Screening and Evaluation of tRF-Glu-CTC-013 as a Biomarker and Key Regulator in the Development of Cardiac Hypertrophy.

tRNA-derived small RNAs (tsRNAs) are a newly recognized class of non-coding RNAs involved in regulating RNA processing and translational control. Pathological cardiac hypertrophy, characterized by left ventricular remodeling under chronic stress, serves as a critical precursor to severe cardiovascular pathologies including myocardial ischemia, infarction, and heart failure. Utilizing an angiotensin II (Ang II)-induced mouse cardiac hypertrophy model combined with tsRNA transcriptome profiling, we identified differentially expressed tsRNAs and investigated their functional relevance.

Screening and identification of versican as a sensitive biomarker and potential therapeutic target in basal cell carcinoma.

Basal cell carcinoma (BCC) is the most common type of non-melanoma skin cancer (NMSC). However, few biomarkers have been developed for the diagnosis of BCC. This study aimed to uncover novel BCC biomarkers for diagnosis and treatment via transcriptome and pathogenesis investigations.

Risk prediction model for difficulty in weaning from mechanical ventilation in critically ill patients: results from a multicentre retrospective study.

Objectives: We aimed to establish a diagnostic system using retrospective data to predict difficult wean from mechanical ventilation.

Design: A multicentre retrospective study SETTING: Five tertiary hospitals from China.

Participants: Critically ill patients received mechanical ventilation between January 2018 and December 2022.

Sleep quality, anxiety, and depression among perioperative caregivers of children with tethered cord syndrome: a cross-sectional survey analysis.

Objectives: This study aimed to investigate the relationship between sleep quality, anxiety, and depression among perioperative caregivers of children with tethered cord syndrome.

Methods: A cross-sectional study design was employed to recruit primary caregivers of children undergoing surgery for tethered cord syndrome from Fujian Children's Hospital between February 2022 and December 2023. Participants were required to complete some questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), the Self-Rating Anxiety Scale, and the Self-Rating Depression Scale.

Development and validation of a nomogram-based risk prediction model for unfavorable outcomes in pediatric traumatic brain injury: a retrospective study.

Introduction: Pediatric traumatic brain injury (PTBI) is linked to significant disability and mortality. This study aimed to identify risk factors for unfavorable outcomes in patients with PTBI and develop a predictive risk model.

Methods: A retrospective analysis was conducted on patients with PTBI treated at the 900th Hospital from September 2021 to June 2023.

Compact Carbon-Based Ultra-High-Power Electrodes: A Sodium Alginate-Induced Self-Shrinkage and Densification Approach.

The trade-off between compact energy storage and high-power performance presents a significant challenge in device development. While densifying carbon materials enhances volumetric energy density by optimizing the balance between porosity and packing density, it often disrupts electronic conductivity due to random physical contact between nanomodules, limiting the power performance. This work presents a sodium alginate (SA)-induced self-shrinkage densification strategy that overcomes this limitation by incorporating nanometer-sized "spacers," namely carbon quantum dots (CQDs), into graphene nanosheets and crosslinking them by carbonizing SA accompanying with the shrinkage.

The dual functions of the pentacyclic triterpenoid madecassic acid in ameliorating doxorubicin-induced cardiotoxicity and enhancing the antitumor efficacy of doxorubicin.

Doxorubicin (DOX) is an anthracycline that has excellent anticancer effects during tumor chemotherapy, but it can cause cardiotoxic effects and its clinical use has been limited. Therefore, finding new drugs or methods to prevent or reverse the cardiac damage caused by DOX therapy in cancer patients is essential. Previous studies have identified potential cardioprotective effects of (), and madecassic acid (MA) is a pentacyclic triterpenoid derived from .

A case report of nasal myiasis caused by in a patient with respiratory failure.

Nasal myiasis is a nasal infestation caused by myiasis, a parasitic disease affecting the nasal cavity. It is a rare condition. The nasal cavity is in close proximity to the sinuses, eyes, and cranial cavity.

A Novel "Endocrine Hormone": The Diverse Role of Extracellular Vesicles in Multiorgan Insulin Resistance.

Insulin resistance is the primary contributor to the disruption in glucose homeostasis in the body, playing a significant causative role in many metabolic diseases. Insulin resistance is characterized by compensatory insulin secretion and reduced insulin responsiveness in target organs. Dysregulation of the interaction between insulin-secreting cells and insulin-responsive target organs is an important factor driving the progression of insulin resistance.

Amphibious Hybrid Laser Tweezers for Fluid and Solid Domains.

Optical trapping is a potent tool for achieving precise and noninvasive manipulation of small objects in a vacuum and liquids. However, due to the substantial disparity between optical forces and interfacial adhesion, target objects should be suspended in fluid environments, rendering solid contact surfaces a restricted area for conventional optical tweezers. In this work, by relying on a single continuous wave (CW) laser, we demonstrate an optical manipulation system applicable for both fluid and solid domains, namely, amphibious hybrid laser tweezers.

LATS1 inhibitor and zinc supplement synergistically ameliorates contrast-induced acute kidney injury: Induction of Metallothionein-1 and suppression of tubular ferroptosis.

Contrast-induced acute kidney injury (CI-AKI) is a prevalent cause of renal dysfunction among hospitalized patients, yet the precise pathogenesis and effective therapeutic strategies remain elusive. In this study, we investigated the role of tubular ferroptosis in both experimental CI-AKI models and in primary tubular epithelial cells (PTECs) treated with ioversol. Using whole exome sequencing, we identified metallothioneins (MTs) as being among the most significantly downregulated genes following ioversol exposure.

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure.

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understood. We generated cardiomyocyte-specific Ddx17-knockout mice (Ddx17-cKO), cardiomyocyte-specific Ddx17 transgenic mice (Ddx17-Tg), and various models of cardiomyocyte injury and heart failure (HF).

Pt Single-Atoms on Structurally-Integrated 3D N-Doped Carbon Tubes Grid for Ampere-Level Current Density Hydrogen Evolution.

To date, the excellent mass-catalytic activities of Pt single-atoms catalysts (Pt-SACs) toward hydrogen evolution reaction (HER) are categorically confirmed; however, their high current density performance remains a challenge for practical applications. Here, a binder-free approach is exemplified to fabricate self-standing superhydrophilic-superaerphobic Pt-SACs cathodes by directly anchoring Pt-SAs via Pt-NC coordination bonds to the structurally-integrated 3D nitrogen-doped carbon tubes (N-CTs) array grid (denoted as Pt@N-CTs). The 3D Pt@N-CTs cathode with optimal Pt-SACs loading is capable of operating at a high current density of 1000 mA cm with an ultralow overpotential of 157.

Fabrication of OVs enriched BiOCl microflowers doped with Fe for effective destruction of two typical contaminants.

In this study, a one-step solvothermal method was used to fabricate Fe doped BiOCl microflowers with abundant oxygen vacancies (OVs) in the presence of glacial acetic acid. Various analytical techniques were employed to characterize the structural, morphological, and optical properties of the prepared samples. The presence of OVs was confirmed by low temperature electron paramagnetic resonance (EPR) analysis.

Autonomous nanorobots with powerful thrust under dry solid-contact conditions by photothermal shock.

Nanorobotic motion on solid substrates is greatly hindered by strong nanofriction, and powerful nanomotors‒the core components for nanorobotic motion‒are still lacking. Optical actuation addresses power and motion control issues simultaneously, while conventional technologies with small thrust usually apply to fluid environments. Here, we demonstrate micronewton-thrust nanomotors that enable the autonomous nanorobots working like conventional robots with precise motion control on dry surfaces by a photothermal-shock technique.

Better biocompatibility of nitrogen-doped graphene compared with graphene oxide by reducing cell autophagic flux blockage and cell apoptosis.

Nitrogen-doped graphene (C N), a novel graphene-based materials, has been proposed as a potential alternative to graphene oxide (GO) in biomedical applications. However, due to the challenges in synthesizing C N, reports in the biomedical field are currently rare. Here, we have modified the reported procedure and successfully synthesized C N nanoparticles at 120°C, which we refer to as C N-120.

2, 2-dimethylthiazolidine hydrochloride protects against experimental contrast-induced acute kidney injury via inhibition of tubular ferroptosis.

Contrast-induced acute kidney injury (CI-AKI) has become the third leading cause of AKI acquired in hospital, lacking of effective interventions. In the study, we identified the renal beneficial role of 2, 2-dimethylthiazolidine hydrochloride (DMTD), a safer compound which is readily hydrolyzed to cysteamine, in the rodent model of CI-AKI. Our data showed that administration of DMTD attenuated the impaired renal function and tubular injury induced by the contrast agent.

Corrigendum: DDX5 and DDX17-multifaceted proteins in the regulation of tumorigenesis and tumor progression.

[This corrects the article DOI: 10.3389/fonc.2022.

Knowledge mapping of exosomes in metabolic diseases: a bibliometric analysis (2007-2022).

Background: Research on exosomes in metabolic diseases has been gaining attention, but a comprehensive and objective report on the current state of research is lacking. This study aimed to conduct a bibliometric analysis of publications on "exosomes in metabolic diseases" to analyze the current status and trends of research using visualization methods.

Methods: The web of science core collection was searched for publications on exosomes in metabolic diseases from 2007 to 2022.

Phosphoenolpyruvate induces endothelial dysfunction and cell senescence through stimulation of metabolic reprogramming.

Endothelial dysfunction is a key early link in the pathogenesis of atherosclerosis, and the accumulation of senescent vascular endothelial cells causes endothelial dysfunction. Phosphoenolpyruvate (PEP), which is a high-energy glycolytic intermediate, protects against ischemia-reperfusion injury in isolated rat lung, heart, and liver tissue by quickly providing ATP. However, it was reported that serum PEP concentrations are 13-fold higher in healthy elderly compare to the young.

Apigenin alleviates oxidative stress-induced myocardial injury by regulating SIRT1 signaling pathway.

Apigenin is a natural flavonoid which is widely found in vegetables and fruits. However, the mechanism of apigenin in oxidative stress-induced myocardial injury has not been fully elucidated. We established an isoproterenol (Iso)-induced myocardial injury mouse model and a hypoxia/reoxygenation (H/R)-induced H9c2 cell injury model, followed by pretreatment with apigenin to explore its protective effects.

Boosted photocatalytic performance of OVs-rich BiVO hollow microsphere self-assembled with the assistance of SDBS.

In this study, monoclinic phase bismuth vanadate (BiOV) photocatalyst with unique hollow microsphere morphology was successfully prepared by a hydrothermal method in the existence of sodium dodecyl benzene sulfonate (SDBS). The prepared photocatalysts were characterized by X-ray diffraction (XRD), scanning electron (SEM) and X-ray photoelectron spectrometer (XPS) and UV-vis diffuse reflectance spectroscopy (UV-vis DRS). Experimental results show that SDBS definitely changes the microstructure of BiVO, which is allocated to the template role of SDBS in the preparation process.