Utilizing multiplex reverse transcription-multiple cross displacement amplification-lateral flow biosensor technology for detecting H1N1, H3N2 and H7N9 influenza A virus subtypes.

Respiratory infections caused by influenza A viruses (IAVs) pose a global threat annually, leading to significant mortality in severe cases. IAVs are classified into various subtypes, and a combination of multiplex reverse transcription-multiple cross displacement amplification (mRT-MCDA) and lateral flow biosensor (LFB) has been developed to detect three subtypes (H1N1, H3N2, and H7N9) that have been frequently observed in recent years. This technology simultaneously reverse transcribes and amplifies two target genes, hemagglutinin (HA) and neuraminidase (NA), at a constant temperature of 63 °C in just 40 min.

Emotional habituation as a protective factor for resilience: Insights from ERP and hierarchical linear modeling.

Emotional habituation, a basic form of neural plasticity, regulates emotions adaptively, yet its role in stress resilience remains unclear. This study integrated laboratory-based EEG habituation measures and ecological experience sampling to examine valence-specific habituation as a resilience factor against daily life stress in 69 undergraduates. Habituation slopes were derived from Late Positive Potential (LPP) amplitude and arousal trajectories when participants viewed repeated pictures.

Engineering Superhydrophilic and Fouling-Free COF Armor for Ultrafast Oil-Water Separation.

Polymeric nanofibrous membranes are promising candidates for highly efficient oily wastewater separation, however, they suffer from irreversible membrane fouling. Herein, hydrophilic β-ketoenamine-linked covalent organic frameworks (COFs)-modified polyacrylonitrile (PAN) nanofibrous membranes (PNMs-COF) are developed, and the microstructures and hydrophilicities of the membranes are finely tailored. The hydrophilic rigid COF armor can induce the formation of hydrogen bonds with water, increase the polar component of the apparent surface tension, enhancing the driving force toward water and increasing the repulsion against oil droplets.

Reliability and Validity of the Affect Regulation-Based Resilience Scale (ARRS): Complementing Coping and Emotion-Regulation Approaches.

The Affect Regulation-based Resilience Scale (ARRS) was developed as an integrative tool to assess adults' psychological resilience. Utilizing a two-phase approach, the process consisted of item generation followed by rigorous psychometric evaluation. Initial interviews informed item selection, which subsequent analyses including confirmatory factor analysis and validity and reliability analysis using two adult samples (n = 424 and n = 425).

Base-Catalyzed Chemo-, Regio- and Stereoselective Addition of Quinazolinones to Trifluoromethylated Internal Alkynes for Access to N3-Vinylquinazolinones.

A base-catalyzed addition of quinazolinones to unsymmetrical trifluoromethylated internal alkynes was accomplished for straightforward access to various N3-vinylquinazolinones. Excellent chemo-, regio-, and stereoselectivity were achieved along with moderate to good efficacy for broad substrate scope under environmentally benign conditions. Moreover, N3-vinylquinazolinone adducts could be readily transformed into a useful fused tetracyclic scaffold via one-step intramolecular oxidative cross-coupling.

The effects of childhood adversity: Two specific neural patterns.

Childhood adversity (CA) is associated with an elevated risk of psychopathology across the lifespan and altered brain functions are thought to play an important role in linking CA to mental vulnerability. Previous research has proposed that CA generally influences emotion processing and particularly affects reward processing and cognitive control, yet convergent evidence for CA-related neural and functional networks underlying these processes remains to be fully understood. To investigate the impact of CA on functional brain activations, the present study performed Activation Likelihood Estimation (ALE) analyses across neuroimaging studies involving three task domains: emotion processing, cognitive control, and reward processing.

Isolation of Fluconazole-Resistant South Asian Clade Candida auris in Beijing, China.

Since first isolate of Candida (C.) auris was recognized in 2018 in China, over 60 cases of C. auris colonization or infection have been reported up to 2022, with at least two distinct genetic clade.

A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for lecanemab.

Background: Lecanemab is a humanized murine IgG1 antibody. Recent Phase 3 clinical trials have demonstrated its ability to reduce brain amyloid-β (Aβ) load and slow cognitive decline in patients with early Alzheimer's disease (AD). However, since its approval, reports on adverse effects (AEs) associated with lecanemab have been limited.

An inverted U-shaped relationship between chronic stress and the motivation to expend effort for reward.

Dysfunction in the motivation to expend effort for reward is considered a crucial symptom of stress-related mental illness. Few studies have explored the relationship between chronic stress and the motivation to exert effort for reward, along with its underlying neural mechanisms. We investigated this relationship in ninety undergraduates who were undergoing a chronic stressor: preparing for the National Postgraduate Entrance Examination (NPEE).

Eye configuration influences the detection advantage of direct gaze.

Research has shown that individuals detect direct eyes (those directed to the observer) more quickly and accurately than averted eyes (those directed elsewhere), a phenomenon known as the direct-gaze advantage. However, the underlying mechanisms of this advantage remain poorly understood. The current study employed a visual search task to investigate whether the direct-gaze advantage in capturing attention is contingent upon a specific configuration (face configuration or eyes configuration).

Isoegomaketone improves radiotherapy efficacy and intestinal injury by regulating apoptosis, autophagy and PI3K/AKT/mTOR signaling in a colon cancer model.

The current study aimed to investigate the effect of isoegomaketone (IK) as a radiosensitizer for colon cancer and its effect on intestinal injury, and to verify its potential mechanism. A total of 40 BALB/c nude mice were selected to construct a HT‑29 tumor‑bearing mice model with T lymphocyte deficiency. Tumor size was measured every other day, and the survival of mice was counted.

Not all emotional expressions facilitate recognition of other-race faces in Chinese infants.

Previous research has shown that the addition of happy or angry expressions to other-race faces can assist infants in overcoming the perceptual narrowing of face race and reinstating their recognition of other-race faces. In the present study, we examined how different facial expressions (happy, angry, fearful, and neutral) influence the recognition of African faces among Chinese infants aged 8 to 12 months. We employed a visual familiarization task and measured infants' looking time.

Magnetic Molecularly Imprinted Polymers with Hydrophilic Shells for the Selective Enrichment and Detection of Rosmarinic Acid in Aqueous Extraction.

Rosmarinic acid (RA) is a natural active compound widely found in many plants belonging to the family of , , and so on, which has various important bioactivities, including being anti-oxidative, anti-inflammatory, antiviral, etc. Herein, novel hydrophilic magnetic molecularly imprinted polymers (HMMIPs) with a regular core-shell structure were successfully developed using RA as a template molecule, acrylamide (AM) as a functional monomer, N-N 'methylenebisacrylamide (MBA) as a cross-linking agent, and water as the porogen. After a series of characterization and adsorption performance analyses, it was found that HMMIPs are hydrophilic with an adsorption capacity of 8.

UV-radiation manufacturing of natural macromolecular products salecan and tannic acid-based functional gel material as superadsorbent for toluidine blue remediation.

Adsorbent materials constructed from natural macromolecular products are favored because of their wide range of sources, biodegradability, and environmental friendliness. Salecan is a novel extracellular polysaccharide with ideal physicochemical and biological activities. Here, we have designed a polymer gel through UV-initiated polymerization of [2-(Methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA) in the mixture of salecan and tannic acid.

A U-shaped relationship between chronic academic stress and the dynamics of reward processing.

Despite the potential link between stress-induced reward dysfunctions and the development of mental problems, limited human research has investigated the specific impacts of chronic stress on the dynamics of reward processing. Here we aimed to investigate the relationship between chronic academic stress and the dynamics of reward processing (i.e.

Demonstration of in-vivo simultaneous 3D imaging with F-FDG and NaI using Compton-PET system.

Simultaneous imaging of the SPECT tracer I and PET tracer F is important in the diagnosis of high- and low-grade thyroid cancers because high-grade thyroid cancers have high F-FDG and low I uptake, while low-grade thyroid cancers have high I and low F-FDG uptake. In this study, NaI and F-FDG were simultaneously imaged using the Compton-PET system, in vivo. The angular resolution and sensitivity of the Compton camera with 356 keV gamma ray measured using a Ba point source were 12.

Racial salience modulated the face race lightness illusion: A comparative study of Caucasians and Asians.

Previous research has demonstrated the existence of the face race lightness (FRL) illusion. It indicates that Black faces tend to appear darker than White faces, even when their luminance values are objectively adjusted to be the same. However, the debate over the exclusive influence of face-race categories on the FRL illusion continues, with the impact of racial groups on the illusion remaining relatively unexplored.

Developmental changes in numerosity and area perception in school-age children.

Humans can quickly estimate the quantity of objects in their environment through the Approximate Number System (ANS). However, the developmental trajectories of numerical and spatial perception in school-aged children are not well understood. This study aimed to address this issue by examining the performance of 7-year-olds, 9-year-olds, and 11-year-olds in the dot-number and dot-area tasks.

NIR-II light therapy improves cognitive performance in MPTP induced Parkinson's disease rat models: A preliminary experimental study.

Cognitive impairment is an important component of non motor symptoms in Parkinson's disease (PD), and if not addressed in a timely manner, it can easily progress to dementia. However, no effective method currently exists to completely prevent or reverse cognitive impairment associated with PD. We therefore aimed to investigate the therapeutic effect of near-infrared region II light (NIR-II) region illumination on cognitive impairment in PD through behavioral experiments (water maze and rotary rod) and multiple fluorescence immunohistochemistry techniques.

Developmental changes of the impact of visual cues on ANS acuity across grades 1-5: Different patterns of visual cues on numerosity processing.

Numerous studies have consistently demonstrated the presence of the approximate number system (ANS) throughout development. Research has also revealed that visual cues may influence the ANS acuity, which may change with age. However, most studies have drawn conclusions based on performance differences between incongruent and congruent trials, which may be confounded by an individual's ability to inhibit interference.

PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma.

Immune checkpoint inhibitors (ICIs) have achieved impressive success in lung adenocarcinoma (LUAD). However, the response to ICIs varies among patients, and predictive biomarkers are urgently needed. PCDH11X is frequently mutated in LUAD, while its role in ICI treatment is unclear.

Fabrication of polysaccharide-coated oleanolic acid-curcumin-coassembled nanoparticles (OA/Cur NPs): Enhancement of colloidal stability and water solubility.

Natural terpenoid carriers, such as oleanolic acid (OA), can enhance the water solubility and stability of hydrophobic compounds such as curcumin (Cur). However, improving the colloidal stability of nanoparticle emulsions and resolving the redispersion problem of freeze-dried nanoparticle powders remain significant challenges. In this study, we fabricated coassembled oleanolic acid-curcumin nanoparticles (OA/Cur NPs) and applied a polysaccharide surface coating method to improve their colloidal stability and water solubility.