Stimuli-Responsive Luminescent Properties of Dinuclear Cu(I) Complexes Regulated by Hydrogen-Bonding Donors.

The selection of hydrogen-bonding donors is crucial for the development of stimuli-responsive luminescent materials that rely on weak hydrogen-bonding interactions. In this study, we report two novel dinuclear Cu(I) complexes, [Cu(μ-η(,),η(,)-dpa)(μ-dppm)](ClO) () and [Cu(μ-η(,),η(,)-dpa)(μ-dppa)](ClO)·2CHCOCH (), which differ in their diphosphine linkers (CH in dppm vs NH in dppa). X-ray crystallography reveals weak CH···O hydrogen bonds between dppm-CH and perchlorate-O in and weak NH···O interactions between dppa-NH and acetone-O in .

Multistimuli-Responsive Copper(I) Complexes Exhibiting Thermally Activated Delayed Fluorescence.

Multistimuli-responsive luminescence has attracted increasing attention due to its promising applications. This study presents two new Cu(I) heteroleptic complexes and , each featuring distinct N-heterocyclic fragments (pyrazinyl and pyridyl). Both complexes display reversible multistimuli-responsive luminescence and thermally activated delayed fluorescence.

Eleven undescribed sesquiterpenoids with multiple skeleton types and cytotoxicity from the South China Sea soft coral Lemnalia sp.

Marine organisms have great potential for medical and bioproducts applications, with corals having been in the spotlight as an important research target for the discovery of new bioactive marine natural products. Eleven undescribed sesquiterpenoids, named lemnalinoids A-K (1-11), and one known sesquiterpenoid (12) were isolated from the South China Sea soft coral Lemnalia sp. The structures and absolute configurations of new compounds were elucidated by extensive analysis of spectroscopic data, single crystal X-ray diffraction, quantum chemical calculations and TDDFT-ECD calculations.

Leukocyte-Rich Platelet-Rich Plasma Is Superior to Leukocyte-Poor Platelet-Rich Plasma in Improving Muscle Healing by Promoting Angiogenesis.

Therapies involving platelet-rich plasma (PRP) have been validated in extant research to be efficacious for acute muscle injury treatment. The influence of PRP leukocyte concentration on muscle regeneration under acute muscle injury conditions is uncertain. We executed our current research with the purpose of probing the influence exerted by leukocyte-poor PRP (LP-PRP) treatment and that exerted by leukocyte-rich PRP (LR-PRP) treatment on muscle regeneration.

Platelet rich plasma promotes cell migration of adipose-derived stem cells by up-regulation of focal adhesion kinase and paxillin.

Skeletal muscle injuries are prevalent in competitive sports, often disrupting elite athletes' training programs. Platelet-rich plasma (PRP) is abundant in growth factors, cytokines, and chemokines, making it a potential solution for treating muscle injuries. Adipose-derived stem cells (ADSCs) therapy presents promise for tissue regeneration, given their self-renew and differentiation capabilities.

Research hotspots and trends in gut microbiota and nonalcoholic fatty liver disease: A bibliometric study.

Background: Recent research indicates that the intestinal microbial community, known as the gut microbiota, may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). To understand this relationship, this study used a comprehensive bibliometric analysis to explore and analyze the currently little-known connection between gut microbiota and NAFLD, as well as new findings and possible future pathways in this field.

Aim: To provide an in-depth analysis of the current focus issues and research developments on the interaction between gut microbiota and NAFLD.

Five undescribed chromone-phenylpyridone hybrids from Cineraria repanda-derived Penicillium oxalicum with cytotoxic and antibacterial activity.

Five previously undescribed phenylpyridones, designated as citridones H-L (1-5), along with seven known compounds, were characterized from the rice medium culture of the Cineraria repanda-derived endophytic fungus Penicillium oxalicum. Their structures were elucidated through detailed interpretation of UV, NMR, and HR-ESI-MS data. The absolute configurations of C-2 and C-3 in compounds 1-4 were determined by spectroscopic analysis and ECD calculations, while the C-5' configurations were established through computational C NMR and DP4+ analyses.

Assessing changes in brain structure in new-onset children with acute lymphoblastic leukemia.

Background: Brain structure injury was presented in acute lymphoblastic leukemia (ALL) after treatment; however, its alterations in new-onset stage are still unclear. We aim to explore white matter (WM) and grey matter (GM) alterations using surface-based morphometry (SBM) and tract-based spatial statistics (TBSS) in new-onset pediatric ALL.

Methods: Thirty-five ALL and 33 typically developing (TD) children were prospectively recruited and underwent three-dimensional T1-weighted and diffusion tensor (DTI) imaging.

Quantitative evaluation of CTP derived time-density alterations versus CTP for collateral status prediction with stroke.

Background And Objectives: Collateral status is a pivotal determinant of clinical outcomes in acute ischemic stroke (AIS); however, its evaluation can be challenging. We investigated the predictive value of CT perfusion (CTP) derived time and density alterations versus CTP for collateral status prediction in AIS.

Methods: Consecutive patients with anterior circulation occlusion within 24 h were retrospectively included.

Litoamentenes A-K, eleven undescribed cembranoids with cytotoxicity from the South China Sea soft coral Litophyton amentaceum.

Eleven undescribed cembrane-type diterpenoids, named litoamentenes A-K (1-11), were isolated from the soft coral Litophyton amentaceum collected from the South China Sea. Their structures were elucidated by extensive analysis of spectroscopic data, comparison with the literature data, single crystal X-ray diffraction, quantum chemical calculations and TDDFT-ECD calculations. This is the first systematic investigation of L.

Lemneolemnanes A-D, Four Uncommon Sesquiterpenoids from the Soft Coral sp.

Four undescribed sesquiterpenoids, lemneolemnanes A-D (-), have been isolated from the marine soft coral sp. The absolute configurations of the stereogenic carbons of - were determined by single-crystal X-ray crystallographic analysis. Compounds and are epimers at C-3 and have an unusual skeleton with a formyl group on C-6.

Isolation of undescribed cladosporols and spirobisnaphthalenes from a plant pathogen Cladosporium cladosporioides F-10-2-A.

Two undescribed cladosporol derivatives, cladosporols J-K (1-2), and three previously unreported spirobisnaphthalenes, urnucratins D-F (3-5), as well as eleven known cladosporols (6-16), were characterized from Cladosporium cladosporioides (Cladosporiaceae), a common plant pathogen isolated from the skin of Chinese toad. Cladosporols J-K (1-2) with a single double bond have been rarely reported, while urnucratins D-F (3-5) featured an unusual benzoquinone bisnaphthospiroether skeleton, contributing to an expanding category of undiscovered natural products. Their structures and absolute configurations were determined using extensive spectroscopic methods, including NMR, HRESIMS analyses, X-ray single crystal diffraction, as well as through experimental ECD analyses.

Structure-Guided Discovery of Diverse Cytotoxic Dimeric Xanthones/Chromanones from C-7-2-1 and Their Interconversion Properties.

Xanthone-chromanone homo- or heterodimers are regarded as a novel class of topoisomerase (Topo) inhibitors; however, limited information about these compounds is currently available. Here, 14 new (-) and 6 known tetrahydroxanthone chromanone homo- and heterodimers (-) are reported as isolated from C-7-2-1. Their structures and absolute configurations were unambiguously demonstrated by a combination of spectroscopic data, single-crystal X-ray diffraction, modified Mosher's method, and electronic circular dichroism analyses.

Lidocaine inhibits migration of tenocytes by downregulating focal adhesion kinase and paxillin phosphorylation.

Lidocaine is the most frequently applied local infiltration anesthetic agent for treating tendinopathies. However, studies have discovered lidocaine to negatively affect tendon healing. In the current study, the molecular mechanisms and effects of lidocaine on tenocyte migration were evaluated.

Glymphatic system dysfunction in pediatric acute lymphoblastic leukemia without clinically diagnosed central nervous system infiltration: a novel DTI-ALPS method.

Background And Objective: Central nervous system (CNS) infiltration commonly occurs in children with acute lymphoblastic leukemia (ALL). Nevertheless, CNS infiltration is rarely detected at the initial diagnosis. The glymphatic system, which regulates cerebrospinal fluid (CSF) and interstitial fluid transport, is considered one of the possible routes of CNS infiltration by leukemia cells.

Lidocaine Inhibited Tendon Cell Proliferation and Extracellular Matrix Production by Down Regulation of Cyclin A, CDK2, Type I and Type III Collagen Expression.

Lidocaine injection is a common treatment for tendon injuries. However, the evidence suggests that lidocaine is toxic to tendon cells. This study investigated the effects of lidocaine on cultured tendon cells, focusing on the molecular mechanisms underlying cell proliferation and extracellular matrix (ECM) production.

Post-ingestion conversion of dietary indoles into anticancer agents.

There are health benefits from consuming cruciferous vegetables that release indole-3-carbinol (I3C), but the transformation of I3C-related indoles remains underinvestigated. Here we detail the post-ingestion conversion of I3C into antitumor agents, 2-(indol-3-ylmethyl)-3,3-diindolylmethane (LTr1) and 3,3-diindolylmethane (DIM), by conceptualizing and materializing the reaction flux derailing (RFD) approach as a means of unraveling these stepwise transformations to be non-enzymatic but pH-dependent and gut microbe-sensitive. In the upper (or acidic) gastrointestinal tract, LTr1 is generated through Michael addition of 3-methyleneindolium (3MI, derived from I3C) to DIM produced from I3C via the formaldehyde-releasing (major) and CO-liberating (minor) pathways.

Four bioactive new steroids from the soft coral collected in South China Sea.

Four new polyhydroxylated steroids lobophysterols E-H (-), together with three known compounds (-), were isolated from the soft coral collected at Xisha Island, China. The structures of the new compounds were elucidated by extensive spectroscopic analysis and comparison with NMR data of structurally related compounds reported in the literature. The absolute configuration of - was determined by X-ray diffraction.

Secondary metabolites from marine sponges of the genus : a comprehensive update insight on structural diversity and bioactivity.

As one of the most common marine sponges in tropical and subtropical oceans, the sponges of the genus , have emerged as unique and yet under-investigated pools for discovery of natural products with fabulous molecular diversity and myriad interesting biological activities. The present review highlights the chemical structure and biological activity of 355 compounds that have been isolated and characterized from the members of sponges, over the period of about five decades (from 1971 to November 2021). For a better understanding, these numerous compounds are firstly classified and presented according to their carbon skeleton as well as their biosynthetic origins.

Carbon-nitrogen bond formation to construct novel polyketide-indole hybrids from the indole-3-carbinol exposed culture of .

A plenty of cytochrome P450s have been annotated in the genome. Inspired by the fact that some P450s have been reported to catalyze the carbon-nitrogen (C-N) bond formation, we were curious about whether hybrids through C-N bond formation could be generated in the indole-3-carbinol (I3C) exposed culture of . As expected, two skeletally undescribed polyketide-indole hybrids, designated as indolpolyketone A and B ( and ), were isolated and assigned to be constructed through C-N bond formation.