Effect of obesity on myocardial tissue characteristics in patients with hypertrophic cardiomyopathy: a cardiovascular magnetic resonance-based study.

Background: Obesity is associated with cardiac steatosis in healthy adults and is independently associated with increased left ventricular (LV) mass and could contribute to the progression of heart failure-related composite events in patients with hypertrophic cardiomyopathy (HCM). However, it is unclear whether the increased LV mass is accompanied by increased fibrosis. We aimed to assess the impact of increased body mass index (BMI) on myocardial tissue characteristics in patients with HCM.

Effect of carbon chain length and concentration of perfluorinated compounds on polytetrafluoroethylene microplastics transport behavior.

Perfluorooctanoic acid (PFOA) and perfluoropentanoic acid (PFPeA), as important components of perfluorinated compounds (PFAS), are not only ecologically hazardous, but also have surfactant properties that can alter the transport behavior of polytetrafluoroethylene (PTFE) in porous media. In this experiment, the effect of PFAS on the transport of PTFE in porous media under different pH, ionic strength (IS) and ion valence states was studied. The results showed that the recovery rate of PTFE decreased gradually with the decrease of pH and the increase of IS and ion valence states.

RNA Editing Analysis Reveals Methyl Jasmonic Acid Regulation of Fucoxanthin and Fatty Acid Metabolism in .

is a marine diatom with significant biotechnological potential, particularly in producing high-value bioactive compounds such as fucoxanthin and unsaturated fatty acids, which possess significant pharmaceutical and nutraceutical properties. However, the naturally low yields of these compounds present a major challenge for large-scale production. Methyl jasmonic acid (MeJA), a plant-derived signaling molecule, has been shown to enhance the biosynthesis of these metabolites in .

Case report: Scleromalacia caused by rheumatoid arthritis combined with high intraocular pressure, first discovered due to ocular trauma.

A 53-year-old man with rheumatoid arthritis was first diagnosed with scleromalacia at the ophthalmology clinic after experiencing ocular trauma. The patient presented with decreased vision and abnormalities were subsequently found in his other eye. An ophthalmologist performed emergency debridement and suturing surgery on the ruptured right eyeball, discovering that the sclera was thinned to only 1/5 to 1/3 of its normal thickness.

Naringenin and apigenin ameliorates corticosterone-induced depressive behaviors.

Background: Depression is a common kind of mental illness, and it becomes the main health burden in the world.

Purpose: The aim of this study was to investigate the antidepressant effects of naringin and apigenin isolated from Ramatis.

Methods: Firstly, 20 mg/kg corticosterone (CORT) was injected into mice to establish an model of depression.

Investigating the basis for the antidepressant effects of using an integrated metabolomic strategy.

Objectives: (GS) is a natural antidepressant but its mechanisms of action remain unclear. In the present study, taxifolin (Tax) was selected to determine the role of flavonoids in the antidepressant effects of GS.

Materials And Methods: Urine samples from C57BL/6 mice were analyzed based on ultra performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-Q/TOF-MS).

A metabolomic study on the anti-depressive effects of two active components from .

(Chr) is a traditional Chinese medicine (TCM) that has been used in the treatment of inflammation-linked diseases for hundreds of years. Naringenin (Nar) and apigenin (Api) are the major active components in aqueous extracts of . The aim of our study was to clarify the roles of Chr, Nar and Api in ameliorating depression-like behaviour induced by corticosterone.