Spatial and Functional Characterization of IL1RL1+ Mast Cells Reveals Immune Regulatory Roles in Renal Cancer.

Background: Interleukin-1 receptor-like 1 (IL1RL1, also known as ST2) plays a critical role in immune regulation. Pan-cancer analysis has revealed that IL1RL1 is closely associated with cellular immune functions; however, its role in clear cell renal cell carcinoma (ccRCC) and the tumor microenvironment (TME) remains poorly defined.

Methods: We analyzed IL1RL1 expression patterns using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases.

Synthesis of Mesoporous Alumina with High Specific Surface Area via Reverse Precipitation Method for Enhanced Adsorption and Regeneration of Congo Red.

Various forms of alumina have attracted considerable attention for their ability to remove anionic dyes from wastewater, attributed to their high specific surface area, and environmental safety. In this study, a series of modified alumina materials were synthesized for the first time using the reverse precipitation method with dual aluminum sources and without template agent to explore their applicability in various scenarios, including adsorption processes and regeneration cycles. The results revealed that non-modified alumina exhibited superior adsorption properties, while silicon-modified alumina demonstrated exceptional thermal stability during high temperature calcination.

Global, regional, and National Burden of chronic kidney disease attributable to dietary risks from 1990 to 2021.

Background: Dietary risks are increasingly reported as a cause of chronic kidney disease (CKD). However, the trends in the burden of CKD attributable to dietary risks have yet to be fully elucidated.

Methods: This study extracted two major indicators related to CKD caused by dietary risks from the Global Burden of Disease (GBD) database for the years 1990 to 2021, including deaths and disability-adjusted life years (DALYs).

Causal relationship between gut microbiota and male erectile dysfunction: a Mendelian randomization analysis.

Background: Several observational studies have reported an association between gut microbiota and male erectile dysfunction (ED). However, it remains unclear whether there is a causal relationship between gut microbiota and male ED. Thus, we aimed to investigate the potential causal relationship between gut microbiota and male ED through Mendelian randomization (MR) analysis.

Prognostic value of in bladder cancer and its role in the tumor microenvironment.

Background: Bladder cancer (BC), as a common type of cancer, has a poor prognosis, also some common invasive prognostic or therapeutic markers are difficult to obtain, which makes further treatment of BC difficult. Glycyl-tRNA synthetase (), as one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids, has been identified as a target in many diseases, including tumors.

Methods: Bioassay analysis revealed that was in high expression in most cancer tissues.

Is switching intravesical chemotherapeutic agents beneficial in short-term recurrent high-risk non-muscle-invasive bladder tumors? A 5-year retrospective study.

Objective: To explore if switching intravesical chemotherapeutic agents is beneficial in short-term recurrences of high-risk non-muscle-invasive bladder cancer (NMIBC) following the failure of preceding intravesical therapy.

Materials And Methods: From June 2010 to October 2015, 205 patients with NMIBC who experienced tumor recurrence within a year after receiving first-line intravesical chemotherapy (IVC) were classified into two groups. After a second complete transurethral resection (TUR) process, we immediately altered the intravesical instillation agent for 107 patients (group A).

MicroRNA-367-3p directly targets RAB23 and inhibits proliferation, migration and invasion of bladder cancer cells and increases cisplatin sensitivity.

Objectives: This study investigated the biological role of miR-367-3p upregulation in bladder cancer and verified the mutual relation between miR-367-3p and RAB23.

Materials And Methods: Expression levels of miR-367-3p were determined by RT-qPCR in bladder cancer cell lines and human bladder cancer tissues. The effects of miR-367-3p on proliferation, migration and invasion were evaluated by cell colony formation assays, wound healing assays and trans-well assays, respectively.

Development and validation of a nomogram for predicting osteoporosis in prostate cancer patients: A cross-sectional study from China.

Background: The specific risk factors contributing to the development of osteoporosis and the appropriate timing of treatment in Chinese prostate cancer (PCa) patients remain unclear. Our objective was to develop and validate a nomogram capable of predicting the occurrence of osteoporosis in PCa patients.

Methods: We conducted a cross-sectional study with PCa patients attending the Second Hospital of Tianjin Medical University, collecting data from June 2021 to February 2023.

Comprehensive analysis of predictive factors for upstaging in intraprostatic cancer after radical prostatectomy: Different patterns of spread exist in lesions at different locations.

Background: Accurate assessment of the clinical staging is crucial for determining the need for radical prostatectomy (RP) in prostate cancer (PCa). However, the current methods for PCa staging may yield incorrect results. This study aimed to comprehensively analyze independent predictors of postoperative upstaging of intraprostatic cancer.

Clinical Analysis of Perioperative Outcomes on Neoadjuvant Hormone Therapy before Laparoscopic and Robot-Assisted Surgery for Localized High-Risk Prostate Cancer in a Chinese Cohort.

Objective: To analyze the perioperative outcomes of neoadjuvant hormone therapy (NHT) before laparoscopic and robot-assisted surgery for localized high-risk prostate cancer in a Chinese cohort.

Methods: The clinical data of 385 patients with localized high-risk prostate cancer who underwent radical prostatectomy (RP) in our hospital from January 2019 to June 2021 were analyzed retrospectively, including 168 patients with preoperative NHT and 217 patients with simple surgery. Clinical characteristics were compared in the above two groups, the laparoscopic RP (LRP) cohort (n = 234) and the robot-assisted laparoscopic radical prostatectomy (RALP) cohort (n = 151), respectively.

Multi-omics analysis of expression and prognostic value of NSUN members in prostate cancer.

Background: Prostate cancer is the most common tumor in men worldwide, seriously threatening the health of older men, and 5-methylcytosine (m5C) RNA modification has been shown to have a significant impact on the development and progression of various tumors. However, as the most critical methyltransferase for m5c RNA modification, the role of the NSUN members (NSUN1-7) in prostate cancer is unclear.

Methods: We obtained sequencing data of genes and related clinical data of prostate cancer from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) database and analyzed the correlation between NSUN members' expression and prognosis.

Cuproptosis-Associated lncRNA Establishes New Prognostic Profile and Predicts Immunotherapy Response in Clear Cell Renal Cell Carcinoma.

Clear cell renal cell carcinoma (ccRCC) accounts for 80% of all kidney cancers and has a poor prognosis. Recent studies have shown that copper-dependent, regulated cell death differs from previously known death mechanisms (apoptosis, ferroptosis, and necroptosis) and is dependent on mitochondrial respiration (Tsvetkov et al., Science, 2022, 375 (6586), 1254-1261).

Predicting Prognosis and Distinguishing Cold and Hot Tumors in Bladder Urothelial Carcinoma Based on Necroptosis-Associated lncRNAs.

Background: In reference to previous studies, necroptosis played an important role in cancer development. Our team decided to explore the potential prognostic values of long non-coding RNAs (lncRNAs) associated with necroptosis in bladder urothelial carcinoma (BLCA) and their relationship with the tumor microenvironment (TME) and the immunotherapeutic response for accurate dose.

Methods: To obtain the required data, bladder urothelial carcinoma transcriptome data were searched from Cancer Genome Atlas (TCGA) (https://portal.

Removal of phosphorus in wastewater by sinusoidal alternating current coagulation: performance and mechanism.

The effects of initial total phosphorus (TP) concentration, current density, conductivity and initial pH value on the removal rate of TP and energy consumption, as well as the behaviour and mechanism of phosphorus removal, were investigated by sinusoidal alternating current coagulation (SACC). The flocs produced by SACC were characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy FTIR and X-ray photo electron spectroscopy. The thermodynamic and kinetic behaviours of phosphorus removal by iron sol adsorption were also studied in detail.

Preparation of Carbon-Covered Phosphorus-Modified Alumina with Large Pore Size and Adsorption of Rhodamine B.

In this study, phosphorus-modified alumina with large pore size was synthesized through a coprecipitation method. The carbon-covered, phosphorus-modified alumina with large pores was prepared by impregnating with glucose and carbonizing to further improve the adsorption of organic dyes. The morphology and structure of these composites were characterized by various analysis methods, and Rhodamine B (RhB) adsorption was also examined in aqueous media.

TACC3 promotes prostate cancer cell proliferation and restrains primary cilium formation.

Although primary cilia abnormalities have been frequently observed in multiple cancers, including prostate cancer (PCa), the molecular mechanisms underlying primary ciliogenesis repression in PCa cells remain unclear. Transforming acidic coiled-coil protein-3 (TACC3), whose deregulation has been implicated in the pathogenesis of several types of cancer, is a key centrosomal protein that plays a crucial role in centrosome/microtubule dynamics, potentially impacting primary cilium generation. Here, we showed that TACC3 was markedly upregulated in PCa and that knockdown of TACC3 restrained tumorigenesis and tumor growth in vitro and in vivo.

Using an anaerobic digestion tank as the anodic chamber of an algae-assisted microbial fuel cell to improve energy production from food waste.

Anaerobic digestion is sensitive to a wide variety of inhibitory substances that are the primary cause of anaerobic digester failure. Herein, an anaerobic digestion (AD) tank, which also functioned as the anodic chamber of an algae-assisted microbial fuel cell (AMFC), was established to treat food waste (FW) under an inhibition-relieved condition. About 2.

Gene mutation detection of urinary sediment cells for NMIBC early diagnose and prediction of NMIBC relapse after surgery.

Early diagnose of bladder cancer could lead to good prognosis and high 5-year-survival rate. Among bladder cancer, about 75% patients with were nonmuscle-invasive bladder cancer (NMIBC). Patients were painful and easily get infected during bladder cancer diagnosis, which mainly depends on invasive cystoscopy and low-sensitivity urine exfoliation cytology.

Quantized Sampled-Data Control for T-S Fuzzy System Using Discontinuous LKF Approach.

In this study, the stability for a class of sampled-data Takagi-Sugeno (T-S) fuzzy systems with state quantization was investigated. Using the discontinuous Lyapunov-Krasoskii functional (LKF) approach and the free-matrix-based integral inequality bounds processing technique, a stability condition with less conservativeness has been obtained, and the controller of the sampled-data T-S fuzzy system with the quantized state has been designed. Furthermore, based on the results, the sampled-data T-S fuzzy system without the state quantization was also discussed, and the required controller constructed.

Distinguishing Different Emotions Evoked by Music via Electroencephalographic Signals.

Music can evoke a variety of emotions, which may be manifested by distinct signals on the electroencephalogram (EEG). Many previous studies have examined the associations between specific aspects of music, including the subjective emotions aroused, and EEG signal features. However, no study has comprehensively examined music-related EEG features and selected those with the strongest potential for discriminating emotions.

Biofilm development dynamics and pollutant removal performance of ceramsite made from drinking-water treatment sludge.

Alum-sludge ceramsite and denitrifying bacteria (XP-1, XP-2, CL-1, CL-3) were used as substrate and constructed biofilm for enhancing the removal of pollutants from wastewater. The results showed that, due to the large specific surface area, the maximum growth rate was 0.49 mg/(g·day) on the sludge ceramsite, and the mass of biofilm attached onto sludge ceramsite was 5.

Microalgae nourished by mariculture wastewater aids aquaculture self-reliance with desirable biochemical composition.

Increased awareness of freshwater consumption for microalgal cultivation and excessive investment for aquaculture feeds has driven studies towards building a recycling system. Thereby, mariculture wastewaters (MW) modified with monosodium glutamate residue (MSGR) or NaNO & KHPO were used to culture microalgae, and then whether generated microalgae could meet nutritional standards for aquatic animals was evaluated. The results showed that MW + MSGR was the optimum medium for microalgae as aquaculture feeds: microalgae could accumulate plentiful high-quality protein with essential amino acid indices exceeding 0.

Salinity-induced cellular cross-talk in carbon partitioning reveals starch-to-lipid biosynthesis switching in low-starch freshwater algae.

Salinity stress has been verified to be a successful approach to enhance lipid production in high-starch marine algae, and salinity-induced carbon flow switching has been proposed as an algal response specific to brackish water. With the aim of testing this assumption, Chlorella sorokiniana SDEC-18, a low-starch freshwater alga, was grown in BG11 medium with NaCl addition at various concentrations (0, 2, 5, 10, 20, and 30 g/L). The results showed that salinity stress promoted carbon redistribution and starch conversion to lipid.

Rare adrenal gland incidentaloma: an unusual Ewing's sarcoma family of tumor presentation and literature review.

Background: Members of the Ewing's sarcoma family of tumor (ESFT) are malignant neoplasms and rarely observed in the adrenal gland.

Case Presentation: We report an extremely exceptional case of ESFT rising from the adrenal gland in a 57-year-old Chinese man. The patient was hospitalized with abdominal swelling for 2 months.