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Background: Pulmonary rehabilitation (PR) is an effective intervention for people with chronic obstructive pulmonary disease (COPD). However, fewer than 5% of eligible individuals receive pulmonary rehabilitation, largely due to limited by the accessibility of rehabilitation and difficulties associated with travel and transport. Supervised home-based tele-rehabilitation (SHTR) is an alternative model to center-based pulmonary rehabilitation. We will determine whether supervised home-based tele-rehabilitation is non-inferior to center-based pulmonary rehabilitation.
Methods: The participants will undergo an 8-week rehabilitation program. Pulmonary rehabilitation comprises four main modules: exercise training, education, nutritional support, and psychological and behavioral interventions. We mainly focus on the module of exercise training and education. The education module includes information on exercise training, nutrition, and psychology, which are presented in an educational booklet provided to each participant. Blinded assessors will evaluate the outcomes at baseline, post-intervention, and 6 months after the intervention. The primary outcome is the change in the 6-minute walking distance. Secondary outcomes will assess changes in the patients' 1-minute sit-to-stand test, maximal inspiratory pressure (MIP), scales (CAT, mMRC, HAD), diaphragm ultrasound (TD, DE, DIF), changes in extrathoracic muscle volume and mass, completion rate of patient exercise prescriptions, occurrence of adverse events, as well as disease exacerbation and rehospitalization rates after rehabilitation and during the 6-month follow-up.
Discussion: In order to improve the accessibility of pulmonary rehabilitation and patient-related outcomes, it is necessary to propose an alternative model of pulmonary rehabilitation. This trial will establish whether a supervised home-based tele-rehabilitation is not inferior to traditional center-based pulmonary rehabilitation.
Trial Registration: Chinese Clinical Trial Registry ChiCTR2300076969. Registered on October 25, 2023.
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http://dx.doi.org/10.2147/COPD.S467945 | DOI Listing |
Dermatol Ther (Heidelb)
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Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, 40138, Bologna, Bologna, Italy.
Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have gained prominence for their efficacy in treating type 2 diabetes and obesity. Recent evidence suggests that their pleiotropic effects-beyond glycemic control and weight loss-include anti-inflammatory, immunomodulatory, and antioxidative effects, which may beneficially support various dermatologic conditions such as psoriasis, hidradenitis suppurativa, acanthosis nigricans, and Hailey-Hailey disease. However, GLP-1 RAs are also associated with emerging cutaneous adverse drug reactions, including bullous, exanthematous and vasculitic manifestations, and other rare side effects.
View Article and Find Full Text PDFJ Neurooncol
September 2025
Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Purpose: Frailty measures are critical for predicting outcomes in metastatic spine disease (MSD) patients. This study aimed to evaluate frailty measures throughout the disease process.
Methods: This retrospective analysis measured frailty in MSD patients at multiple time points using a modified Metastatic Spinal Tumor Frailty Index (MSTFI).
Monaldi Arch Chest Dis
September 2025
Department of Chest Disease, Istanbul Faculty of Medicine, Istanbul University.
Assessment of exercise capacity is useful in monitoring patients and planning a rehabilitation program for subjects with pulmonary hypertension (PH). No study has investigated the relationship of different field tests, except for the six-minute walk test (6MWT), with balance, activities of daily living (ADL), and quality of life (QoL) in subjects with PH. This study aimed to investigate the relationship of different field tests with balance, ADL, and QoL in subjects with PH.
View Article and Find Full Text PDFCureus
August 2025
Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JPN.
Cerebral infarction is a rare but serious complication after pulmonary resection for lung cancer. A 78-year-old man with hypertension and diabetes underwent video-assisted thoracoscopic right middle lobectomy for stage IA2 adenocarcinoma. On postoperative day 1, he developed acute right hemiparesis and motor aphasia.
View Article and Find Full Text PDFJ Paediatr Child Health
September 2025
Department of Rehabilitation Medicine, University of Occupational and Environmental Health, Kitakyushu, Yahatanishi-ku, Japan.
Aim: This study aimed to investigate the implementation rate and timing of pulmonary physical rehabilitation for very low-birth-weight infants (VLBWI) with respiratory distress syndrome (VLBWIs with RDS) in Japan and clarify the current status and challenges of this intervention.
Methods: This observational study analysed nationwide administrative data associated with the diagnostic procedure combination system in Japan (2014-2019 fiscal year). A total of 16 429 VLBWIs with RDS were included.