Reactive oxygen species-responsive virus-mimicking nanodrug for the treatment of influenza A virus infection.

Drug therapy is an important measure to reduce the morbidity and mortality of influenza. However, small molecule drugs have inherent limitations, such as poor water solubility, non-specific biological distribution, and susceptibility to degradation during blood circulation, which impose a great burden on patients, both physically and mentally. Inspired by the high levels of reactive oxygen species (ROS) at the site of influenza A virus (IAV) infection, we have developed an intelligent responsive virus-mimicking nanodrug (Zana@HA-Lip) based on a biomimetic approach, reduces the damage of the drug to normal tissues or organs while achieving the purpose of antiviral therapy by precisely releasing the drug at the lesion site.

Biomimetic lipid nanocarriers overcome hypoxia barriers in lung cancer therapy.

Lung cancer, a major cause of cancer-related deaths, poses significant therapeutic challenges due to tumor hypoxia. Various drug delivery systems are designed to alleviate tumor hypoxia. However, their effectiveness is limited by complex physiological barriers, as well as issues like biocompatibility and colloidal stability.

Transgenerational effects of heavy metal contamination on two Trichogramma egg parasitoids and potential impacts on biological control.

The increased basic knowledge of biological control agents' bio-ecology under environmental stress provides useful information for optimizing integrated pest management. With an increasing awareness of cadmium (Cd) pollution in agroecosystems, this study evaluated the transgenerational effects and host preference of two widely distributed and utilized egg parasitoids, Trichogramma dendrolimi and Trichogramma japonicum through bottom-up effects mediated by Cd. The host rice moth Corcyra cephalonica was reared on a diet with 20 mg/kg Cd exposure for 1 generation; eggs were collected, and then exposed to Trichogramma.

Apoptotic Cell-Mimicking Nanocarriers Enhance Splenic Red Pulp Delivery through Lipid Pool Modulation.

Spleen-targeted nanovaccines hold promise for enhancing immune responses and protective effect, yet their effectiveness is hindered by challenges such as inevitable liver retention, limited speed of immune activation, and poor biocompatibility. Natural lipids typically possess excellent biocompatibility, allowing for favorable interactions with cells and tissues in the body, thereby reducing immune responses and toxicity. In this study, we proposed a selective spleen-targeting strategy for custom designing the nanocarriers utilizing the biomimetic concept of apoptotic cell membranes and natural lipid pool modulation.

Plant Volatile Methyl Salicylate Primes Wheat Defense Against the Grain Aphid by Altering the Synthesis of Defense Metabolites.

Wheat (Triticum aestivum L.) is one of the most important staple crops all over the world. Its productivity is adversely affected by aphid infestation.

Transfer and biological effects of cadmium along a tomato - thrip - predatory bug food chain.

The heavy metal, cadmium (Cd) is an increasingly serious issue in agricultural ecosystems, mediating bottom-up effects on plants, herbivores and natural enemies. We measured how Cd modifies interactions between tomato Solanum lycopersicum, western flower thrips Frankliniella occidentalis, and the predatory bug Orius sauteri by examining Cd effects on the growth of tomato, the fitness of western flower thrips, and the survival and behavior of predators. The photosynthetic parameters of Pn (net photosynthetic rate), Gs (stomatal conductance), Ci (intercellular CO concentration), and Tr (transpiration rate) of tomato plants significantly decreased with the increase of Cd concentration.

Heavy metal exposure reduces larval gut microbiota diversity of the rice striped stem borer, Chilo suppressalis.

Cadmium (Cd), a widely distributed environmental pollutant in agroecosystems, causes negative effects on crops and herbivores through bottom-up processes. The gut microbial community of an insect can play a critical role in response to metal stress. To understand how microbiota affect the stress responses of organisms to heavy metals in agroecosystems, we initially used 16S rRNA sequencing to characterize the larval gut microbiota of Chilo suppressalis, an important agricultural pest, exposed to a diet containing Cd.

Multihierarchical Regulation To Achieve Quantum Dot Nanospheres with a Photoluminescence Quantum Yield Close to 100.

Quantum dots (QDs) exhibit superior brightness and photochemical stability, making them the preferred option for highly sensitive single-molecule detection compared with fluorescent dyes or proteins. Nevertheless, their high surface energy leads to nonspecific adsorption and poor colloidal stability. In the past decades, we have found that QD-based fluorescent nanoparticles (FNs) can not only address these limitations but also enhance detection sensitivity.

Association between baseline office blood pressure level and the incidence and development of long-term frailty in the community-dwelling very elderly with hypertension.

Frailty is the most important risk factor causing disability in the elderly. Hypertension is one of the most common chronic diseases in the elderly and is closely related to frailty, but there is still controversy about the association between blood pressure and frailty. To explore the association between baseline blood pressure level and the incident and development of long-term frailty in the community-dwelling very elderly (i.

Lipid-Centric Design of Plasma Membrane-Mimicking Nanocarriers for Targeted Chemotherapeutic Delivery.

The plasma membranes (PM) of mammalian cells contain diverse lipids, proteins, and carbohydrates that are important for systemic recognition and communication in health and disease. Cell membrane coating technology that imparts unique properties of natural plasma membranes to the surface of encapsulated nanoparticles is thus becoming a powerful platform for drug delivery, immunomodulation, and vaccination. However, current coating methods fail to take full advantage of the natural systems because they disrupt the complex and functionally essential features of PMs, most notably the chemical diversity and compositional differences of lipids in two leaflets of the PM.

Biological traits of the zoophytophagous predatory mirid Nesidiocoris poppiusi (Heteroptera: Miridae), a candidate biocontrol agent in China.

Mirid predators are increasingly used in biological control of multiple greenhouse crops pests. However, due to great morphological similarity and tiny body size, some mirid predators have been largely confused with their allied species. Nesidiocoris tenuis Reuter as a commercial mirid predator was confused largely with Nesidiocoris poppiusi Carvalho in China.

Cadmium contamination triggers negative bottom-up effects on the growth and reproduction of Frankliniella occidentalis (Thysanoptera: Thripidae) without disrupting the foraging behavior of its predator, Orius sauteri (Heteroptera: Anthocoridae).

Heavy metal contaminants may influence tri-trophic interactions among plants, herbivores, and their natural enemies and affect the results of pest management practices. We examined how the widely distributed heavy metal cadmium (Cd) could modify interactions between kidney bean, Phaseolus vulgaris L., western flower thrips, Frankliniella occidentalis Pergande, and a predator, Orius sauteri (Poppius) by examining Cd effects on the feeding damage on leaves, the growth and reproduction of the thrips, and the feeding and plant location selection behaviors of predators.

Inducing Autophagy and Blocking Autophagic Flux via a Virus-Mimicking Nanodrug for Cancer Therapy.

Maximizing the therapeutic capacity of drugs by allowing them to escape lysosomal degradation is a long-term challenge for nanodrug delivery. Japanese encephalitis virus (JEV) has evolved the ability to escape the endosomal region to avoid degradation of internal genetic material by lysosomes and further induce upregulation of cellular autophagy for the purpose of their mass reproduction. In this work, to exploit the lysosome escape and autophagy-inducing properties of JEV for cancer therapy, we constructed a virus-mimicking nanodrug consisting of anti-PDL1 antibody-decorated JEV-mimicking virosome encapsulated with a clinically available autophagy inhibitor, hydroxychloroquine (HCQ).

Prostatic Abscess Combined With Spleen Abscess Due to Multi-Drug-Resistant Gram-Negative Bacilli: A Case Report and Literature Review.

The prostatic abscess is a rare complication of a bacterial infection of the prostate. Since the early use of potent antibiotics to treat urinary tract infections, the incidence of the prostatic abscess has declined significantly. In keeping with that, prostatic abscess combined with abscesses in the spleen or other distant organs become an extremely rare but fatal clinical condition.

Predatory Ability of (Coleoptera: Coccinellidae) and (Hemiptera: Anthocoridae) for Suppression of Fall Armyworm (Lepidoptera: Noctuidae).

The lepidopteran pest, (JE Smith), spread rapidly after its first detection in China and has caused significant yield loss to maize production in the southwestern part of the country. Although natural enemies of are present in the field, biological control using naturally distributed predators is ineffective because their underlying populations are too low. To enhance our understanding of the potential role of natural enemies in regulating this invasive pest, functional response experiments were conducted to quantify the response of two predators, (Poppius) (Hemiptera: Anthocoridae) and (Pallas) (Coleoptera: Coccinellidae), in terms of consumption of .

Accurate and Efficient Lipoprotein Detection Based on the HCR-DNAzyme Platform.

Cardiovascular disease is one of the main causes of death in the world, which is closely associated with dyslipidemia. Dyslipidaemia is usually manifested as a relatively higher level of low-density lipoprotein (LDL) and lower level of high-density lipoprotein (HDL). Thus, the quantitative detection of the LDL and HDL particles is of great importance to predict the risk of cardiovascular diseases.

Joint effects of cadmium and copper on Apis mellifera forgers and larvae.

Honey bees (Apis mellifera L.) are important ecological and agricultural resources. They are among the most widely available pollinators and provide products as well as services.

Metal-organic frameworks based fluorescent sensor array for discrimination of flavonoids.

Metal-organic frameworks (MOFs) are hotly investigated as a novel kind of fluorescent sensing materials in recent years. However, the application of MOF sensing to drug analysis is still very difficult yet, because the structural similarity among drug homolog-ues exceeds the discrimination ability of MOFs. Array sensing technique, which relies on the combined responses of a group of sensing materials, is a viable way to solve this problem.

Pyrene-based MOFs as fluorescent sensors for PAHs: an energetic pathway of the backbone structure effect on response.

The sensing performance of metal-organic frameworks (MOFs), a novel kind of crystalline fluorescent sensing materials, would be profoundly affected by their backbone structures. The current understanding about the backbone effect is limited to the modulation of analyte accommodation through pore structures. Herein, three topologically different pyrene-based MOFs, including NU-1000, NU-901 and ROD-7, were investigated as potential fluorescent sensors for polycyclic aromatic hydrocarbons (PAHs).

Metal-organic framework-based fluorescent sensing of tetracycline-type antibiotics applicable to environmental and food analysis.

Antibiotics have been noted as an important class of emerging contaminants in the environment. Metal-organic frameworks (MOFs), which have been intensely investigated as a novel kind of sensing material, have been tentatively applied to the detection of antibiotics in recent years. In this work, a nanoscale MOF (In-sbdc) with a strong (quantum yield = 13%) and stable emission in water was synthesized.

Polyculture and Monoculture Affect the Fitness, Behavior and Detoxification Metabolism of (Hemiptera: Aleyrodidae).

Herbivores respond differently to the level of plant diversity encountered. Gennadius (Hemiptera: Aleyrodidae) are highly polyphagous herbivores which cause considerable damage to various crops. Herein, we reared this species both in polyculture and monoculture, including preferred and less preferred host plants such as Chinese cabbage ( L.

MOF based fluorescent assay of xanthine oxidase for rapid inhibitor screening with real-time kinetics monitoring.

The activity assay of xanthine oxidase (XO) is of great application value in clinical diagnosis because the abnormal level of this enzyme is related to a series of pathological states. In this work, a Zr based metal-organic framework (BTB-MOF) with stable photoluminescence in pure water and buffer solution was synthesized. The examination about the fluorescent responses of this material to xanthine and its oxidation product, uric acid, showed that, although both of them affected the emission of BTB-MOF in quenching form, the efficiencies presented much difference.

Enzyme-Assisted Metal-Organic Framework Sensing System for Diethylstilbestrol Detection.

As novel fluorescent-sensing materials, metal-organic frameworks (MOFs) have shown great potential in environmental monitoring. However, most of the researches are limited to traditional pollutants, whereas the application of MOFs to the detection of the pollutants with more complicated structures, such as endocrine disrupting chemicals (EDCs), has rarely been explored. The difficulties faced in the sensing of EDCs include their electronic stability and the structural similarity among homologues, which could be overcome by the incorporation of enzymatic reaction.