Electroacupuncture suppresses motor impairments via microbiota-metabolized LPS/NLRP3 signaling in 6-OHDA induced Parkinson's disease rats.

Emerging evidence indicates that electroacupuncture (EA) exerts significant therapeutic effects on Parkinson's disease (PD)-related symptoms, with the immune mechanisms of the gut-brain axis playing a pivotal role in PD pathophysiology. This study aimed to explore whether EA mitigated PD-related symptoms and conferred neuroprotection to dopaminergic neurons in a 6-hydroxydopamine (6-OHDA) rat model by modulating the microbiota-metabolized lipopolysaccharide (LPS)/NLRP3 pathway. EA treatment ameliorated motor and anxiety symptoms in 6-OHDA rats and elevated the levels of TH.

Chromosome-level genome assembly of Marco Polo Blister Beetle (Hycleus marcipoli).

Hycleus marcipoli is an agricultural pest that feeds on the flowers and leaves of leguminous plants, including Desmodium spp., as well as sweet potatoes. It exhibits hypermetamorphic development-an exceptionally complex life cycle shared by the genus and subfamily.

Comparative Analysis of Codon Usage Bias in Transcriptomes of Eight Species of Formicidae.

Ants are among the most widely distributed eusocial insects, and desert ants, in particular, serve as important model organisms for studying animal navigation. : In this study, we provide high-quality de novo transcriptomes for eight ant species: (Nylander, 1849), Wheeler, 1933, Santschi, 1937, (Emery, 1901), Zhu, Wu, Duan & Xu, 2022, Wheeler, 1927, Wheeler, 1927, and Emery, 1925. : The GC content of coding sequences (CDSs) ranged from 43.

Evaluation of the safety and efficacy of manual removal and irrigation in cerumen removal in children.

ObjectiveTo analyze the safety and efficacy of manual removal and irrigation in cerumen removal in children.MethodsA case-control study that prospectively collected the data of 6-month to 18-year-old children who underwent cerumen removal in the outpatient Department of Children's Hospital of Chongqing Medical University.ResultsA total of 347 ears were analyzed.

Methyl isoeugenol suppresses NLRP3 inflammasome-mediated pyroptosis via activation of Nrf2/NQO1/HO-1 signaling in cerebral ischemia-reperfusion injury.

Microglial neuroinflammation is considered to be a vital injury factor aggravating ischemia-reperfusion (I/R) injury on the progression of cerebral ischemic stroke. Mounting evidences have verified the effect of pyroptosis mediated by NLRP3 inflammasome on modulating microglial phenotype, and maintaining the microglial M1/M2 phenotype balance could be a novel target to ameliorate cerebral I/R injury. Herein, we focused on the anti-neuroinflammatory effect of methyl isoeugenol, a bioactive compound isolated from Acorus tatarinowii Schott, on nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated NLRP3 inflammasome in vivo or in vitro.

Buyang Huanwu Decoction prevents hemorrhagic transformation after delayed t-PA infusion via inhibiting NLRP3 inflammasome/pyroptosis associated with microglial PGC-1α.

Ethnopharmacological Relevance: Delayed tissue-type plasminogen activator (t-PA) thrombolysis, which has a restrictive therapeutic time window within 4.5 h following ischemic stroke (IS), increases the risk of hemorrhagic transformation (HT) and subsequent neurotoxicity. Studies have shown that the NLRP3 inflammasome activation reversely regulated by the PGC-1α leads to microglial polarization and pyroptosis to cause damage to nerve cells and the blood-brain barrier.

Prognostic Analysis of Patients with Primary Extranodal Lymphoma: A Retrospective Study.

Background: Originating from extranodal organs or tissues, primary extranodal lymphoma (PENL) acts in different primary sites with diverse clinical performances and PENL has remarkable geographical differences and lacks the relevant reports in each region.

Patients And Methods: Two hundred and twenty PENL patients were enrolled, and the relevant clinical and laboratory indicators were analyzed. In addition, statistical methods were applied to analyze the effects of different factors on overall survival (OS) and progression-free survival (PFS) of patients.

Rate Dependent Krasnoselskii-Pokrovskii Modeling and Inverse Compensation Control of Piezoceramic Actuated Stages.

The piezoceramic actuated stages have rate-dependent hysteresis nonlinearity, which is not simply related to the current and historical input, but also related to the frequency of the input signal, seriously affects its positioning accuracy. Consider the influence of frequency on hysteresis modeling, a rate-dependent hysteresis nonlinearity model that is based on Krasnoselskii-Pokrovskii (KP) operator is proposed in this paper. A hybrid optimization algorithm of improved particle swarm optimization and cuckoo search is employed in order to identify the density function of rate-dependent KP model, avoiding the blind search process caused by the high randomness of Levy's flight in the cuckoo search algorithm, and improving the parameter identification performance.

Adaptive fuzzy dynamic surface sliding mode control of large-scale power systems with prescribe output tracking performance.

This paper focuses on an adaptive fuzzy based dynamic surface sliding mode control (ADSSMC) strategy for multi-machine power systems with SVC. The main characteristics of the proposed ADSSMC strategy are: (1) System robustness and the convergency speed of all surface error are enhanced by combining dynamic surface control with sliding mode, leading to the structural complexity of the controller in backstepping control scheme is eliminated; (2) By introducing an error performance conversion function, the errors of desired trajectory and system output are always within a predetermined range; (3) In the adaptive regulation laws, the number of estimated parameters of the control system is significantly reduced due to the utilization of the estimations of weight vector norm instead of the weight vectors itself. The stability analysis proves that the proposed ADSSMC control strategy can guarantee the boundaries of all signals in the closed-loop control system.

Enantioselective synthesis of indoloquinolizidines via asymmetric catalytic hydrogenation/lactamization of imino diesters.

We have developed a highly efficient cascade sequence for asymmetric synthesis of indoloquinolizidines with absolute control of cis-H2/H12b relative geometry in good to excellent yields and excellent enantioselectivities. This cascade was triggered by the Ru(II)-TsDPEN-catalyzed asymmetric transfer hydrogenation of imino diesters, with subsequent spontaneous lactamization with discrimination between the two diastereotopic 2-alkoxy-2-oxoethyl groups. The synthetic utility of this strategy was demonstrated by the asymmetric preparation of dihydrocorynantheol, geissoschizol, and isogeissoschizol.

Diastereoselective syntheses of indoloquinolizidines by a Pictet-Spengler/lactamization cascade.

An expedient diastereoselective synthesis of highly functionalized indolo[2,3-α]quinolizidines adopting a cis H2/H12b geometry has been realized by a Pictet-Spengler/lactamization cascade sequence. The absolute stereochemistry at C2, C3, and C12b was governed by the originally created chirality of the Michael adduct through organocatalyzed conjugate addition of dialkyl malonates to α,β-unsaturated aldehydes.

Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition-Pictet-Spengler sequence.

The enantioselective three-component Michael addition-Pictet-Spengler sequence of beta-ketoesters 1, alpha,beta-unsaturated aldehydes 2 and tryptamines 4 represents a facile and rapid one-pot access to highly substituted indoloquinolizidines in moderate to excellent yields and good to excellent enantioselectivities.