Phytochrome B stabilizes the KNOX transcription factor BP/KNAT1 to promote light-initiated seed germination in Arabidopsis thaliana.

Seed germination is a critical step in the life cycle of plants. The far-red/red light photoreceptor phytochrome B (phyB) plays a dominant role in promoting seed germination, mainly by modulating the metabolism of gibberellin (GA) and abscisic acid (ABA), although the underlying mechanism remains poorly understood. In this study, we identified BREVIPEDICELLUS (BP)/KNAT1, a KNOX transcription factor that acted downstream of phyB and activated light-initiated seed germination in Arabidopsis thaliana.

Single-cell sequencing reveals the role of endothelial subsets in promoting early gastric cancer progression.

Early gastric cancer (EGC) represents a critical stage in preventing and controlling the progression from gastritis to advanced gastric cancer (AGC). Therefore, identifying the single-cell characteristics of EGC, particularly the cellular composition of the tumor microenvironment (TME), as well as identifying potential predictive markers and therapeutic targets, could significantly enhance the monitoring of gastric cancer and improve clinical cure rates. We constructed a comprehensive single-cell RNA sequencing atlas for 184,426 high-quality gastric cancer cells from various stages, utilizing clinical biopsies and surgical samples.

Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism.

Introduction: Fungal infections represent a global health concern with significant implications for human well-being. Among them, refractory and sight-threatening fungal keratitis (FK) poses a serious threat to ocular health. This underscores an urgent need for developing novel antifungal agents to meet clinical demands.

Association Between Size of Left Ventricle and Long-Term Cardiovascular Events.

Background: The prognostic significance of small left ventricle (LV) in the general population and its association with cardiovascular disease remain elusive.

Methods: Using data from the UK Biobank, 39 363 participants underwent baseline cardiovascular magnetic resonance imaging and were categorized into 3 groups based on left ventricular end-diastolic volume index: small, normal, and large LV. Cox proportional hazards models were applied to evaluate the association between LV size and composite cardiovascular outcomes.

Low dietary intake of marine n-3 fatty acids and seafood significantly contributes to metabolic syndrome burden in China.

Marine n-3 polyunsaturated fatty acids (PUFAs) and seafood intakes have been shown to decrease the risk of metabolic syndrome (MetS), whereas data on related MetS burden in China remain absent. We hypothesize that low marine n-3 PUFAs and seafood consumption are a significant contributor to the burden of MetS in China. The time trend of marine n-3 PUFAs consumption and seafood was evaluated based on the China Health and Nutrition Survey.

Nanograin-enhanced surface-layer strengthening of 3D printed intervertebral cage induced by sandblasting.

3D-printed customized titanium alloy (Ti6Al4V, TC4) as load-bearing prostheses and implants, such as intervertebral cages, have been widely used in clinical practice. Native biological inertia and inadequate bone in-growth of porous titanium alloy scaffolds hampered their clinical application efficiency and then extended the healing period. To improve the osseointegration capacity of 3D-printed intervertebral cages, sandblasting was selected to execute their surface treatment.

Correction of I in human induced pluripotent stem Cell-derived cardiomyocyte carrying DPP6 mutation in early repolarization syndrome by CRISPR/Cas9 genome editing.

Early repolarization syndrome (ERS) is defined as occurring in patients with early repolarization pattern who have survived idiopathic ventricular fibrillation with clinical evaluation unrevealing for other explanations. The pathophysiologic basis of the ERS is currently uncertain. The objective of the present study was to examine the electrophysiological mechanism of ERS utilizing induced pluripotent stem cells (iPSCs) and CRISPR/Cas9 genome editing.

Case report: Endoscopic retrieval of a proximally migrated pancreatic stent using the basket-through- the-sphincterotome technique.

Background: The retrieval of a proximally migrated pancreatic duct (PD) stent via endoscopic retrograde cholangiopancreatography (ERCP) is technically challenging, often requiring surgical intervention. We report a case with proximal migration of a pancreatic stent that was successfully removed by a basket-through-the-sphincterotome technique.

Case Presentation: A 46-year-old man with prior history of chronic pancreatitis was admitted to our hospital with 1 month history of epigastric discomfort.

Macrophage Gpx4 deficiency aggravates foam cell formation by regulating the expression of scavenger receptors, ABCA1, and ABCG1.

Macrophage-derived foam cell formation is critical for the initiation and development of atherosclerosis, which contributes to atherosclerotic cardiovascular disease (ASCVD). Glutathione peroxidase 4 (GPX4), a crucial ferroptosis regulator, protects cells from excessive oxidative stress by neutralizing lipid peroxidation. However, the role of macrophage GPX4 in foam cell formation remains unknown.

Timing of endoscopy for acute variceal bleeding in patients with cirrhosis (CHESS1905): A nationwide cohort study.

Background: Endoscopy plays an important role in the management of acute variceal bleeding (AVB) in patients with cirrhosis. This study aimed at determining the optimal endoscopy timing for cirrhotic AVB.

Methods: Patients with cirrhosis with AVB across 34 university hospitals in 30 cities from February 2013 to May 2020 who underwent endoscopy within 24 hours were included in this study.

Administration of macrolide antibiotics increases cardiovascular risk.

Background: The increased risk of cardiovascular events in patients prescribed macrolides has been subject to debate for decades.

Methods: Medline, EMBASE databases and ClinicalTrials.gov were searched from inception until August 31, 2022 for studies investigating the link between macrolides and cardiovascular risk.

Systolic Blood Pressure and Cardiovascular Risk in Normotensive Adults.

Objective: To examine the association of systolic blood pressure (SBP) and cardiovascular risk in normotensive adults.

Patients And Methods: This study analyzed data from 7 prospective cohorts between September 29, 1948, and December 31, 2018. Complete information on history of hypertension and baseline blood pressure measurements were required for inclusion.

Current uses of electro-cautery lumen apposing metal stents in endoscopic ultrasound guided interventions.

The electro-cautery lumen apposing metal stent (EC-LAMS) is a newly developed device that integrates the electro-cautery cyctotome with the one-step metal stent delivery and releasing system in recent years. LAMS was first designed to complete the drainage of pancreatic fluid collection under endoscopic ultrasound guidance, and the technological innovation of EC-LAMS has made more off-labeled indications of endoscopic intervention for gastrointestinal diseases realized, such as abdominal fluid drainage, bile duct, or gallbladder drainage through stomach or duodenum, gastrointestinal anastomosis, and the establishment of fistulous channel for further endoscopic operation when necessary. The unique feature of this metal stent is that it has the design of a saddle shape and a large lumen, and can almost connect the adjacent structures to minimize the risk of perforation and leakage.