Long-term Exposure to PM Components and Cardiovascular Admissions in Medicare Patients.

Background: Fine particulate matter (PM) has been previously linked to cardiovascular diseases (CVDs). PM is a mixture of components, each of which has its own toxicity profile which are not yet well understood. This study explores the relationship between long-term exposure to PM components and hospital admissions with CVDs in the Medicare population.

[Construction and optimization of the artificially enhanced promoter TCIN5B].

To construct stress-responsive promoters, we mined the transcriptome data of the industrial strain A223 under stress. The transcription factor CIN5 showed significantly increased expression under stress but exhibited limited resistance. Further analysis of CIN5-interacting genes revealed that the binding motif "TTACGTAATC" (named CIN5BS) of CIN5 displayed transcription-enhancing activity.

Efficient Support Vector Regression for Wideband DOA Estimation Using a Genetic Algorithm.

High-precision direction of arrival (DOA) of wideband signals is a very important technology in the field of radar and communication. In this work, we propose an efficient support vector regression (SVR) architecture via a genetic algorithm (GA) for wideband DOA estimation, which exhibits high estimation performance and generalization performance. By adopting the two-sided correlation transformation (TCT) algorithm, the network is trained only from reference frequency data to increase the training efficiency.

Advancing SnO Electron Transport Layer for Efficient Perovskite Photovoltaics: A Critical Review.

Currently, the latest photovoltaic technology based on perovskite solar cells (PSCs) has attracted much attention due to the low cost, exciting power conversion efficiency of over 26%, large scalability, and flexibility of PSCs. During the development course, optimization of the electron transport layer (ETL) plays an important role in boosting the photovoltaic performance of PSCs, where the use and modification of SnO with high chemical stability, low-temperature processability, and suitable energy band levels substantially are shown to solve the problems of poor charge transport, perovskite crystallization, and inferior stability at the PSC interface. Herein, we dedicate ourselves to providing a comprehensive review of the advanced development of the SnO ETL for realizing efficient PSCs.

An in vivo "turning model" reveals new RanBP9 interactions in lung macrophages.

The biological functions of the scaffold protein Ran Binding Protein 9 (RanBP9) remain elusive in macrophages or any other cell type where this protein is expressed together with its CTLH (C-terminal to LisH) complex partners. We have engineered a new mouse model, named RanBP9-TurnX, where RanBP9 fused to three copies of the HA tag (RanBP9-3xHA) can be turned into RanBP9-V5 tagged upon Cre-mediated recombination. We created this model to enable stringent biochemical studies at cell type specific level throughout the entire organism.

The impacts of air pollution on mortality and hospital readmission among Medicare beneficiaries with Alzheimer's disease and Alzheimer's disease-related dementias: a national retrospective cohort study in the USA.

Background: Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) are prevalent neurodegenerative disorders, posing a critical worldwide public health challenge. Ambient air pollution has been identified as a potential risk factor for AD progression based on toxicological and epidemiological studies. We aimed to evaluate the impacts of air pollution-including fine particulate matter (PM), nitrogen dioxide (NO), summer ozone (O), and oxidant-on readmission or death among Medicare enrollees previously hospitalised with an AD/ADRD diagnosis code.

Effect of high mobility group box 1 pathway inhibition on gene expression in the prefrontal cortex of mice exposed to alcohol.

Introduction: The high mobility group box 1 (HMGB1) pathway plays a pivotal role in the development of alcohol-induced brain injury. Glycyrrhizinic acid (GlyA) is widely regarded as an inhibitor of HMGB1. The objective is to investigate the impact on gene expression in the prefrontal cortex,we sequenced the transcriptome in control, alcohol-exposed, and HMGB1-inhibited groups of mice.

Strain Engineering and Halogen Compensation of Buried Interface in Polycrystalline Halide Perovskites.

Inverted perovskite solar cells based on weakly polarized hole-transporting layers suffer from the problem of polarity mismatch with the perovskite precursor solution, resulting in a nonideal wetting surface. In addition to the bottom-up growth of the polycrystalline halide perovskite, this will inevitably worse the effects of residual strain and heterogeneity at the buried interface on the interfacial carrier transport and localized compositional deficiency. Here, we propose a multifunctional hybrid pre-embedding strategy to improve substrate wettability and address unfavorable strain and heterogeneities.

Synergistic Effects of Particle Radioactivity (Gross β Activity) and Particulate Matter ≤2.5 μm Aerodynamic Diameter on Cardiovascular Disease Mortality.

Background Although the effects of fine particulate matter (particulate matter ≤2.5 μm aerodynamic diameter [PM]) on cardiovascular disease (CVD) morbidity and mortality are well established, little is known about the CVD health effects of particle radioactivity. In addition, there are still questions about which of the PM physical, chemical, or biological properties are mostly responsible for its toxicity.

Muscle Energy Technique plus Neurac Method in Stroke Patients with Hemiplegia Complicated by Diabetes Mellitus and Assessment of Quality of Life.

Objective: To analyze the role of muscle energy technique (MET) plus Neurac method in stroke patients with hemiplegia complicated by diabetes mellitus and the impact on quality of life.

Methods: From January 2021 to December 2021, 100 stroke patients with hemiplegia complicated by diabetes mellitus treated in our institution and assessed for eligibility were recruited and randomly assigned (1 : 3) via the random sampling method to either the conventional rehabilitation group or the experimental group. The patients in the experimental group were randomized (1 : 1 : 1) into either the MET group (receives MET), the Neurac group (receives Neurac), or the joint group (receives MET plus Neurac).

Chain Terminators and Glutathione Weaken Wheat Dough under Excess Nitrogen Input.

An excessive nitrogen (N) supply may weaken dough due to an imbalance between N and sulfur (S) in the grains. However, the mechanism underlying the weakening effect of excessive N supply has yet to be fully elucidated. In this study, we evaluated the effect of the N rate × S rate interaction on the ratio of N to S (N/S ratio), grain protein concentration, amount and composition of protein fractions, and dough properties of a bread wheat cultivar.

Physiological and Proteomic Analyses Indicate Delayed Sowing Improves Photosynthetic Capacity in Wheat Flag Leaves Under Heat Stress.

Background And Aims: Climate warming has become an indisputable fact, and wheat is among the most heat-sensitive cereal crops. Heat stress during grain filling threatens global wheat production and food security. Here, we analyzed the physiological and proteomic changes by delayed sowing on the photosynthetic capacity of winter wheat leaves under heat stress.

Optimized seeding rate and nitrogen topdressing ratio for simultaneous improvement of grain yield and bread-making quality in bread wheat sown on different dates.

Background: Sowing date, seeding rate, and nitrogen (N) topdressing ratio have strong effects on grain yield (GY) and bread-making quality (BQ) in bread wheat. Simultaneous improvement in GY and BQ in bread wheat has long been a challenge due to the inverse relationship between GY and grain protein concentration (GPC). In this study, we investigated whether the GY and BQ of bread wheat sown on different dates could be improved simultaneously by optimizing the seeding rate and the N topdressing ratio.

[Interactive effects of irrigation regime and planting density on grain yield and water use efficiency in winter wheat].

To get an optimal irrigation regime and planting density for simultaneous improvement of grain yield (GY) and water use efficiency (WUE) in winter wheat, we examined the responses of 'Tainong 18' (with bigger ears) and 'Shannong 22' (with medium-sized ears) under four irrigation regimes, including 0, 45, 60, and 75 mm. Those two cultivars were planted at four densities: Tainong 18 at 135×10, 270×10, 405×10, and 540×10 plants·hm and Shannong 22 at 90×10, 180×10, 270×10, and 360×10 plants·hm. The interactive effects of irrigation regimes and plant densities on GY, water consumption characteristics, and WUE were investigated.

A protocol of systematic review and meta-analysis of Mozart's Music for drug-resistant epilepsy.

Background: This study will aim to assess the effectiveness of Mozart's Music (MM) for the management of patients with drug-resistant epilepsy (DRE).

Methods: In this study, we will search MEDLINE, EMBASE, Cochrane Library, Web of Science, CINAHL, Chinese Scientific Journal Database Information, WANGFANG, and China National Knowledge Infrastructure from their inauguration to March 1, 2020 without language and publication time restrictions. We will also identify other literature resources, such as reference lists of any related reviews.

Stress-driven dynamic regulation of multiple tolerance genes improves robustness and productive capacity of Saccharomyces cerevisiae in industrial lignocellulose fermentation.

Yeast productivity in lignocellulosic ethanol fermentation is clearly impeded by stress. Enhancing the robustness of xylose-fermenting yeast is important for improving lignocellulosic ethanol production. In this study, the glutathione biosynthesis pathway and acetic acid degradation pathway were strengthened to enhance yeast tolerance to stress due to elevated reactive oxygen species (ROS) and acetic acid.

Rehabilitation training combined acupuncture for limb hemiplegia caused by cerebral hemorrhage: A protocol for a systematic review of randomized controlled trial.

Background: Previous studies have reported that rehabilitation training combined acupuncture (RTA) can be used for the treatment of limb hemiplegia (LH) caused by cerebral hemorrhage (CH). However, its effectiveness is still unclear. In this systematic review study, we aim to evaluate the effectiveness and safety of RTA for LH following CH.