Anaerobic digestion of food waste under non-conventional operating conditions: enhancing process stability while reducing energy and chemical inputs.

Decentralized anaerobic treatment presents a sustainable alternative for managing the substantial generation of food waste. However, the associated high costs may render this option less feasible for small- to medium-scale systems. To explore a novel strategy for cost reduction in anaerobic digestion systems used for food waste treatment, this study applied organic loading rates (OLR) ranged from 0.

Are Immune-Integrative Biomarkers Predictors of Systemic Inflammation in Show Jumping Horses?

Objective: This study evaluated the dynamics of blood immune-inflammatory biomarkers in response to exercise-induced changes in jumping horses.

Methods: For this purpose, adult Brazilian Sport Horses (n = 9), aged 10.1 years, both sexes, underwent a specific training test consisting of warm-up, flatwork, and jumping exercises, and recovery on a 900 m sand track over 40 min.

Artificial Intelligence, Molecular Dynamics, and Beyond: Computational Insights In Cosmetics Research and Formulation Design.

The vast field of cosmetics is mainly explored through experimental methods, while computational tools find broader application in structuralbiology. The world of formulations remains relatively untouched or nondisclosed due to commercial interests. This work aims to better understand the applications of in silico methods in cosmetics research, at the molecular level, and how the recent work is advancing the state of the art.

Parental Emotion Socialization and Difficulties in Emotion Regulation in Adolescents: A Network Analysis.

Parental emotion socialization strategies influence adolescent emotion regulation development. However, there are still doubts about the supportive/unsupportive role of each strategy. This may be likely due to limitations of prior research that analyzed these strategies in isolation, without considering their interdependence.

Hormone receptor discrepancy and molecular subtype changes in canine mammary carcinomas and synchronous lymph node metastasis.

Mammary tumors are the most prevalent neoplasms in intact female dogs; up to 50 % are considered malignant and have the potential to metastasize to regional lymph node and distant organs. Changes in tumor molecular subtype, including its receptor status, can occur during mammary tumor progression. This study aimed to explore hormone receptor discrepancies and the relationship between molecular subtypes in primary mammary tumors (PTs) and paired lymph node metastases (LNMs).

A Smartphone Application Based on Dialectical Behavior Therapy Skills for Binge Eating Episodes: Study Protocol for a Randomized Controlled Trial.

: With the rapid progression of technology, applications have been proposed as a promising alternative to conventional psychotherapeutic treatment. Nonetheless, research on unguided self-help applications for binge eating remains scarce, with most existing studies utilizing cognitive behavioral therapy (CBT) principles. Therefore, this paper presents the protocol for a randomized controlled trial designed to evaluate the efficacy and acceptability of eMOTE, a standalone application designed specifically for women in Portugal who binge eat.

Giardia-induced Type 2 mucosal immunity attenuates intestinal inflammation caused by co-infection or colitis in mice.

Diarrhoeal diseases are the second leading cause of death in children worldwide. Epidemiological studies show that co-infection with the protozoan parasite Giardia intestinalis decreases diarrhoeal severity. Here we show a high incidence of asymptomatic Giardia infection in school-aged children from Nigeria.

Molecular detection and characterization of Trichomonas spp. in wild birds in the Brazilian Pantanal.

Members of the family Trichomonadidae, particularly Trichomonas gallinae, are globally distributed avian parasites that primarily infect birds from the orders Columbiformes, Falconiformes, and Strigiformes. Although infections in Passeriformes are often subclinical, clinical cases have been reported. Transmission occurs through direct contact or indirectly via contaminated food or water, enabling infection across various avian orders, including Anseriformes, Falconiformes, Galliformes, Gruiformes, Passeriformes, Piciformes, Psittaciformes, and Strigiformes.

Smartphone Applications for Eating Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Objective: Given the rising prevalence of eating disorders (EDs), smartphone applications (apps) have received growing clinical attention, but their overall effectiveness remains undetermined. This study aimed to conduct a meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of app interventions for EDs and to identify the psychological approaches featured in these interventions.

Method: The online databases SCOPUS, PubMed, and EBSCO were searched for trials published up to February 2025.

AI, docking, and molecular dynamics to track the binding of structural peptides to different keratin models.

The present work shows a computational approach to assess the interactions of different nature-inspired peptides with hair keratin models. An updated keratin model was validated, and comparisons with previous models were traced, thereby highlighting the time-evolution of both the model and the in silico methods. Importantly, the computational methodology presented here allows for the study of peptide-protein interactions between unknown or unsolved structures.

Validation of a High-Throughput Microfluidic Real-Time PCR for the Detection of Vector-Borne Agents in Wild Birds from the Brazilian Pantanal.

Despite numerous studies on haemosporidians in wild birds from Brazil, the presence of other vector-borne agents (VBA) such as spp., spp., and Onchocercidae filariids in avian hosts remains largely unknown.

Efficacy of a formulation of chlorfenvinphos and dichlorvos on Rhipicephalus microplus in vivo test in Bahia, Brazil.

This study aimed to evaluate the efficacy of a commercial formulation containing the combination of chlorfenvinphos and dichlorvos on Rhipicephalus microplus in a field test in northeastern Brazil. Adult crossbred cattle naturally infested with R. microplus were restrained in a trunk to count partially engorged female ticks between 4.

Antitumor activity and selectivity of a nanostructured peroxo polyoxoniobate.

and experiments were carried out to evaluate the activity and antitumor selectivity of new niobium oligomers. A polyoxoniobate (PONb) structure linked to the methylene blue dye (PONb-MB) showed promising results for some types of tumor cells. Molecular structures were determined for PONb and PONb-MB based on spectroscopic analyses using density functional theory calculations.

Exploring the Chemopreventive and Antioxidant Effects of Spearmint Leaf Hydroethanolic Extract in HPV16-transgenic Mice.

Background/aim: Human papillomavirus (HPV) is the most common sexually transmitted infectious agent and, in cases of persistent infection, may cause cancer. This study evaluated the toxicological and antitumor properties of extract (MSE) in KP14HPV16 mice, which carry HPV16 oncogenes.

Materials And Methods: Thirty-three female FVB/n mice (), including 17 HPV-transgenic and 16 wild-type (WT) mice, were divided into six groups.

Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis.

In murine models of visceral leishmaniasis (VL), the parasitization of resident Kupffer cells (resKCs) drives early Leishmania infantum growth in the liver, leading to granuloma formation and subsequent parasite control. Using the chronic VL model, we demonstrate that polyclonal resKCs redistributed to form granulomas outside the sinusoids, creating an open sinusoidal niche that was gradually repopulated by monocyte-derived KCs (moKCs) acquiring a tissue specific, homeostatic profile. Early-stage granulomas predominantly consisted of CLEC4FKCs.

When Seizures Lead to the Incidental Finding of Silicone Oil Migration.

Silicone oil, commonly used as a temporary intraocular tamponade in retinal detachment repair, may have retrobulbar migration as a possible complication of the procedure to the cerebral ventricles. This report presents the case of a 73-year-old male patient with multiple cardiovascular risk factors and diffuse atherosclerotic disease who underwent vitrectomy of the left eye several years earlier due to retinopathy and was diagnosed through retrospective analysis of all cerebral imaging studies, with the migration of silicone oil particles, from the vitreous humor of the eye to the intraventricular space. He was admitted due to transient altered consciousness in the context of a probable seizure, with acute hyperdensity in the temporal horn of the left lateral ventricle observed in the cranial computed tomography (CT), suggestive of hemorrhage, along with signs of prior hemorrhage in the frontal horn of the same ventricle.

The differential impact of processing speed and cognitive flexibility on cognitive emotion regulation strategies and depression.

Introduction: Existing cognitive models for depression propose interactions between cognitive emotion regulation strategies (CERS) and cognitive processes. However, often oversimplify these interactions and do not accommodate the complexity of interactions. We aimed to construct and explore the micro-level properties of a network model that can integrate this complexity of the interactions and explore through computational simulations the differential impact of improvements/deterioration in cognitive flexibility and processing speed in the network.

Enantiorecognition in a multi-component environment.

We demonstrate that enantiopreference in the binding of , over , astaxanthin (AXT) to albumin manifests itself only for racemic (but not enantiopure) carotenoids. The observed enantioselectivity is rationalized using chiroptical spectroscopies supported by molecular docking, molecular dynamics and quantum-chemical calculations. These methods offer a plausible explanation for the observed enantiopreference, as they reveal a unique binding mode of the (3,3')-AXT form with the protein in contrast to multiple (random) possibilities for albumin binding with the (3,3')-AXT, and also a higher interaction energy of the latter enantiomer with the protein.

Incipient soils: New habitats in proglacial areas of the Maladeta massif (Central Pyrenees).

Since the Little Ice Age, the deglaciation of the Maladeta massif (Central Pyrenees) has been almost continuous; since then, the glaciated surface has been reduced by 87.9 % until 2021. This deglaciation has led to an increase in proglacial areas, allowing the development of new habitats.

Let-7b, miR-29b, and miR-125b as Potential Biomarkers for Differentiating Canine Mammary Carcinoma Histological Types.

Epigenetics is the study of changes in organisms that result from modifications in gene expression rather than alterations in the genetic code itself [...

Effect of fructooligosaccharides in full-hydrated lactic acid bacteria membrane models during thermal stress: A molecular simulation study.

Fructooligosaccharides (FOS) are a promising choice for cryoprotection of lactic acid bacteria (LAB). However, the mechanism by which this protection takes place is not well understood. Molecular simulation is a key tool for gathering insights into complex physicochemical problems like this.

Leishmania mexicana N-Acetyltransferease 10 Is Important for Polysome Formation and Cell Cycle Progression.

Leishmania presents a complex life cycle that involves both invertebrate and vertebrate hosts. By regulating gene expression, protein synthesis, and metabolism, the parasite can adapt to various environmental conditions. This regulation occurs mainly at the post-transcriptional level and may involve epitranscriptomic modifications of RNAs.

Digital Feedback Loop in Paraxial Fluids of Light: A Gate to New Phenomena in Analog Physical Simulations.

Easily accessible through tabletop experiments, paraxial fluids of light are emerging as promising platforms for the simulation and exploration of quantumlike phenomena. In particular, the analogy builds on a formal equivalence between the governing model for a Bose-Einstein condensate under the mean-field approximation and the model of laser propagation inside nonlinear optical media under the paraxial approximation. Yet, the fact that the role of time is played by the propagation distance in the analog system imposes strong bounds on the range of accessible phenomena due to the limited length of the nonlinear medium.