The Novel HLA-DPB1*1650:01 N Allele Was Identified by Next-Generation Sequencing.

HLA-DPB1*1650:01 N differs from HLA-DPB1*135:01:01:01 in exon 2 codon 62 (CAG>TAG), introducing a premature stop codon.

First Implementation of Edge-Contacted α-InSe Ferroelectric Semiconductor Field-Effect Transistors and their Application to Artificial Heterosynapse.

α-InSe, a 2D van der Waals ferroelectric semiconductor, is a promising channel for advanced nonvolatile memory devices such as ferroelectric semiconductor field-effect transistors (FeS-FETs). However, prior studies have largely overlooked the critical influence of source/drain (S/D) contact configurations on memory performance. Here, an edge-contact configuration is demonstrated for the first time in α-InSe FeS-FETs that mitigates strong Fermi-level pinning via 1D interface pinning dipoles and modulates the initial Schottky barrier height (SBH).

Exploring Task Patterns in EHR Workflows Using Action Sequence Embedding and Graph-Based Analysis.

This study investigates clinician workflows in electronic health records (EHR) using a novel combination of context-based embedding and graph-based dimensionality reduction techniques to EHR-based audit log sequences. We identified distinct clinical task groups, suggesting the potential for semi-automated, unsupervised methods for characterizing EHR-based workflow patterns.

Differences in physician electronic health record use by telemedicine intensity: evidence from 2 academic medical centers.

Objective: Evaluate the association between telemedicine intensity and ambulatory physician electronic health record (EHR) use following the COVID-19 pandemic.

Materials And Methods: This retrospective study included ambulatory physicians in 11 specialties at 2 large academic medical centers (Washington University in St Louis [WashU], University of California San Francisco [UCSF]). EHR use measures, including time-based and frequency-based, were analyzed in the post-COVID-19 period (March 1, 2021, through March 7, 2022).

Investigating the diversity and stylization of contemporary user generated visual arts in the complexity entropy plane.

The advent of computational and numerical methods in recent times has provided new avenues for analyzing art historiographical narratives and tracing the evolution of art styles therein. Here, we investigate an evolutionary process underpinning the emergence and stylization of contemporary user-generated visual art styles using the complexity-entropy (C-H) plane, which quantifies local structures in paintings. Informatizing 149,780 images curated on the DeviantArt and Bēhance platforms from 2010 to 2020, we analyze the relationship between local information in the C-H space and multi-level image features generated by a deep neural network and a feature extraction algorithm.

Changes in Quality and Metabolites of Pickled Purple Radish During Storage.

This study investigated the changes in the physicochemical properties and metabolites of pickled purple radish during storage. Pickles of purple radish ('Boraking') prepared by the addition of acetic acid and sugar were stored in the dark at 4 °C for 60 days. The color of the pickled purple radish changed from purple to pink, while the pickling solution changed from pink to purple.

Enhanced In-Sensor Computing with Spike Number-Dependent Plasticity Characteristics in an InGaSnO Optical Neuromorphic Device for Accelerating Machine Vision.

In-sensor computing systems based on optical neuromorphic devices have attracted increasing attention to improve the efficiency and accuracy of machine vision systems. However, most materials used in optical neuromorphic devices exhibit spike timing-dependent plasticity (STDP) behavior in response to input light signals, leading to complex in-sensor computing and reduced machine vision accuracy. To address this issue, we introduce an indium gallium tin oxide (IGTO) semiconductor designed to enhance spike number-dependent plasticity (SNDP) in response to input light signals while eliminating the STDP behavior.

Complete genome sequences of the KACC 18744, KACC 18716, and KACC 19094.

We report the whole genome sequences of KACC 18744, KACC 18716, and KACC 19094, to investigate the genomic diversity of bacterial type strains distributed in Korea.

Enhancement of the Proton-Electron Coupling Effect by an Ionic Oxide-Based Proton Reservoir for High-Performance Artificial Synaptic Transistors.

Artificial synapses for neuromorphic computing have been increasingly highlighted, owing to their capacity to emulate brain activity. In particular, solid-state electrolyte-gated electrodes have garnered significant attention because they enable the simultaneous achievement of outstanding synaptic characteristics and mass productivity by adjusting proton migration. However, the inevitable interface traps restrict the protons at the channel-electrolyte interface, resulting in the deterioration of synaptic characteristics.

Exosomal miR-6126 as a novel therapeutic target for overcoming resistance of anti-cancer effect in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) stands as the sixth most prevalent cancer globally, presenting a substantial health challenge, particularly due to late-stage diagnoses that limit treatment effectiveness. Sorafenib, a multi-kinase inhibitor, is the primary chemotherapeutic agent for advanced HCC, but it only extends survival by 2-3 months. However, drug resistance remains a major clinical challenge, necessitating the exploration of new molecular mechanisms, including the role of microRNAs (miRNAs) in sorafenib resistance.

Interfacially Assembled Anion Exchange Membranes for Water Electrolysis.

High-performance and durable anion exchange membranes (AEMs) are critical for realizing economical green hydrogen production through alkaline water electrolysis (AWE) or AEM water electrosysis (AEMWE). However, existing AEMs require sophisticated fabrication protocols and exhibit unsatisfactory electrochemical performance and long-term durability. Here we report an AEM fabricated via a one-pot, in situ interfacial Menshutkin reaction, which assembles a highly cross-linked polymer containing high-density quaternary ammoniums and nanovoids inside a reinforcing porous support.

Control of sensitivity in metal oxide electrolyte gated field-effect transistor-based glucose sensor by electronegativity modulation.

In this study, the sensitivity of electrolyte-gated field-effect transistor-based glucose sensors using oxide semiconductor materials was controlled via electronegativity modulation. By controlling the enzymatic reaction between glucose and glucose oxidase, which is affected by the surface potential, the sensitivity of the glucose sensor can be effectively adjusted. To evaluate the sensitivity characteristics of the glucose sensor according to electronegativity control, devices were fabricated based on InO through Ga and Zn doping.

Enhanced Diagnostic Accuracy in Hepatitis B: Human vs. Sheep-Derived Antibodies in HBsAg Confirmatory Testing.

Background: HBsAg confirmatory testing is crucial for accurately diagnosing HBV infection and avoiding false positives. We compared the performance of human-derived and sheep-derived anti-HBs reagents in the Elecsys HBsAg confirmatory test (Roche Diagnostics, Germany).

Methods: Samples with a HBsAg COI of 0.

Ultralow-Power Programmable 3D Vertical Phase-Change Memory with Heater-All-Around Configuration.

Recent advancements in phase-change memory (PCM) technology have predominantly stemmed from material-level designs, which have led to fast and durable device performances. However, there remains a pressing need to address the enormous energy consumption through device-level electrothermal solutions. Thus, the concept of a 3D heater-all-around (HAA) PCM fabricated along the vertical nanoscale hole of dielectric/metal/dielectric stacks is proposed.

Improvement of the Stability of Quantum-Dot Light Emitting Diodes Using Inorganic HfO Hole Transport Layer.

One of the major challenges in QLED research is improving the stability of the devices. In this study, we fabricated all inorganic quantum-dot light emitting diodes (QLEDs) using hafnium oxide (HfO) as the hole transport layer (HTL), a material commonly used for insulator. Oxygen vacancies in HfO create defect states below the Fermi level, providing a pathway for hole injection.

Enhanced Electrical Polarization in van der Waals α-InSe Ferroelectric Semiconductor Field-Effect Transistors by Eliminating Surface Screening Charge.

A van der Waals (vdW) α-InSe ferroelectric semiconductor channel-based field-effect transistor (FeS-FET) has emerged as a next-generation electronic device owing to its versatility in various fields, including neuromorphic computing, nonvolatile memory, and optoelectronics. However, screening charges cause by the imperfect surface morphology of vdW α-InSe inhibiting electrical polarization remain an unresolved issue. In this study, for the first time, a method is elucidated to recover the inherent electric polarization in both in- and out-of-plane directions of the α-InSe channel based on post-exfoliation annealing (PEA) and improve the electrical performance of vdW FeS-FETs.

Anticancer effects of high-dose extracellular citrate treatment in pancreatic cancer cells under different glucose concentrations.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive solid tumor. Recently, the uptake of extracellular citrate by the sodium-dependent citrate transporter (NaCT), encoded by , has been demonstrated to exert profound effects on cancer cell metabolism. However, research on the function of extracellular citrate in PDAC pathogenesis and the relationship between NaCT expression and the tumor metabolic microenvironment is limited.

Reduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant infection by blocking the epidermal growth factor receptor (EGFR) pathway.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants presents challenges in global efforts to transition from the pandemic to an endemic stage. The spike protein of the SARS-CoV-2 virus, which is pivotal for cell entry, exhibits significant mutations in its variants, potentially affecting infectivity and therapeutic efficacy. Recent findings indicate upregulation of the epidermal growth factor receptor (EGFR) pathway, a key target in cancer therapy, by the spike protein of SARS-CoV-2.

Ticagrelor monotherapy in ST-elevation myocardial infarction: An individual patient-level meta-analysis from TICO and T-PASS trials.

Background: Patients with ST-elevation myocardial infarction (STEMI) tend to be excluded or under-represented in randomized clinical trials evaluating the effects of potent P2Y12 inhibitor monotherapy after short-term dual antiplatelet therapy (DAPT).

Methods: Individual patient data were pooled from randomized clinical trials that included STEMI patients undergoing drug-eluting stent (DES) implantation and compared ticagrelor monotherapy after short-term (≤3 months) DAPT versus ticagrelor-based 12-month DAPT in terms of centrally adjudicated clinical outcomes. The co-primary outcomes were efficacy outcome (composite of all-cause death, myocardial infarction, or stroke) and safety outcome (Bleeding Academic Research Consortium type 3 or 5 bleeding) at 1 year.

Real-Time Ultraviolet Monitoring System with Low-Temperature Solution-Processed High-Transparent p-n Junction Photodiode with a Fast Responsive and High Rectification Ratio.

We introduce an enhanced performance organic-inorganic hybrid p-n junction photodiode, utilizing poly[bis(4-phenyl) (2,4,6-trimethylphenyl)amine] (PTAA) and ZnO, fabricated through a solution-based process at a low temperature under 100 °C. Improved interfacial electronic structure, characterized by shallower Gaussian standard deviation of the density-of-state distribution and a larger interface dipole, has resulted in a remarkable fold increase of ∼10 in signal-to-noise ratio for the device. This photodiode exhibits a high specific detectivity (2.

Lubricant-Coated Organ-on-a-Chip for Enhanced Precision in Preclinical Drug Testing.

In drug discovery, human organ-on-a-chip (organ chip) technology has emerged as an essential tool for preclinical testing, offering a realistic representation of human physiology, real-time monitoring, and disease modeling. Polydimethylsiloxane (PDMS) is commonly used in organ chip fabrication owing to its biocompatibility, flexibility, transparency, and ability to replicate features down to the nanoscale. However, the porous nature of PDMS leads to unintended absorption of small molecules, critically affecting the drug response analysis.

Modification of Anaerobic Digestion Model No. 1 for modeling anaerobic digestion of cattle manure with changing solids retention time.

In this study, Anaerobic Digestion Model No.1 (ADM1) was modified to incorporate changes in biochemical parameters due to solids retention time (SRT) variations. Cattle manure (CM) and thermally hydrolyzed CM were selected for testing.