Transcutaneous auricular vagus nerve stimulation enhances structural and functional remodeling in sensorimotor networks following intracerebral hemorrhage in rats.

Background: Intracerebral hemorrhage (ICH) leads to severe neurological deficits by disrupting brain structure and function, particularly in the sensorimotor cortex. Effective interventions to promote post-ICH brain remodeling remain limited. This study investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on structural and functional remodeling in the sensorimotor networks of rats with ICH, using multi-scale analyses spanning micro-, meso-, and macro-levels.

The association between occupational silica exposure and leukemia: a systematic review and meta-analysis of cohort studies.

Respirable crystalline silica is a proven lung carcinogen, but there is limited information of the carcinogenic effects of silica on non-respiratory organs. We aimed to systematically review cohort studies and conduct a meta-analysis to explore the relationship between occupational exposure to silica and the risk of leukemia development. We performed an exhaustive search across three databases (PubMed, Embase, and Web of Science) to identify pertinent cohort studies published since 1987.

Stabilization of γ-CsPbI Nanoplatelets via Tailored Surface Coordination for High-Performance Rec. 2020 Pure-Red LEDs.

Pure-red perovskite light-emitting diodes (PeLEDs) are critical for next-generation displays, while existing systems based on mixed Br/I compositions, quasi-2D phases, or colloidal 0D quantum dots are still facing challenges in fulfilling the requirements of the Recommendation BT.2020 (Rec. 2020) red standard.

A comparative study of arthroscopic treatment of popliteal cyst with internal drainage and internal drainage combined with cyst wall resection.

Purpose: To compare the clinical outcomes of arthroscopic internal drainage (AID) and arthroscopic internal drainage combined cyst wall resection(AID + CWR) in treatment of the popliteal cysts.

Methods: In this prospective randomized study, 60 patients (October 2022) at Beijing Tsinghua Changgung Hospital were divided into Group A (AID, n = 30) and Group B (AID + CWR, n = 30). Operative duration, blood loss, intra-articular pathologies, and complications were recorded.

[Effectiveness of arthroscopic double fixation and enhanced suture of long head of biceps tendon for repairing rotator cuff tear].

Objective: To investigate the effectiveness of arthroscopic double fixation and enhanced suture of long head of biceps tendon (LHBT) for repairing rotator cuff tear.

Methods: A retrospective analysis was conducted on 31 patients with rotator cuff tears and LHBT injuries admitted between June 2022 and November 2023. All patients underwent arthroscopic double fixation and enhanced suture of LHBT .

Rational Design of Organic Manganese Halides for High Quantum Efficiency and Stability.

Organic manganese halides have gained attention as luminescent materials due to their characteristics, such as low toxicity, ease of synthesis, and high photoluminescence quantum yield (PLQY). This study challenges the common belief that increasing the Mn-Mn distance invariably boosts PLQY. It introduces a 3D diagram illustrating the importance of ground-state and excited-state band alignments in influencing PLQY.

Population Genetics and Trajectory Simulation Reveals the Invasion Process of the Fall Armyworm () in the Eastern Hemisphere.

As a migratory agricultural pest, the fall armyworm has been in the spotlight since it invaded Africa in 2016. Invasive populations have now colonized much of the Eastern Hemisphere, causing severe damage to a wide range of crops. However, there is still disagreement internationally on the origin and mode of invasion of fall armyworm populations, especially from the Americas to China.

Population genomics of migratory and resident Spodoptera frugiperda reveals key genes and loci driving migration traits.

Background: The fall armyworm (Spodoptera frugiperda, FAW) is one of the most devastating invasive pests in the world, owing to its extraordinary migration performance. Research has clarified the migratory pathways and external environmental factors affecting FAW migration. However, the internal genes and loci regulating migration or reside in FAW remain largely unknown.

Intestinal Bacterial Dysbiosis and Liver Fibrosis in Mice Through Gut-Liver Axis and NLRP3 Inflammatory Pathway Caused by Fine Particulate Matter.

Fine particulate matter (PM) is associated with risks of liver diseases and intestinal bacterial dysbiosis, in which the gut-liver axis regulation mechanisms induced by PM exposure are still limited so far. In this study, after 12 weeks of exposure to atmospheric PM (64 μg/m) and clean air in winter in Taiyuan, China, we collected liver and intestinal tissues and serum in male mice to perform toxicology experiments. The results showed that PM significantly exacerbated the pathological injury in the liver and intestine and liver fibrosis in mice, along with elevated levels of pro-inflammatory cytokines and lipopolysaccharide (LPS) levels in the serum.

Occurrence and Multi-Locus Genotyping of in Black Goats from Fujian Province, China.

is a zoonotic parasite that causes gastrointestinal diseases in both humans and animals. To evaluate the prevalence and genetic diversity of in black goats, we collected 539 fecal samples from nine districts in Fujian Province, China. The presence of was confirmed through nested PCR targeting the SSU rRNA gene, and genotyping was performed at the beta-giardin, glutamate dehydrogenase, and triosephosphate isomerase loci.

Remodeling and Characterization Analysis of Corticospinal Tract in Patients with Intracerebral Hemorrhage in the Basal Ganglia.

To investigate corticospinal tract (CST) injury and remodeling in patients with basal ganglia intracerebral hemorrhage (ICH) and explore the characterization capabilities of the corresponding parameters. In this prospective study, baseline, scale, and diffusion-weighted imaging (DWI) data were collected from patient cohorts. Participants were stratified into favorable (0-3 points) and unfavorable (4-6 points) prognosis groups, based on Modified Rankin Scale (mRS) after 3-6 months.

Invasive or non-invasive vagus nerve stimulation modulation of brain function and remodeling after stroke: a review.

Background: The main reason restricting stroke patients from reintegrating into society is neurological deficits. Of particular interest is the potential vagus nerve stimulation (VNS) potentially offers for sustaining improvement in neurological deficits. The goal of the present study is to provide a summary of the findings from research that has been carried out to elucidate the mechanisms and demonstrate the efficacy and safety of the clinical application of VNS, as well as to identify research gaps in the field, in order to offer references for subsequent further research and application.

Study of association between embryo growth arrest (EGA) and atmospheric fine particulate matter pollution (PM) and spatial metabolomics of villi derived from pregnant women.

Fine particulate matter (PM) is related to embryo growth arrest (EGA). In this study, we collected demographic information from EGA cases and early pregnancy controls in Taiyuan, China, between 2022 and 2023 and obtained villi and serum samples from these participants. We employed multilevel mixed-effects logistic regression models to estimate the odds ratios (ORs).

Associations between people experiencing homelessness (PEH) and neurodegenerative disorders (NDDs): A systematic review and meta-analysis.

Background: Homelessness represents a widespread social issue globally, yet the risk of neurodegenerative diseases (NDDs) associated with people experiencing homelessness (PEH) has not received sufficient attention. Therefore, this study aimed to explore the risk of NDDs among PEH and its variation across countries and regions through meta-analysis and systematic review.

Methods: Searching from databases such as PubMed and Web of Science, relevant research articles on PEH and NDDs were identified.

The association between fire smoke exposure and emergency department (ED) visits and hospital admissions (HA): A systematic review and meta-analysis.

The negative impact of fire smoke on human health is widely recognized. However, studies have not adequately compared subtle differences in rates of emergency department (ED) visits and hospital admissions (HA) for various diseases, nor have they grounded comparisons in differences in healthcare systems across countries. To bridge this gap, we conducted a systematic meta-analysis to assess global health risks associated with fire smoke exposure.

Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCSK9. Recently, it was verified that VHH-B11 binds one linear epitope in the PCSK9 hinge region.

Prognostic Factors for Recurrent Glioma: A Population-Based Analysis.

Background: The overall survival (OS) for patients with recurrent glioma is meager. Also, the effect of radionecrosis and prognostic factors for recurrent glioma remains controversial. In this regard, developing effective predictive models and guiding clinical care is crucial for these patients.

Effect of Preheating and Post-Heating on the Microstructures and Mechanical Properties of TC17-TiAlNb Joint with Electron Beam Welding.

To enhance welding quality and performance, preheating and post-heating are usually employed on high-temperature materials, concurrently with welding. This is a novel technique in vacuum chamber electron beam welding (EBW). TC17 and TiAlNb alloys are the hot topics in aero-engine parts, and the welding of dissimilar materials is also a broad prospect.

Occupational exposure to silica and risk of gastrointestinal cancers: a systematic review and meta-analysis of cohort studies.

Background: Although silica is a proven lung carcinogen, there is no convincing evidence linking crystalline silica to gastrointestinal malignancies.

Methods: We detailedly searched studies on the link between gastrointestinal malignancies and occupational silica exposure. Studies published between 1987 and 2023 were found by searching PubMed, Scopus, Cochrane Library, and Web of Science databases.

Between the center and periphery: Commodification, formalisation, and infrastructuralisation of grassroots innovation.

The question of whether China can become a creative nation has been a topic of much debate in academic circles. The Chinese government has expressed its belief that China can develop a unique form of creativity to move the country from the periphery to the center of the global creative ecosystem. This perspective has led to a series of state-led trials and experiments, including the adoption of cultural and creative industries, creative clusters and cities, and the recent maker movement.

Non-Faradaic optoelectrodes for safe electrical neuromodulation.

Nanoscale optoelectrodes hold the potential to stimulate optically individual neurons and intracellular organelles, a challenge that demands both a high-density of photoelectron storage and significant charge injection. Here, we report that zinc porphyrin, commonly used in dye-sensitized solar cells, can be self-assembled into nanorods and then coated by TiO. The J-aggregated zinc porphyrin array enables long-range exciton diffusion and allows for fast electron transfer into TiO.

Targeted nanotheranostics for the treatment of epilepsy through in vivo hijacking of locally activated macrophages.

Epilepsy refers to a disabling neurological disorder featured by the long-term and unpredictable occurrence of seizures owing to abnormal excessive neuronal electrical activity and is closely linked to unresolved inflammation, oxidative stress, and hypoxia. The difficulty of accurate localization and targeted drug delivery to the lesion hinders the effective treatment of this disease. The locally activated inflammatory cells in the epileptogenic region offer a new opportunity for drug delivery to the lesion.

Evaluation of gut microbiota composition to screening for potential biomarker in AFB1-exposed sheep.

Aflatoxin B1 (AFB1) is an inevitable contaminant in animal feed and agricultural products, which seriously threatens the health of animals. However, there is currently no better diagnostic tool available than depending on clinical symptoms, pathophysiology, biochemical indicators, etc. Here, we profiled the fecal microbiomes of sheep exposed to and not exposed to AFB1 to identify potential non-invasive biomarkers of AFB1 intoxication by 16S rRNA gene sequencing technology, while measuring serum biochemical indexes.