Discovered in 1994 in lesions of an AIDS patient, Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the gammaherpesvirus subfamily of the family, which contains a total of nine that infect humans. These viruses all contain a large envelope glycoprotein, glycoprotein B (gB), that is required for viral fusion with host cell membrane to initial infection. Although the atomic structures of five other human herpesviruses in their postfusion conformation and one in its prefusion conformation are known, the atomic structure of KSHV gB has not been reported.

Muscle strength trajectories and outcomes in critically ill patients: A prospective multicentre cohort study.

Objectives: To investigate the trajectories and determinants of muscle strength in ICU patients and their impact on 1-, 6-, and 12-month mortality outcomes.

Design: Prospective multicenter cohort study.

Settings: Ten ICUs across five tertiary hospitals in Fujian Province, China.

Global, regional, and national burden of myocarditis in children aged 0-14 years, 1990-2021: analysis for the global burden of disease study 2021.

Objective: There are limited epidemiological data on myocarditis in children aged 0-14 years. This study aims to investigate the trends in incidence, mortality, disability-adjusted life years (DALYs), and corresponding estimated annual percentage change (EAPC) of myocarditis in children aged 0-14 years from 1990 to 2021.

Methods: We utilized the 2021 Global Burden of Disease, Injuries, and Risk Factors Study (GBD) analytical tools to examine the incidence, mortality, and DALYs of myocarditis in children aged 0-14 years, considering factors such as age, sex, region, sociodemographic index (SDI), and data from 204 countries or regions.

Mediating and moderating factors between stigma and adaptability to return to work for cancer survivors.

Adaptability to return to work is a process by which cancer survivors(CSs) utilize accessible resources to reconstruct themselves. While the stigma, financial situation and social support are known to influence their adaptability to return to work, the mechanisms by which these factors work remain unclear. This study proposes a moderated mediation model to signify a pathway linking stigma to the adaptability to return to work.

Trajectory and determinants of intensive care unit-acquired weakness in critical illness: A multicentre, prospective, longitudinal study.

Background: Intensive care unit-acquired weakness (ICU-AW) is prevalent and adversely affects patient outcomes. Muscle strength progression and response to rehabilitation differ across ICU populations. However, the trajectories, determinants and prognoses of muscle strength changes remain unclear.

Butorphanol Alleviates Hypoxia/Reoxygenation-Induced Myocardial Injury by Activating Wnt/β-Catenin Signal Pathway.

Ischemic heart disease remains a global health problem with high morbidity and mortality. Butorphanol, as a novel opioid, has been discovered with its cardioprotective properties. The purpose of this study was to explore that butorphanol can alleviate hypoxia/reoxygenation (H/R)-induced myocardial injury by activating the Wnt/β-catenin signal pathway.