Potential interactive effect of placental heavy metals and gestational diabetes mellitus on neonatal anthropometric measures: a birth cohort study.

Studies demonstrate that prenatal exposure to heavy metals can impair fetal growth and development. Meanwhile, gestational diabetes mellitus (GDM), a frequent pregnancy complication, may also influence fetal development. Given the potential coexistence of these two risk factors, further investigation is needed to elucidate their combined effects on fetal development.

Association of placental single and mixed metal burdens with offspring dyslipidemia: Can vitamin D levels during pregnancy alleviate this effect?

Metals can partly accumulate in the placenta and disrupt placental function, thereby affecting fetal programming. Prenatal metal exposure may be associated with long-term lipid health in offspring, but this association has not been studied in birth cohorts. In the Ma'anshan birth Cohort (MABC), placental tissue concentrations of fourteen metals were quantified.

Maternal blood pressure during pregnancy and children's cardiometabolic function: A birth cohort study.

Background And Aim: The evidence regarding the effect of the trajectory of blood pressure (BP) during pregnancy on children's cardiometabolic risk (CMR) was absence. The purpose of this study was to explore the relationship between maternal BP in the first, second, and third trimester of pregnancy and the trajectory of maternal BP during pregnancy and children's cardiometabolic function.

Methods And Results: 2159 mother-child pairs with singleton live births from the Ma'anshan Birth Cohort were included in the study.

Interaction between maternal thyroid hormone levels and pregnancy-related anxiety on birth outcomes-A birth cohort study.

Background: Maternal thyroid hormone levels and pregnancy-related anxiety (PRA) influence pregnancy outcomes. However, their potential interactive effects on birth outcomes remain poorly understood.

Methods: This large prospective cohort study was conducted from May 2013 to September 2014 at the Ma'an Shan Maternal and Child Health Center.

Placental and cord serum inflammatory cytokines and children's domain-specific neurodevelopment at 18 months: effect modification by maternal vitamin D status.

Background: Epidemiological studies that have simultaneously explored the effects of placental and cord blood inflammatory cytokine levels on neurodevelopment in offspring, as well as the role of maternal vitamin D in these associations, are lacking. To investigate the associations of placental and cord blood inflammatory cytokine levels with neurodevelopment in 18-month-old children, and the potential modification effect by maternal vitamin D.

Methods: Based on the Ma'anshan birth cohort, the current study involved 1241 mother-child pairs.

Effects of early-life antibiotic use on emotional and behavioral development trajectories in preschool children.

Background: Limited research exists on the link between antibiotic use and emotion and behavior, particularly the lack of continuous emotional and behavioral assessment. Emotions and behaviors reflect key modifiable dimensions of brain function and evolve during childhood growth and development. This paper aimed to examine the antibiotic use (yes/no), categories and duration in association with preschool children's emotional and behavioral development trajectory.

Sex-and stage-specific effect of prenatal exposure to organophosphate esters with children's physical growth patterns and adiposity rebound timing: Modification by breastfeeding.

Introduction: Exploring the stage-specific effects of prenatal exposure to organophosphate esters (OPEs) on offspring growth and developmental trajectories is critical for early-life health management.

Methods: Based on 2519 mother-child dyads from the Ma'anshan Birth Cohort, we examined the concentrations of OPEs in maternal urine during the three trimesters. Seventeen follow-up visits were made to the children, and physical data were collected.

Association of maternal thyroid peroxidase antibody exposure with children's emotional and behavioral problems.

Objective: Maternal thyroid peroxidase antibody (TPOAb) positivity has been associated with a variety of pregnancy complications and has potential neuropsychological developmental implications for the offspring. The aim of our study was to explore the effect of maternal TPOAb levels on emotional and behavioral problems in children.

Design: The study was designed as a cohort study.

Impact of tea and coffee consumption during pregnancy on children's cognitive development.

Evidence on the association between maternal tea/coffee consumption and children's cognitive development is limited. This study included 1423 mother-child pairs from the Chinese National Birth Cohort (CNBC). Maternal tea/coffee consumption status was collected in the 1st, 2nd and 3rd trimesters of pregnancy.

Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma'anshan Birth Cohort Study in China.

Background: Animal studies suggest cardiovascular systems may be primary targets for barium toxicity. This study aims to examine longitudinal associations of prenatal and early childhood barium exposure with cardiometabolic risk (CMR) in preschoolers.

Methods And Results: We determined serum or plasma barium concentrations during 3 trimesters, delivery, and early childhood (5 years) from 2291 mother-child dyads within the Ma'anshan Birth Cohort.

Prenatal placental metal accumulation and its association with child attention deficit/hyperactivity disorder and autism spectrum disorder symptom at 3 years of age: The role of psychosocial-environmental support in infancy.

The placenta is recognized as a barrier to the passage of harmful substances and is an ideal biomonitoring sample for assessing cumulative prenatal exposure to metals. However, scientific knowledge is insufficient regarding the effects of cumulative prenatal exposure to metal mixtures on behavioral development in early life. This study included 2154 mother-infant pairs from the Ma'anshan Birth Cohort study.

Association Between Maternal Thyroid Hormone Concentration with Normal Thyroid Function During Pregnancy and Preschoolers' Glycolipid Metabolism: A Birth Cohort Study.

Thyroid hormones (THs) are essential endocrine hormones that play key roles in individual's growth and development. There is limited knowledge about the association between maternal TH concentrations variations with normal thyroid function during pregnancy and offspring's glycolipid metabolism. A total of 1130 mother-child pairs from the Ma'anshan birth cohort were included in this prospective study.

Sleep Duration, Sleep Habits, and Social Jetlag From 4 to 6 years Their Impacts on Myopia Among School-Aged Children: The Ma'anshan Birth Cohort Study.

Purpose: To examine the associations of sleep parameters and their trajectories at preschool age with myopia among school-aged children by using a birth cohort study design.

Patients And Methods: All participants were recruited from the Ma'anshan Birth Cohort Study. Sleep duration, sleep habits, and social jetlag were collected in 4 years, 5.

Pregnancy-related anxiety modifies the effects of maternal exposure to organophosphate esters on preschoolers' behavioral development.

Longitudinal associations with psychological factors modifying the effects of chemicals have not been sufficiently explored in epidemiologic studies. Our birth cohort study is the first to assess the associations between prenatal organophosphate ester (OPE) exposure and child behavior and to determine whether these associations change with pregnancy-related anxiety (PRA). Ultra-performance liquid chromatography‒tandem mass spectrometry (LC‒MS) was used to measure the tris(2-chloroethyl) phosphate (TCEP) and OPE metabolites in the 1st, 2nd and 3rd trimester urine samples.

The effect of bedtime snacks on morning fasting blood glucose in gestational diabetes mellitus: a randomized controlled trial.

Importance: While guidelines recommend bedtime snacks for women with gestational diabetes mellitus (GDM), there is insufficient evidence championed those recommendation.

Objective: To evaluate if bedtime snacking is effective in preventing high fasting blood glucose incidence among women with GDM.

Design: An open-label, parallel-group, randomized controlled trial was conducted from December 2023 to July 2024 at Ma'anshan Maternal and Child Health Care Center, Anhui, China.

Sex- and trimester-specific impact of gestational co-exposure to organophosphate esters and phthalates on insulin action among preschoolers: Findings from the Ma'anshan birth cohort.

Introduction: Prenatal exposure to organophosphate esters (OPEs) and phthalic acid esters (PAEs) is ubiquitous among pregnant individuals. However, research exploring the relationship between prenatal co-exposure to OPEs and PAEs and childhood insulin function remains limited.

Methods: In this study, utilizing data from 2,246 maternal-fetal dyads in the Ma'anshan Birth Cohort, associations between co-exposure to OPEs and PAEs and insulin action were analyzed.

Associations of prenatal arsenic exposure with myopia in primary school children: Modifying effects of vitamin D levels.

The increasing role of environmental pollutants and nutrients in the development of myopia. Further longitudinal evidence is needed to elucidate the effects of early-life environmental pollutants on myopia and nutrients to protect against pollutant-induced myopia. We used mother-child dyads from the Ma'anshan Birth Cohort (n = 2028) to explore the modifying effects of maternal vitamin D status of prenatal and childhood arsenic exposure with refractive parameters and myopia.

Associations of Placental Inflammation and Oxidative Stress Biomarkers with Glucolipid Metabolism in Children: A Birth Cohort Study in China.

Background: The maternal intrauterine immune environment may affect offspring long-term health. We aimed to investigate the association between the intrauterine placental immunological milieu and glycolipid metabolic health in children.

Methods And Results: This study enrolled 1803 mother-child pairs from the Ma'anshan birth cohort (2013-2014).

Sex-specific effect of maternal thyroid peroxidase antibody exposure during pregnancy on 5- to 6-year-old children's cardiometabolic risk score: the Ma'anshan birth cohort study.

Objective: To explore the association between maternal thyroid peroxidase antibody (TPOAb) exposure and 5- to 6-year-old children's cardiometabolic risk (CMR).

Methods: A total of 2129 mother-child pairs were recruited from the Ma'anshan Birth Cohort (MABC) study. Serum TPOAb was retrospectively measured in pregnant women using an electrochemiluminescence immunoassay.

Associations of prenatal exposure to individual and mixed organophosphate esters with ADHD symptom trajectories in preschool children: The modifying effects of maternal Vitamin D.

Background: Organophosphate esters (OPEs) are a class of environmental chemicals with endocrine-disrupting properties. Epidemiologic studies have demonstrated that prenatal OPEs exposure is associated with neurodevelopmental disorders in offspring. However, studies assessing the effects of prenatal OPEs exposure on the dynamic changes in attention deficit hyperactivity disorder (ADHD) symptoms in preschoolers are scarce.

Association between Dietary Patterns during Pregnancy and Children's Neurodevelopment: A Birth Cohort Study.

Background: Research studies have showed that maternal diet may influence fetal neurodevelopment, but most studies have only assessed single nutrients or food groups.

Objective: To investigate the impact of maternal prenatal dietary patterns during pregnancy on child neurodevelopment.

Methods: Study participants were obtained from the China National Birth Cohort.

Sex-Specific Associations between Maternal Thyroid Peroxidase Antibodies and Cognitive Development in Preschool Children: A Prospective Cohort Study.

An association between maternal thyroid dysfunction throughout pregnancy and the subsequent risk of neurodevelopmental abnormalities in offspring has been demonstrated. However, the potential effects of maternal thyroid autoimmunity on neurodevelopment in the absence of maternal hypothyroidism remain unclear. Therefore, in this study, we explored the association between maternal thyroid peroxidase antibody (TPOAb) positivity and cognitive development in preschool children.