Platinum/nitrogen-co-doped TiO as photocatalyst and light-free catalytic adsorbent for gaseous formaldehyde.

Platinum and nitrogen co-doped titanium dioxide (Pt/N-TiO, with 1 wt% Pt and an N/Ti molar ratio of 1) has been synthesized. This Pt/N co-doping strategy creates Schottky junctions, reduces the bandgap energy (3.25 to 2.

Metagenomic profiling of gut microbime: associating their role with the advancement of diabetic nephropathy.

Emerging evidence suggests that alterations in the gut microbiome should play a critical role in the development and progression of type 2 diabetes and its complication such as diabetic nephropathy (DN). Nevertheless, a considerable gap remains in our understanding of the interconnection between DN pathogenesis and gut microbiota arrangement. In this context, this review highlights recent research on the connection between the intestinal microbiota and DN risk, with a particular focus on the role of microbial metabolites in disease development.

Anti- Compounds of Hance Branch.

Hance (Viburnaceae), the Korean elderberry, is widely used in herbal medicine and in the food industry. It is known to have various pharmacological effects, including antitumor, antioxidant, anti-inflammatory, and antimicrobial activities. During our search for anti- compounds from natural resources, the methanol extract of the branch significantly inhibited the growth of .

Bioactive Phenolics from Vinegar-Egg Accelerates Acute Wound Healing by Activation of Focal Adhesion and Mitogen-Activated Protein Kinase Signaling.

Background/objectives: Vinegar-egg is a traditional health-promoting beverage prepared by soaking eggs in vinegar. While both eggs and vinegar are common dietary components with well-documented nutritional and pharmacological activities, eggs treated with vinegar have been rarely studied. This study aims to identify and characterize bioactive compounds in vinegar-egg and investigate their potential wound-healing activities.

APOE-high myeloid cells are uniquely associated with metastatic intrathoracic lymph nodes obtained by EBUS-TBNA in primary lung cancer.

The draining lymph node (LN) is the most frequent and often first site of cancer metastasis. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is frequently performed as a standard practice in lung cancer diagnosis and staging, its diagnostic accuracy remains modest, primarily due to the minuscule sample size of needle aspirates. With the advent of single-cell technologies, we comprehensively analyzed the immune cell repertoire in a series of EBUS-TBNA samples.

Roridin E and satratoxin H, macrocyclic trichothecene mycotoxins, induce endoplasmic reticulum stress-dependent apoptosis through ribosome interaction in B16 mouse melanoma cells.

Podostroma cornu-damae, commonly known as the red deer's horn mushroom, is a highly toxic species responsible for severe poisonings characterized by vomiting, diarrhea, dehydration, impaired consciousness, and potentially death. This mushroom is notorious for its content of macrocyclic trichothecene mycotoxins. In our ongoing research aimed at discovering bioactive natural compounds, we isolated thirteen macrocyclic trichothecene mycotoxins (P1-P13) from the methanol extract of a plate culture of P.

HPLC-ESI-HRMS/MS-Based Metabolite Profiling and Bioactivity Assessment of .

A comprehensive metabolic profiling of (L.) G. Don was performed using tandem mass spectrometry, along with an evaluation of the biological activities of its various solvent extracts.

The smoking of heat-not-burn (HNB) cigarette products and its effects on indoor air quality.

In this research, the concentration levels of volatile organic compounds (VOCs) are monitored in a designated smoking booth using heat-not-burn (HNB) cigarettes (in reference to 1R6F cigarette) with controlled variables of number of cigarettes smoked (1, 3, and 6 cigarettes), booth ventilation (closed vs. open), and time after the release of cigarette smoke (T = 0, T = 5, T = 10, and T = 20 min)). The total VOC concentration (TVOC) released from an HNB cigarette is compared as a collective group (TV) and as three individual subgroups (TV: TV for 14 standardized VOCs (G), TV for 17 reference VOCs (G), and TV for 10 carbonyl compounds (CCs: G).

Anti-adipogenic effects of -acetyltyramine from termite-associated sp. M45.

Obesity remains a global health challenge, and novel small-molecule modulators of adipogenesis are urgently needed. Here, we investigated the anti-adipogenic potential of metabolites isolated from termite-associated sp. M45.

Extra Positive Air Pressure to Prevent Microbial Contamination in Dental Handpieces: An Experimental Study.

Objectives: This study aims to evaluate the effect of applying extra positive air pressure (AP) in dental handpieces (HPs) on preventing external bacterial penetration.

Materials And Methods: To investigate the suck-back phenomenon during HP operation, we examined the correlation between AP variations and the occurrence of suck-back under controlled conditions. To assess the suck-back phenomenon during HP operation, AP changes were evaluated by monitoring water displacement using a glass tube or a manometer.

Effects of antimicrobial preservatives on protein folding stability and subvisible particle formation in monoclonal antibody trastuzumab.

To prevent microbial contamination, antimicrobial preservatives need to be added in multi-dose biopharmaceuticals; however, it often introduces risks to protein stability, potentially compromising therapeutic efficacy. In this study, we investigated the effects of different preservatives (benzyl alcohol, m-cresol, phenoxyethanol, and benzalkonium chloride) on the biophysical stability of trastuzumab, a monoclonal antibody widely used for treatment of HER2 receptor-positive cancers. Among the preservatives tested, benzyl alcohol (1.

Comprehensive Investigation of Polymorphic Stability and Phase Transformation Kinetics in Tegoprazan.

Tegoprazan (TPZ) is a potassium-competitive acid blocker (P-CAB) used to treat conditions such as gastroesophageal reflux disease, peptic ulcer, and infection. It exists in three solid forms: amorphous, Polymorph A, and Polymorph B. This study investigates the molecular basis of polymorph selection, focusing on conformational bias and solvent-mediated phase transformations (SMPTs).

Oral Metronomic Delivery of Atorvastatin and Docetaxel via Transporter-Targeted Nanoemulsions Enhances Antitumor Efficacy and Immune Modulation in Colon Cancer.

: This study aimed to enhance the oral delivery and therapeutic synergy of atorvastatin (AT) and docetaxel (DT) through a metronomic schedule using a transporter-targeted nanoemulsion (NE), with the goal of improving antitumor efficacy and immune modulation. : AT and DT were co-encapsulated in a NE system (AT/DT-NE#E) incorporating deoxycholic acid-DOTAP (D-TAP), biotin-conjugated phospholipid (Biotin-PE), and d-α-tocopherol polyethylene glycol succinate (TPGS) to exploit bile acid and multivitamin transport pathways and inhibit P-glycoprotein efflux. The optimized NE was characterized physicochemically and evaluated for permeability in artificial membranes and Caco-2/HT29-MTX-E12 monolayers.

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor-Microenvironment-on-a-Chip.

The efficacy evaluation of anticancer drugs derived from natural products has traditionally relied on animal models, highlighting the need for more efficient preclinical assessment platforms. In this study, a binary tumor-microenvironment-on-a-chip (T-MOC) system is introduced to assess the therapeutic potential of illudin S and roridin E, two cytotoxic compounds derived from Omphalotus japonicus and Podostroma cornu-damae, respectively. The binary T-MOC model integrates independently developed vascular and invasive ductal carcinoma compartments, effectively mimicking in vivo drug delivery barriers and physiological dynamics.

Ultrathin K-doped g-CN/BiOBr heterojunctions with S-scheme charge transfer for efficient photodegradation of tetracycline.

Residual tetracycline (TC) in aquatic ecosystems poses a significant risk to the health of both flora and fauna. Advanced catalysts with strong photocatalytic capabilities have emerged as a promising solution for not only TC degradation but also water purification. Here, the photocatalytic destruction (PCD) of TC has been investigated using ultrathin potassium-doped g-CN/BiOBr heterojunctions (KCNx/By, where x and y are the percent mass ratio values of KOH/melamine and KCN/BiOBr, respectively).

Nanomaterials-mediated electrochemical detection of neutrophil gelatinase-associated lipocalin for chronic kidney disease: Advances, challenges, and future prospects.

Chronic kidney disease (CKD) is characterized by a gradual and permanent deterioration in kidney function, resulting in disruption of the body's internal balance. Traditional diagnostic methods based on serum metabolites often suffer from inaccuracy for CKD diagnosis due to interference from factors such as age, gender, and comorbidities. Neutrophil gelatinase-associated lipocalin (NGAL) is considered an effective clinical marker for early and reliable CKD diagnosis due to its rapid elevation in both serum and urine following renal tubular injury.

Activation of cryptic biosynthetic pathways in Saccharopolyspora spinosa through deletion of the spinosyn gene cluster: induction of cryptic and bioactive natural products.

Saccharopolyspora spinosa, a member of the Pseudonocardiaceae family, was originally isolated from soil in the Virgin Islands and is renowned for producing spinosad, a broad-spectrum insecticidal secondary metabolite. While research on S. spinosa has historically focused on spinosad production, little is known about the broader spectrum of secondary metabolites encoded by its genome.

The viability of mildly oxidized microporous carbons for adsorptive removal of gaseous aromatic hydrocarbons in humid air.

The adsorption efficacy of commercial activated carbon (AC) toward volatile organic compounds (VOCs) is generally impeded by the presence of moisture under real environmental conditions. To address this limitation, surface modification strategies such as oxidative treatments are employed to enhance the hydrophilicity of AC. In this study, coconut shell-based AC (CSAC) is subjected to mild hydrogen peroxide (HO) oxidation at 100 and 125 °C, producing samples labeled as CSAC100 and CSAC125, respectively.

A review of deoxyribonucleic acid-based single-nucleotide polymorphisms in diabetic kidney disease among Asian populations: Challenges and future directions.

Diabetic kidney disease (DKD) is a persistent disorder that occurs as a result of long-term diabetes mellitus with genetic and environmental risk factors. The identification of DKD associated single-nucleotide polymorphisms (SNPs) is pivotal for patient screening. This manuscript briefly outlines the pathophysiology and the role of genetic factors in DKD expansion.

Recent advances in nanomaterial-based adsorbents for removal of pharmaceutical pollutants from wastewater.

To cope with the environmental risks posed by pharmaceutical waste, adsorption is considered a viable option due to its simplicity, cost-effectiveness, and reliability. This review explores the opportunities and challenges involved in applying nanomaterial-based adsorbents in their metallic, non-metallic, and hybrid forms for removal of common pharmaceuticals (, antibiotics, beta-blockers, analgesics, non-steroidal anti-inflammatory drugs, endocrine disrupters, and anticancer drugs) from water. To improve the selectivity and scalability of diverse adsorbents against such targets, the adsorption capacity and partition coefficient (PC) of each adsorbent are evaluated.

Lambertianic Acid from Inhibits Muscle Atrophy in Dexamethasone-Induced C2C12 Muscle Atrophy Cells.

, an evergreen tree belonging to the Cupressaceae family, has been traditionally used to treat various ailments, including fever, cough, diarrhea, diuresis, cold symptoms, and gastrointestinal disorders in folk medicine. As part of our ongoing investigation aimed at discovering bioactive natural products and elucidating their mechanisms of action from various natural sources, we investigated a methanol (MeOH) extract of leaves. This investigation led to the isolation and identification of a labdane-type diterpene, lambertianic acid (LA), via column chromatography and HPLC purification.

Titanium carbide MXene/anatase titanium dioxide-supported gold catalysts for the low-temperature oxidation of benzene in indoor air.

In the present study, the oxidative removal of benzene (model carcinogenic aromatic volatile organic compound (VOC)) from indoor air is investigated using titanium carbide (TiC) MXene/anatase titanium dioxide (TiO)-supported gold (Au) catalysts under dark and low-temperature (DLT: 30-90 °C) conditions. The reduction pre-treatment (catalyst labelled with the 'R' suffix) has been used to form metallic Au (Au) nanoparticles and anatase TiO in the MXene structure. The relative ordering in the Au catalysts, if assessed in terms of room-temperature (RT) benzene (5 ppm) conversion (X (%)) at 10,191 h gas hourly space velocity, is found as: 0.

Nanoarchitectonics in colloidal hydrogels: Design and applications in the environmental and biomedical fields.

The concept of nanoarchitectonics, derived from the science of nanoarchitecture, has driven the development of advanced colloidal hydrogels with enhanced functionalities for a wide range of applications. This review explores technological perspectives of nanoarchitectonics, especially in regard to colloidal hydrogels. Nanoarchitectonics applied to colloidal hydrogels allows nanoscale control over the structure and functionality of hydrogels to impart dynamic properties such as stimuli-responsiveness, controlled release, and enhanced mechanical strength.

Erythromycin Stress Upregulates Antiangiogenic Metabolites in the Gut Bacterium .

The interplay among antibiotics, gut microbiota, and disease pathogenesis remains poorly understood, particularly in the context of rare gut bacteria. This study identifies a novel correlation between erythromycin-induced stress and the production of antiangiogenic metabolites in , a human gut bacterium. We report the isolation and structural characterization of aneuristatin (), a metabolite featuring a unique pyrrolo[1,2-]pyrazine scaffold, along with seven structurally related metabolites (-) from ATCC 12856.

Optimal Timing of Surgery After Insertion of Self-Expandable Metallic Stent to Obstructive Colorectal Neoplasm as a Bridge to Surgery.

Background And Aims: Colonic stenting using self-expandable metallic stents (SEMS) as a bridge to surgery offers an effective alternative to emergency surgery for the management of malignant colorectal obstruction. However, the optimal timing of elective surgery after stenting remains controversial.

Methods: This retrospective multicenter cohort study analyzed 380 patients with obstructive colorectal cancer who were treated with SEMS as a bridge to surgery.