Targeting CD276 with Adapter-CAR T-cells provides a novel therapeutic strategy in small cell lung cancer and prevents CD276-dependent fratricide.

Background: Survival rates in Small Cell Lung Cancer (SCLC) remain dismal, posing a huge medical need for novel therapies. T-cells, engineered to express chimeric antigen receptors (CAR-T) have demonstrated clinical activity against a variety of haematological malignancies. Yet, efficacy against solid tumour entities remains limited.

‑Heterocyclic Carbene-Based Group 4 Catalysts for the Terpolymerization of Cyclohexene Oxide and Cyclic Anhydrides with CO.

A series of bis-phenolate saturated -heterocyclic carbene (NHC) group 4 complexes ([κ-O,C,O]-NHC)-M-(OPr)-Cl-(THF) (M = Ti, ; Zr, ; Hf, ) in the presence of [PPN]Cl as cocatalyst were investigated and showed high activity in the tandem terpolymerization of phthalic anhydride (PA), cyclohexene oxide (CHO) with CO. The resultant terpolymers revealed a diblock pattern leading selectively to poly-(ester--carbonate). Subsequently, other titanium complexes ([κ-O,C,O]-NHC)-TiX bearing various coligands (X = Cl, ; OPr, ; OAc, ; OAc, ) also displayed high activity with a turnover frequency (TOF) up to 460 h that is comparable to .

Microbiological culture versus 16S/18S rRNA gene PCR-sanger sequencing for infectious keratitis: a three-arm, diagnostic cross-sectional study.

Background: To compare the diagnostic performance of microbiological culture and 16S/18S rRNA gene polymerase chain reaction (PCR)-Sanger sequencing for infectious keratitis (IK) and to analyse the effect of clinical disease severity on test performance and inter-test concordance.

Methods: This was a three-arm, diagnostic cross-sectional study. We included all eligible patients who presented with presumed bacterial/fungal keratitis to the Queen's Medical Centre, Nottingham, UK, between June 2021 and September 2022.

Autonomous Atmospheric Water Harvesting over a Wide RH Range Enabled by Super Hygroscopic Composite Aerogels.

Sorption-based atmospheric water harvesting (SAWH) offers a sustainable strategy to address the global freshwater shortage. However, obtaining sorbents with excellent performance over a wide relative humidity (RH) range and devices with fully autonomous water production remains challenging. Herein, magnesium chloride (MgCl) is innovatively converted into super hygroscopic magnesium complexes(MC), which can effectively solve the problems of salt deliquescence and agglomeration.

A 7-year review of clinical characteristics, predisposing factors and outcomes of post-keratoplasty infectious keratitis: the Nottingham infectious keratitis study.

Background/objectives: Post-keratoplasty infectious keratitis (PKIK) is a unique sight-threatening clinical entity which often poses significant therapeutic challenges. This study aimed to examine the clinical presentation, risk factors, management, and clinical outcomes of PKIK.

Methods: This was a retrospective study of all patients who presented to the Queen's Medical Centre, Nottingham, with PKIK between September 2015 and August 2022 (a 7-year period).

An Asymmetric Hygroscopic Structure for Moisture-Driven Hygro-Ionic Electricity Generation and Storage.

The interactions between moisture and materials give rise to the possibility of moisture-driven energy generation (MEG). Current MEG materials and devices only establish this interaction during water sorption in specific configurations, and conversion is eventually ceased by saturated water uptake. This paper reports an asymmetric hygroscopic structure (AHS) that simultaneously achieves energy harvesting and storage from moisture absorption.

Plasmonic protein electricity generator.

Interest in acquiring green energy from sunlight is driving research into the incorporation of biological photosynthetic materials into biohybrid devices. A potential way to enhance solar energy conversion by photosynthetic proteins is to couple them to plasmonic nanomaterials to enhance absorption of incident radiation. In this work, a variety of plasmonic nanoparticles were used to boost the photocurrent output of a Protein Electricity Generator (PEG).

Fate of Photoinduced Electron Transfer Reactions with Temperature- and pH-Induced Assembly/Disassembly of Star Block Copolymer Micelles.

The assembly/disassembly of star block copolymers induced by changes in temperature or pH of the medium is anticipated to have interesting implications for hosting/releasing drugs and tuning chemical reactions. This study investigates the possibility of employing the dually sensitive self-assembly of an ethylene oxide-propylene oxide star block copolymer, Tetronic T904, to influence photoinduced electron transfer (ET) reactions, on switching from the assembled state (micelle) when temperature is above the critical micelle temperature (CMT) and pH of the medium is above the p of T904 to the dissociated (unimer) state when either the temperature is below the CMT or the polymer is protonated. Steady-state and time-resolved fluorescence techniques have been used to characterize the microenvironments of the reactants in T904 solutions under different temperature and pH conditions and to determine ET rate constants.

Solar-Driven Gas-Phase Moisture to Hydrogen with Zero Bias.

Band structure engineering offers a perfect route to tune the transport properties of electrons and holes independently, especially in semiconductors for water splitting. Here, we explore the possibility of achieving a bias-free single-step solar to chemical energy conversion using gas-phase moisture as the reactant while generating hydrogen as the reaction product. A metal-based superhygroscopic hydrogel scavenges moisture from the ambient environment and serves as the water source.

Shadow enhanced self-charging power system for wave and solar energy harvesting from the ocean.

Hybrid energy-harvesting systems that capture both wave and solar energy from the oceans using triboelectric nanogenerators and photovoltaic cells are promising renewable energy solutions. However, ubiquitous shadows cast from moving objects in these systems are undesirable as they degrade the performance of the photovoltaic cells. Here we report a shadow-tribo-effect nanogenerator that hybrids tribo-effect and shadow-effect together to overcome this issue.

Unsaturated and Benzannulated -Heterocyclic Carbene Complexes of Titanium and Hafnium: Impact on Catalysts Structure and Performance in Copolymerization of Cyclohexene Oxide with CO.

Tridentate, bis-phenolate -heterocyclic carbenes (NHCs) are among the ligands giving the most selective and active group 4-based catalysts for the copolymerization of cyclohexene oxide (CHO) with CO. In particular, ligands based on imidazolidin-2-ylidene (saturated NHC) moieties have given catalysts which exclusively form polycarbonate in moderate-to-high yields even under low CO pressure and at low copolymerization temperatures. Here, to evaluate the influence of the NHC moiety on the molecular structure of the catalyst and its performance in copolymerization, we extend this chemistry by synthesizing and characterizing titanium complexes bearing tridentate bis-phenolate imidazol-2-ylidene (unsaturated NHC) and benzimidazol-2-ylidene (benzannulated NHC) ligands.

Carbon Nanotube Reinforced Strong Carbon Matrix Composites.

As an excellent candidate for lightweight structural materials and nonmetal electrical conductors, carbon nanotube reinforced carbon matrix (CNT/C) composites have potential use in technologies employed in aerospace, military, and defense endeavors, where the combinations of light weight, high strength, and excellent conductivity are required. Both polymer infiltration pyrolysis (PIP) and chemical vapor infiltration (CVI) methods have been widely studied for CNT/C composite fabrications with diverse focuses and various modifications. Progress has been reported to optimize the performance of CNT/C composites from broad aspects, including matrix densification, CNT alignment, microstructure control, and interface engineering, .

Self-powered all weather sensory systems powered by Rhodobacter sphaeroides protein solar cells.

Natural photosynthetic proteins can convert solar energy into electrical energy with close to 100% quantum efficiency, and there is increasing interest in their use for sustainable photoelectrochemical devices. The primary processes of photosynthesis remain operational and efficient down to extremely low temperatures, and natural photosystems exhibit a variety of self-healing mechanisms. Herein we demonstrate the use of an amphiphilic triblock copolymer, Pluronic F127, to fabricate a self-healing photosynthetic protein photoelectrochemical cell that operates optimally at sub-zero temperatures.

Hexavalent chromium sequestration from electronic waste by biomass of .

The idea of eliminating noxious metal ions from electronic waste contaminated water has led to the use of the metal adsorbing ability of biological matter. The principle of an ion exchanger of biological origin is the key in exhibiting this metal binding feature of microbial biomass. In this study, dead biomass of was immobilized using sodium alginate and tested as a biosorbent for hexavalent chromium elimination from effluent.

Hydro-Assisted Self-Regenerating Brominated N-Alkylated Thiophene Diketopyrrolopyrrole Dye Nanofibers-A Sustainable Synthesis Route for Renewable Air Filter Materials.

With rising global concerns over the alarming levels of particulate pollution, a sustainable air quality management is the need of the hour. Air filtration research has gained momentum in recent years. However, the research perspective is still blinkered toward formulating new fiber systems for the energy-intensive electrospinning process to fabricate high quality factor air filters.

Portable Trilayer Photothermal Structure for Hybrid Energy Harvesting and Synergic Water Purification.

Many exciting developments have unfolded on the recently emerged research topic of solar-driven interfacial evaporation, which is a promising technology for water purification. However, the sole heat source, i.e.