Single-carbon-atom transfer to -quinone methides from TMSCFBr.

Single-carbon-atom transfer reactions offer a powerful strategy for constructing complex molecular architectures by sequential assembly of substituents around the atomic carbon core. However, the limited availability of atomic carbon sources has significantly hindered progress in this field. Herein, we demonstrate a single-carbon atom transfer reaction utilizing commercially available TMSCFBr as an atomic carbon equivalent.

Prognostic indicators and nomograms for postoperative survival among younger patients with non-small cell lung cancer.

Background: Non-small cell lung cancer (NSCLC) diagnosed in younger patients represents a rare and distinct entity within lung cancer, yet prognostic indicators for younger patients surgically treated for NSCLC remain unclear. We aimed to analyze the long-term surgical outcomes in a large cohort and to identify predictors and to develop nomograms for effective survival prediction.

Methods: The Surveillance, Epidemiology, and End Results (SEER) database [2010-2020] was queried for pathologically confirmed NSCLC cases who underwent cancer-directed surgery.

Psoralen remodels the articular cartilage microenvironment by pharmacologically regulating the Nrf2 pathway in osteoarthritis treatment.

Osteoarthritis (OA) is a common degenerative joint disease featuring extracellular matrix degradation and apoptosis in the inflammatory microenvironment. Psoralea, a traditional Chinese herb derived from the dried and ripe fruits of the leguminous plant Psoralea corylifolia, possesses anti-inflammatory and antioxidant properties relying on the expression upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2). Psoralen, a compound derived from Psoralea, can be well applied to the treatment of various diseases, while researches have not fully explored its therapeutic effect for OA.

Online profiling of volunteers in public health emergencies: insights from COVID-19 in China.

Background: During public health emergencies, the diverse backgrounds of volunteers pose numerous management challenges. This study aims to develop an online profiling model of volunteers using social media data to achieve a more comprehensive and objective understanding of them.

Methods: In the proposed model, the study designed five profiling tags: basic information, sentiment, topic features, interest preferences, and online social engagement.

Can China's national comprehensive medical reform increase medical resources and reduce healthcare burden: evidence from Chinese provinces.

Objectives: China's national comprehensive medical reform (NCMR) is an important attempt in the reform of healthcare system, and quantitative evaluation of its effect is of great significance for continuously deepening medical reform, grasping the reform direction, and building a healthy China. Therefore, focusing on medical resources and medical burden, this study aims to systematically explore the policy effectiveness and the provincial heterogeneity of NCMR, as well as the potential influencing factors.

Methods: Utilizing the collected multi-period panel data of 31 provinces in mainland China in 2006-2021, we regarded the release of the two batches of pilot provinces in NCMR as a quasi-natural experiment and comprehensively adopted a Staggered difference-in-differences (DID) model and Synthetic Control Method (SCM), combined with word frequency statistics and grouping regression analysis.

Utilizing Saliva Metabolomics for Diagnosing Gastric Cancer and Exploring the Changes in Saliva Metabolites After Surgery.

Purpose: Gastric cancer (GC) is a disease with high prevalence and mortality, but we lack convenient and accurate methods to screen for this disease. Thus, we aimed to search for some salivary biomarkers and explore changes in metabolites in patients' saliva after radical gastrectomy.

Patients And Methods: A total of 152 subjects were divided into three groups (healthy group, GC group, and one-week postoperative group).

Exposure modes determined the effects of nanomaterials on antibiotic resistance genes: The different roles of oxidative stress and quorum sensing.

The effects of co-occurrent pollutants on antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) have raised attentions. However, how the different realistic exposure scenarios determining the effects of nanomaterials (NMs) on ARGs, was still unknown. Herein, the effects of NMs on ARGs under two realistic scenarios was investigated by short-term and long-term exposure modes.

Risk Factors of Distant Metastatic Parathyroid Carcinoma and Insights into Therapeutic Perspectives.

Background: Distant metastatic parathyroid carcinoma (DM-PC) is a rare but often lethal entity with limited data about prognostic indicators. We sought to investigate the risk factors, patterns, and outcomes of DM-PC.

Methods: In this observational cohort study, 126 patients who underwent surgery for PC at a tertiary referral center from 2010 to 2023 were enrolled, among whom 38 had DMs.

Entry pathways determined the effects of MPs on sludge anaerobic digestion system: The views of methane production and antibiotic resistance genes fates.

Sludge is one of the primary reservoirs of microplastics (MPs), and the effects of MPs on subsequent sludge treatment raised attention. Given the entry pathways, MPs would exhibit different properties, but the entry pathway-dependent effect of MPs on sludge treatment performance and the fates of antibiotic resistance genes (ARGs), another high-risk emerging contaminant, were seldom documented. Herein, MPs with two predominant entry pathways, including wastewater-derived (WW-derived) and anaerobic digestion-introduced (AD-introduced), were used to investigate the effects on AD performance and ARGs abundances.

A new frontier in precision medicine: Exploring the role of extracellular vesicles in chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease characterized by progressive respiratory difficulties. It has a high incidence and disability rate worldwide. However, currently there is still a lack of highly effective treatment methods for COPD, only symptom relief is possible.

Chest tube removal at different gas flows in prolonged air leak: a randomized non-inferiority trial.

Objectives: To evaluate the safety and feasibility of removing drainage tubes at larger size of air leak in patients with prolonged air leak after pulmonary surgery.

Methods: Ninety-five patients who underwent pulmonary surgery with prolonged air leak in our centre were enrolled in this randomized controlled, single-centre, non-inferiority study. The drainage tube was clamped with a stable size of air leak observed over the last 6 h, which was quantified by gas flow rate using the digital drainage system.

Treatment of post-traumatic complete bony ankylosed elbow using total arthroplasty and hernia patch - A case report.

Introduction And Importance: The elbow is one of the most mobile joints, and its movement is very important. Bony ankylosed elbow is an uncommon condition leading to complete loss of activity of elbow, and then lead to severe disability and limitation in activities of daily living.

Case Presentation: A 63-year-old woman sustained comminuted fracture of left distal humerus.

"One community at a time": promoting community resilience in the face of natural hazards and public health challenges.

Background: Resilience is vital for facing natural disasters and public health challenges. Despite the significance of resilience-building activities, there is a scarcity of locally-tailored planning and response strategies, leaving communities incapable of addressing the unique challenges posed by natural disasters and public health crises. This study aims to explore how the "One Community at a Time" approach enhances community resilience in facing natural hazards and public health challenges.

Spatial-temporal evolution pattern and optimization path of family education policy: An LDA thematic model approach.

Family education policy plays a crucial role in modernizing family education. By examining the temporal and spatial evolution of this policy, its inherent logic, constructs, and optimal pathways can be better understood. The study analyzed local family education policy documents, extracting six major themes using the Latent Dirichlet Allocation (LDA) model, and presented them according to the calculated mean theme probability.

Hyaluronic acid-gold nano-optical probes and determination of their effect on the inhibition of osteoarthritis progression.

Osteoarthritis seriously affects the health of elderly individuals. In this study, hyaluronic acid-gold nano-optical probes (HA-GNPs) were prepared, and their effect on osteoarthritis and its underlying mechanism were explored. The HA-GNPs were synthesised via a one-step synthesis method and characterised and detected via ultraviolet-visible spectrophotometry, dynamic light scattering (particle size analysis), zeta potential analysis, and scanning and transmission electron microscopy.

Deubiquitinase USP33 promotes the glycolysis and growth of osteosarcoma by modifying PFKFB3 ubiquitination and degradation.

Osteosarcoma (OS) is the most common malignant tumor of the bone tissue with the lowest survival rate among all pediatric cancers. OS cells grow vigorously under malnutrition; however, the mechanism by which they adapt to metabolic stress via metabolic reprogramming remains undefined. Here, we demonstrated that USP33, a member of the DUBs family, was significantly upregulated in the tissues of patients with OS compared to normal tissues.

Steel Strip Defect Sample Generation Method Based on Fusible Feature GAN Model under Few Samples.

Due to the shortage of defect samples and the high cost of labelling during the process of hot-rolled strip production in the metallurgical industry, it is difficult to obtain a large quantity of defect data with diversity, which seriously affects the identification accuracy of different types of defects on the steel surface. To address the problem of insufficient defect sample data in the task of strip steel defect identification and classification, this paper proposes the Strip Steel Surface Defect-ConSinGAN (SDE-ConSinGAN) model for strip steel defect identification which is based on a single-image model trained by the generative adversarial network (GAN) and which builds a framework of image-feature cutting and splicing. The model aims to reduce training time by dynamically adjusting the number of iterations for different training stages.

Construction and validation of a hypoxia-related risk signature identified EXO1 as a prognostic biomarker based on 12 genes in lung adenocarcinoma.

Background: Increasing evidence has demonstrated the clinical importance of hypoxia and its related factors in lung adenocarcinoma (LUAD).

Methods: RNA-seq datasets from The Cancer Genome Atlas (TCGA) were analyzed using the differentially expressed genes in hypoxia pathway by the Least Absolute Shrinkage and Selection Operator (LASSO) model. Applying gene ontology (GO) and gene set enrichment analysis (GSEA), a risk signature associated with the survival of LUAD patients was constructed between LUAD and normal tissue.

Effect of perioperative aspirin continuation on bleeding after pneumonectomy.

Background: To investigate the effect of continuous oral aspirin in perioperative period on bleeding in pneumonectomy.

Methods: A total of 170 patients who underwent pneumonectomy in our hospital from March 2021 to March 2022 were selected as the study objects. All patients took oral aspirin before surgery and did not take other antiplatelet agent or anticoagulants at the same time.

Risk factor analysis of postoperative cerebral infarction in thoracic surgery patients by propensity-score matching-a single institution retrospective cohort study.

Background: Postoperative cerebral infarction (PCI) is serious complication for thoracic surgery patients, however, the risk factors still unclear. This study sought to investigate the incidence risk factors of postoperative cerebral infarction after thoracic surgery.

Methods: Patients who underwent thoracic surgery from 2011 to 2022 at Beijing Chaoyang Hospital were identified and followed-up for 30 days postoperatively to determine the primary outcome of PCI.

N6-Methyladenosine Modification of CIRCKRT17 Initiated by METTL3 Promotes Osimertinib Resistance of Lung Adenocarcinoma by EIF4A3 to Enhance YAP1 Stability.

Background: Circular RNAs (circRNAs) play a key role in regulating the drug resistance of numerous human tumors. However, whether circKRT17 involves in the osimertinib resistance of lung adenocarcinoma (LUAD) remains undetermined.

Methods: Relative mRNA/circRNA and protein levels were detected by qRT-PCR and western blotting.