The Value of the Naples Prognostic Score at Diagnosis as a Predictor of Cervical Cancer Progression.

: The Naples prognostic score (NPS), which incorporates inflammatory and nutritional indicators, is increasingly used as a prognostic score for various malignancies. Nonetheless, few studies have specifically evaluated the NPS as a prognostic factor for cervical cancer. This study aimed to assess the value of NPS at diagnosis as a predictor of cancer progression.

Complete mitogenomes of venomous fish Paracentropogon rubripinnis and Inimicus japonicus elucidate phylogenetic relationships in Scorpaeniformes.

The Scorpaeniformes order encompasses a diverse array of teleost fish, including commercially important and venomous species. Fish venoms offer significant pharmacological potential, but incomplete phylogenetic understanding has hindered research. Resolving relationships among venomous fish families is crucial for studying venom evolution and discovering novel bioactive compounds.

Self-contracting, battery-free triboelectric wound healing strip with strong wet adhesion.

Conventional wound closure techniques, such as suturing and stapling, often cause infection, delayed healing, and tissue damage, particularly in fragile or compromised tissues. A sutureless, battery-free adhesive strip (SBF strip) is developed to integrate shape-memory-assisted mechanical approximation with impedance-matched electrical stimulation for enhanced tissue repair. The device incorporates a shape memory polymer (SMP) responsive at near-body temperature and a robust wet-adhesive interface (> 200 J m), enabling rapid attachment and uniform closure under mild heating (40 °C).

Metal-stabilized G-quadruplexes: biological insights and sensing applications.

Repeat sequences account for approximately 45% of the human genome, and can produce noncanonical DNA secondary structures that include G-quadruplexes (G4s). Among these, G4s are unique, in that their formation and stability are largely influenced by metal cations, such as Na＋, K＋, Ca2＋, and Mg2＋. These cations stabilize G4 structures, while also influencing their folding and biological activities.

Behavior and Early-Age Performance of Continuously Reinforced Concrete Bus Pad.

The behavior of the cast-in-place continuously reinforced concrete (CRC) bus pad applied to bus stop pavement in a central bus-only lane was experimentally analyzed under environmental and moving vehicle loads, and the early-age performance of the CRC bus pad was evaluated using experimental data and finite element analysis results. Using various measurement sensors, the concrete slab strain, longitudinal steel bar strains, horizontal and vertical displacements, and crack behavior of the CRC bus pad due to environmental loads were measured, and the dynamic responses of the concrete slab and steel bars due to moving vehicle loads were also measured. Additionally, a method for converting strain gauge measurements of a cracked concrete slab to the strain of an uncracked concrete slab was also proposed.

Solvent Exclusion Effect on Infrared Absorption Spectroscopy.

Absorption spectroscopy of a solution containing an analyte solute typically uses the transmission through a solvent as a reference based on the assumption that the solvent does not absorb light. However, when a solvent absorbs light, the resulting absorbance becomes lower and often negative because of the reduced number of solvent molecules due to the space taken by solute molecules. The solvent exclusion (SE) effect is problematic for accurate quantitation and analysis across various absorption spectroscopies, especially near the broad, strong water absorption peaks.

Transcriptional Landscape and Biomarker Discovery for Endoplasmic Reticulum Stress in Alzheimer's Disease: An Ex Vivo Study Using Patients-Derived Dermal Fibroblasts.

Objective: Numerous studies have identified various risk factors associated with Alzheimer's disease (AD). However, the experimental limitations of disease modeling make it challenging to directly interpret their effects. These limitations include constraints of postmortem samples, animal experiments, and challenges associated with brain tissue studies.

Roles of spin-state dangling bonds and strain in the electronic structure of polytetrafluoroethylene for charge transfer from first-principles.

Utilizing first-principles density functional theory, we computed the surface electronic structure of a polytetrafluoroethylene (PTFE) slab with various dangling bond (DB) configurations. As the number of surface DBs increases, the lowest unoccupied level (LUL) associated with electron affinity (EA) decreases, resulting in a rise in the DBs' formation energy, indicating an unstable state and electron deficiency. Particularly in spinless DB states, only one localized lowest unoccupied surface state (LUSS) forms below the conduction band minimum (CBM).

Postoperative tumor suppression via ROS scavenging, VEGF capture, and photothermal therapy using a split aptamer-loaded hydrogel.

Surgical resection is the primary treatment for early-stage breast cancer. However, residual tumor cells often lead to postsurgery recurrence. Current adjuvant therapies focus on eliminating residual tumors but overlook the postsurgery tumor microenvironment (TME) on residual tumor growth, resulting in limited therapeutic efficacy.

TIGIT blockade increases efficacy of PD-1 blockade combined with radiation therapy in triple-negative breast cancer model.

Background And Purpose: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) suppresses functions of CD8 T cells, and radiation therapy (RT) induces stimulation of regulatory T cells (Tregs), thereby limiting antitumor efficacy. This study aims to investigate the role of TIGIT in the immunosuppressive tumor environment and evaluate the potential of TIGIT blockade (αTIGIT) to enhance antitumor immune responses.

Methods: We analyzed public transcriptomic data to identify the expression patterns of TIGIT on T cells in breast cancer and its prognostic impact.

Exploring a Novel Metallophosphoesterase for Polycarbonate Degradation via Transcriptome Analysis.

Polycarbonate (PC), a widely used thermoplastic, poses significant environmental challenges due to its persistence and the release of bisphenol A (BPA), a known xenoestrogen. Here, we report the isolation of Bacillus subtilis JNU01 (BsJNU01), capable of utilizing PC as its sole carbon source. Through transcriptomic analysis, we identified metallophosphoesterase from BsJNU01 (BsMPPE), the first reported metallophosphoesterase capable of degrading polycarbonate by catalyzing the hydrolysis of carbonate ester bonds.

Effects of whole-body vibration exercise on cardiorespiratory fitness, muscular strength and body fat in women with overweight and obesity: A randomized pilot study.

Background And Aim: Whole-body vibration (WBV) exercise has been acknowledged as an alternative exercise method for improving functional capacity. We examined the effects of an 8-week WBV exercise on cardiorespiratory fitness (CRF), muscular strength (MS) and body composition in young women.

Methods And Results: Twenty-six inactive women with overweight and obesity (age: 30.

SlH3 and SlH4 promote multicellular trichome formation and elongation by upregulating woolly in tomato.

Trichomes are tiny outgrowths on the plant epidermis that serve defensive purposes against various stresses. While the regulatory mechanisms underlying unicellular trichome development are well understood, those governing multicellular trichome formation remain largely unexplored. In this study, we reveal a new regulatory pathway involving the () and genes, which encode C2H2 zinc finger proteins that participate in multicellular trichome development in tomato ().

Direct Integration of Spent LiMnO with High Voltage Aqueous Zinc-Manganese Redox Flow Batteries as a Practical Upcycling Process.

With the explosive growth of lithium-ion batteries (LIBs), research on the recycling of spent batteries is widely conducted. However, conventional processes involve complex procedures, high costs, and environmental issues. This study introduces the electrochemical upcycling of spent LiMnO (LMO) cathode material, incorporating pre-filtration (PF) and pre-reduction (PR) processes to enable its direct application in redox flow batteries (RFBs).

AMPK activation by glycogen expenditure primes the exit of naïve pluripotency.

Embryonic and epiblast stem cells in pre-and post-implantation embryos are characterized by their naïve and primed states, respectively which represent distinct phases of pluripotency. Thus, cellular transition from naïve-to-primed pluripotency recapitulates a drastic metabolic and cellular remodeling after implantation to adapt to changes in extracellular conditions. Here, we found that inhibition of AMPK occurs during naïve transition with two conventional inhibitors of the MEK1 and GSK3β pathways.

Explainable Synthesizability Prediction of Inorganic Crystal Polymorphs Using Large Language Models.

We evaluate the ability of machine learning to predict whether a hypothetical crystal structure can be synthesized and explain those predictions to scientists. Fine-tuned large language models (LLMs) trained on a human-readable text description of the target crystal structure perform comparably to previous bespoke convolutional graph neural network methods, but better prediction quality can be achieved by training a positive-unlabeled learning model on a text-embedding representation of the structure. An LLM-based workflow can then be used to generate human-readable explanations for the types of factors governing synthesizability, extract the underlying physical rules, and assess the veracity of those rules.

Soybean oil supplement induces increased approaching behavior to humans and alters serotonin concentrations in horses.

Enhancement of human-horse interaction is crucial for safety in equine management, as poor relationships between humans and horses can lead to accidents. Serotonin is a neurotransmitter that is highly related to social affinity in animals and several studies have been documented that supplementation of tryptophan, which is a precursor of serotonin, can increase calmness of horses. This study aimed to assess the effect of tryptophan through soybean oil supplementation on serotonin concentrations and the behavior of horses.

Does Frequent Use of Advanced Energy Devices Improve Hysterectomy Outcomes?

: The objective of this study was to assess the efficient use of advanced energy devices by examining the impact of their usage frequency on surgical outcomes of total laparoscopic hysterectomies. : A retrospective study was conducted between 2020 and 2023 by a single surgeon. The patients' medical records and surgical videos were reviewed.

Mammalian ubiquitous promoter isolated from proximal regulatory region of bovine MSTN gene.

Gene therapy is a promising method for treating inherited diseases by directly delivering the correct genetic material into patient cells. However, the limited packaging capacity of vectors poses a challenge. Minimizing promoter size is a viable strategy among various approaches to address this issue.

In Situ Experimental Analysis and Performance Evaluation of Airport Precast Concrete Pavement System Subjected to Environmental and Moving Airplane Loads.

The behavior of airport precast concrete pavement (APCP) involving new design and construction concepts was experimentally analyzed under environmental and moving airplane loads, and the long-term performance of the APCP was evaluated using fatigue failure analysis. The strain characteristics and curling behavior of the APCP under environmental loads were comprehensively analyzed. The APCP slabs exhibited a pronounced curling phenomenon similar to conventional concrete pavement slabs.

Estimation of world seroprevalence of SARS-CoV-2 antibodies.

In this paper, we estimate the seroprevalence against COVID-19 by country and derive the seroprevalence over the world. To estimate seroprevalence among adults, we use serological surveys (also called the serosurveys) conducted within each country. When the serosurveys are incorporated to estimate world seroprevalence, there are two issues.

Synthesis, nonlinear optical activity, solvents effect, β-cyclodextrin effect, and cytotoxic activity on skin fibroblast and breast cancer cell lines of a new chalcone derivative of nabumetone.

The use of small organic molecules, such as chalcones, for efficient applications as organic luminescent materials has attracted increasing attention owing to their interesting optical, photophysical, and biological properties. In this study, a new chalcone, 1-(4-isopropylphenyl)-5-(6-methoxynaphthalen-2-yl)pent-1-en-3-one (INM), was synthesized via base condensation between nabumetone and cuminaldehyde. INM was subsequently identified and characterized by FT-IR, NMR spectroscopy (H and C), mass spectrometry, elemental analysis, X-ray diffraction, thermogravimetric analysis, and FESEM studies.

Configurable Synaptic and Stochastic Neuronal Functions in ZnTe-Based Memristor for an RBM Neural Network.

This study presents findings that demonstrate the possibility of simplifying neural networks by inducing multifunctionality through separate manipulation within a single material. Herein, two-terminal memristor W/ZnTe/W devices implemented a multifunctional memristor comprising a selector, synapse, and a neuron using an ovonic threshold switching material. By setting the low-current level (µA) in the forming process, a stable memory-switching operation is achieved, and the capacity to implement a synapse is demonstrated based on paired-pulse facilitation/depression, potentiation/depression, spike-amplitude-dependent plasticity, and spike-number-dependent plasticity outcomes.

Benchtop IR Imaging of Live Cells: Monitoring the Total Mass of Biomolecules in Single Cells.

Absolute quantity imaging of biomolecules on a single cell level is critical for measurement assurance in biosciences and bioindustries. While infrared (IR) transmission microscopy is a powerful label-free imaging modality capable of chemical quantification, its applicability to hydrated biological samples remains challenging due to the strong IR absorption by water. Traditional IR imaging of hydrated cells relies on powerful light sources, such as synchrotrons, to mitigate the light absorption by water.