Advances in the treatment of lower-extremity ischemia-reperfusion injury.

Lower-limb ischemia-reperfusion injury (LL-IRI) is a frequent and serious complication following reperfusion therapy for lower-limb arterial occlusion. It can be caused by trauma, arterial stenosis, thrombotic occlusion, and atherosclerosis. As a prevalent peripheral vascular disease, LL-IRI results in local tissue damage and triggers systemic inflammatory responses that can lead to multiple-organ dysfunction syndrome, as well as multiorgan failure and death in severe cases.

Study on the Influence of Unbalanced Phase Difference Combinations on Vibration Characteristics of Rotor Systems.

Taking the cantilever rotor of a turbine engine as the research object, a dynamic and finite-element model of the cantilever rotor is established, and the effectiveness of the model is verified by the rotor test platform. The transfer function method is used to balance the rotor system under unbalanced excitation, and the experiments prove that the method adopted in this paper has a good balancing effect and effectively reduces the vibration of the unbalanced rotor. On this basis, the experimental tests and simulation analyses of the rotor vibration response under different unbalanced phases and difference combinations are carried out, and the influence of the unbalanced phase's difference combinations on unbalance and dynamic balance is analyzed.

Effects of glacial forcing on lithospheric motion and ridge spreading.

Glacial cycles significantly influenced Earth's surface processes throughout the Quaternary, impacting the climate, sea level, and seismic and magmatic activity. However, the effects of glaciation and deglaciation (that is, glacial forcing) on lithospheric motion are unknown. To study these effects, we formulated high-resolution numerical models with realistic lithospheric structures, including weak plate margins, lithospheric thickness variations and crustal structure.

Whole-genome resequencing reveals the selection of adaptive evolution during the domestication of pearl oyster Pinctada maxima.

The aquatic environment has a major effect on the domestication of species for aquaculture in nearshore environments. Disruptions in the ion composition of marine ecosystems have a major effect on the growth and development of aquaculture populations. However, research on the adaptation of domesticated bivalves to nearshore environments and the potential underlying regulatory mechanisms is limited.

Impact of normocapnia vs. mild hypercapnia on prognosis after cardiac arrest: A systematic review and meta-analysis.

Objective: To explore the impact of mild hypercapnia or normocapnia on the prognosis of patients after the return of spontaneous circulation (ROSC) following cardiac arrest (CA).

Methods: This systematic review and meta-analysis followed the guidelines in the PROSPERO report. Information was retrieved in PubMed, Cochrane Library, Embase, and Web of Science to collect all publications in English from January 1, 2000, to March 1, 2024, involving post-CA with mild hypercapnia.

Progress in the study of curcumin metabolism .

Curcumin has diverse biological functions, especially antioxidant and anti-inflammatory properties, but clinical trials have been hindered by its low bioavailability and pharmacokinetic properties. To achieve therapeutic efficacy, understanding curcumin's metabolism is crucial. We reviewed current research on curcumin metabolism in PubMed, Google Scholar, and CNKI.

UV-Light-Induced Morphological Transformation of Spiropyran Assemblies from Irregular Sheet-like Structures to Nanospheres.

Studies on self-assembling systems with a controllable morphology responding to light stimulation are significant for revealing the process and mechanism of assembly. Here, a molecule of spiropyran derivative () possessing photoresponsive assembly morphology is constructed. self-assembles into irregular sheet-like structures whose morphology can be significantly transformed into regular nanospheres under continuous ultraviolet light stimulation.

Light-Modulated Morphological Transformation of Spiropyran Derivative from Nanosphere to Nanorod.

The construction of tunable morphological systems has important implications for understanding the mechanism of molecular self-assembly. In this study, a spiropyran derivative M1 is reported with light-responsive assembly morphology, which can be tuned from nanosphere to nanorod by ultraviolet light irradiation. The absorption spectra show that M1 molecules are transformed from closed-ring (SP) isomers into open-ring (MC) isomers and start to form H-aggregates with increasing irradiation time.

Reconstruction of Solid Electrolyte Interphase with SrI Reactivates Dead Li for Durable Anode-Free Li-Metal Batteries.

Without excess Li, anode-free Li-metal batteries (AFLMBs) have been proposed as the most likely solution to realizing highly-safe and cost-effective Li-metal batteries. Nevertheless, short cyclic life puzzles conventional AFLMBs due to anodic dead Li accumulation with a local current concentration induced by irreversible electrolyte depletion, insufficient active Li reservoir and slow Li transfer at the solid electrolyte interphase (SEI). Herein, SrI is introduced into carbon paper (CP) current collector to effectively suppress dead Li through synergistic mechanisms including reversible I /I redox reaction to reactivate dead Li, dielectric SEI surface with SrF and LiF to prevent electrolyte decomposition and highly ionic conductive (3.

Electrolyte Engineering for High-Voltage Lithium Metal Batteries.

High-voltage lithium metal batteries (HVLMBs) have been arguably regarded as the most prospective solution to ultrahigh-density energy storage devices beyond the reach of current technologies. Electrolyte, the only component inside the HVLMBs in contact with both aggressive cathode and Li anode, is expected to maintain stable electrode/electrolyte interfaces (EEIs) and facilitate reversible Li transference. Unfortunately, traditional electrolytes with narrow electrochemical windows fail to compromise the catalysis of high-voltage cathodes and infamous reactivity of the Li metal anode, which serves as a major contributor to detrimental electrochemical performance fading and thus impedes their practical applications.

Boosting the High Performance of BiFeO-BaTiO Lead-Free Piezoelectric Ceramics: One-Step Preparation and Reaction Mechanisms.

One of the notorious problems in BiFeO-based piezoelectric ceramics is how to limit the formation of BiFeO and BiFeO impurities to achieve excellent piezoelectric performance. In this study, a one-step preparation technology, namely, excluding PVA, calcining, and sintering are completed in one step, instead of three steps in the ordinary sintering method, is developed to prepare BiFeO-BaTiO (BF-BT) ceramics. The significance of this one-step method is that the thermodynamically unstable region of BiFeO is successfully avoided based on the Gibbs free energy of BiFeO, BiFeO, and BiFeO.

A Single-Layer Composite Separator with 3D-Reinforced Microstructure for Practical High-Temperature Lithium Ion Batteries.

Incorporation of ceramic materials into separators has been frequently applied in both research and industry to improve the overall high-temperature performances of lithium ion batteries. However, inorganic ceramic particles tend to form aggregation in separators and even fall off in the separator matrix due to the inferior combination between ceramic particles and polymer matrix, giving rise to a decrease in separator porosity and thus the degradation of battery performances. Herein, a single-layer core-shell architecture is designed to reinforce the polymer matrix through encircling Al O particles by poly(vinylidene fluoride) with strong inter-molecular interaction.

A Novel Extreme Learning Machine Classification Model for e-Nose Application Based on the Multiple Kernel Approach.

A novel classification model, named the quantum-behaved particle swarm optimization (QPSO)-based weighted multiple kernel extreme learning machine (QWMK-ELM), is proposed in this paper. Experimental validation is carried out with two different electronic nose (e-nose) datasets. Being different from the existing multiple kernel extreme learning machine (MK-ELM) algorithms, the combination coefficients of base kernels are regarded as external parameters of single-hidden layer feedforward neural networks (SLFNs).

Cytotoxic and apoptotic effects of constituents from Millettia pachycarpa Benth.

The aim of this study is to investigate the cytotoxic and apoptotic effects of constituents from the seeds of Millettia pachycarpa Benth. Fourteen compounds (1-14) including one novel chalcone (10) were isolated as active principles from Chinese herbal medicine M. pachycarpa Benth.

Application of step-wise gradient high-performance counter-current chromatography for rapid preparative separation and purification of diterpene components from Pseudolarix kaempferi Gordon.

In general, simultaneously separation and purification of components with a broad polarity range from traditional Chinese medicine (TCM) is a challenge by an ordinary high-speed counter-current chromatography (HSCCC) method. In this paper, we describes a rapid and efficient separation method of combining three-step gradient elution and two-step flow-rate gradient elution using high-performance counter-current chromatography (HPCCC) to separate 8 diterpene compounds simultaneously within 80 min in a single run from the alcohol extract of Pseudolarix kaempferi Gordon. This separation process produced 166 mg pseudolaric acid B O-β-d-glucopyranoside (PABGly), 152 mg pseudolaric acid C (PAC), 8 mg deacetylpseudolaric acid A (deacetylPAA), 5 mg pseudolaric acid A O-β-d-glucopyranoside (PAAGly), 484 mg pseudolaric acid B (PAB), 33 mg pseudolaric acid B methyl ester (PAB methyl ester), 10mg pseudolaric acid A (PAA) and 18 mg pseudolaric acid H (PAH) from 1.

Separation of anthraquinone compounds from the seed of Cassia obtusifolia L. using recycling counter-current chromatography.

Recycling counter-current chromatography (CCC) together with step-gradient CCC and medium-pressure liquid chromatography (MPLC) was employed to separate nine anthraquinone compounds from Cassia obtusifolia L. in this study. The results showed that recycling CCC is a powerful tool for compounds that are difficult to separate with common elution mode.

Elution-extrusion counter-current chromatography separation of five bioactive compounds from Dendrobium chrysototxum Lindl.

The elution-extrusion counter-current chromatography (EECCC) method was firstly developed by Berthod in 2003 and has been used in natural products separation in recent years. The advantages of this method have been well documented such as reducing the separation time and solvent consumption. In the EECCC method, the time point of the extrusion step is very important during the whole separation process as it directly affects the resolutions, separation time and solvent consumption.

Separation of honokiol and magnolol by intermittent counter-current extraction.

Recently, intermittent counter-current extraction (ICcE) has been developed and shown its advantage in improving resolution between targeted compounds. However, how to choose suitable parameters to increase the throughput has not been systematically studied yet. In present work, we first calculated theoretically the conditions to carry out ICcE elution mode.

Purification of honokiol derivatives from one-pot synthesis by high-performance counter-current chromatography.

This paper describes the application of high-performance counter-current chromatography (HPCCC) as a fast, useful and economic alternative for the separation and purification of seven honokiol derivatives (two of them are isomers), which were synthesized by a one-pot procedure. Five honokiol derivatives were successfully separated by n-hexane-ethyl acetate-methanol-water solvent system at three different volume ratios in a step-gradient elution. Two derivatives were obtained through a cycle elution mode.

Enrichment and isolation of barbigerone from Millettia pachycarpa Benth. using high-speed counter-current chromatography and preparative HPLC.

Enrichment of the anti-tumor compound barbigerone along with a rotenoid derivative from Millettia pachycarpa Benth. was performed by a two-step high-speed counter-current chromatography (HSCCC) separation process. In the first step, 155.

Thermochemical structures beneath Africa and the Pacific Ocean.

Large low-velocity seismic anomalies have been detected in the Earth's lower mantle beneath Africa and the Pacific Ocean that are not easily explained by temperature variations alone. The African anomaly has been interpreted to be a northwest-southeast-trending structure with a sharp-edged linear, ridge-like morphology. The Pacific anomaly, on the other hand, appears to be more rounded in shape.