When giving social support is beneficial for well-being?

This study investigates the conditions under which the provision of social support enhances subjective well-being, focusing specifically on the autonomy and effectiveness of social support among a sample of 206 university students. Utilizing a 2 × 2 between-subjects experimental design, the findings reveal that the autonomy of social support provision significantly influences subjective well-being, with participants in the voluntary group reporting markedly higher levels of subjective well-being than those in the non-voluntary. Additionally, the perceived effectiveness of social support is shown to significantly affect subjective well-being; individuals who regarded the support as effective exhibited substantially higher levels of subjective well-being compared to those who deemed it ineffective.

Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis.

Oral administration of probiotics holds promise for alleviating ulcerative colitis (UC), yet their efficacy is inevitably compromised by the hostile gastrointestinal (GI) environment. Here, we devised a strategy by coating β-glucan (GN) prebiotic onto the surface of Lactobacillus plantarum (Lp) probiotic at the single-cell level (Lp@CGN) based on bioorthogonal chemistry in a layer-by-layer manner. This achieved to form a firm, dense, and multifunctional GN-based "armor" with advances of superior protective properties, colon-targeted degradation, and prebiotic benefits.

Profiling the differential phosphoproteome between breast milk and infant formula through a titanium (IV)-immobilized magnetic nanoplatform.

Breast milk (BM) fulfills the nutritional needs of infants and sets the standard for infant formula (IF). However, profiling the differential phosphoproteome between BM and IF remains unclear. Herein, a titanium (IV) (Ti)-immobilized magnetic nanoplatform (FeO@GO@PDA-Ti) was constructed by self-assembly polymerization of dopamine on magnetic graphene oxide, followed by immobilizing Ti through chelation for phosphopeptide enrichment.

Efficacy and safety of a Chinese medicine formula Diankuang Mengxing Decoction combined with antipsychotics in the treatment of schizophrenia: A meta-analysis of randomized controlled trials.

Background: In patients with schizophrenia, Diankuang Mengxing Decoction with antipsychotics is one of the treatments for it. However, little information is available regarding the difference between the therapeutic effect of Diankuang Mengxing Decoction with antipsychotics and other treatments. Systematic evaluation is conducted to assess the efficacy and safety of Diankuang Mengxing Decoction and other antipsychotics, which are used to treat schizophrenia.

Co-immobilization of amine dehydrogenase and glucose dehydrogenase for the biosynthesis of (S)-2-aminobutan-1-ol in continuous flow.

Reductive amination by amine dehydrogenases is a green and sustainable process that produces only water as the by-product. In this study, a continuous flow process was designed utilizing a packed bed reactor filled with co-immobilized amine dehydrogenase wh84 and glucose dehydrogenase for the highly efficient biocatalytic synthesis of chiral amino alcohols. The immobilized amine dehydrogenase wh84 exhibited better thermo-, pH and solvent stability with high activity recovery.

Preparation of Lanthanum-Modified Tea Waste Biochar and Its Adsorption Performance on Fluoride in Water.

In this study, tea waste was used as a raw material, and TBC (tea waste biochar) was prepared by pyrolysis at 700 °C. La(NO)·6HO was used as the modifier to optimize one-way modification; the orthogonal experiment was undertaken to determine the optimal preparation conditions; and La-TBC (lanthanum-modified biochar) was obtained. The key factors for the adsorption of fluoride by La-TBC were investigated by means of batch adsorption experiments, and kinetics and isothermal adsorption experiments were carried out on the adsorption of fluoride in geothermal hot spring water.

Inhibition of ferroptosis ameliorates hypertensive nephropathy through p53/Nrf2/p21 pathway by Taohongsiwu decoction: Based on network pharmacology and experimental validation.

Ethnopharmacological Relevance: Hypertensive nephropathy (HN) is a complication of hypertension. Taohongsiwu decoction (THSWD) is used clinically but its application in the prevention and treatment of HN remains unelucidated.

Aim Of Study: This study aims to explore the potential targets and molecular mechanisms of THSWD in the treatment of HN.

The effect of Taohong Siwu decoction combined with antihypertensive medicine in the treatment of hypertension: Meta-analysis.

Background: Taohong Siwu Decoction (THSWD) is a classic prescription of traditional Chinese medicine. Recent research has shown that the practical components of THSWD have specific curative effects on various cardiovascular diseases, including hypertension, suggesting THSWD could effectively lower blood pressure (BP) with fewer side effects. However, little information is available regarding the effectiveness of THSWD combined with antihypertensive medicine on hypertension.

Cytochrome C catalyzed oxygen tolerant atom-transfer radical polymerization.

Atom-transfer radical polymerization (ATRP) is a well-known technique for controlled polymer synthesis. However, the ATRP usually employed toxic heavy metal ionas as the catalyst and was susceptible to molecular oxygen, which made it should be conducted under strictly anoxic condition. Conducting ATRP under ambient and biocompatible conditions is the major challenge.

Engineered cytochrome fused extracellular matrix enabled efficient extracellular electron transfer and improved performance of microbial fuel cell.

Microbial fuel cell (MFC) was a promising technology for energy harvesting from wastewater. However, inefficient bacterial extracellular electron transfer (EET) limited the performance as well as the applications of MFC. Here, a new strategy to reinforce the EET by engineering synthetic extracellular matrix (ECM) with cytochrome fused curli was developed.

Microstructure and Properties of Glass Fiber-Reinforced Polyamide/Nylon Microcellular Foamed Composites.

The automobile and aerospace industries require lightweight and high-strength structural parts. Nylon-based microcellular foamed composites have the characteristics of high strength and the advantages of being lightweight as well as having a low production cost and high product dimensional accuracy. In this work, the glass fiber-reinforced nylon foams were prepared through microcellular injection molding with supercritical fluid as the blowing agent.

Transplantation of Mesenchymal Stromal Cells Expressing the Human Preproenkephalin Gene Can Relieve Pain in a Rat Model of Neuropathic Pain.

Transgenic therapy for central neuralgia faces the problems of low expression and weak targeting and affects superficial but not deep neurons. In this study, we generated a lentivirus vector with human preproenkephalin gene (hPPE) expression driven by the transcriptional amplification strategy system (TAS) and established a primary bone marrow-derived mesenchymal stromal cell (BMSC) line stably expressing hPPE for transplantation into a rat model of neuropathic pain rat. The paw thermal withdrawal latency assay and paw mechanical withdrawal threshold assay showed that unlike control BMSCs and BMSCs with hPPE overexpression driven by the CMV or Synapsin 1 (SYN1) promoter, TAS-hPPE BMSCs had a robust and lasting analgesic effect.

Study on the prevention of infection in terminal cancer patients applying epidural analgesia by adding cefazolin to anesthetics: a randomized controlled trial.

Objective: To observe the antibacterial effect of adding cefazolin into anesthetics in patients with terminal cancer undergoing long-term epidural analgesia.

Methods: Patients undergoing epidural analgesia with terminal cancer were randomly divided into two groups: the conventional drug group (group C) and the cefazolin group (group G). Both groups were given levobupivacaine and morphine, while cefazolin was added to group G.

The effect of increased abdominal pressure on internal jugular vein catheterization under ultrasound-guidance on conscious patients: A randomised controlled trial.

Background: The shape and cross-sectional area (CSA) of internal jugular vein (IJV) are easily affected by external factors. That causes venous collapsibility. We tried to distend IJV by increasing the pressure on patients' abdomen in order to improve the success rate of internal jugular vein catheterization (IJVC).

Aqueous Gold Nanoparticles Generated by AC and Pulse-Power-Driven Plasma Jet.

In this study, we developed a simple-to-use approach based on an atmospheric pressure plasma jet to synthesize aqueous Au nanoparticles (AuNP). Special attention was paid to the different reaction dynamics and AuNP properties under AC and pulse-power-driven plasma jets (A-Jet and P-Jet, respectively). The morphology of the AuNP, optical emissions, and chemical reactions were analyzed.

Comparison between ultrasound-guided paravertebral nerve block and subarachnoid block for elderly male patients under unilateral-opened inguinal hernia repair operation: A randomised controlled trial.

Background: Paravertebral block (PVB) as a sole anesthetic technique is difficult even in experienced hands. Hence, this study was undertaken to study the safety and efficacy of PVB and to compare with subarachnoid block (SAB) for inguinal hernia repair surgery (IHRS) in elderly male patients.

Materials And Methods: Sixty-five male patients aged 65 to 89 scheduled for IHRS were allocated randomly by computer-generated randomisation sequence into two groups.

Effect of Mold Opening Process on Microporous Structure and Properties of Microcellular Polylactide⁻Polylactide Nanocomposites.

Cell structure is a key factor that determines the final properties of microcellular polylactide (PLA) product. In the mold opening process, adjusting the rate of mold opening can effectively control cell structure. PLA and PLA composites with a void fraction as high as 50% were fabricated using the mold opening technique.

Tailoring Bandgap of Perovskite BaTiO₃ by Transition Metals Co-Doping for Visible-Light Photoelectrical Applications: A First-Principles Study.

The physical and chemical properties of V-M″ and Nb-M″ (M″ is 3d or 4d transition metal) co-doped BaTiO₃ were studied by first-principles calculation based on density functional theory. Our calculation results show that V-M″ co-doping is more favorable than Nb-M″ co-doping in terms of narrowing the bandgap and increasing the visible-light absorption. In pure BaTiO₃, the bandgap depends on the energy levels of the Ti 3d and O 2p states.

The optimal combination of mechanical ventilator parameters under general anesthesia in obese patients undergoing laparoscopic surgery.

Objective: Pulmonary dysfunction after laparoscopic surgery is commonly seen in the high-risk group of obese patients. To reduce or avoid this complication caused by an improper combination of mechanical ventilation parameters, we conducted the following trial of 3 factors with 3 levels of mechanical ventilation, aimed to obtain the low airway pressure with good ventilator effects.

Methods: Patients were randomly allocated as a sample of cases according to the "30≤weight/height(2)<40" obesity index.

[Electrospinning technology in tissue engineering scaffolds].

Tissue engineering technology provides a new method to repair ill tissue and worn-out organs. In tissue engineering, scaffolds play an important role in supporting cell growth, inducing tissue regeneration, controlling tissue structure and releasing active factor. In the last decade, electrospinning technology developed rapidly and opened vast application fields for scaffolds.

Development and in vitro characterizations of bifendate nanosuspensions.

It is reported that nano-sizing is one of the promising methods for improving the dissolution rate and oral bioavailability of poorly water-soluble drugs. In this study, bifendate (DDB) suspensions have been successfully produced by employing two different techniques, the precipitation-ultrasonication method and the precipitation-combined microfluidization method. According to the preliminary test, in the precipitation-ultrasonication process, the concentrations of polyvinylpyrrolidone K30 (PVPK30) and lecithin in the anti-solvent, the concentration of DDB in the organic phase and the precipitation temperature were optimized at 0.

A mini review of nanosuspensions development.

Nanosuspension drug delivery has obtained great success in the preparation of insoluble drugs. The nanosuspension technology can confer a series of special characteristics to the drugs, such as the enhanced dissolution rate and saturation solubility. This mini review first described the differences between the nanocrystals and nanosuspensions.

Studies on pharmacokinetics and tissue distribution of bifendate nanosuspensions for intravenous delivery.

It is reported that the nanosuspension is one of the promising formulations for poorly water-soluble drugs. In order to enhance the in vitro and in vivo behaviours of DDB (bifendate), DDB-NSP (DDB nanosuspensions) have been produced by the precipitation-combined microfluidization method. The optimized DDB-NSP were transformed into dry powders by freeze-drying and then investigated by transmission electron microscopy, laser diffraction and X-ray diffraction (XRD) experiments.