SPL and THD improvement of a cantilever-diaphragm piezoelectric MEMS loudspeaker with Double-S actuators.

Piezoelectric MEMS loudspeakers based on cantilever diaphragms have demonstrated promising electroacoustic efficiency and low-frequency sound pressure level (SPL). However, their total harmonic distortion (THD) significantly increases near the first resonant frequency, and high-frequency SPL (above 10 kHz) rapidly decreases due to the resonance frequency and bandwidth limitations, severely affecting sound quality. This work presents a piezoelectric MEMS loudspeaker featuring a 2.

Divergent C-C and C-N Cross-Coupling of Aryl Halides with Formamide via Photoredox/Nickel Dual Catalysis.

A photocatalyst-tuned, Ni-catalyzed system enables switchable C-C or C-N coupling of aryl halides with formamide, directly synthesizing unprotected benzamides or -arylformamides. Selectivity is governed by PC/base pairs. Benzophenone/KHPO affords C-C-coupled benzamides, while thioxanthone TXO/NaHCO yields C-N-coupled -arylformamides.

NEK7-induced phosphorylation of EGFR on serine 1070 drives the acquired lenvatinib resistance in hepatocellular carcinoma.

Background And Aims: Lenvatinib is recognized as a first-line therapy for inoperable hepatocellular carcinoma (HCC) patients. Growing evidence indicates that lenvatinib resistance can be acquired in HCC cells via kinase rewiring.

Approach And Results: We established acquired lenvatinib-resistant organoids and HCC cell lines.

Short-Chain Carboxylic Acids Influencing Mineralization Mechanisms of Ferrihydrite Transformation to Hematite and Goethite.

Transformation of poorly ordered ferrihydrite (Fh) into crystalline phases controls nutrient and contaminant transport. This process is strongly influenced by organic compounds; however, the mechanism remains unclear due to the structural complexity of organic compounds, particularly carboxylic density. We selected well-defined short-chain organic acids (OAc), i.

A knowledge-based clinical decision support system for personalized health examination items in China: design and evaluation.

Background: Health examination identifies risk factors and diseases at an early stage through a series of health examination items. In China, however, the incidence of consulting services for health examination items is low and the current health examination item package is insufficiently personalized. Therefore, we created and evaluated a clinical decision support system (CDSS) for personalized health examination items.

Microtubule associated serine/threonine kinase-3 inhibits the malignant phenotype of breast cancer by promoting phosphorylation-mediated ubiquitination degradation of yes-associated protein.

Background: Microtubule associated series/threonine kinase-3 (MAST3) is a member of microtubule associated serine/threonine kinase family (MAST1-4, MAST-like), and the expression and underlying molecular mechanism of MAST3 in human tumors, including breast cancer, is not yet elucidated.

Methods: We employed immunohistochemistry to assess the significant expression of MAST3 in breast cancer tissue samples. Additionally, we utilized an overexpression vector and shRNA to bi-directionally regulate MAST3 expression, aiming to observe the impact of MAST3 on the proliferation, migration, and invasion capabilities of breast cancer cells.

Efficient detection of SARS-CoV-2 IgG by a smartphone-based high-throughput fiber optic sensor.

The World Health Organization has indicated that Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2) is likely to persist for an extended period, with the potential emergence of new mutated strains. To effectively control the spread of the virus, there is an urgent need for simple, rapid, and reliable assays to identify SARS-CoV-2 infections, particularly in community hospitals or clinical centers. This study introduces a smartphone-based high-throughput fiber-optic immunosensor (HFIS) for rapid SARS-CoV-2 IgG detection.

Exploring the Dynamics of Dietary Self-Monitoring Adherence Among Participants in a Digital Behavioral Weight Loss Program: Model Development Study.

Background: Self-monitoring of dietary behaviors is typically a central component of behavioral weight loss programs, and it is widely recognized for its effectiveness in promoting healthy behavior changes and improving health outcomes. However, understanding the adherence dynamics of self-monitoring of dietary behaviors remains a challenge.

Objective: We aimed to develop a prognostic model for adherence to self-monitoring of dietary behaviors using the Adaptive Control of Thought-Rational (ACT-R) cognitive architecture and to qualitatively investigate adherence dynamics and the impact of various interventions through model-based analyses.

Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype.

Background: Colorectal cancer (CRC) frequently metastasizes to the liver, worsening patient outcomes. The formation of a pre-metastatic niche (PMN) is essential for this process, but how the primary colon tumor orchestrates the PMN formation remains unclear.

Methods: This study investigated the role of CRC-derived exosomes using CT-26 murine colon carcinoma cells.

Tailoring pore size to enhance dissolution of layered double oxides for efficient nitrogen and phosphorus recovery via crystallization of struvite from wastewater.

Nitrogen and phosphorus recovery from wastewater to produce struvite fertilizer can simultaneously alleviate water eutrophication and phosphorus scarcity. Coupled magnesium mineral dissolution and reprecipitation has been emphasized for struvite formation by avoiding excessive Mg salts addition and pH adjustment. However, the recovery efficiency is limited by the low solubility of magnesium mineral.

A systematic review of reported symptomatic Elizabethkingia infection cases in children and adults.

Background: Elizabethkingia infections are caused by the species Elizabethkingia, which recently has become important as a cause of serious infection among neonates and immunocompromised adults. The systematic review summarized clinical data on symptomatic infections caused by Elizabethkingia, including species identification, patient outcomes, and therapeutic approaches.

Methods: The PRISMA guidelines were followed in conducting the systematic review.

Short-term starvation boosts anti-PD-L1 therapy by reshaping tumor-associated macrophages in hepatocellular carcinoma.

Background And Aims: Immune checkpoint inhibitors have revolutionized systemic HCC treatment. Nevertheless, numerous patients are refractory to immune checkpoint inhibitor therapy. It is currently unknown whether diet therapies such as short-term starvation (STS) combined with immune checkpoint inhibitors can be used to treat HCC.

Accessing Azetidines through Magnesium-Mediated Nitrogen Group Transfer from Iminoiodinane to Donor-Acceptor Cyclopropanes.

Herein, we report a Lewis acid-mediated ring expansion of donor-acceptor cyclopropanes (DACs) to substituted azetidines via nucleophilic nitrogen group transfer from readily accessible iminoiodinane. This protocol operates under mild, transition-metal-free conditions, and showcases excellent chemoselectivity, along with broad functional group tolerance. We report for the first time that challenging alkyl donor-acceptor cyclopropanes can undergo ring expansion leading to aliphatic azetidines without relying on external oxidants or precious transition-metal catalysts.

Synthesis and antitumor effects of novel betulinic acid derivatives bearing electrophilic moieties.

Betulinic acid (BA) is a kind of naturally occurring lupane pentacyclic triterpenoid, possessing various biological activities including antiviral, anti-inflammatory and antitumor activity. Covalent inhibitors, characterized by electrophilic warheads that form covalent bonds with specific amino acid residues of target proteins, have garnered enormous attention in anticancer agent discovery over the past decade owing to their exceptional selectivity and efficacy. In this study, BA was structurally modified with electrophilic groups, and 23 derivatives of BA were synthesized.

CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression.

RETREG1/FAM134B is known for its role as a reticulophagy receptor. Our previous study established that RETREG1 is upregulated in hepatocellular carcinoma (HCC) and contributes to disease progression by activating the AKT signaling pathway. However, the specific mechanisms underlying the elevated expression of RETREG1 in HCC remain unclear.

Utilization of Immune Checkpoint Inhibitors in Human Epidermal Growth Factor Receptor 2-Negative, Advanced Metastatic, or Unresectable Gastric Cancer Under All Combined Positive Score Grading: Evaluation of Efficacy Based on Individual Patient Data Reconstruction and Secondary Analyses.

Purpose: The efficacy of several novel combinations of anti-programmed cell death protein 1 or its ligand antibodies with chemotherapy, which have become the new standard first-line combination therapy with favorable outcomes, was still not certain in patients with different combined positive score (CPS) grades. This research aimed to evaluate the efficacy of immune checkpoint inhibitor immunotherapy or immunochemotherapy at different CPS grades, compared with chemotherapy.

Methods: Kaplan-Meier (KM) curve reconstruction was employed to assess the overall survival (OS) and progression-free survival (PFS) of patients with gastric cancer.

Integrating spatial-temporal features into prediction tasks: A novel method for identifying the potential water pollution area in large river basins.

Forecasting potential water pollution areas (PWPA) is essential for effective watershed management. However, there remains a limited understanding of the spatial-temporal features that influence water quality (WQ), and advanced technical methods for WQ forecasting. This study developed an integrated framework utilizing spatial-temporal graph convolution networks (STGCN) to enhance comprehension of the spatial-temporal features influencing WQ and to develop a practical module for integrating features into the WQ prediction.

Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma.

Onecut2 (OC2) plays a vital regulatory role in tumor growth, metastasis and angiogenesis. In this study, we report the regulatory role and specific molecular mechanism of OC2 in the apoptosis of hepatocellular carcinoma (HCC) cells. We found that OC2 knockout via the CRISPR/CAS9 system not only significantly inhibited the proliferation and angiogenesis of HCC cells but also significantly promoted apoptosis.

Effects of Virtual Reality Therapy for Patients With Breast Cancer During Chemotherapy: Randomized Controlled Trial.

Background: Patients with breast cancer endure high levels of psychological and physical pain. Virtual reality (VR) may be an acceptable, safe intervention to alleviate the negative emotions and pain of patients with cancer.

Objective: We aimed to test the long-term effects of VR on psychological distress and quality of life (QOL) with traditional care in Chinese patients with breast cancer.

Genome-Wide Identification and Characterization of Gene Family in C Crops.

In plants, RopGEF-mediated ROP signaling is pivotal in cellular signaling pathways, including apical growth, pollen germination and perception, intercellular recognition, as well as in responses to biotic and abiotic stresses. In this study, we retrieved a total of 37 RopGEF members from three C Crops, of which 11 are from millet, 11 from sorghum, and 15 from maize. Based on their phylogenetic relationships and structural characteristics, all RopGEF members are classified into four subfamilies.

Comparison of a Supervised Home-Based Tele-Rehabilitation with Center-Based Pulmonary Rehabilitation: Protocol for a Randomized Non-Inferiority Multicenter Study in Ningxia.

Background: Pulmonary rehabilitation (PR) is an effective intervention for people with chronic obstructive pulmonary disease (COPD). However, fewer than 5% of eligible individuals receive pulmonary rehabilitation, largely due to limited by the accessibility of rehabilitation and difficulties associated with travel and transport. Supervised home-based tele-rehabilitation (SHTR) is an alternative model to center-based pulmonary rehabilitation.