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http://dx.doi.org/10.1016/j.avsg.2025.05.031 | DOI Listing |
Clin Orthop Relat Res
September 2025
Leni & Peter W. May Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Peripheral nerve injury commonly results in pain and long-term disability for patients. Recovery after in-continuity stretch or crush injury remains inherently unpredictable. However, surgical intervention yields the most favorable outcomes when performed shortly after injury.
View Article and Find Full Text PDFBackground And Aims: Dental caries in children remains a global health challenge. Fissure sealant therapy (FST) is an effective preventive measure, yet parental acceptance remains low. This study aimed to identify predictors of parental FST behavior for children aged 6-12 years in Bandar Abbas, Iran, using the health belief model (HBM).
View Article and Find Full Text PDFJ Rehabil Med Clin Commun
September 2025
Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, BG Trauma Center Tuebingen, Tuebingen, Germany.
Objective: Acetabular fractures are among the most severe injuries in trauma surgery. In younger patients, they typically result from high-energy trauma and are often associated with polytrauma. Treatment complexity and rehabilitation outcomes are influenced by overall injury severity.
View Article and Find Full Text PDFNat Chem Biol
September 2025
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Many pharmaceutical targets partition into biomolecular condensates, whose microenvironments can significantly influence drug distribution. Nevertheless, it is unclear how drug design principles should adjust for these targets to optimize target engagement. To address this question, we systematically investigated how condensate microenvironments influence drug-targeting efficiency.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, United States of America.
Research into the mechanisms underlying neuromodulation by tES using in-vivo animal models is key to overcoming experimental limitations in humans and essential to building a detailed understanding of the in-vivo consequences of tES. Insights from such animal models are needed to develop targeted and effective therapeutic applications of non-invasive brain stimulation in humans. The sheer difference in scale and geometry between animal models and the human brain contributes to the complexity of designing and interpreting animal studies.
View Article and Find Full Text PDF