Advanced power structure for enhanced optical performance of AMOLED displays at low luminance levels.

To improve the image quality of active-matrix organic light-emitting diode (AMOLED) displays at low luminance levels, a novel power structure is proposed. Its effectiveness was validated by fabricating a 13-inch AMOLED panel with a tandem OLED and evaluating its optical performance. Compared to the conventional structure, the proposed structure reduced panel luminance deviation by 12% and color deviation by 41%, while also achieving a 41% reduction in hysteresis-induced color shift.

Efficacy of Cross-Linked Collagen Membranes for Bone Regeneration: In Vitro and Clinical Studies.

This study aimed to evaluate the efficacy of cross-linked collagen membranes. Two types of collagen membranes were compared: a non-cross-linked collagen membrane (group A) and a cross-linked (group B) collagen membrane. In the in vitro study, the degradation rate in the presence of collagenase, the tear strength of the membranes, and the cytotoxicity of the cross-linked collagen membrane were evaluated.

Clinical Evaluation of AI-Based Three-Dimensional Dental Implant Planning: A Multicenter Study.

Objectives: Dental implants have become more straightforward and convenient with advancements of digital technology in dentistry. Implant planning utilizing artificial intelligence (AI) has been attempted, yet its clinical efficacy remains underexplored. We aimed to assess the clinical applicability of AI-based implant planning software as a decision-support tool in comparison with those placed by clinicians which were clinically appropriate in their three-dimensional positions.

Efficacy and toxicity of PARP inhibitor in elderly patients with homologous recombination-deficient newly diagnosed advanced ovarian cancer: the role of dose modification.

Objective: To investigate the impact of age on the progression-free survival (PFS) and dose modification, discontinuation and adverse events of poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi) maintenance therapy in homologous recombination-deficient (HRD) ovarian cancer patients.

Methods: We analyzed 324 patients with advanced stage III-IV epithelial ovarian cancer who had either BRCA mutation or HRD between July 2019 and November 2022. The primary objective was to evaluate the efficacy of PARPis by comparing PFS between patients who received PARPis and those who did not, specifically within 2 age groups: patients aged <60 years and those aged ≥60 years.

A novel multi-target compound mitigates amyloid plaques, synaptic deficits, and neuroinflammation in Alzheimer's disease models.

Alzheimer's disease (AD) is characterized by progressive cognitive decline, amyloid plaque accumulation, synaptic dysfunction, and neuroinflammation. This study reports the therapeutic potential of (S)-4-amino-5,5-difluoro-N'-methyl-N'-phenylpentanehydrazide hydrochloride (RA-058HM), a novel compound, in ameliorating these pathological features of AD in the 5xFAD mouse model. RA-058HM was administered orally for 8 weeks, and its multi-target effects - including relief from neuroinflammation, normalization of synaptic transmission, reduction of amyloidogenesis (plaque and soluble oligomers, as well as BACE1 levels), and rescue of cognitive function-were evaluated.

Efficacy and Safety of Chemotherapy Combined with Hormonal Therapy in Heavily Pretreated Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ELSA/KGOG3049): A Multicenter Pilot Study.

The effects of combining chemotherapy with hormonal therapy based on hormone receptor (HR) expression in epithelial ovarian, fallopian tube, or primary peritoneal (EOC) remain unclear. This study evaluated the efficacy and safety of physician-chosen chemotherapy combined with hormonal therapy in patients with heavily pretreated advanced EOC, stratified by HR expression. This phase II, multicenter, pilot study included patients with heavily pretreated advanced EOC, allocated to estrogen receptor (ER)-dominant or progesterone receptor (PR)-dominant arms.

Surgical outcomes of rectosigmoid colon resection versus rectosigmoid wall stripping for superficial rectal wall tumors at cytoreductions for advanced ovarian cancer.

Objective: This study aimed to evaluate surgical outcomes of rectosigmoid resection versus rectosigmoid wall stripping for superficial tumor involvement during cytoreductive surgery for advanced ovarian cancer.

Methods: This retrospective study included patients with the International Federation of Gynecology and Obstetrics stage III to IV ovarian cancer who underwent rectosigmoid resection or rectosigmoid wall stripping during primary or interval cytoreductive surgery between January 2021 and January 2024. Inverse probability of treatment weighting was used to balance baseline characteristics.

Impact of time elapsed since diagnosis on neuropathic symptoms, sexual function, lymphedema, and overall quality of life in ovarian cancer survivors (KGOG 3068).

Objective: To assess the impact of time since treatment on the quality of life (QOL), neurotoxicity, sexual function, lymphedema, and utility in ovarian cancer survivors.

Methods: This secondary analysis of a cross-sectional study examined the QOL, neurotoxicity, sexual function, lymphedema, and utility in 172 epithelial ovarian cancer survivors treated with first-line platinum-based chemotherapy without recurrence. Associations between time since treatment and overall QOL (National Comprehensive Cancer Network/functional assessment of cancer therapy ovarian symptom index-18 [NFOSI-18]), neurotoxicity (neurotoxicity subscale, version-4 [NTX-4]), sexual function (female sexual function index, 6-item Korean version [FSFI-6K]), lymphedema (gynecologic cancer lymphedema questionnaire [GCLQ]), and utility (EuroQol 5-dimension [EQ-5D]) were visualized using jittered box plots.

Neutrophil extracellular traposis in cancer patients with acute ischemic stroke.

Background: Patients with cancer exhibit an increased risk of acute ischemic stroke (AIS), and neutrophil extracellular traposis (NETosis) has been proposed as a mechanism underlying cancer-associated hypercoagulability. However, studies validating these findings in independent cohorts are limited.

Objective: We sought to explore whether NETosis-associated markers (plasma DNA and nucleosomes) are increased in patients with active cancer and AIS, and whether these increases correlate with coagulopathy markers in cancer patients.

Ultrasonic synthesis of conducting polymers intercalated potassium vanadate nanofiber composites as cathode for aqueous zinc-ion batteries.

Aqueous zinc-ion batteries (AZIBs) have gained attention as next-generation energy storage systems due to their safety, cost-effectiveness, and eco-friendliness. However, their commercialization is hindered by the structural instability and low electrochemical performance of cathode materials. Herein, we present poly(3,4-ethylenedioxythiophene) (PEDOT)-intercalated potassium vanadate nanofibers (E-PVNF) with oxygen vacancies, synthesized via a sonochemical method.

A rice husk-derived SiO/C composite for effective lithium-sulfur battery separator modification.

Lithium-sulfur (Li-S) batteries offer several advantages including high specific capacity, high energy density, cost-effectiveness, and non-toxicity. However, challenges such as the shuttle effect and low electrical conductivity hinder the reversibility during cycling. Herein, we introduce a sustainable rice husk-derived SiO/porous carbon composite (S-MRH) for separator modification in high-performance Li-S batteries.

Developing standardized informed consent for hysterectomy and vulva cancer surgery.

Informed consent is a fundamental aspect of surgical care, designed to reinforce patient autonomy, promote shared decision-making, and potentially mitigate legal conflicts by ensuring the provision of comprehensive and consistent information. in clinical practice. The Korean Society of Gynecologic Oncology (KSGO) previously published detailed informed consent documents for cervical, endometrial, and ovarian cancer surgery.

Improvement of flicker phenomenon at low frequencies in AMOLED displays by applying compensation scheme of variable reset voltage.

In this study, we propose a novel compensation scheme that utilizes variable reset voltage (VRV) to mitigate the flicker phenomenon observed in low temperature poly-Si and oxide (LTPO) active-matrix organic light emitting diode (AMOLED) displays at low frequencies. We have experimentally demonstrated that the flicker caused by luminance fluctuations at low frequencies is the result of interactions between the slow transient de-trapping of the oxide thin film transistor (TFT) and hysteresis of the driving TFT (D-TFT). Although slow transient de-trapping of the oxide TFT is difficult to be compensated, we have demonstrated that D-TFT hysteresis can be modulated by adjusting the gate in panel (GIP) timing and reset voltage.

Biomechanical Evaluation of a Novel Non-Engaging Abutment and Screw in Internal Implant Systems: Comparative Fatigue and Load Testing.

Dental implants rely on precise prosthetic design and biomechanical stability to ensure long-term success. This study evaluates the mechanical performance of non-engaging abutments in multi-unit combined screw- and cement-retained prostheses (CSCRP) using two internal implant systems: the BlueDiamond (BD) and AnyOne (AO) systems. Unlike conventional implant systems that utilize the same type of screw for both engaging and non-engaging abutments, the BD system employs a distinct screw design for non-engaging abutments.

The Association Between Location of BRCA Mutation and Efficacy of PARP Inhibitor as a Frontline Maintenance Therapy in Advanced Epithelial Ovarian Cancer.

Background: The location of BRCA mutations within functional domains may affect sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapy. This study aimed to evaluate the progression-free survival (PFS) benefit from the PARP inhibitor in relation to the location of mutations in / in newly diagnosed ovarian cancer.

Materials And Methods: Patients with advanced stage III-IV epithelial ovarian cancer who had deleterious or were analyzed.

Neoadjuvant Chemotherapy with Dual Immune Checkpoint Inhibitors for Advanced-Stage Ovarian Cancer: Final Analysis of TRU-D Phase II Nonrandomized Clinical Trial.

Purpose: This open-label, investigator-initiated, phase II study was conducted to evaluate the safety, survival, and neoadjuvant outcomes of neoadjuvant chemotherapy (NAC) combined with dual immune checkpoint inhibitors in advanced-stage epithelial ovarian cancer (EOC).

Patients And Methods: Between June 2019 and July 2021, 45 patients with unresectable stage III to IV EOC were enrolled. The patients received three cycles of NAC combined with durvalumab and tremelimumab.

Chat Generative Pre-Trained Transformer (ChatGPT) in Oral and Maxillofacial Surgery: A Narrative Review on Its Research Applications and Limitations.

This review aimed to evaluate the role of ChatGPT in original research articles within the field of oral and maxillofacial surgery (OMS), focusing on its applications, limitations, and future directions. : A literature search was conducted in PubMed using predefined search terms and Boolean operators to identify original research articles utilizing ChatGPT published up to October 2024. The selection process involved screening studies based on their relevance to OMS and ChatGPT applications, with 26 articles meeting the final inclusion criteria.

Enhanced Reliability of High-Quality -IGZO TFTs for Micro-LED Backplanes: Mitigating Instability at Elevated Temperatures.

This study examined the reliability of state-of-the-art -IGZO thin-film transistors (TFTs) for next-generation micro-LED (μ-LED) display applications under high drain current stress at 120 °C. Although the control -IGZO TFTs annealed at 300 °C exhibited excellent stability under the traditional PBTS conditions at 60 °C, the PBTS test at the elevated temperature of 120 °C resulted in a significant positive shift (Δ). In contrast, the high-quality (HQ) -IGZO TFTs annealed at 400 °C exhibited markedly improved electrical stability, even in the PBTS test at 120 °C.

A randomized, multicenter, open-label phase III trial of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in platinum-resistant recurrent ovarian cancer: a rationale and study design of the KOV-HIPEC-02 trial.

Background: This study aimed to identify the survival benefits of hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery for platinum-resistant recurrent ovarian cancer.

Primary Objectives: The primary objective is to evaluate the efficacy of cytoreductive surgery and HIPEC on progression-free survival in platinum-resistant recurrent ovarian cancer.

Study Hypothesis: The implementation of cytoreductive surgery and HIPEC combined with doxorubicin and mitomycin C may extend progression-free survival with manageable safety in patients with platinum-resistant recurrent ovarian cancer.

RA-PR058, a novel ramalin derivative, reduces BACE1 expression and phosphorylation of tau in Alzheimer's disease mouse models.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by cognitive decline, anxiety-like behavior, β-amyloid (Aβ) accumulation, and tau hyperphosphorylation. BACE1, the enzyme critical for Aβ production, has been a major therapeutic target; however, direct BACE1 inhibition has been associated with adverse side effects. This study investigates the therapeutic potential of RA-PR058, a novel ramalin derivative, as a multi-targeted modulator of AD-related pathologies.

Evaluation of low-crystallinity apatite as a novel synthetic bone graft material: In vivo and in vitro analysis.

Objectives: To overcome the shortcomings of sintered bone graft materials, low-crystallinity apatite (LCA) was developed using a non-heated approach to enhance resorption and integration during bone regeneration. This study aimed to evaluate the efficacy of LCA as a synthetic bone graft material for bone reconstruction.

Methods: LCA was compared to three conventional synthetic bone graft materials: biphasic calcium phosphate (BCP) 37, BCP 64, and octacalcium phosphate (OCP).

N-((perfluorophenyl)amino)glutamine regulates BACE1, tau phosphorylation, synaptic function, and neuroinflammation in Alzheimer's disease models.

Alzheimer's disease (AD) is the most common type of dementia. Its incidence is rising rapidly as the global population ages, leading to a significant social and economic burden. AD involves complex pathologies, including amyloid plaque accumulation, synaptic dysfunction, and neuroinflammation.

Predictive impact of clinical factors on chemosensitivity in advanced high-grade serous ovarian carcinoma according to chemotherapy response score.

The use of neoadjuvant chemotherapy (NAC) as a first-line therapy for advanced high-grade serous ovarian carcinoma (HGSOC) has increased. However, several studies have reported NAC-induced platinum resistance. This study aimed to evaluate the predictive impact of clinical factors on chemotherapy response score (CRS) and to select patients who would respond well to NAC.