Esophageal stenting and endoscopic vacuum therapy for esophageal defects: a systematic review and meta-analysis of observational studies.

Background: Spontaneous esophageal perforation, especially Boerhaave syndrome, carries high morbidity and mortality. Minimally invasive treatments like esophageal stenting and endoscopic vacuum therapy (EVT) are increasingly used, but optimal management remains unclear.

Objective: This systematic review and meta-analysis evaluates the efficacy and safety of esophageal stenting and EVT in managing esophageal defects by assessing sealing rates, failure rates, and mortality.

Nanomagnesium promotes moso bamboo tolerance to cadmium toxicity: insights from photosynthesis phenomics, oxidative metabolism, and cellular adjustments.

Cadmium (Cd) stress severely hampers plant growth in forest ecosystems. Although magnesium oxide nanoparticles (MgONPs) are known to reduce Cd toxicity in numerous plant species, their detoxification mechanisms in Moso bamboo () remain unexplored. The present study investigates how MgONPs mitigate the Cd-induced phytotoxic effects in by examining morpho-physiological and cellular oxidative repair mechanisms.

In silico characterization, physiochemical analysis, and antifungal evaluation of the Zea mays PR-1 protein.

Pathogenesis-related protein 1 (PR-1) is a critical component of plant defense mechanisms, exhibiting significant antifungal activity. This study focused on the PR-1 protein from Zea mays and five other plant species (Triticum aestivum, Hordeum vulgare, Oryza sativa, Avena sativa, and Secale cereale) to explore their physicochemical, structural, and functional characteristics. The PR-1 gene from Z.

High-performance PVC/polyacrylate-graphene oxide membranes for Pb (II) and Hg (II) ion removal from polluted water: synthesis, characterization, and adsorption studies.

Heavy metals cause significant harm to both flora and fauna. Hence, it is mandatory to efficaciously eliminate them from drinking water preceding their release into the ecosystem. Herein, we first prepared Na-polyacrylate (PA) powder from sim-sim balls and graphene oxide (GO) using sugar cane bagasse as an adsorptive material.

"Complication without context? Rethinking outcome attribution in pediatric oncologic surgery".

Jain et al. explored associations between surgical complications and survival in pediatric solid tumors, concluding that higher Clavien-Dindo grades are linked to recurrence and mortality. While the study offers timely insights into perioperative risk, critical methodological limitations-including lack of multivariate adjustment, cohort heterogeneity, imprecise blood loss estimation, and omission of ERAS protocols-undermine causal interpretations.

Evaluating pesticide-induced toxicity in Cyprinus carpio using hemato-biochemical biomarkers.

The increasing use of pesticides threatens aquatic ecosystems. This study evaluated the toxic effects of carbosulfan, pyriproxyfen, thiamethoxam, and their mixture on the hemato-biochemical profile of Cyprinus carpio over a 30-day exposure period. The 96 h LC values, determined via probit analysis, were 5.

Coagulation activity of chitin binding protein from garden candytuft seeds in water treatment.

In densely populated developing countries, water is limited, thus reservoirs are used and turbidity of the water rises during raining seasons. Because of this, a wide variety of chemical coagulants are required that raises the expense of treatment. The present research emphasizes mainly on using a plant-derived component as a natural coagulant and making ensure its supply is environmentally friendly and sustainable.

Critique of cardiac rehabilitation progress and in-hospital outcomes following mitral transcatheter edge-to-edge repair: a call for comprehensive assessment and long-term follow-up.

Hori et al. (2025) present a valuable contribution to the growing body of literature on cardiac rehabilitation (CR) following mitral transcatheter edge-to-edge repair (M-TEER). Their study highlights the importance of early rehabilitation progress during hospitalization, but raises several concerns regarding its comprehensiveness and generalizability.

Reappraising machine learning models for vascular calcification in CKD: methodological concerns and clinical gaps.

Lin et al. (Int Urol Nephrol, 2025) contribute to the literature on abdominal aortic calcification (AAC) in chronic kidney disease (CKD) using interpretable machine learning. However, several limitations hinder its clinical applicability.

Cloning and Expression Studies of Osmotin-Like Protein Gene from Solanum nigrum in Escherichia coli.

Plants face various biotic and abiotic stresses, necessitating the activation of defense mechanisms, including pathogenesis-related (PR) proteins. Osmotin-like proteins (OLPs), belonging to the PR-5 family, play a crucial role in plant defense by enhancing resistance to pathogens and environmental stresses. However, the functional characterization of OLPs remains limited.

"Beyond Glucose Control: A Critical Appraisal of Virtual vs. In-Person Care for Gestational Diabetes".

the article by Dolatabadi et al. offers timely insights into the use of virtual care in managing gestational diabetes mellitus (GDM), but several critical limitations temper the strength and applicability of its conclusions. This Letter to the Editor outlines concerns regarding the study's retrospective design, its omission of patient-reported and adherence-related outcomes, and its limited generalizability.

Broadening the Scope: Enhancing Caregiver Research in Christianson Syndrome Through Diversity and In-Depth Exploration.

The article by St. Pierre et al provides valuable insights into the challenges faced by caregivers of individuals with Christianson syndrome (CS), focusing on emotional burden, symptom progression, and coping strategies. However, several key areas require further exploration.

Missing the beat: Unaddressed dimensions in the electrocardiographic evaluation of Duchenne muscular dystrophy.

The recent study by Krishnamurthy et al. explores electrocardiographic (ECG) patterns in Duchenne muscular dystrophy (DMD), a timely topic in cardiomyopathy surveillance. However, the study omits crucial aspects that could enhance clinical relevance: early ECG deviations in young asymptomatic patients, genotype-informed risk stratification, integration with imaging modalities, and implications for patient monitoring protocols.

Between precision and prudence: reappraising robotic resection for thoracic apex tumors.

In response to the article by Fukui et al. on robotic-assisted thoracic surgery (RATS) for neurogenic tumors at the thoracic apex, we offer a critical appraisal emphasizing the risks and overlooked safeguards associated with this approach. While this study highlights the feasibility of preoperative imaging in surgical selection, it reports notably high rates of postoperative neurological complications, including persistent deficits.

Classification of possible solutions regarding business engineering problems by using complex Pythagorean fuzzy rough WASPAS approach.

Business engineering creates novel business solutions using a social and technological system. Business engineering is facing several challenges like (1) complexity management (2) rapid technological advancements (3) Resource constraints (4) Interdisciplinary collaboration etc., and there is a need to classify the solutions for these issues faced by the business community.

Unpacking the gender divide: a critical examination of sex disparities in chronic heart failure.

Sex-based disparities in chronic heart failure (CHF) extend beyond clinical outcomes, encompassing psychological burden, self-care behaviors, and quality of life. In response to Sawatari and Niitani's recent findings, we critically examine underlying mechanisms and systemic contributors to these disparities. Drawing on evidence from psychocardiology, multimorbidity research, and sex-specific heart failure phenotypes, we argue that future investigations must adopt a biopsychosocial framework.