High-Entropy Co-Based Oxygen Electrodes with Enhanced Thermomechanical Compatibility for Reversible Protonic Ceramic Cells.

Reversible protonic ceramic cells (R-PCCs) are a kind of distinguished long-time energy conversion and storage device. The utilization of oxygen electrodes is vital to achieve high electrochemical performances for R-PCCs, demanding high catalytic activity toward oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and appropriate thermal expansion coefficients (TEC). Herein, novel high-entropy perovskites PrBaSrLaNdMeO (Me = Co, Fe, Mn) are explored.

Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial.

Background: Patients undergoing maintenance dialysis for kidney failure are at substantial risk of cardiovascular morbidity and mortality. We aimed to establish if spironolactone reduces heart failure and cardiovascular deaths in these patients.

Methods: ACHIEVE was an international, parallel-group, randomised controlled trial done in 143 dialysis programmes in 12 countries.

The mortality of chronic kidney disease in Chinese subjects: a 12-year cohort based on clinical data in electronic health record.

Background: Chronic kidney disease (CKD) is a global health problem with increasing prevalence. The objective of this study was to investigate the CKD mortality rate in a large cohort study based on electronic health record (EHR).

Methods: This was a retrospective cohort based on Hospital's EHR.

Current clinical profiles for Chinese hemodialysis patients.

The prevalence of hemodialysis (HD) patients in China is escalating, necessitating a comprehensive understanding of their clinical profiles. This study offers an in-depth analysis of the baseline data from the China Dialysis Outcomes and Practice Patterns Study (DOPPS) Phase 7 (DOPPS7), aiming to assess the current clinical characteristics and target ranges for the most recent years. It also compares these findings with those from DOPPS Phase 5.

Epitaxial growth of monolayer white phosphorus on Cd(0001).

As a promising two-dimensional (2D) material, phosphorene has attracted tremendous research interest in both fundamental research and potential applications. Up to now, black phosphorene, blue phosphorene, violet phosphorene, and ultrathin nanosheets of red phosphorus have been successfully synthesized by mechanical exfoliation or epitaxial growth, while the synthesis of 2D white phosphorus (WP) has not been achieved. Here, we report the epitaxial growth of monolayer WP on Cd(0001) by means of low temperature (90 K) deposition.

On-surface visualization of the influence of the chemical environment on halogen-hydrogen bonds at submolecular scale.

The halogen-hydrogen bond has demonstrated remarkable potential in controlling molecular assembly and precisely steering reaction pathways on surfaces. However, few attempts have been devoted to explore the fundamental characteristics of halogen-hydrogen bonds in real space. Herein, we systematically investigate the influence of the local chemical environment of hydrogen atoms on halogen-hydrogen bonds.

Analysis of red blood cell lifespan and associated influencing factors in anemic dialysis patients.

Introduction: Renal anemia is one of the most common complications in dialysis patients. The shortened red blood cell (RBC) lifespan is an important mechanism of renal anemia. This study aims to investigate the RBC lifespan and its influencing factors in anemic dialysis patients.

Current Therapeutic Targets for Alcohol-Associated Liver Disease.

Alcohol-associated liver disease (ALD) is a liver disorder induced by chronic excessive alcohol consumption, affecting approximately 3.5% of the global population. The spectrum of ALD encompasses simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and the potential development of hepatocellular carcinoma.

Hospital type and clinical outcomes in peritoneal dialysis: Findings from the PDTAP study.

BackgroundThere are inequalities in resource allocation and services across peritoneal dialysis (PD) centers in China. This study aimed to explore the association between hospital type (university-affiliated vs. non-university-affiliated hospitals) and clinical outcomes in PD patients.

Prevalence, practice pattern, and mortality of hyperkalemia in Chinese patients undergoing hemodialysis in the visualize HD study.

Visualize-HD study aimed to examine prevalence of hyperkalemia (HK), associated practice patterns, and mortality in Chinese patients undergoing hemodialysis (HD). The study included patients aged ≥ 18 years and undergoing chronic HD for ≥ 3 months. Primary outcome was to examine the association between suspected risk factors and HK prevalence at the HD facility level.

Gαi3: a crucial biomarker and therapeutic target in bladder cancer.

This study investigates the role of Gαi3 in bladder cancer, focusing on its expression, functions, and mechanisms. Bioinformatics reveal that Gαi3 is overexpressed in bladder cancer, linked to poorer survival and higher tumor grades. Single-cell sequencing data confirm Gαi3 overexpression in bladder cancer epithelial cells.

Association of air pollutants exposure and increased risk of peritoneal dialysis-related peritonitis: An observational study from PDTAP cohort.

IntroductionAlthough the impact of air pollutants on infectious diseases is well-known, there is limited evidence regarding its effects on peritoneal dialysis (PD) patients. This study aimed to investigate the association between air pollutants and PD-related peritonitis.MethodsThis is an observational study affiliated to the PD Telemedicine-assisted Platform Cohort Study (PDTAP study), which is a national-level cohort study in China.

The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol.

Background: The mineralocorticoid aldosterone may contribute to the risk of cardiovascular morbidity and mortality in patients receiving maintenance dialysis. Whether spironolactone, a mineralocorticoid receptor antagonist, improves outcomes for patients receiving maintenance dialysis is unclear.

Objective: To assess the efficacy and safety of spironolactone in patients receiving maintenance dialysis.

Comparison of middle molecule removal with expanded hemodialysis versus haemodiafiltration among Chinese hemodialysis patients.

Background: This study aimed to compare uremic toxin removal with expanded hemodialysis against post-dilution online haemodiafiltration therapy in Chinese patients with chronic kidney failure in a single treatment.

Methods: This randomized, controlled, open-label, parallel, multicenter trial enrolled prevalent patients on hemodialysis. The study endpoints were to establish the non-inferiority of expanded hemodialysis versus haemodiafiltration in removing beta-2-microglobulin (β2M) and lambda-free light chains (λFLC) and to evaluate the reduction ratios of urea, alpha-1-microglobulin (α1M), myoglobin, complement factor D, kappa-free light chains (κFLC) and Chitinase-3-like protein 1 (YKL-40) during a mid-week dialysis session.

Improving precision instrument cleaning with a quality control module: implementation and outcomes.

Objective: To evaluate the effectiveness of a cleaning quality control module integrated into a hospital's Disinfection Supply Center (DSC) for improving the cleaning quality of precision surgical instruments.

Methods: In June 2023, a cleaning quality control module was implemented in our hospital's DSC to optimize reprocessing procedures. This module recorded deviations through textual, photographic, and video records.

Betanin, a Natural Product from Red Beets, Improves Endothelial Dysfunction through Activation of Autophagy.

Objective: Endothelial dysfunction is the altered pathological ability of endothelial cells to modulate the passage of cells and solutes across vessels, which underlies the development of inflammatory diseases. Betanin (betanidin-5-O-β-glucoside), a natural product rich in red beets, is a water-soluble nitrogen-containing pigment, and its potential protective effects on cardiovascular disease have been reported. In this study, we investigated the protective role of betanin in vascular endothelial dysfunction induced by TNFα and explored potential mechanisms.

Executive summary for the China Kidney Disease Network (CK-NET) 2017-2018 Annual Data Report.

Chronic kidney disease (CKD) has become a public health issue. Rapid urbanization in China has been intimately linked to shifts in the spectrum of CKD, particularly as regards CKD related to diabetes mellitus. By amalgamating diverse data streams and harnessing cutting-edge technologies, the China Kidney Disease Network aspires to evolve into a comprehensive surveillance framework for kidney diseases in China.

Intestinal epithelial cells in health and disease.

This comprehensive review delves into the pivotal role of intestinal epithelial cells in the context of various diseases. It provides an in-depth analysis of the diverse types and functions of these cells, explores the influence of multiple signaling pathways on their differentiation, and elucidates their critical roles in a spectrum of diseases. The significance of the gastrointestinal tract in maintaining overall health is extremely important and cannot be exaggerated.

Bacterial biofilm on peritoneal dialysis catheters: A retrospective observational study.

Biofilm formation significantly impacts infection risks in peritoneal dialysis (PD) patients. However, few studies focused on biofilms on PD catheters. This study aims to explore the formation and characteristics of bacterial biofilm on PD catheters.

Epidemiological Trends and Public Health Implications of Dengue Fever in Zhejiang Province, China: A Decadal Analysis from National to Cangnan Perspectives.

Objective: To analyze dengue fever outbreaks in China, Zhejiang Province, and a local region to provide a scientific basis for early warning surveillance and the prevention and control of dengue epidemics.

Methods: This retrospective study examines dengue fever data from China and Zhejiang Province over the past decade, including incidence, mortality, seasonal distribution, age characteristics, and regional distribution. Local data from the past decade were also analyzed.

Fluorogenic Linkage Integration for Nonfluorescent Transformations (FLINT).

Since its creation, single-molecule optical imaging has revolutionized the study of catalytic processes, yet its application largely relies on probing fluorogenic reactions. To overcome this limitation, we propose the Fluorogenic Linkage Integration for Nonfluorescent Transformation (FLINT) approach, an imaging method to resolve nonfluorogenic reactions at the single-molecule level. Using glucose oxidation as a model reaction, we coupled this nonfluorogenic reaction with a fluorogenic Amplex Red (AR) → resorufin (RF) transformation to create a cascading reaction.

A Pan-Inhibitor of Phosphate Transporters AP306 in Hemodialysis Patients.

Introduction: Hyperphosphatemia in patients undergoing dialysis is not well-controlled. AP306 is a pan-inhibitor of phosphate transporters, designed to block the active uptake of phosphate through the gastrointestinal tract.

Methods: In this phase 2 randomized, active-controlled, open-label study, hemodialysis patients with serum phosphate between 5.

Associations between iron markers with hemoglobin and outcomes in peritoneal dialysis patients: results from the PDTAP study.

Background And Hypothesis: Iron metabolism markers, such as transferrin saturation (TSAT) and ferritin, are crucial in anemia management in patients with CKD and those undergoing dialysis, yet optimal levels remain unelucidated.

Methods: We conducted a prospective multicenter cohort study using data from the nationwide Peritoneal Dialysis Telemedicine-based Management Platform (PDTAP) to analyze TSAT, ferritin, and hemoglobin (Hb) levels, and their associations with mortality in the peritoneal dialysis (PD) population.

Results: Our study included 4429 PD patients, analyzing data through restricted cubic splines and Cox regression models, adjusted for multiple confounders.

Cardiorenal Benefits of SGLT2 Inhibitors in Patients with Chronic Kidney Disease and Concomitant Hypertension.

Background: Uncontrolled hypertension is both a driver of chronic kidney disease (CKD) and a complication of the disease, as well as a risk factor for cardiovascular disease (CVD). Therefore, renal protective agents with antihypertensive properties are desirable for management of cardiorenal syndrome in CKD. Sodium-glucose cotransporter-2 (SGLT2) inhibitors are emerging as a new class of renal protective agents, with robust efficacy in delaying progression of CKD and reducing cardiovascular events.

YTHDF1/RNF7/p27 axis promotes prostate cancer progression.

Prostate cancer (PCa) is a prevalent malignant tumor of the urinary system and remains the most common cancer among males. In this study, we showed that YTHDF1, one of the reader proteins involved in the N6-methyladenosine (m6A) modification signaling pathway, is highly expressed in PCa cancerous tissues and cells, which correlates with poor clinical outcomes. Our study revealed that YTHDF1 knockdown inhibits tumor cell proliferation, migration, and xenograft tumor formation by decreasing p27 protein stability through proteasome degradation signaling.