The efficacy of trastuzumab deruxtecan in Chinese breast cancer patients: a real-world multicenter study.

Introduction: In mainland China, trastuzumab deruxtecan was first authorized in February 2023 as a monotherapy for the treatment of patients with HER-2-positive adult breast cancer who were either unresectable or had metastasized after receiving one or more anti-HER-2 treatments. In July 2023, trastuzumab deruxtecan was approved for the treatment of patients with metastatic disease who had undergone at least one previous systemic therapy, as well as those with unresectable or metastatic adult breast cancer who had low expression of HER-2 and who had experienced a relapse within six months of finishing adjuvant chemotherapy.

Methods: The study included seven participants with HER-2 low expression breast cancer and eighteen participants with HER-2-positive advanced breast cancer from six study centers in Shandong Province, China.

Investigating the Underlying Mechanisms of Ma-Xing-Shi-Gan-Tang on Asthma via Metabolomics and Network Pharmacology.

Objective: Ma-xing-shi-gan-tan (MXSGT) was first published in "Shang-han-lun". It functions as a heat-clearing agent, lung-clearing formula, and asthma reliever. This study aims to evaluate the therapeutic effect of MXSGT on asthma and elucidate its underlying mechanisms.

Romiplostim versus Recombinant human thrombopoietin in umbilical cord blood transplantation: a single-center retrospective study.

Delayed platelet engraftment (DPE) is a prevalent complication following umbilical cord blood transplantation (UCBT), accompanied by increased transplant-related mortality. This study aims to evaluate the efficacy, safety, and tolerability of romiplostim and recombinant human thrombopoietin (rhTPO) in enhancing platelet engraftment after UCBT. A total of 19 patients scheduled to receive UCBT were randomly assigned to the romiplostim group (250 µg once weekly from day 5 to platelet engraftment after UCBT, n = 7) or rhTPO group (300 U/kg once daily from days 5 to 18 after UCBT, n = 12).

Associations between childhood maltreatment and overt aggression in depressed adolescents: the mediating effect of alexithymia and insomnia.

Background: Overt aggression may be associated with childhood maltreatment (CM), insomnia, and alexithymia, but the underlying mechanisms of these associations have not been fully explored in adolescents with major depressive disorder (MDD). Therefore, the present study aimed to deeply analyze the relationships between overt aggression and CM, insomnia, and alexithymia in adolescents with MDD, to reveal the mediating mechanisms, and to provide a theoretical basis for clinical interventions.

Methods: From December 2024 to December 2025, this study included 251 adolescents with MDD.

Maternal outcomes among pregnant women with shunt-related congenital heart disease-associated pulmonary hypertension: a retrospective study.

Background: Studies on pregnant women with shunt-related congenital heart disease (CHD)-associated pulmonary hypertension (PH) are scarce and limited by small sample sizes. This study aimed to describe the outcomes of pregnant women.

Methods: Outcomes of pregnant women with shunt-related CHD-associated PH were retrospectively evaluated from 2010 to 2020.

Homeopathy for Heteropathy: FSS and Its Components for the Treatment of Alzheimer's Disease and Endometriosis.

Foshou San (FSS), which is a traditional Chinese compound formula. So far, a variety of components have been isolated and identified from its complex composition. These findings endow it with diverse pharmacological activities.

Peroxymonosulfate activated M-MOF-74 (M = Co, Fe, Ni) visible light photocatalysts for methylene blue degradation enhancement.

Persulphate-based advanced oxidation technology efficiently and cost-effectively removes organic dyes from water but designing stable photocatalytic systems and understanding their reaction mechanisms remain key challenges. Metal-organic frameworks (MOFs) have attracted considerable research attention for degrading organic pollutants owing to their high porosity, tunable structure, and ease of modification. In this study, a series of M-MOF-74 (M = Co, Fe, Ni) photocatalysts are synthesized by a hydrothermal method for methylene blue (MB) degradation.

Autophagy signaling mediated by non-coding RNAs: Impact on breast cancer progression and treatment.

Autophagy, a conserved cellular mechanism which detoxifies and degrades intracellular structures or biomolecules, has been identified as an important factor in the progression of human breast cancer and the development of treatment resistance. Non-coding RNAs (ncRNAs), a broad family of RNA, have the ability to influence various processes, including autophagy, due to their diverse downstream targets. ncRNAs play an important role in suppressing or activating autophagy by targeting autophagy-triggering components such as the ULK1 complex, Beclin1, and ATGs.

Comprehensive analysis of non-coding RNAs in the ovaries of high and low egg production hens.

Egg production performance a critical economic trait in the poultry industry. The regulatory mechanisms underlying egg production performance mediated by non-coding RNAs remain to be characterized. To systematically investigate ovarian lncRNAs, circRNAs, and miRNAs associated with laying efficiency, we conducted comparative transcriptomic analyses using RNA sequencing (RNA-seq) of ovarian tissues from phenotypically divergent groups - high egg production (HEP) and low egg production (LEP) hens.

Comprehensive analysis of the physiological, metabolome, and transcriptome provided insights into anthocyanin biosynthesis and degradation of Malus crabapple.

Malus crabapple is highly regarded for its ornamental and garden applications, with leaf color changes serving as an essential indicator of aesthetic appeal. Despite this significance, studies focusing on crabapple leaf color transformations, particularly the fading of purplish-red hues, remain limited. This research investigates the physiological and molecular mechanisms driving leaf color changes in crabapple through physiological, transcriptional, and metabolic assays.

Novel one-/two-photon excited carbazole/quinolinium photosensitizers manifest nanomolar and hypoxia-resistant tumor photodynamic therapy by accelerating apoptosis, ferroptosis, and autophagy.

Photodynamic therapy (PDT) holds potential in cancer treatment, but the development of photosensitizers with high-efficient PDT remains a challenge. Herein, we designed and synthesized a series of novel tricyclic carbazole/quinolinium hybrids-KNKQ, KAKQ, and KPKQ-as photosensitizers, and subsequently evaluated their photodynamic anticancer activities and the associated mechanisms. Among them, KPKQ exhibited the most prominent one-/two-photon activated photodynamic characteristics, generating •O, •OH, and O.

The status and correlation factors of fatigue in patients with ankylosing spondylitis (FACIT-F): a cross-sectional study based on the Chinese population.

Objective: To analyze the status and correlation factors of fatigue in patients with ankylosing spondylitis (AS), and provide a reference for improving the fatigue status of patients with AS.

Method: Using the AS-specific disease database of the Chinese Rheumatology Registration and Research Information Platform, patients with AS from 9 centers in China were selected as study subjects from March 2022 to September 2023. Functional Assessment of Chronic Illness Therapy Scale (FACIT-F) score, AS disease activity score-C-reactive protein (ASDAS-CRP), AS disease activity score-erythrocyte sedimentation rate (ASDAS-ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Function Index (BASFI), Bath Ankylosing Spondylitis Measurement Index (BASMI), Patient Global Assessment (PGA) score, night pain score, Depression Anxiety Stress Scale (DASS-21) and AS International Community Health Index Assessment (ASAS-HI) were observed.

Prediction model for psychological disorders in ankylosing spondylitis patients based on multi-label classification.

Objective: This study aims to develop a predictive model to assess the likelihood of psychological disorders in patients with ankylosing spondylitis (AS) and to explore the relationships between different factors and psychological disorders.

Methods: Patients were randomly divided into training and test sets in an 8:2 ratio. The Boruta algorithm was applied to select predictive factors, and a multi-label classification learning algorithm based on association rules (AR) was developed.

Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China.

Objective: Here, we ascertained the clinical characteristics of Chinese patients with autoimmune gastritis (AIG) and determined the correlation of dietary and lifestyle factors with AIG occurrence and development to establish a noninvasive predictive model for AIG.

Methods: In this case-control study, we enrolled 479 patients from seven independent centers nationwide in China; of them, 279 had AIG, 112 had chronic atrophic gastritis mostly in the antrum, and 88 had chronic nonatrophic gastritis. Their clinical and lifestyle data were systematically collected and analyzed.

Novel ꞵ-carboline/cyanoisoflavone photosensitizers for ferroptosis-induced efficient chemo-photodynamic synergistic cancer therapy.

Photodynamic therapy (PDT) is an emerging therapeutic modality to selectively eradicate pathological cells, such as cancer cells. Hence, we designed and synthesized a series of novel ꞵ-carboline/cyanoisoflavone photosensitizers A1-A3. All compounds possessed potent type-I/-II photodynamic properties.

Racial Disparities and Trends in Outcomes of Patients with Gastrointestinal Stromal Tumors.

Background: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. However, there are limited studies on the latest survival trends and the impact of racial disparities on GIST patients' outcomes.

Methods: We obtained 12,808 GIST patients between 2001 and 2020 from the Surveillance, Epidemiology, and End Results (SEER) database in 17 original sites.

First-in-human study on tolerability, pharmacokinetics and pharmacodynamics of single and multiple escalating doses of XKH001, a recombinant humanized monoclonal antibody against IL-25 in healthy Chinese volunteers.

Background: XKH001 is a recombinant humanized IgG1 monoclonal antibody against IL-25 for the treatment of type 2 inflammatory diseases. This study aimed to evaluate the tolerability, pharmacokinetics, and pharmacodynamics of XKH001 in humans for the first time.

Research Design And Methods: This clinical investigation adopted a randomized, double-blind, and placebo-controlled single ascending dose (SAD) and multiple ascending dose (MAD) design.

Deciphering endocrine function of adipose tissue and its significant influences in obesity-related diseases caused by its dysfunction.

Current research has found that adipose tissue is not only involved in energy metabolism, but also a highly active endocrine organ that secretes various adipokines, including adiponectin, leptin, resistin and apelin, which are involved in the regulation of physiology and pathology of tissues and organs throughout the body. With the yearly increasing incidence, obesity has become a risk factor for a variety of pathological changes, including inflammation and metabolic syndrome in various system (endocrine, circulatory, locomotor and central nervous system). Thus these symptoms lead to multi-organ dysfunctions, including the heart, liver, kidneys, brain and joints.

Current status and influencing factors of nutrition management in patients with digestive tract cancer from the integrated perspective of medical care staff, patients, and family caregivers: a qualitative study.

Background: The research aimed to collect experience and viewpoints related to the nutrition management of patients with digestive tract cancers from medical care staff, patients, and family caregivers and provide reasonable and effective references for the mode of nutrition management of these patients.

Methods: Using a phenomenological qualitative research method, six physicians, six nurses, three nutritionists, six patients, and six family caregivers from a tertiary A cancer hospital in Jiangsu Province were chosen by purposive sampling methods from February to June 2023. Data was collected through semi-structured in-depth interviews and analyzed by the content analysis method.

Metabolomic analysis reveals an important role of sphingosine 1-phosphate in the development of HFMD due to EV-A71 infection.

Hand, foot, and mouth disease (HFMD) is a serious pediatric infectious disease that causes immeasurable physical and mental health burdens. Currently, there is a lack of information on the mechanisms of HFMD severity and early diagnosis. We performed metabolomic profiling of sera from 84 Enterovirus A71 (EV-A71) infections and 45 control individuals.

The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1.

Unlabelled: Enterovirus A71 (EV-A71) is a common small RNA virus that is highly neuroinvasive. Emerging evidence indicates that the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation. However, the potential role of the C5a-C5aR1 axis in EV-A71 encephalitis remains largely elusive.

Comparative analysis of BAG1 and BAG2: Insights into their structures, functions and implications in disease pathogenesis.

As BAG family members, Bcl-2 associated athanogene family protein 1 (BAG1) and 2 (BAG2) are implicated in multiple cellular processes, including apoptosis, autophagy, protein folding and homeostasis. Although structurally similar, they considerably differ in many ways. Unlike BAG2, BAG1 has four isoforms (BAG1L, BAG1M, BAG1S and BAG1 p29) displaying different expression features and functional patterns.

Two Stable Pillar-Layered Zn-LMOFs for Highly Fluorescence Sensing of Inorganic Pollutants and Nitro Aromatic Compounds in Water.

Luminescent metal-organic frameworks (LMOFs) are a potential class of functional materials for the photoluminescent detection of a wide range of analytes as well as for the detection of pollutants in wastewater. Herein, by using the pillar-layered strategy, two new luminescence Zn-LMOFs ( and ) were successfully solvothermal synthesized. The 2D layers are both consisting of Zn and TPHC [TPHC = (1,1':2',1″-terphenyl)-3,3″,4,4',4″,5'-hexacarboxylic acid] ligands and then pillared by the different N-donor ligands to form the 3D Zn-LMOFs with topology.