Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Lin et al. (Int Urol Nephrol, 2025) contribute to the literature on abdominal aortic calcification (AAC) in chronic kidney disease (CKD) using interpretable machine learning. However, several limitations hinder its clinical applicability. The cross-sectional design restricts causal inference, while the lack of external validation limits generalizability. Critical confounders such as pharmacologic interventions and lifestyle factors are omitted, risking bias in the model. In addition, treating CKD as a binary variable oversimplifies its complexity. Despite the promising use of SHAP analysis, the study lacks clinical translation for actionable risk stratification and personalized treatment. Future research should address these gaps to enhance the model's clinical utility.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-025-04597-wDOI Listing

Publication Analysis

Top Keywords

machine learning
8
reappraising machine
4
learning models
4
models vascular
4
vascular calcification
4
calcification ckd
4
ckd methodological
4
methodological concerns
4
clinical
4
concerns clinical
4

Similar Publications

Background: Circumcision is a widely practiced procedure with cultural and medical significance. However, certain penile abnormalities-such as hypospadias or webbed penis-may contraindicate the procedure and require specialized care. In low-resource settings, limited access to pediatric urologists often leads to missed or delayed diagnoses.

View Article and Find Full Text PDF

The calculation of the highest occupied molecular orbital-lowest unoccupied molecular orbital (HOMO-LUMO) gap for chemical molecules is computationally intensive using quantum mechanics (QM) methods, while experimental determination is often costly and time-consuming. Machine Learning (ML) offers a cost-effective and rapid alternative, enabling efficient predictions of HOMO-LUMO gap values across large data sets without the need for extensive QM computations or experiments. ML models facilitate the screening of diverse molecules, providing valuable insights into complex chemical spaces and integrating seamlessly into high-throughput workflows to prioritize candidates for experimental validation.

View Article and Find Full Text PDF

Purpose: To develop and validate a multimodal deep-learning model for predicting postoperative vault height and selecting implantable collamer lens (ICL) sizes using Anterior Segment Optical Coherence Tomography (AS-OCT) and Ultrasound Biomicroscope (UBM) images combined with clinical features.

Setting: West China Hospital of Sichuan University, China.

Design: Deep-learning study.

View Article and Find Full Text PDF

Predicting Unplanned Readmission Risk in Patients With Cirrhosis: Complication-Aware Dynamic Classifier Selection Approach.

JMIR Med Inform

September 2025

College of Medical Informatics, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China, 86 13500303273.

Background: Cirrhosis is a leading cause of noncancer deaths in gastrointestinal diseases, resulting in high hospitalization and readmission rates. Early identification of high-risk patients is vital for proactive interventions and improving health care outcomes. However, the quality and integrity of real-world electronic health records (EHRs) limit their utility in developing risk assessment tools.

View Article and Find Full Text PDF

Diagnostic and Screening AI Tools in Brazil's Resource-Limited Settings: Systematic Review.

JMIR AI

September 2025

Faculty of Medicine, Universidade Federal de Alagoas, Av. Lourival Melo Mota, S/n - Tabuleiro do Martins, Maceió, 57072-900, Brazil, 558232141461.

Background: Artificial intelligence (AI) has the potential to transform global health care, with extensive application in Brazil, particularly for diagnosis and screening.

Objective: This study aimed to conduct a systematic review to understand AI applications in Brazilian health care, especially focusing on the resource-constrained environments.

Methods: A systematic review was performed.

View Article and Find Full Text PDF