Enantiorecognition in a multi-component environment.

We demonstrate that enantiopreference in the binding of , over , astaxanthin (AXT) to albumin manifests itself only for racemic (but not enantiopure) carotenoids. The observed enantioselectivity is rationalized using chiroptical spectroscopies supported by molecular docking, molecular dynamics and quantum-chemical calculations. These methods offer a plausible explanation for the observed enantiopreference, as they reveal a unique binding mode of the (3,3')-AXT form with the protein in contrast to multiple (random) possibilities for albumin binding with the (3,3')-AXT, and also a higher interaction energy of the latter enantiomer with the protein.

Effect of fructooligosaccharides in full-hydrated lactic acid bacteria membrane models during thermal stress: A molecular simulation study.

Fructooligosaccharides (FOS) are a promising choice for cryoprotection of lactic acid bacteria (LAB). However, the mechanism by which this protection takes place is not well understood. Molecular simulation is a key tool for gathering insights into complex physicochemical problems like this.

Efficient delivery of carotenoids to adipocytes with albumin.

Carotenoids are very effectively delivered by albumin to adipocytes. The uptake of carotenoids to the cells occurs in the form of self-aggregates that localize in the vicinity of the adipocyte membrane, as shown by high spatial resolution Raman spectroscopy. The binding of carotenoids to albumin and the mechanism of their transport were elucidated with the help of chiroptical spectroscopies, in tandem with molecular docking and molecular dynamics simulations.

Paradoxical embolism: a rare cause of acute upper limb ischemia.

Paradoxical embolism is a rare cause of arterial embolism, even more those resulting in acute ischemia of the upper limb. A case of a 45-year-old patient with acute paradoxical upper limb embolization and acute limb ischemia is presented. A review of the most recent evidence on the diagnosis and management of paradoxical embolism were explored.

Management of median arcuate ligament syndrome: a case-based review.

Dunbar syndrome or median arcuate ligament syndrome is a rare pathology that has a great impact on the quality of life of patients. This brief report aims to present a case report of a successful treatment of Dunbar syndrome and to review the current management of this entity. We present the case of a 37 year-old patient, who was treated by median arcuate ligament laparoscopic resection.

Cardiovocal Syndrome - An Aortic Arch Aneurysm As A Rare Cause Of Vocal Cord Paralysis.

Introduction: Cardiovocal or Ortner's syndrome is a rare cause of vocal cord paralysis. Damage to the left recurrent laryngeal nerve may be caused by an aortic arch aneurysm, in even rarer cases.

Clinical Case: A 60-year-old woman presented with hoarseness lasting for six months.

Effect of different types of surfactants on the microstructure of methyltrimethoxysilane-derived silica aerogels: A combined experimental and computational approach.

Hypothesis: Surfactants interfere with sol-gel particle/pore growth, influencing the structure and properties of silica aerogels. Their ability to induce microscopic changes in the aerogel's structure may be useful to improve/control the thermal insulation performance of aerogels.

Experiments: The influence of different types of surfactants (anionic, cationic and non-ionic) on the microstructural arrangement and macroscopic properties of methyltrimethoxysilane (MTMS)-based aerogels was evaluated for the first time, using an experimental and computational comparative approach.