Freeze-thaw-induced regulation of petroleum hydrocarbon adsorption in cold-region soils: Role of organic matter dynamics.

Numerous global regions are increasingly exposed to environmental risks from oil extraction and transportation, where contaminated soils are frequently subjected to seasonal and diurnal freeze-thaw cycles (FTCs). As a key interfacial process, soil adsorption can regulate the fate and mobility of petroleum hydrocarbons (PHCs), whereas the effect of FTCs on PHC adsorption remains poorly understood. This study integrated in-situ freeze-thaw treatments with adsorption experiments to examine the freeze-thaw effects on soil properties and their influence on the adsorption of representative PHCs under varying hydrothermal conditions.

Investigating the shared genetic architecture between adiposity measures and obesity-related cancers.

Fat distribution patterns are increasingly linked to obesity-related cancers; however, their shared genetic determinants remain unclear. To identify shared genetic architecture between adiposity measures and obesity-related cancers. Utilizing large-scale summary statistics from genome-wide association study, we conducted genome-wide cross trait analyses of nine adiposity measures [body mass index (BMI), waist-to-hip (WTH) ratio, waist-to-hip ratio adjusted for BMI, arm fat ratio, trunk fat ratio, leg fat ratio, abdominal subcutaneous adipose tissue, gluteofemoral adipose tissue, and visceral adipose tissue] in five obesity-related cancers (colorectal cancer, esophageal adenocarcinoma, breast cancer, endometrial cancer, and ovarian cancer) to characterize their shared genetic architecture, biological pathways, and causal relationships.

Preparation and properties of a UV-curable coating containing rare earth CeO.

A UV-curable coating with UV and blue light protection was prepared by incorporating modified rare earth nano cerium dioxide (CeO) treated with the silane coupling agent KH570. The structures of the modified CeO and the resulting UV-curable coating were characterized using Fourier Transform Infrared Spectroscopy, X-ray diffraction, scanning electron microscopy, and thermogravimetric analysis. UV spectral analysis was conducted to evaluate the UV shielding performance of the coating.

Use of ultrasonic left ventricular pressure-strain loops to predict weaning failure in critically ill patients: a pilot study.

Background: Left ventricular (LV) pressure-strain loops (PSLs) can overcome afterload of the LV to evaluate myocardial work. This study used PSLs to evaluate LV function during the weaning of invasive mechanical ventilation (IMV) patients, and explored the clinical value of myocardial work parameters in evaluating weaning outcomes.

Methods: In total, 70 IMV patients were retrospectively included in the study and divided into weaning success and failure groups based on their results 48 hours after weaning.

Histone hyperacetylation disrupts spermatogonial stem cells homeostasis and impairs spermiogenesis.

Background: It is well-known that epigenetic regulation is involved in the negative effects of environmental physical, chemical and biological factors exposures on organs. To investigate the effects and mechanisms of histone hyperacetylation caused by environmental stress on spermatogenesis, we used the histone deacetylase inhibitor Panobinostat (PANO) to establish the hyperacetylation models in mice.

Methods: To investigate the effects of PANO on testicular function of male reproductive system, we conducted the evaluation of sperm quality parameters in mice.

Serum 25-hydroxyvitamin D, vitamin D-related variants, and risk of chronic liver disease.

The associations of serum 25-hydroxyvitamin D (25(OH)D) with cirrhosis and liver cancer have not been well examined. It remained unclear whether functional vitamin D-related variants modify these associations. During follow-up of 401,551 UK Biobank participants with valid 25(OH)D data, we documented 4404 incident non-alcoholic fatty liver disease (NAFLD), 1989 incident cirrhosis, and 480 incident liver cancer.

Prenatal Diagnosis of Foetal Structural Anomalies Using Medium-Coverage Whole Genome Sequencing (CMA-Seq): A Large-Scale Comparative Study With CMA in 3973 Pregnancies.

Objective: To evaluate the feasibility and effectiveness of medium-coverage whole genome sequencing (CMA-seq) for prenatal diagnosis of foetal structural anomalies, and to compare its performance with conventional chromosomal microarray analysis (CMA).

Design: A prospective clinical study combined with a systematic meta-analysis.

Setting: A tertiary maternal and child health hospital in Chongqing, China.

From field to food: Impact of nitrogen and phosphorus fertilizers on mung bean starch synthesis, structure, and functional properties.

Nitrogen (N) and phosphorus (P) are essential nutrients that play a critical role in mung bean growth and grain quality. This study aimed to evaluate the combined effects of four N and four P fertilizer levels on the synthesis, structure, and functional properties of mung bean starch. The combined application of N and P fertilizers significantly increased starch accumulation by enhancing key enzyme activities.

Circadian rhythm disruption aggravates alveolar bone loss in rat apical periodontitis.

Background: Circadian rhythm disruption (CRD) affects the expression levels of a range of biological clock genes, such as brain and muscle ARNT-Like-1 (BMAL1), which is considered to be an important factor in triggering or exacerbating inflammatory response. However, the underlying effect of CRD on the pathogenesis of apical periodontitis, a common oral inflammatory disease, currently remains unknown. Exploring the effects and pathogenic mechanisms of CRD on apical periodontitis will be beneficial in providing new ideas for the prevention and treatment of apical periodontitis.

Cell-Type-Specific Splicing of Transcription Regulators and by in the Developing Neocortex.

How master splicing regulators cross talk with each other and to what extent transcription regulators are differentially spliced remain unclear in the developing brain. Here, cell-type-specific RNA-Seq analyses of the developing neocortex uncover variable expression of the Rbfox1/2/3 genes and enriched alternative splicing events in transcription regulators, altering protein isoforms or inducing nonsense-mediated mRNA decay. Transient expression of Rbfox proteins in radial glial progenitors induces neuronal splicing events preferentially in transcription regulators such as and Surprisingly, Rbfox proteins promote the inclusion of a mammal-specific alternative exon and a previously undescribed poison exon in Simultaneous ablation of in the neocortex downregulates neuronal isoforms and disrupts radial neuronal migration.

Construction and multiple validations of a robust ferroptosis-related prognostic model in bladder cancer: A comprehensive study.

Ferroptosis is iron-dependent programmed cell death that inhibits tumor growth, particularly in traditional treatment-resistant tumors. Prognostic models constructed from ferroptosis-related genes are lacking; prognostic biomarkers remain insufficient. We acquired gene expression data and corresponding clinical information for bladder cancer (BC) samples from public databases.

Diabetes Mellitus Inhibits Hair Follicle Regeneration by Inducing Macrophage Reprogramming-Mediated Pyroptosis.

Background: Diabetes mellitus (DM) is known to inhibit skin self-renewal and hair follicle stem cell (HFSC) activation, which may be key in the formation of chronic diabetic wounds. This study aimed to investigate the reasons behind the suppression of HFSC activation in DM mice.

Methods: Type 1 DM (T1DM) was induced in 6-week-old mice via streptozotocin, and hair follicle growth was subsequently monitored.

Cell-type-specific splicing of transcription regulators and by in the developing neocortex.

How master splicing regulators crosstalk with each other and to what extent transcription regulators are differentially spliced remain unclear in the developing brain. Here, cell-type-specific RNA-Seq of the developing neocortex uncover that transcription regulators are enriched for differential splicing, altering protein isoforms or inducing nonsense-mediated mRNA decay. Transient expression of Rbfox proteins in radial glia progenitors induces neuronal splicing events preferentially in transcription regulators such as and .

Hongjin Xiaojie Capsule, a Chinese patent medicine, for treating moderate to severe cyclical breast pain: A single-blind randomized controlled trial.

Background: Moderate to severe breast pain has major effects on the quality of life for patients. Patent Chinese medicines are widely used in the treatment of breast pain due to their stable dosage form and good efficacy.

Objective: To evaluate the beneficial effects and safety of Hongjin Xiaojie Capsule (HJXJC), a Chinese patent medicine, for the treatment of cyclical breast pain.

Causality of genetically determined metabolites on susceptibility to prevalent urological cancers: a two-sample Mendelian randomization study and meta-analysis.

Background: Prevalent urological cancers, including kidney, prostate, bladder, and testicular cancers, contribute significantly to global cancer incidence and mortality. Metabolomics, focusing on small-molecule intermediates, has emerged as a tool to understand cancer etiology. Given the knowledge gap in this field, we employ a two-sample Mendelian randomization (MR) analysis to investigate the causal relationships between genetically determined metabolites (GDMs) and the susceptibility to four common urological cancers.

Satellite observations reveal anthropogenic pressure significantly affects the suspended particulate matter concentrations in coastal waters of Hainan Island.

Suspended particulate matter (SPM) plays a crucial role in assessing the health status of coastal ecosystems. Satellite remote sensing offers an effective approach to investigate the variations and distribution patterns of SPM, with the performance of various satellite retrieval models exhibiting significant spatial heterogeneity. However, there is still limited information on precise remote sensing retrieval algorithms specifically designed for estimating SPM in tropical areas, hindering our ability to monitor the health status of valuable tropical ecological resources.

Sleep patterns, genetic susceptibility, and risk of cirrhosis among individuals with nonalcoholic fatty liver disease.

Background: The associations between sleep patterns or behaviors and the risk of cirrhosis and the influence of genetic susceptibility on these associations among NAFLD participants remain inadequately elucidated.

Methods: This study conducted a prospective follow-up of 112,196 NAFLD participants diagnosed at baseline from the UK Biobank cohort study. Five sleep behaviors were collected to measure a healthy sleep score.

Diagnosis of cervical lymphoma using a YOLO-v7-based model with transfer learning.

To investigate the ability of an auxiliary diagnostic model based on the YOLO-v7-based model in the classification of cervical lymphadenopathy images and compare its performance against qualitative visual evaluation by experienced radiologists. Three types of lymph nodes were sampled randomly but not uniformly. The dataset was randomly divided into for training, validation, and testing.

Alcohol and colorectal cancer risk, subclassified by mutational signatures of DNA mismatch repair deficiency.

Background: We examined whether the association between alcohol consumption and colorectal cancer (CRC) incidence was stronger for tumors with higher contributions of defective mismatch repair (dMMR)-related tumor mutational signatures.

Methods: We used data from 227 916 men and women who participated in the Nurses' Health Study (1980-2016), the Nurses' Health Study II (1991-2017), and the Health Professionals Follow-Up Study (1986-2016). Dietary data were collected every 4 years through validated food frequency questionnaires.

Post-diagnostic multivitamin supplement use and colorectal cancer survival: A prospective cohort study.

Background: Use of multivitamin supplements has been associated with lower incidence of colorectal cancer (CRC). However, its influence on CRC survival remains unknown.

Methods: Among 2424 patients with stage I-III CRC who provided detailed information about multivitamin supplements in the Nurses' Health Study and Health Professionals Follow-up Study, the authors calculated multivariable hazard ratios (HRs) of multivitamin supplements for all-cause and CRC-specific mortality according to post-diagnostic use and dose of multivitamin supplements.

Development of Inverse-Opal-Structured Charge-Deficient CoS@nitrogen-Doped-Carbon to Catalytically Enable High Energy and High Power for the Two-Electron Transfer I/I Electrode.

The iodine (I) electrode involving two-electron transfer chemistry by converting between I and I, has the potential to deliver theoretically doubled capacity and higher working voltage platforms, thus achieving higher energy density. However, owing to the slow kinetics of the cascade two-electron transfer reactions, the system suffers from large overpotentials and low power density, especially at high working currents and low temperatures. Here, an inverse-opal-structured cobalt sulfide@nitrogen-doped-carbon (CoS@NC) catalyst with unique charge-deficient states is developed to promote the reaction kinetics of the I/I electrode.

Preparation, Characterization, and Properties of UV-Curable Coating Doped with Nano-SiO.

In this study, a hydrophobic, wear-resistant ultraviolet (UV)-curable coating was investigated as an alternative to traditional coatings with low hardness and high susceptibility to scratching. The SiO nanoparticles were ground and modified using high-energy ball milling, during which the surface energy of nano-SiO particles rapidly increased as their particle size decreased. Different proportions of modified nano-SiO particles were added to the coating and cured into a film.