Unveiling the Microstructure Evolution and Mechanical Strengthening Mechanisms in Mg-2Y-Zn Alloys.

This work systematically investigates the Zn-content-dependent phase evolution (1-12 at.%) and its correlation with mechanical properties in as-cast Mg-2Y-Zn alloys. A sequential phase transformation is observed with the Zn content increasing: the microstructure evolves from X-phase dominance (1-2 at.

Betanin, a Natural Product from Red Beets, Improves Endothelial Dysfunction through Activation of Autophagy.

Objective: Endothelial dysfunction is the altered pathological ability of endothelial cells to modulate the passage of cells and solutes across vessels, which underlies the development of inflammatory diseases. Betanin (betanidin-5-O-β-glucoside), a natural product rich in red beets, is a water-soluble nitrogen-containing pigment, and its potential protective effects on cardiovascular disease have been reported. In this study, we investigated the protective role of betanin in vascular endothelial dysfunction induced by TNFα and explored potential mechanisms.

A decade of vertebrate palaeontology research: global taxa distribution, gender dynamics and evolving methodologies.

Using 12 104 publications from 2014 to 2023 in the DeepBone database, this study employs bibliometric methods, including full-text latent Dirichlet allocation (LDA) modelling, co-occurrence network analysis and geographic mapping with ArcGIS, to examine three key aspects of vertebrate palaeontology development: geographic distribution of newly established taxa, gender demographics among researchers and research trends. Gender data were analysed using automated tools with manual verification to ensure accuracy, while methodological evolution was investigated through systematic text mining and classification. Among 8336 newly established taxa, mammals (34.

Effect of substituting Al with Zn on the microstructure and mechanical properties of the as-cast Mg-4Y-4Al alloy.

The effects of alloying elements (Al and Zn) on the second-phase transformation and deformation mechanisms were revealed using the microstructure characteristics, and the mechanical behaviour of Mg-4Y-(4 - x)Al-xZn was systematically investigated. The results showed that the Al‒Y phase (AlY and AlY) was formed in the Mg‒4Y‒4Al alloy. When both Al and Zn were contained, the AlZnY phase was produced, and correspondingly, as the Al-Y phase decreases.

SARS-CoV-2 E protein-induced THP-1 pyroptosis is reversed by Ruscogenin.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an emerging pathogenic coronavirus, has been reported to cause excessive inflammation and dysfunction in multiple cells and organs, but the underlying mechanisms remain largely unknown. Here we showed exogenous addition of SARS-CoV-2 envelop protein (E protein) potently induced cell death in cultured cell lines, including THP-1 monocytic leukemia cells, endothelial cells, and bronchial epithelial cells, in a time- and concentration-dependent manner. SARS-CoV-2 E protein caused pyroptosis-like cell death in THP-1 and led to GSDMD cleavage.

FDSS-Based DFT-s-OFDM for 6G Wireless Sensing.

Integrated sensing and communications (ISAC) is emerging as a key technology of 6G. Owing to the low peak-to-average power ratio (PAPR) property, discrete Fourier transform spread orthogonal frequency-division multiplexing (DFT-s-OFDM) is helpful to improve the sensing range and suitable for high-frequency transmission. However, compared to orthogonal frequency-division multiplexing (OFDM), the sensing accuracy of DFT-s-OFDM is relatively poor.

Empirical antibiotic treatment strategies for community-acquired pneumonia: a network meta-analysis.

Objectives: This network meta-analysis aimed to compare the efficacy and safety of fluoroquinolone (FQ) monotherapy, β-lactam (BL) monotherapy and β-lactam/macrolide (BL-M) combination therapy in hospitalized patients with community-acquired pneumonia (CAP).

Methods: Pubmed, Embase and the Cochrane Library were searched for randomized controlled trials (RCTs) comparing FQ monotherapy, BL monotherapy and BL-M combination therapy up to July 2021. The outcomes of interest included all-cause mortality, clinical success, microbiological success and drug-related adverse events.

Early Adolescent Social Anxiety: Differential Associations for Fathers' and Mothers' Psychologically Controlling and Autonomy-Supportive Parenting.

Although psychologically controlling and autonomy-supportive parenting are important indicators of social anxiety during early adolescence, less research has explored distinct roles of father and mother parenting, especially in interdependent-oriented culture. This 3-year longitudinal study examined the reciprocal associations between such parenting and early adolescent social anxiety from multi-informants in the Chinese context. A sample of 1,140 Chinese early adolescents (51.

Chemically Recyclable CO -Based Solid Polyesters with Facile Property Tunability.

Synthesizing chemically recyclable solid polymeric materials is a significant strategy to potentially achieve carbon neutral production of new polymers and alleviate plastic pollution, especially when the synthesis is based on CO and inexpensive co-feedstocks available in large scales. Additionally, polymeric materials should have high enough molecular weight to exhibit distinguished properties from low molar mass polymers to serve for a broader range of application scenarios. However, up to now, strategies for developing solid-state CO -based chemically recyclable polyesters with both high molecular weight and facile property tunability are still unprecedented.

Chemically recyclable polyesters from CO, H, and 1,3-butadiene.

Chemically recyclable solid polymeric materials with commercializable properties only using CO and inexpensive bulk chemicals as chemical feedstock can open a brand-new avenue to economically viable, large-scale fixation of CO over a long period of time. Despite previous great advancements, development of such a kind of CO-based polymers remains a long-term unsolved research challenge of great significance. Herein, we reported the first methodology to polymerize six-membered lactone with two substituents vicinal to the ester group (), a compound previously found to be non-polymerizable.

A computational evaluation of targeted oxidation strategy (TOS) for potential inhibition of SARS-CoV-2 by disulfiram and analogues.

In the new millennium, the outbreak of new coronavirus has happened three times: SARS-CoV, MERS-CoV, and SARS-CoV-2. Unfortunately, we still have no pharmaceutical weapons against the diseases caused by these viruses. The pandemic of SARS-CoV-2 reminds us the urgency to search new drugs with totally different mechanism that may target the weaknesses specific to coronaviruses.

Universal Anticancer Cu(DTC) Discriminates between Thiols and Zinc(II) Thiolates Oxidatively.

Aerobic organisms must rely on abundant intracellular thiols to reductively protect various vital functional units, especially ubiquitous zinc(II) thiolate sites of proteins, from deleterious oxidations resulting from oxidizing environments. Disclosed here is the first well-defined model study for reactions between zinc(II) thiolate complexes and copper(II) complexes. Among all the studied ligands of copper(II), diethyldithiocarbamate (DTC) displays a unique redox-tuning ability that enables copper(II) to resist the reduction by thiols while retaining its ability to oxidize zinc(II) thiolates to form disulfides.

Draft Genome Sequence of Rhodobacteraceae Strain PD-2, an Algicidal Bacterium with a Quorum-Sensing System, Isolated from the Marine Microalga Prorocentrum donghaiense.

Rhodobacteraceae strain PD-2 was isolated from the marine microalga Prorocentrum donghaiense. It has algicidal activity toward its host and could produce N-acylhomoserine lactone signals. Here, we present the draft genome of strain PD-2, which contains 5,227,214 bp with an average GC content of 66.