Clinical observation and immune effect of high-intensity focused ultrasound (HIFU) treatment on patients with colorectal cancer liver metastasis.

Background: This study evaluates the clinical and immune effects of high-intensity focused ultrasound (HIFU) on liver metastases from colorectal cancer (CRC).

Methods: A retrospective analysis was conducted on 64 CRC patients with liver metastases treated with HIFU at Qingdao University's HIFU Cancer Center. Variables such as sex, age, ECOG status, tumor location, KRAS mutation status, HBV infection, number and size of liver metastases, and previous systemic treatments were analyzed.

Enzymatic preparation of structured phospholipids from soybean phosphatidylcholine and investigation of their phase behavior.

The present study aimed to investigate the application of lysophospholipids from enzymatic degumming products and different acyl donors to form structured soybean phospholipids in the lipase-mediated acidolysis reaction. Sn-1 and sn-2 fatty acid compositions of structured phospholipids from soybean phosphatidylcholine (SP-SPC) were examined, indicating that the relative content of saturated fatty acid in SP-SPC sn-2 fatty acids increased. Liquid chromatography-mass spectrometry analysis suggested that there were seven SP-SPC molecules.

Combined multispectral analysis and molecular docking to research the interaction of soybean isolate protein with different kinds of phospholipid liposomes and its effect on liposome properties.

Liposomes were modified due to suboptimal stability. Soybean lecithin liposomes (SLip), hydrogenated soybean lecithin liposomes (HLip), and egg yolk lecithin liposomes (ELip) were modified with different concentrations of soybean isolate protein (SPI) to form SLip-SPI, HLip-SPI, and ELip-SPI. The physical properties, interactions, and stability of liposomes were investigated.

Instability of natural deep eutectic solvents (NADESs) induced by Amadori rearrangement and its effects on cryopreservation of yeast cells.

Natural deep eutectic solvents (NADESs) showing higher cryoprotective effects are attracting concerns, because during the storage, system browning always occurs in aldose/amino acid-based NADESs, which generated brown substances remarkably weaken the cryoprotective effects. In this study, proline/glucose-based (PG) and proline/sorbitol-based (PS) NADESs were prepared, of which storage stability, browning profile, brown substance, and cryoprotective effects were investigated. Results showed that PG at molar ratios of 1:1, 2:1, and 3:1, as well as PS at 1:1, and 2:1 can form NADESs, among which only the PG-based ones could get browning after storage.

Uniform intensity chiral optical field by multifocal synthesis.

Chiral optical beams that carry orbital angular momentum (OAM) have a broad range of applications such as optical tweezers, chiral microstructure fabrication, and optical communications. However, some chiral optical beams have inhomogeneous intensity distribution that limits the application in these fields. In this Letter, two different types of chiral optical fields with uniform intensity and arbitrary length were proposed based on the amplitude encoding method and multifocal synthesis.

Inflammatory biomarkers may be associated with poor outcomes after mechanical thrombectomy.

Background: Mechanical thrombectomy (MT) has become the mainstay of treatment for acute ischemic stroke (AIS) recently. This case-control study aimed to identify the pivotal role of inflammation in the prognosis of AIS patients after MT.

Methods: Altogether, 70 AIS patients who underwent MT were retrospectively recruited for this study.

Tunable thermoresponsive hydrogels for temperature regulation and warning in fruit and vegetables preservation.

Fresh fruit and vegetables usually suffer from quality deterioration when exposed to inappropriate temperatures. Common energy-input temperature regulation is widely applied but there remain challenges of increasing energy consumption. Passive temperature management regulates the heat transfer without energy consumption, showing a sustainable strategy for food preservation.

Effect of deodorization conditions on fatty acid profile, oxidation products, and lipid-derived free radicals of soybean oil.

Oxidative stability is a key quality characteristic of edible oils, and the oil's antioxidant capacity decreases during the deodorization stage. This study explores the changes in radical formation, molecular structure, oxidative characteristics, fatty acids, and main bioactive compounds in soybean oil during deodorization. The lag phase decreased, whereas the total amount of spins of free radicals increased as the deodorization time increased from 90 to 150 min.

Coalescence-Induced Self-Propelled Particle Transport with Asymmetry Arrangement.

We experimentally investigated the coalescence-induced droplet-particle jumping phenomenon on a submillimeter scale in symmetric and asymmetric particle arrangements with poly(methyl methacrylate) (PMMA) particles and stainless steel (SS) particles. Coalescence-induced droplet-particle jumping exhibited excellent capability and interesting behavior for both droplet jumping enhancement and particle transport. The particle increased the normalized droplet jumping velocity from 0.

Ultrasonic-assisted extraction of grape seed procyanidins, preparation of liposomes, and evaluation of their antioxidant capacity.

The residue remaining after oil extraction from grape seed contain abundant procyanidins. An ultrasonic-assisted enzyme method was performed to achieve a high extraction efficiency of procyanidins when the optimal extraction conditions were 8 U/g of cellulase, ultrasound power of 200 W, ultrasonic temperature of 50 ℃, and ultrasonic reaction time of 40 min. The effects of free procyanidins on both radical scavenging activity and thermal stability at 40, 60, and 80 ℃ of the procyanidins-loaded liposomal systems prepared by the ultrasonic-assisted method were discussed.

Circulating exosomal miR-16-5p and let-7e-5p are associated with bladder fibrosis of diabetic cystopathy.

Diabetic cystopathy (DCP) is a prevalent etiology of bladder dysfunction in individuals with longstanding diabetes, frequently leading to bladder interstitial fibrosis. Research investigating the initial pathological alterations of DCP is notably scarce. To comprehend the development of fibrosis and find effective biomarkers for its diagnosis, we prepared streptozotocin-induced long-term diabetic SD rats exhibiting a type 1 diabetes phenotype and bladder fibrosis in histology detection.

Construction and Validation of Protein Expression-related Prognostic Models in Clear Cell Renal Cell Carcinoma.

To construct a prognostic evaluation model for clear cell renal cell carcinoma (ccRCC) patients using bioinformatics method and to screen potential drugs for ccRCC ccRCC RNA sequencing data, clinical data, and protein expression data were downloaded from the TCGA database. Univariate Cox and Lasso regression analyses were performed on the combined data to screen out the proteins related to the prognosis, and they were included in a multivariate Cox proportional hazard model. The patients were divided into high and low-risk groups for a survival difference analysis.

[Retracted] Long noncoding RNA UCID sponges miR‑152‑3p to promote colorectal cancer cell migration and invasion via the Wnt/β‑catenin signaling pathway.

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that there appeared to be matching data panels comparing between the Transwell invasion and migration assays shown in Figs. 2C and 5C; moreover, one of the data panels shown in Fig. 2D had previously appeared in a paper written largely by different authors (the author 'T‑D Shan' was held in common) at different research institutes in the journal in 2016 [Shan T‑D, Xu, J‑H, Yu T, Li J‑Y, Zhao L‑N, Ouyang H, Luo S, Lu X‑J, Huang C‑Z, Lan Q‑S : Knockdown of linc‑POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer.

TIPE1 inhibits the growth of Ewing's sarcoma cells by suppressing Wnt/β-catenin signaling.

Background: Ewing's sarcoma is the second most common bone and soft tissue malignancy in children and adolescents. Tumor necrosis factor-α-induced protein 8-like 1 (TIPE1) functions as a tumor suppressor in several cancers. Activation of Wnt/β-catenin signaling in subpopulations of tumor cells contributes to phenotypic heterogeneity and disease progression in Ewing's sarcoma.

Cuproptosis regulator-mediated patterns associated with immune infiltration features and construction of cuproptosis-related signatures to guide immunotherapy.

Background: Liver hepatocellular carcinoma (HCC) is a prevalent cancer that lacks a sufficiently efficient approach to guide immunotherapy. Additionally, cuproptosis is a recently identified regulated cell death program that is triggered by copper ionophores. However, its possible significance in tumor immune cell infiltration is still unclear.

Combined Effects of Radiative and Evaporative Cooling on Fruit Preservation under Solar Radiation: Sunburn Resistance and Temperature Stabilization.

Excessive solar radiation and high temperature often cause considerable loss and waste of fruits during transportation, retail, and storage. In the current study, a natural deep eutectic solvent-based polyacrylamide/poly(vinyl alcohol) hydrogel with nanoparticles (NPs/NADES@PAAm/PVA) is developed for fruit quality protection from solar radiation and high-temperature stress by achieving the combined effect of radiative and evaporative cooling. NPs/NADES@PAAm/PVA presents an average solar reflectance of ∼0.

Adjuvant-free cellulose nanofiber vaccine induces permanent humoral immune response in mouse.

Vaccines have become one of the most effective strategies to deal with various infectious diseases and chronic noninfectious diseases, such as SARS virus, Novel Coronavirus, cancer, etc. However, recent studies have found that the neutralizing antibody titers induced by vaccines would drop to half level or even lower after vaccination. In this study, we designed a novel small-sized positively charged nanofiber-1 (PEI-CNF-1) as a vaccine carrier, which can induce a high long-term humoral immune response by controlled release of antigen.

Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism.

Background: Renal carcinoma is one of the most common malignant tumors in the urinary system. Autophagy can be both activated and inhibited in renal carcinoma, and it plays a double-edged role in the development of renal carcinoma. In the early stage of cancer, autophagy can suppress tumors.

Construction and Validation of a Necroptosis-Related Signature Associated With the Immune Microenvironment in Liver Hepatocellular Carcinoma.

Liver hepatocellular carcinoma (LIHC) is a widespread and often deadly neoplasm. There is increasing evidence that necroptosis mediates numerous tumor-associated behaviors, as well as the regulation of the tumor microenvironment, suggesting its use as a biomarker for tumor prognosis. Data on mRNA expression and necroptosis regulators were acquired from the TCGA and KEGG databases, respectively.

The lncRNA Tincr Regulates the Abnormal Differentiation of Intestinal Epithelial Stem Cells in the Diabetic State the miR-668-3p/Klf3 Axis.

Background: Diabetes mellitus (DM) is among the most common chronic diseases, and diabetic enteropathy (DE), which is a complication caused by DM, is a serious health condition. Long noncoding RNAs (lncRNAs) are regulators of DE progression.

Objective: However, the mechanisms of action of multiple lncRNAs involved in DE remain poorly understood.

Effects of drying temperature on umami taste and aroma profiles of mushrooms (Suillus granulatus).

Temperature is one of the most important factors for drying edible mushrooms. To evaluate the effects of different hot-air drying (HAD) temperatures on the umami taste and aroma profile of Suillus granulatus (S. granulatus) mushrooms, we measured umami substances and volatile compounds of S.

Ferroptosis‑related long non‑coding RNAs and the roles of LASTR in stomach adenocarcinoma.

Ferroptosis is a form of programmed cell death that participates in diverse physiological processes. Increasing evidence suggests that long noncoding RNAs (lncRNAs) regulate ferroptosis in tumors, including stomach adenocarcinoma (STAD). In the present study, RNA‑sequencing data from The Cancer Genome Atlas database and ferroptosis‑related markers from the FerrDb data resource were analyzed to select differentially expressed lncRNAs.

DNA-repair status should be assessed in treatment-emergent neuroendocrine prostate cancer before platinum-based therapy.

Objectives: This study sought to provide contemporary data from a multi-institution with respect to DNA-repair genes (DRGs) status and its impact on effects of platinum-based chemotherapy in treatment-emergent neuroendocrine prostate cancer (t-NEPC), for which little data exist.

Patients And Methods: All patients were retrospectively collected with eligible biopsied tissues for targeted next generation sequencing (NGS). The main outcomes were radiologic progression-free survival and overall survival according to Response Evaluation Criteria in Solid Tumors, version 1.