Functional Metallocenes as Cofactors Promote the Catalytic Performance of Mimetic Enzymes.

Coenzymes (cofactors) are essential for bio-redox reactions, group transfer reactions, and heterogeneous reactions of bio-enzymes, as well as the auxiliary transfer of electrons or atoms to promote bio-enzyme activity. However, when mimetic enzymes are scaled to the micro or nanoscale levels, both the absence of cofactor activity and the presence of migrating internal atoms cause self-depletion, eventually limiting sustained usage. Herein, cofactor regulation, a key issue long neglected in traditional mimetic enzyme construction is addressed.

Diurnal hourly near-surface ozone concentration derived from geostationary satellite in China.

Near-surface O is a harmful atmospheric pollutant and a key component of urban photochemical pollution. The availability of satellite ozone concentration products is predominantly restricted to daytime, resulting in a lack of understanding of nighttime ozone pollution (e.g.

Application of tissue pneumoperitoneum technique around lymph nodes in thoracoscopic lung cancer resection.

Background: Thoracoscopic surgery is a primary treatment for lung cancer, with lobectomy and mediastinal lymph node dissection being the predominant surgical approaches for invasive lung cancer. While many thoracic surgeons can proficiently perform lobectomy, thorough and standardized lymph node dissection remains challenging. This study aimed to explore a safer and more efficient surgical method for mediastinal lymph node dissection in lung cancer.

Diversity and function of mountain and polar supraglacial DNA viruses.

Mountain and polar glaciers cover 10% of the Earth's surface and are typically extreme environments that challenge life of all forms. Viruses are abundant and active in supraglacial ecosystems and play a crucial role in controlling the supraglacial microbial communities. However, our understanding of virus ecology on glacier surfaces and their potential impacts on downstream ecosystems remains limited.

Spatio-temporal association mining of intercity PM pollution: Hubei Province in China as an example.

The complex interaction between emissions, meteorology, and atmospheric chemistry makes accurate predictions of particulate pollution difficult. Advanced data mining techniques can reveal potential laws, providing new possibilities for understanding the evolution and causes of air pollution. Based on the Granger method and block modeling analysis, this paper explored the intercity spillover effects of hourly PM in Hubei Province, China, to determine the specific role (i.

Coarse sea spray inhibits lightning.

The known effects of thermodynamics and aerosols can well explain the thunderstorm activity over land, but fail over oceans. Here, tracking the full lifecycle of tropical deep convective cloud clusters shows that adding fine aerosols significantly increases the lightning density for a given rainfall amount over both ocean and land. In contrast, adding coarse sea salt (dry radius > 1 μm), known as sea spray, weakens the cloud vigor and lightning by producing fewer but larger cloud drops, which accelerate warm rain at the expense of mixed-phase precipitation.

Midpalatal Suture CBCT Image Quantitive Characteristics Analysis Based on Machine Learning Algorithm Construction and Optimization.

Background: Midpalatal suture maturation and ossification status is the basis for appraising maxillary transverse developmental status.

Methods: We established a midpalatal suture cone-beam computed tomography (CBCT) normalized database of the growth population, including 1006 CBCT files from 690 participants younger than 24 years old. The midpalatal suture region of interest (ROI) labeling was completed by two experienced clinical experts.

The Efficacy of Needle-Warming Moxibustion Combined with Hyperbaric Oxygen Therapy for Ischemic Stroke and Its Effect on Neurological Function.

Objective: To elucidate the therapeutic efficacy of needle-warming moxibustion (NWM) combined with hyperbaric oxygen therapy (HBOT) in the treatment of patients with ischemic stroke and its effect on neurological function.

Methods: One hundred patients with ischemic stroke admitted to the Xuzhou Medical University Affiliated Hospital of Lianyungang from January 2019 to July 2021 were enrolled. Among them, 45 patients treated with NWM were set as the control group, and the rest 55 patients treated by NWM combined with HBOT were included in the research group.

Improving PM predictions during COVID-19 lockdown by assimilating multi-source observations and adjusting emissions.

The Coronavirus Disease 2019 (COVID-19) outbreak caused a suspension of almost all non-essential human activities, leading to a significant reduction of anthropogenic emissions. However, the emission inventory of the chemistry transport model cannot be updated in time, resulting in large uncertainty in PM predictions. This study adopted a three-dimensional variational approach to assimilate multi-source PM data from satellite and ground observations and jointly adjusted emissions to improve PM predictions of the WRF-Chem model.

Unique T4-like phages in high-altitude lakes above 4500 m on the Tibetan Plateau.

Viruses are the most abundant biological entities in the biosphere; however, little is known about viral ecology in high altitude lakes. Here, we characterized viruses from 13 lakes, nine of which located ≥4500 m above sea level, on the Tibetan Plateau, the highest plateau on Earth. The abundance of virus-like particle (VLP) in Tibetan lakes ranged from 4.

CALIOP retrieval of droplet effective radius accounting for cloud vertical homogeneity.

Monitoring cloud droplet effective radius (re) is of great significance for studying aerosol-cloud interactions (ACI). Passive satellite retrieval, e.g.

Symptomatic intracranial hemorrhage in patients with admission hyperglycemia and diabetes after mechanical thrombectomy: A systematic review and meta-analysis.

Objectives: Symptomatic intracranial hemorrhage (sICH) is a severe complication of revascularization therapy. We aimed to investigate the association of admission hyperglycemia and sICH after mechanical thrombectomy in patients with acute ischemic stroke.

Methods: We systematically searched PubMed, EMBASE and Cochrane Library to identify studies that reported incidence of sICH in patients with admission hyperglycemia and normoglycemia, or with and without a history of diabetes, or glucose level in patients with sICH and non-sICH from inception to December 10, 2019.

Estimation of hourly PM concentration in China and its application in population exposure analysis.

Particulate pollution is closely related to public health. PM (particles with an aerodynamic size not larger than 1 μm) is much more harmful than particles with larger sizes because it goes deeper into the body and hence arouses social concern. However, the sparse and unevenly distributed ground-based observations limit the understanding of spatio-temporal distributions of PM in China.

Estimating hourly full-coverage PM over China based on TOA reflectance data from the Fengyun-4A satellite.

It is challenging to retrieve hourly ground-level PM on a national scale in China due to the sparse site measurements and the limited coverage of Low Earth Orbit (LEO) satellite observations. The new geostationary meteorological satellite of China, Fengyun-4A (FY-4A), provides a unique opportunity to fill this gap. In this study, the Random Forest (RF) algorithm was applied to retrieve hourly PM of China directly from FY-4A Top-of-Atmosphere (TOA) reflectance data.

Outcomes of mechanical thrombectomy with pre-intravenous thrombolysis: a systematic review and meta-analysis.

Background And Purpose: Whether pre-intravenous thrombolysis (IVT) provides any extra benefits to mechanical thrombectomy (MT) remains controversial. We conducted a systematic review and meta-analysis to compare MT with pre-IVT (IVT + MT) and MT without pre-IVT (MT) for acute ischemic stroke of large vessel occlusion.

Methods: We systematically searched PubMed, EMBASE and Cochrane Library to identify studies comparing outcomes between IVT + MT and MT from inception to Jan 24, 2019.

Roles of Relative Humidity in Aerosol Pollution Aggravation over Central China during Wintertime.

Aerosol pollution elicits considerable public concern due to the adverse influence on air quality, climate change, and human health. Outside of emissions, haze formation is closely related to meteorological conditions, especially relative humidity (). Partly due to insufficient investigations on the aerosol hygroscopicity, the accuracy of pollution prediction in Central China is limited.

Stacking machine learning model for estimating hourly PM in China based on Himawari 8 aerosol optical depth data.

Aerosol optical depth (AOD) from polar orbit satellites and meteorological factors have been widely used to estimate concentrations of surface particulate matter with an aerodynamic diameter <2.5 μm (PM). However, estimations with high temporal resolution remain lacking because of the limitations of satellite observations.

Ground-level PM2.5 estimation over urban agglomerations in China with high spatiotemporal resolution based on Himawari-8.

High concentrations of particulate matter with diameter of <2.5 μm (PM2.5) demonstrate severe effects on human health, especially in the metropolitan agglomerations of China.

Two-stage model for estimating the spatiotemporal distribution of hourly PM1.0 concentrations over central and east China.

Widespread and severe PM (particulate matter ≤1.0 μm) pollution in China has a significant negative influence on human health. However, knowledge of the regional spatiotemporal distribution of PM has been hindered by sparsely distributed PM concentration data.

Estimation of spatiotemporal PM distributions in China by combining PM observations with satellite aerosol optical depth.

Particulates smaller than 1.0 μm (PM) have strong associations with public health and environment, and considerable exposure data should be obtained to understand the actual environmental burden. This study presented a PM estimation strategy based on the generalised regression neural network model.

Estimating hourly PM concentrations from Himawari-8 aerosol optical depth in China.

Particulate matter with diameter less than 1 μm (PM) has been found to be closely associated with air quality, climate changes, and even adverse human health. However, a large gap in our knowledge concerning the large-scale distribution and variability of PM remains, which is expected to be bridged with advanced remote-sensing techniques. In this study, a hybrid model called principal component analysis-general regression neural network (PCA-GRNN) is developed to estimate hourly PM concentrations from Himawari-8 aerosol optical depth in combination with coincident ground-based PM measurements in China.

Pharmacokinetics of isochlorgenic acid C in rats by HPLC-MS: Absolute bioavailability and dose proportionality.

Ethnopharmacological Relevance: Isochlorgenic acid C (IAC), one of the bioactive compounds of Lonicera japonica, exhibited diverse pharmacological effects. However, its pharmacokinetic properties and bioavailability remained unresolved.

Aim Of The Study: To determine the absolute bioavailability in rats and the dose proportionality on the pharmacokinetics of single oral dose of IAC.

Clinical investigation on application of water swallowing to MR esophagography.

Objective: To verify the clinical outcomes of applying water swallowing to MR esophagography.

Methods: Thirty patients confirmed postoperatively or histopathologically with thoracic esophageal carcinoma by endoscopic biopsy and 10 healthy volunteers with normal esophagus underwent respectively conventional magnetic resonance imaging (MRI) detection and water swallowing MR esophagography. Of those patients, 4 underwent second examination after radiotherapy.