BMP Signaling Alleviates Allergic Airway Inflammation by Controlling Group 2 Innate Lymphoid Cells Homeostasis.

Recent studies have highlighted the important role of bone morphogenetic proteins (BMPs) in immunoregulation. Our earlier work identified the expression of BMP receptors on lymphoid progenitors and group 2 innate lymphoid cells (ILC2s) in the bone marrow. However, the precise function of BMP signaling in the development and activity of ILC2s remains unclear.

Efficacy and safety of thermal ablation for the treatment of recurrent and persistent secondary hyperparathyroidism: a multicenter retrospective study.

Objective: To evaluate the long-term efficacy and safety of Ultrasound (US)-guided percutaneous thermal ablation for recurrent or persistent secondary hyperparathyroidism (SHPT) and identify predictors of treatment failure.

Materials And Methods: From January 2014 to July 2023, 102 patients with recurrent or persistent SHPT after parathyroidectomy or ablation received thermal ablation. The median follow-up period was 30 months.

The and Genes Regulate Laying Traits in Domesticated Zi Geese.

Domestic geese are typically seasonal breeders, and the timing and number of eggs they lay vary depending on the region and breed. Previous studies evaluated the Zi goose, which is currently the domestic goose breed with the highest egg production. This research divided the reproductive cycle into four periods and compared the ovarian RNA-seq and DNA methylation data of Zi geese across these time points to identify the key genes that increase egg production.

Dual nanozymes-loaded core-shell microneedle patches with antibacterial and NETs-degradation bifunctional properties for periodontitis treatment.

Periodontitis, a chronic inflammatory disease affecting over one billion people worldwide, is characterized by bacterial infections and hyperactive immune responses. Recent studies have revealed that the formation of neutrophil extracellular traps (NETs) contributes significantly to periodontal tissue destruction, and NETs degradation plays a critical role in periodontitis treatment. Current treatments, including mechanical debridement and systemic antibiotics, face limitations such as antibiotic resistance and insufficient local efficacy.

Ultrasound feature-based nomogram model for predicting extrathyroidal extension in papillary thyroid carcinoma.

Background: The ultrasound diagnostic system for extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) has not been thoroughly explored. To develop and validate a nomogram model based on ultrasound features to predict ETE of papillary thyroid carcinoma for preoperative assessment.

Methods: The training set retrospectively included 560 patients from two hospitals with preoperative ultrasound images showing capsule contact and confirmed as unifocal PTC by surgical pathology.

Synergistic transcriptomic and metabolomic analyses in Zi geese ovaries with different clutch lengths.

The clutch is defined as consecutive days of oviposition. Clutch length is an index that reflects ovulation persistence, and is highly correlated with egg production in birds. To identify the genetic markers associated with clutch length in geese, two consecutive experiments were conducted.

pH-shifted synergistic ultrasound-modified extraction of Hericium erinaceus protein.

In this paper, we investigated the effects of different conditions on the extraction rate of Hericium erinaceus protein (HEP), determined the optimal extraction process for alkaline extraction of Hericium erinaceus (HE) protein, and explored the effects of ultrasound-assisted pH-shift treatment on HEP activity. In this study, the extraction rate of HEP demonstrated an initial increase followed by a decline with the rising pH concentration. It also exhibited a gradual increase that plateaued with the increment in the material-liquid ratio, extraction time, and extraction temperature.

Regulates the Proliferation and Apoptosis of Ovarian Granulosa Cells by Targeting in Zhedong White Geese.

The proliferation and apoptosis of ovarian granulosa cells (GC) is critical for follicular development and ovulation, especially for egg-laying performance in female birds. In geese, follicular atrophy is accompanied by follicular GC apoptosis during brooding stages. MicroRNAs are involved in follicular development, atrophy, ovulation, and degeneration.

Effect of ultrasound synergistic pH shift modification treatment on Hericium erinaceus protein structure and its application in 3D printing.

This study investigates the effects of ultrasound synergistic pH shift modification on the structural and functional properties of Hericium erinaceus (HE) proteins. The modification resulted in significant changes in the molecular structure of HE proteins, including increased solubility (49.69 % at pH 1.

US-Guided Thermal Ablation for Secondary Hyperparathyroidism: A Prospective Multicenter Study.

Background Interest in microwave ablation (MWA) and radiofrequency ablation (RFA) use for treating secondary hyperparathyroidism (SHPT) is rising; however, ablation outcomes in patients with SHPT are not well characterized. Purpose To assess the response of parathyroid hormone (PTH), calcium, phosphorus, and alkaline phosphatase (ALP) levels to US-guided parathyroid MWA and RFA and the safety of these treatments in participants with SHPT. Materials and Methods This prospective multicenter cohort study, conducted from September 2017 to March 2022, included participants with SHPT.

Driving mechanisms of the spatial distribution of industrial parks and the relative hazard level of the surrounding environment.

Analyzing the formation mechanisms of industrial parks and quantitatively evaluating the related hazard levels are important for understanding the development and planning of industrial parks, but there is currently a lack of relevant research. In this study, Beijing was taken as a case study. The analysis results showed that (1) the overall spatial distribution of industrial parks in Beijing followed a clustering pattern, with nested spatial distribution pattern, where larger structures contributed 53.

Development of a novel hyaluronic acid/alginate/RANKL degradable microneedle patch for accelerating bone remodeling and orthodontic tooth movement through promoting osteoclastogenesis.

The prolonged duration of orthodontic treatment remains a significant concern for both orthodontists and patients. In this study, we developed a degradable microneedle (MN) patch composed of hyaluronic acid (HA) and sodium alginate (SA) for the delivery of receptor activator of nuclear factor-kappa B ligand (RANKL) to accelerate tooth movement. This MN patch that was crosslinked by calcium chloride (CaCl) exhibited adequate mechanical properties and favorable in vitro mucosal insertion ability.

Migration and Accumulation Simulation Prediction of PPCPs in Urban Green Space Soil Irrigated with Recycled Water: A Review.

The presence of pharmaceuticals and personal care products (PPCPs) in reclaimed water introduces an ongoing challenge as they infiltrate green space soils during irrigation, leading to a gradual buildup that poses considerable ecological risks. The simulation and forecasting of PPCPs accumulation in soil are pivotal for proactive ecological risk management. However, the majority of research efforts have predominantly concentrated on the vertical transport mechanisms of PPCPs in the soil, neglecting a holistic perspective that integrates both vertical and lateral transport phenomena, alongside accumulation dynamics.

AuPt/NF prepared with the lattice induction of substrate was applied to construct the electrochemical immunosensor for PCT detection.

For the electrodeposition, the conductivity and lattice structure of substrate is important to the morphology and lattice of the deposited material. In this study, gold-platinum (AuPt) nanopartical was deposited on nickel foam (NF) based on the lattice induced orientation of the Ni substrate, and the obtained AuPt/NF was applied to construct electrochemical impedimetric immunosensor for procalcitonin (PCT) detection. As a new immunosensor matrix, NF with higher electrical conductance, flexibility and specific surface area, which can improve the plasticity, sensitivity and universality of the immunoelectrode.

FPLS-DC: functional partial least squares through distance covariance for imaging genetics.

Motivation: Imaging genetics integrates imaging and genetic techniques to examine how genetic variations influence the function and structure of organs like the brain or heart, providing insights into their impact on behavior and disease phenotypes. The use of organ-wide imaging endophenotypes has increasingly been used to identify potential genes associated with complex disorders. However, analyzing organ-wide imaging data alongside genetic data presents two significant challenges: high dimensionality and complex relationships.

Dual-signaling and ultrasensitive detection for PCT based on the photoelectric and electrocatalytic hydrogen evolution signals of Pt/Mo-CoFeS.

Few study has been carried out on the construction of immunesensors utilized the photoelectric and catalytic signal of nanomaterial. Here, a dual-signal electrochemical immunosensor was constructed for procalcitonin (PCT) detection based on the excellent photoelectric and hydrogen evolution performance of molybdenum-doped cobalt-iron sulfur nanosheets modified by platinum nanoparticles (Pt/Mo-CoFeS). Due to the electronic structure regulation between Pt and Mo-CoFeS, Pt/Mo-CoFeS exhibits superior photoelectric and hydrogen evolution performance compared to single Mo-CoFeS, which improved the sensitivity of the electrochemical immunosensor.

Long noncoding RNA Glis2 regulates podocyte mitochondrial dysfunction and apoptosis in diabetic nephropathy via sponging miR-328-5p.

Podocyte apoptosis exerts a crucial role in the pathogenesis of DN. Recently, long noncoding RNAs (lncRNAs) have been gradually identified to be functional in a variety of different mechanisms associated with podocyte apoptosis. This study aimed to investigate whether lncRNA Glis2 could regulate podocyte apoptosis in DN and uncover the underlying mechanism.

Merging or ensembling: integrative analysis in multiple neuroimaging studies.

The aim of this paper is to systematically investigate merging and ensembling methods for spatially varying coefficient mixed effects models (SVCMEM) in order to carry out integrative learning of neuroimaging data obtained from multiple biomedical studies. The "merged" approach involves training a single learning model using a comprehensive dataset that encompasses information from all the studies. Conversely, the "ensemble" approach involves creating a weighted average of distinct learning models, each developed from an individual study.

Synthesis, crystal structure and investigation of ion-exchange possibility for sodium tellurate NaTeO(OH).

A new sodium tellurate has been hydrothermally synthesized and comprehensively analysed using spectroscopic and thermogravimetric techniques, resulting in the determination of its composition as NaTeO(OH). The analysis of synchrotron X-ray and neutron diffraction data indicates that NaTeO(OH) has a crystal structure similar to that of the previously reported tellurate, KTeO(OH), with the space group 2/ (No. 14).

Clinical application value of Ultrafast Pulse Wave Velocity in early cardiovascular injury of Immunoglobulin A nephropathy.

Aim: To investigate the application and the related influencing factors of ultrafast pulse wave velocity (ufPWV) in the evaluation of carotid artery elasticity in patients with Immunoglobulin A nephropathy (IgAN).

Material And Methods: A total of 156 IgAN patients and 50 healthy individuals were selected as the control group. The ufPWV technique was employed to measure carotid arterial elasticity parameters, including carotid intima-media thickness (cIMT), pulse wave velocity at the beginning of systole (BS-PWV) and pulse wave velocity at the end of systole (ES-PWV).

[Value of contrast-enhanced percutaneous ultrasound in the diagnosis of rotator cuff tear subtype].

Objective: To explore characteristics of contrast-enhanced ultrasound (CEUS) images features and diagnostic value of rotator cuff tear subtypes.

Methods: From January 2019 to March 2022, percutaneous ultrasound-guided subacromial bursography (PUSB) with persutaneous ultrasound-guide tendon lesionography (PUTL) was performed on 114 patients with suspected rotator cuff injury were evaluated, including 54 males and 60 females ranged in age from 35 to 75 years old with an average of (58.8±8.

Protective Effect of against Cadmium-Induced Damage on Mouse Renal Podocytes (MPC5).

In this study, we investigated the protective effect of (Ast) on mouse podocytes and its possible mechanism of action by constructing a cadmium-induced mouse renal podocytes model. We investigated the effects of cadmium (Cd) toxicity on cell number, morphology, the mitochondrial status of subcellular organelles, protein and gene levels, and the protective effects of Ast by constructing a model of Cd-induced damage to mouse renal podocytes (MPC5) and giving Ast protection at the same time. The results showed that exposure of MPC5 cells to CdCl culture medium containing 6.

Effect of Chinese Medicines combined with transarterial chemoembolization on primary hepatic carcinoma: A systematic review and meta-analysis.

Background: To systematically evaluate the survival rate and postoperative adverse reactions of patients with hepatocellular carcinoma treated with traditional Chinese medicine combined with TACE by meta-analysis.

Methods: Four major literature databases (Cochrane Library, Embase, PubMed, and Web of Science) were retrieved to collect published English articles since 2009. After determining the random effect model or fixed utility model based on a heterogeneity test, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Four-dimensional mapping of dynamic longitudinal brain subcortical development and early learning functions in infants.

Brain subcortical structures are paramount in many cognitive functions and their aberrations during infancy are predisposed to various neurodevelopmental and neuropsychiatric disorders, making it highly essential to characterize the early subcortical normative growth patterns. This study investigates the volumetric development and surface area expansion of six subcortical structures and their associations with Mullen scales of early learning by leveraging 513 high-resolution longitudinal MRI scans within the first two postnatal years. Results show that (1) each subcortical structure (except for the amygdala with an approximately linear increase) undergoes rapid nonlinear volumetric growth after birth, which slows down at a structure-specific age with bilaterally similar developmental patterns; (2) Subcortical local area expansion reveals structure-specific and spatiotemporally heterogeneous patterns; (3) Positive associations between thalamus and both receptive and expressive languages and between caudate and putamen and fine motor are revealed.