Publications by authors named "Heresh Amini"

Background: Fine particulate matter (PM) has been previously linked to cardiovascular diseases (CVDs). PM is a mixture of components, each of which has its own toxicity profile which are not yet well understood. This study explores the relationship between long-term exposure to PM components and hospital admissions with CVDs in the Medicare population.

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Air pollutants have adverse effects on asthma exacerbation in people of all ages. However, fewer studies have examined long-term exposure to particle components in conjunction with nitrogen dioxide (NO) and ozone (O) to assess their mixture effects. We used weighted quantile sum regression to assess the cumulative effects of 15 particle components, including organic compounds and metals, together with NO and O, on counts of inpatient asthma hospitalizations for children 0-18 years of age and adults 19-64 years of age.

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Mobile monitoring has proven to be a very efficient tool to measure and feed into models of air pollution as it complements fixed air quality monitoring networks by adding spatiotemporal resolution. This paper explores best practices, opportunities and challenges related to mobile monitoring of air pollutants, focusing on three key application areas, namely source-, exposure-, and health-related use cases. Use cases are linked to users, ensuring mobile monitoring is effectively tailored to diverse research and policy needs.

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Urban greenspaces have long been recognized for their potential to enhance environmental quality and public health. Despite the well-documented direct benefits of greenspaces, the mediating role of air pollution in the relationship between greenspaces and health outcomes remains less explored in low- and middle-income countries. This study investigates the mediating role of air pollution in the relationship between greenspace and cardiorespiratory admissions in Brazil.

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Ultrafine particles (UFP), commonly expressed as particle number concentrations (PNC), have been associated with harm to human health yet are currently not regulated or routinely monitored in many places. This has limited the potential for studies of health effects of long-term exposure to UFP. The present study aims to understand the spatial and temporal variation in façade-level UFP exposures in Copenhagen, Denmark.

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Background: Fine particulate matter (PM) exposure is adversely linked to atherosclerotic cardiovascular disease (ASCVD). However, most studies focused on PM mass rather than its chemical composition and specific sources. Particulate pollution sources can have distinct, cumulative, and potentially synergistic health impacts.

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Introduction: India experiences high levels of air pollution as measured by fine particulate matter <2.5 μm (PM) across the country. With limited resources, it is imperative to identify the most impacted areas.

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Conventional temperature-based approaches often overlook the intricate nature of thermal stress experienced by individuals. To address this limitation, climatologists have developed thermal indices-composite measures designed to reflect the complex interaction of meteorological factors influencing human perception of temperature. Our study focuses on Brazil, estimating the association between thermal comfort conditions and mortality related to respiratory and circulatory diseases.

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Objectives: We evaluated studies that used the World Health Organization's (WHO) AirQ and AirQ+ tools for air pollution (AP) health risk assessment (HRA) and provided best practice suggestions for future assessments.

Methods: We performed a comprehensive review of studies using WHO's AirQ and AirQ+ tools, searching several databases for relevant articles, reports, and theses from inception to Dec 31, 2022.

Results: We identified 286 studies that met our criteria.

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Background: Air pollution is a recognized risk factor for cardiovascular disease (CVD). Temperature is also linked to CVD, with a primary focus on acute effects. Despite the close relationship between air pollution and temperature, their health effects are often examined separately, potentially overlooking their synergistic effects.

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Article Synopsis
  • Ambient exposure to fine particulate matter (PM) is linked to increased health risks, raising the question of how PM sensitizes the immune response in children.
  • A study involving 277 children investigated the effects of neighborhood PM on inflammatory responses, revealing that higher PM levels correlate with stronger cytokine reactions, particularly from vehicle emissions and dust.
  • Longitudinal findings indicated that residential PM exposure decreased sensitivity to anti-inflammatory agents, but PM levels did not appear to affect biomarkers of low-grade inflammation.
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Background: The decline in global child mortality is an important public health achievement, yet child mortality remains disproportionally high in many low-income countries like Guinea-Bissau. The persisting high mortality rates necessitate targeted research to identify vulnerable subgroups of children and formulate effective interventions.

Objective: This study aimed to discover subgroups of children at an elevated risk of mortality in the urban setting of Bissau, Guinea-Bissau, West Africa.

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Blockchain technology, the backbone of cryptocurrency, is under scrutiny due to the environmental and health hazards linked to its energy-consuming Proof-of-Work (PoW) mining process. This review study provides a comprehensive analysis of the global health implications of PoW mining and cryptocurrency, with a focus on environmental sustainability and human health. The research utilized both traditional databases (PubMed and Web of Science) and additional primary sources.

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High-resolution assessment of historical levels is essential for assessing the health effects of ambient air pollution in the large Indian population. The diversity of geography, weather patterns, and progressive urbanization, combined with a sparse ground monitoring network makes it challenging to accurately capture the spatiotemporal patterns of ambient fine particulate matter (PM) pollution in India. We developed a model for daily average ambient PM between 2008 and 2020 based on monitoring data, meteorology, land use, satellite observations, and emissions inventories.

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Ultrafine particles (UFPs) are airborne particles with a diameter of less than 100 nm. They are emitted from various sources, such as traffic, combustion, and industrial processes, and can have adverse effects on human health. Long-term mean ambient average particle size (APS) in the UFP range varies over space within cities, with locations near UFP sources having typically smaller APS.

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Article Synopsis
  • * The research found that higher levels of pollutants like ethylbenzene, o-xylene, and benzene were linked to increased odds of developing advanced stages of BC, particularly in women from lower socioeconomic backgrounds.
  • * Notably, the study suggests that exposure to multiple air pollutants significantly increases the likelihood of stage I BC in women under 50, indicating a concerning link between air quality and breast cancer severity at diagnosis.
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Background: The relationship between long-term exposure to PM and mortality is well-established; however, the role of individual species is less understood.

Objectives: In this study, we assess the overall effect of long-term exposure to PM as a mixture of species and identify the most harmful of those species while controlling for the others.

Methods: We looked at changes in mortality among Medicare participants 65 years of age or older from 2000 to 2018 in response to changes in annual levels of 15 PM components, namely: organic carbon, elemental carbon, nickel, lead, zinc, sulfate, potassium, vanadium, nitrate, silicon, copper, iron, ammonium, calcium, and bromine.

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Climate change is a major threat to human respiratory health and associated allergic disorders given its broad impact on the exposome. Climate change can affect exposure to allergens, such as pollen, dust mites, molds, as well as other factors such as temperature, air pollution, and nutritional factors, which synergistically impact the immune response to these allergens. Exposome change can differentially exacerbate allergic reactions across subgroups of populations, especially those who are more vulnerable to environmental stressors.

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This is the first study to examine the association between ambient air pollution (PM, O, and NO) and mortality (in different population groups by sex and age) based on a nationwide death record across Brazil over a 15-year period (2003-2017). We used a time-series analytic approach with a distributed lag model. Our study population includes 2,872,084 records of deaths in Brazil between 2003 and 2017.

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Ultrafine particles (UFP; particulate matter <0.1 μm in diameter) may be more harmful to human health than larger particles, but epidemiological evidence on their health effects is still limited. In this study, we examined the association between short-term exposure to UFP and mortality and hospital admissions in Copenhagen, Denmark.

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Extreme air pollution events and moderate exposure to fine particulate matter (PM2.5) are associated with increased cardiometabolic risk. The World Trade Center (WTC) Health Program general responder cohort includes responders to the WTC disaster.

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Background: Epigenome-wide association studies of ambient fine particulate matter (PM) have been reported. However, few have examined PM components (PMCs) and sources or included repeated measures. The lack of high-resolution exposure measurements is the key limitation.

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Anti-mullerian hormone (AMH) concentration is a marker of ovarian reserve that decreases with age. However, a decrease in AMH may occur more rapidly under the influence of environmental factors. The present study investigated the association between long-term exposure to ambient air pollutants with serum concentrations of AMH and the AMH rate of decline.

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Article Synopsis
  • Research in Brazil from 2008 to 2018 investigates the health impacts of low ambient temperatures, focusing on daily hospital admissions for cardiovascular and respiratory diseases.* -
  • The study found that low temperatures significantly increase the risk of hospitalizations, with a relative risk of 1.17 for cardiovascular issues and 1.07 for respiratory problems.* -
  • Older adults and men faced a higher impact from cold temperatures for cardiovascular admissions, while respiratory admissions were similar across sex and age groups; the findings can inform public health strategies.*
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Fine particulate matter (PM) air pollution exposure is associated with short and long-term health effects. Several studies found differences in PM exposure associated with neighborhood racial and socioeconomic composition. However, most focused on total PM mass rather than its chemical components and their sources.

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