Uterine Reaction to Oxytocin and Maternal-Neonatal Outcomes in Inducing Labor: A Retrospective Cohort Study.

Background: Previous studies did not investigate the effect of gradually increasing the concentration of low-dose oxytocin on mother and newborn outcomes. The purpose of this study was to look at the relationship between oxytocin responsiveness and outcomes for both mothers and newborns during labor induction.

Methods: This retrospective cohort study was conducted at Nantong Maternal and Child Health Hospital, and participants were divided into the early reaction to oxytocin group and the later reaction to oxytocin group based on oxytocin response.

Tumor Deposits in Locally Advanced Esophageal Cancer: Redefining TNM Staging and Prognostic Implications after Surgical Resection.

Background: Tumor deposits (TDs), also known as cancer nodules, were initially identified in colorectal adenocarcinoma and are defined as localized accumulations of tumor cells within the peritumoral adipose tissue. Subsequently, similar tumor nodules have also been observed in esophageal cancer(ESCA). Although evidence suggests a correlation between TDs and poor prognosis in ESCA, their qualitative, staging, and prognostic implications remain contentious.

Biocompatible Pickering Emulsions from Byproducts for Promoting Burn Wound Healing.

Biological dressings have emerged as a promising approach for effective wound treatment. However, despite extensive research, the fabrication of biomass-based dressings with antioxidant and anti-inflammatory properties, as well as high biocompatibility, remains a challenge. In this study, the byproducts of as raw materials were used to prepare a biomass-based Pickering emulsion.

Enhanced exogenous RNAi by loop-ended double-stranded RNA in plants.

Exogenous RNA interference (exoRNAi) has emerged as a promising tool for gene silencing in plants, yet a robust and efficient exoRNAi technology remains elusive. Here we evaluated a Loop-ended dsRNA (ledRNA) design for enhancing exoRNAi efficacy. ledRNA has a dumbbell-like structure, consisting of a long dsRNA stem flanked by single-stranded loops, with a nick site at the dsRNA stem.

Application of a dual-loop double-stranded RNA to control small brown planthopper.

RNA interference, induced by double-stranded RNA (dsRNA), has emerged as a biopesticide for pest control. However, the stability of dsRNA remains a challenge in topical delivery, preventing widespread agricultural application. Here, we tested a dsRNA variant, called loop-ended dsRNA or LedRNA, for controlling a notorious vector insect, the small brown planthopper (SBPH).

Association Between Sulfur Microbial Diet With All-Cause, Cardiovascular Disease, and Cancer Mortality: A Population-Based Cohort Study.

This study aimed to determine the associations between sulfur microbial diet (SMD) and all-cause, cardiovascular disease, and cancer mortality. A total of 91 891 adults were included from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. To evaluate adherence to this dietary pattern, the SMD score was calculated with higher scores indicating greater compliance.

Adaptive signal recognition in mines based on deep learning.

To address the challenges of low recognition accuracy and high system complexity arising from the coexistence of multiple wireless communication technologies and severe signal interference in the complex wireless environment of coal mines, this paper proposes a deep learning-based adaptive signal recognition method. By incorporating grouped residual convolution and channel shuffling techniques, the proposed method significantly reduces the number of model parameters (37% fewer than the original WaveNet) while utilizing dilated causal convolution to capture long-range dependencies in the signal, thereby enhancing the model's ability to discriminate multipath interference features. The introduction of a dynamic channel attention mechanism facilitates adaptive adjustment of feature weights, emphasizing key features while suppressing noise interference, thereby improving recognition accuracy.

Clinical efficacy and safety of sintilimab injection plus chemotherapy in patients with stage IB-IIIB non-small cell lung cancer.

Objective: To investigate the clinical efficacy of sintilimab injection and chemotherapy as neoadjuvant therapy for stage IB-IIIB non-small cell lung cancer(NSCLC), and evaluate its clinical safety.

Methods: A retrospective analysis was conducted on the clinical data of patients with stage IB-IIIB NSCLC who underwent neoadjuvant treatment before surgery at Affiliated Hospital of Hebei University, between June 2021 to August 2023. Eighty patients were divided into an observation group(n = 40) and a control group(n = 40) according to their treatment regimens.

The Double-Stranded RNA Binding Proteins DRB1 and DRB2 Are Required for miR160-Mediated Responses to Exogenous Auxin.

DOUBLE-STRANDED RNA BINDING (DRB) proteins DRB1, DRB2, and DRB4 are essential for microRNA (miRNA) production in () with miR160, and its target genes, (), , and , forming an auxin responsive miRNA expression module crucial for root development. : Wild-type plants (Columbia-0 (Col-0)) and the , , and mutants were treated with the synthetic auxin 2,4-dichlorophenoxyacetic acid (2,4-D), and the miR160-mediated response of these four lines was phenotypically and molecularly characterized. : In 2,4-D-treated Col-0, and plants, altered miR160 abundance and , , and gene expression were associated with altered root system development.

LncRNA U731166 Increases the Accumulation of TGFBR1 by Sponging miR-3607-3p in Esophageal Squamous-Cell Carcinomas (ESCC) to Promote Tumor Metastasis.

Background: Long non-coding RNA (lncRNA) U731166 and microRNA (miR)-3607-3p are two ncRNAs with critical roles in cancer biology, while their involvement in esophageal squamous-cell carcinomas (ESCC) is unclear. We predicted that U731166 and miR-3607-3p might interact with each other. This study aimed to investigate their role and interaction in ESCC.

Molecular Manipulation of the miR160/ Expression Module Impacts Root Development in .

In (), microRNA160 (miR160) regulates the expression of (), and throughout development, including the development of the root system. We have previously shown that in addition to DOUBLE-STRANDED RNA BINDING1 (DRB1), DRB2 is also involved in controlling the rate of production of specific miRNA cohorts in the tissues where is expressed in wild-type plants. In this study, a miR160 overexpression transgene () and miR160-resistant transgene versions of and ( and ) were introduced into wild-type plants and the and single mutants to determine the degree of requirement of DRB2 to regulate the miR160 expression module as part of root development.

Relationship between maternal postpartum depression, fatigue, sleep quality and infant growth: A cross-sectional study.

Background: Current research separately analyzed the connection between postpartum depression, fatigue, sleep and infant development. However, depression, fatigue and sleep quality often coexisted as adverse symptoms in postpartum women and influenced infant development together. This study explored the maternal postpartum symptoms on infant growth.

A retrospective analysis of lymph node dissection in Siewert II adenocarcinoma of the esophagogastric junction.

Background: Analyze the pattern of lymph node metastasis in Siewert II adenocarcinoma of the esophagogastric junction (AEG) and provide a basis for the principles of surgical access.

Methods: The clinical data of 112 Siewert type II AEG patients admitted to the Fifth Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University from 2020 to 2022 were retrospectively collected. The probability of lymph node metastasis in each site and the clearance rate of lymph nodes in each site by different surgical approaches were analyzed.

Prenatal endocrine-disrupting chemicals exposure and impact on offspring neurodevelopment: A systematic review and meta-analysis.

Purpose: Considering that endocrine disruptors have certain effects on fetal growth, we conducted a systematic review of epidemiological literature to elucidate the correlation between exposure to endocrine-disrupting chemicals during pregnancy and the neurodevelopment of offspring.

Method: We systematically explored PubMed, Web of Science, and CINAHL databases from inception to April 4, 2023. References from pertinent studies were reviewed, and data regarding the link between maternal prenatal EDC exposure and offspring neurological development were compiled.

The complex association between the immune system and the skeletal system in osteoporosis: A study of single-cell RNA sequencing.

Objective: Osteoporosis (OP) is a disease characterized by decreased bone mass, deteriorated microstructure, and increased fragility and fracture risk. The diagnosis and prevention of OP and its complications have become major public health challenges. Therefore, exploring the complex ecological connections between the immune and skeletal systems may provide new insights for clinical prevention and treatment strategies.

Asymmetric bulges within hairpin RNA transgenes influence small RNA size, secondary siRNA production and viral defence.

Small RNAs (sRNAs) are essential for normal plant development and range in size classes of 21-24 nucleotides. The 22nt small interfering RNAs (siRNAs) and miRNAs are processed by Dicer-like 2 (DCL2) and DCL1 respectively and can initiate secondary siRNA production from the target transcript. 22nt siRNAs are under-represented due to competition between DCL2 and DCL4, while only a small number of 22nt miRNAs exist.

Survival outcomes of neoadjuvant immunochemotherapy versus chemotherapy for locally advanced esophageal squamous cell carcinoma.

Purpose: Neoadjuvant chemotherapy (NCT) is the standard preoperative treatment for resectable locally advanced esophageal squamous cell carcinoma (ESCC). Some studies reported neoadjuvant immunochemotherapy (NICT) could improve pathological response with manageable safety. However, few studies have compared the efficacy and safety of NICT and NCT, especially survival outcomes.

Oblique conformal anastomosis decreased the risks of cervical anastomotic leakage after totally minimally invasive esophagectomy.

Objective: To investigate the effectiveness of the original oblique conformal anastomosis presented in this research in reducing the incidence of cervical anastomotic leak after performing totally minimally invasive esophagectomy (TMIE).

Methods: The esophagus and stomach of 27 fresh pigs, termed the esophagogastric model, were used to simulate human esophagogastric organs for this study's in vitro experimental objectives. Nine esophagogastric models of similar weight were divided into three groups.

SQLE is a promising prognostic and immunological biomarker and correlated with immune Infiltration in Sarcoma.

Squalene epoxidase (SQLE) is an essential enzyme involved in cholesterol biosynthesis. However, its role in sarcoma and its correlation with immune infiltration remains unclear. All original data were downloaded from The Cancer Genome Atlas (TCGA).

Using molecular characteristics to distinguish multiple primary lung cancers and intrapulmonary metastases.

Objectives: Multiple lung cancers may present as multiple primary lung cancers (MPLC) or intrapulmonary metastasis (IPM) with variations in clinical stage, treatment, and prognosis. However, the existing differentiation criteria based on histology do not fully meet the clinical needs. Next-generation sequencing (NGS) may play an important role in assisting the identification of different pathologies.

Synergistic antibacterial mechanism of silver-copper bimetallic nanoparticles.

The excessive use of antibiotics in clinical settings has resulted in the rapid expansion, evolution, and development of bacterial and microorganism resistance. It causes a significant challenge to the medical community. Therefore, it is important to develop new antibacterial materials that could replace traditional antibiotics.

A versatile LTF-GO/gel hydrogel with antibacterial and antioxidative attributes for skin wound healing.

Skin wound healing will become a pressing and difficult problem following injury to the skin structure. Persistent wounds, in particular, become more vulnerable to bacterial infections, which can contribute to persistent skin inflammation. Therefore, it is critical to create a wound dressing that promotes wound healing while also being antimicrobial.

Umbilical artery cord blood glucose predicted hypoglycemia in gestational diabetes mellitus and other at-risk newborns.

Background: To explore the value of umbilical artery cord blood glucose (UACBG) in predicting hypoglycemia in gestational diabetes mellitus (GDM) and other at-risk newborns, and to provide a cut-off UACBG value for predicting hypoglycemia occurrence.

Methods: In this prospective study, we enrolled at-risk infants delivered vaginally, including neonates born to mothers with GDM, premature, macrosomic, and low birth weight. We separated the infants into GDM group and other at-risk group.